Mahmoud Emam

Mahmoud Emam
National Research Center, Egypt | NRC · Department of Phytochemistry and Plant Systematics

Doctor of Philosophy (Natural Products Chemistry)

About

29
Publications
5,177
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282
Citations
Additional affiliations
January 2011 - September 2017
National Research Center, Egypt
Position
  • Researcher

Publications

Publications (29)
Article
Context: Hyperglycaemia plays an important role in the development of non-alcoholic fatty liver disease, which is a common complication in diabetics. Objective: The present study aimed to investigate the chemical composition and the efficacy of Commiphora opobalsamum stem bark butanol fraction in ameliorating liver injury associated with diabete...
Article
Full-text available
In this study, the n-hexane fraction of soft coral Nephthea sp. gathered from the Red Sea was evaluated for its antidermatophyte activity. The antidermatophyte activity was performed versus different fungi, including Microsporum canis, Trichophyton gypseum, and Microsporum mentagrophytes, using a broth microdilution method. The n-hexane fraction sh...
Article
The present study successfully investigated the green synthesis of silver nanoparticles (Ag NPs) using the methanolic extract of the aerial parts of Lavandula coronopifolia. The formation of Ag NPs was confirmed through color change as well as the UV/visible spectra. Further, characterizations were achieved using Fourier Transforms infrared spectro...
Article
Green chemistry‐based bio‐waste has been taken attention toward new components for many applications especially in dermatophytes of animals and humans. The main goal of this study to assist the synthetic pathways, clean and large‐scale synthesis of silver nanoparticles are achieved as promising alternative green techniques with high efficiency, sim...
Article
Full-text available
The deadliest insect, Culex pipiens, plays a critical role in the transmission of multiple diseases to livestock, animals, and humans. In the current work, the waste of Mangifera indica (Mango) seed kernels was extracted with ethyl acetate to profile the gallotannins components. Moreover, the major compounds pentagalloyl glucose (PGG) and mangiferi...
Article
In the present study, the essential oils of Melaleuca bracteata, Melaleuca styphelioides, Melaleuca nesophila, Melaleuca leucadendra, and Melaleuca ericifolia were analyzed via headspace gas chromatography/ mass spectrometry (HS-GC/MS). A consecutive molecular network was constructed via the GNPS (Global Natural Products Social Molecular Networking...
Article
Full-text available
Infections associated with the emergence of multidrug resistance and mosquito-borne diseases have resulted in serious crises associated with high mortality and left behind a huge socioeconomic burden. The chemical investigation of Lavandula coronopifolia aerial parts extract using HPLC–MS/MS led to the tentative identification of 46 compounds belon...
Article
Full-text available
Background The plant kingdom is considered one of the most common sources for structural and biological diversity. In particular, the wild category acquires our attention to investigate the phytochemical and the biological evaluations. Methods Dobera glabra was exposed to phytochemical examination using HPLC-ESI-MS analysis. Furthermore, the anti-...
Article
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Gut microbial β-glucuronidase (GUS) is a potential therapeutic target to reduce gastrointestinal toxicity caused by irinotecan. In this study, the inhibitory effects of 17 natural cinnamic acid derivatives on Escherichia coli GUS (EcGUS) were characterised. Seven compounds, including caffeic acid ethyl ester (CAEE), had a stronger inhibitory effect...
Article
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In this study, the aerial parts of Moricandia sinaica were evaluated for their in vivo analgesic, anti-inflammatory and antipyretic activities. The analgesic activities were examined using acetic acid-induced writhing, the hot plate test and the tail flick method. The anti-inflammatory and the antipyretic activities were evaluated using carrageenan...
Preprint
Full-text available
Green silver nanoparticles (AgNPs) utilize companionable nanomaterials for investigative and therapeutic determinations. The existing study reports the synthesis of AgNPs using Glinus lotoides L. aqueous methanol extract (GLE) besides evaluation of anticancer and antiviral effects of GLE and its synthesized AgNPs (GLE_AgNPs). The formation of GLE_A...
Article
Full-text available
Elkhateeb WA, Daba GM, Elnahas MO, Thomas PW, Emam M. 2020. Metabolic profile and skin-related bioactivities of Cerioporus squamosus hydromethanolic extract. Biodiversitas 21: 4732-4740. Being a functional food capable of showing nutritional as well as medicinal properties have great attention. Mushrooms have been proven as leading targets in this...
Article
Full-text available
Marine microorganisms have drawn great attention as novel bioactive natural product sources, particularly in the drug discovery area. Using different strategies, marine microbes have the ability to produce a wide variety of molecules. One of these strategies is the co-culturing of marine microbes; if two or more microorganisms are aseptically cultu...
Article
Vibrio harveyi is a marine bacterial pathogen which infects a wide range of marine organisms and results in severe loss. Antibiotics have been used for prophylaxis and treatment of V. harveyi infection. However, antibiotic resistance is a major public health threat to both human and animals. Therefore, there is an urgent need for novel antimicrobia...
Article
Full-text available
Cancer is one of the leading causes of death all over the world. Colorectal cancer, and breast cancer are responsible for about 1.5 million deaths in 2018 only. Searching for promising sources of anticancer compounds is a matter of life and death. Actinomycetes are attracting continuous attention due to their ability to produce variety of natural b...
Article
Full-text available
Lichens have recently received great attention due to their pharmacological potentials. The antigenotoxic potential of C. vitellina extract (25 and 50 µg/mL) was assessed in normal human peripheral blood lymphocytes (HPBL) against Mitomycin C (MMC) co-treatments. Flow cytometric analyses of cell cycle distribution, as well as apoptosis (Annexin V/P...
Article
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Screening for sources of biologically active compounds capable of treating cancer is the main target of many researches nowadays. The anticancer as well as antifungal activities of the methanolic extracts of 4 microalgae (Spirulina maxima, Chlorella salina, Nannochloropsis oceanica, and Nannochloropsis oculata) were investigated. Among the microalg...
Poster
Full-text available
Colon-rectal cancer, and breast cancer are responsible for about 1.5 million deaths in 2018 only. Actinomycetes are attracting continuous attention due to their ability to produce variety of natural bioactive metabolites. Screening for novel actinomycetes isolates was conducted from soil mixed with bat faeces collected from a remote cave located ne...
Article
The bio potential behavior of green silver nanoparticles (AgNPs) using Acalypha wilkesiana flowers extract weas evaluated. The AgNPs formed were confirmed using surface plasmon resonance band showed in UV–vis spectrophotometer that characterized with spherical shape in size range from 5 to 45 nm depending on Transmission electron microscopy (TEM) a...
Article
Punica granatum peel (PGP) is widely used in traditional medicinal purposes for chronic wounds owing to containing natural phenolics active components. In current study, active wound dressing hydrogel for chronic wound healing was prepared based on P. granatum peel crude extract (PGPC), ethyl acetate fraction (PGPEA) and their silver nanoforms (Ag-...
Article
The bioactive components of the hydroalcoholic (MeOH 70%) Punica granatum peel crude extract (PGPC) and its methanol fraction (PGPM) were extracted and tentatively identified by LCMS/MS as a number of phenolic compounds which are used as capping agents fasting the reduction of Ag ⁺ to Ag (0) . The prepared silver nano-particles Ag NPs PGPC and Ag N...
Article
Full-text available
A hitherto unknown polyoxygenated flavonol robinobioside (gossypetin-3-O-β-d-robinobioside) was isolated from the leaves of Caesalpinia gilliesii along with thirteen known phenolic secondary metabolites. The isolated compounds were characterized using spectroscopic analysis, including 1D and 2D NMR and mass spectrometry (MS) analyses. The extract r...
Article
To investigate the antioxidant activity and the total phenolic contents of the hydroalcholic extract of Caesalpinia gilliesii leaves and its subfractions, dried powder of C. gilliesii leaves was extracted with 70 % MeOH. The received extract was partitioned to produce n-hexane, n-butanol and residual water subfractions. The obtained antioxidant act...
Article
Rice straw and husk are one of the major agricultural wastes in Egypt, which cause problems for farmers. Hemicellulose is considered one of the major components of straw and husk lignocellulosic biomass. The new methods and techniques for hemicellulose extraction from renewable with low cost and their modification to produce a promising value-added...
Article
Full-text available
Food safety is one of the major concerns due to threatening human health by various foodborne pathogens. The main objective of our study is to investigate the effect of green synthesis of silver nanoparticles (AgNPs) using Acalypha wilkesiana seeds ethyl acetate extract on antimicrobial activity against some pathogenic bacteria and mycotoxigenic fu...
Article
Full-text available
Green synthesis of silver nanoparticles using Caesalpinia gilliesii (Hook) leaves extract (70% MeOH) for the first time as a reducing agent were investigated for their antimicrobial and cytotoxic activity (using the MTT assay). After exposing the oxidizing agent of silver ions to C. gilliesii leaves extract, the rapid reduction in the solution is o...
Article
Full-text available
Staphylococcus aureus is a multidrug resistant Gram positive pathogen employing cyclic peptide-mediated quorum sensing (QS) system, termed agr which regulate the expression of a series of virulence genes including bacterial hemolytic activity. To identify quorum sensing inhibitors (QSIs) that target agr and also biofilm formation, random screening...

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