• Home
  • Mahmoud M.A. Elsayed
Mahmoud M.A. Elsayed

Mahmoud M.A. Elsayed
Faculty of Pharmacy,Sohag University · Pharmaceutics and Clinical Pharmacy

Professor

About

38
Publications
10,048
Reads
How we measure 'reads'
A 'read' is counted each time someone views a publication summary (such as the title, abstract, and list of authors), clicks on a figure, or views or downloads the full-text. Learn more
312
Citations
Additional affiliations
October 2016 - present
Sohag University
Position
  • Head of Faculty
Description
  • Head of Department of Pharmaceutics and Clinical Pharmacy
Education
May 2002 - February 2021
Sohag University, Faculty of Pharmacy
Field of study
  • Pharmacy

Publications

Publications (38)
Article
Full-text available
Emulsification/internal gelation has been suggested as an alternative to extrusion/external gelation in the encapsulation of several compounds including non-steroidal anti-inflammatory drugs such as diclofenac sodium. The objective of the present study was a trial to formulate diclofenac sodium as controlled release microparticles that might be adm...
Article
Full-text available
This study was designed to evaluate the suitability of Pluronic F-127, different grades of Carbopol and cellulosic polymers as gel bases containing tolmetin, a non-steroidal anti-inflammatory drug. In vitro release characteristics, effect of enhancers, viscosity and the mechanism of drug release for different gel bases was studied as well as the an...
Article
Full-text available
Tolmetin sodium (TLM) is a non-steroidal anti-inflammatory drug (NSAIDs). TLM is used to treat inflammation, skeletal muscle injuries, and discomfort associated with bone disorders. Because of the delayed absorption from the gastro intestinal tract (GIT), the currently available TLM dosage forms have a rather protracted start to the effect, accordi...
Article
Full-text available
Background: Hepatitis B virus (HBV) infection is increasing globally, posing a serious public health problem. Hepatitis B virus (HBV) infection and mortality are among the leading causes of death worldwide. Concerns for public health are amplified by the fact that about a third of the world's population is afflicted with HBV. HBV infection may resu...
Article
Full-text available
Skin is the largest mechanical barrier against invading pathogens. Following skin injury, the healing process immediately starts to regenerate the damaged tissues and to avoid complications which usually include colonization by pathogenic bacteria leading to fever and sepsis, which further impairs and complicates the healing process. So, there is a...
Article
The present study planed to develop new fast dissolving tablets (FDTs) of torsemide. Solid dispersions (SDs) of torsemide and sorbitol (3:1) or polyvinylpyrrolidone (PVP) k25 were prepared. The prepared SDs were evaluated for in-vitro dissolution. Fourier transform infrared spectroscopy and differential scanning calorimetry for SDs revealed no drug...
Article
Full-text available
Luteolin (LUT) is a natural flavonoid with low oral bioavailability with restricted clinical applications due to its low solubility. LUT shows significant anti-tumor activity in many cancer cells, including hepatocellular carcinoma (HCC). The most recent trend in pharmaceutical innovations is the application of phospholipid vesicles to improve the...
Article
Full-text available
Article Tolmetin sodium (TS) is a powerful non-steroidal mitigating drug for the treatment of rheumatoid joint inflammation, osteoarthritis, and adolescent rheumatoid joint pain. In addition to its gastrointestinal (GIT) problems, TS has a short biological half-life (1 hr). In a trial to overcome these side effects and control the rate of (TS) rele...
Conference Paper
Full-text available
This study aims to give a comprehensive study of bioavailability enhancement of Etodolac (ETD) by improving its solubility and dissolution rate. ETD is a preferential COX-2 inhibitor. It has anti-inflammatory, analgesic, and anti-pyretic properties. Like other non-steroidal anti-inflammatory drugs (NSAIDs), long-term use of EDL causes gastric irrit...
Article
Full-text available
Colorectal cancer (CRC) is the third major cause of morbidity and mortality worldwide. Hence, many strategies and approaches have been widely developed for cancer treatment. This work prepared and evaluated the antitumor activity of 5-Flurouracil (5-Fu) loaded chromium nanoparticles (5-FuCrNPs). The green biosynthesis approach using Harpullia (H) p...
Article
Full-text available
This work aims to evaluate the effect of environmental factors, including temperature, humidity, and light, on the quality of a drug substance or a formulated product which is utilized for prediction of its shelf life, to determine proper storage conditions and to suggest labeling instructions. Moreover, the data generated during the stability test...
Article
Full-text available
Purpose Niosomes as vesicular frameworks are novel methods of delivering a drug in a sustained manner to enhance its bioavailability and get therapeutic effect over a longer period time. This study conclusively demonstrates the preparation, characterization, and optimization of sustained release ketorolac tromethamine (KT) niosomal organogels to en...
Article
Full-text available
Propolis is a honeybee product that contains a mixture of natural substances with a broad spectrum of biological activities. However, the clinical application of propolis is limited due to the presence of a myriad of constituents with different physicochemical properties, low bioavailability and lack of appropriate formulations. In this study, a mo...
Article
Full-text available
Objective: The aim of this study is to prepare floating hollow microspheres encapsulating Sorafenib (SFN) to enhance its oral bioavailability. Methods: Gastro-floating hollow adhesive microspheres containing SFN were produced by using an emulsion solvent evaporation technique with ether and ethanol as solvents. Ethyl cellulose and carbopol 934P wer...
Article
Full-text available
Purpose: Over the past 30 years, no consistent survival benefits have been recorded for anticancer agents of advanced hepatocellular carcinoma (HCC), except for the multikinase inhibitor sorafenib (Nexavar®), which clinically achieves only ~3 months overall survival benefit. This modest benefit is attributed to limited aqueous solubility, slow dis...
Article
Full-text available
The present study planed to develop new fast dissolving tablets (FDTs) of torsemide. Solid dispersions (SDs) of torsemide and sorbitol (3:1) or polyvinylpyrrolidone (PVP) k25 were prepared. The prepared SDs were evaluated for in-vitro dissolution. Fourier transform infrared spectroscopy and differential scanning calorimetry for SDs revealed no drug...
Article
Full-text available
Torsemide (1-(1-Methylethyl)-3-[[4-[(3 methyl phenyl) amino] pyridin-3-yl] sulphonyl] urea) is an insoluble loop diuretic drug. Torsemide (TSM) is used for the treatment of oedema associated with heart failure, including pulmonary oedema, and with renal and hepatic disorders. It is also used in the treatment of hypertension, either alone or in comb...
Article
Full-text available
The main objective of this study is the preparation of different topical formulations of controlled release niosomal gel containing Ketorolac tromethamine (KT) niosomes to avert problems associated with KT such as gastrointestinal irritation and short half-life. Niosomes as a colloidal carrier of KT were prepared by ether injection method then inco...
Article
Full-text available
The objective of this work was to use a full factorial design and response surface methodology to optimize and prepare fast disintegrating tablets of Itopride hydrochloride (ITOHCl). Tablets were prepared by direct compression technique and evaluated for their drug content, weight variation, hardness, friability, wetting, disintegration time, and i...
Poster
Full-text available
Niosomes have been reported to deliver the drug at a lower concentration over prolonged period of time to the target site and so reducing the potential dose related side effects. The purpose of the present study was to prepare, characterize and optimize Ketorolac Tromethamine (KT) niosomes for topical applications. This could be achieved by using e...
Poster
Full-text available
Eudragit RL100 films containing piroxicam 4 % (w/w of polymer) were prepared and investigated as potential drug delivery systems for the controlled release purpose. Effect of different plasticizers such as glyceryltributyrate (GTB), glyceryl triacetate (GTA), propylene glycol (PG) and polyethylene glycol 400 (PEG 400) on the drug release from the m...
Conference Paper
In this work we develop a novel passive structure whose unit cell incorporates a passive electromagnetic diode and chiral metamaterial structure to break the system's symmetry and achieve Faraday-like rotation with no need for magnetic bias.
Article
We suggest a principle for isolation of circularly polarized waves in magnetically active extreme-parameter metamaterials. Using theoretical analysis and numerical simulations, we show that metamaterials with extreme parameters, such as epsilon-near-zero materials (ENZ), when merged with magneto-optical materials, become transparent for forward cir...
Article
Full-text available
The purpose of this study was to prepare and characterize controlled release ketorolac tromethamine microparticles. To achieve this goal, Eudragit RS100 microparticles loaded by ketorolac tromethamine were prepared by the emulsion solvent evaporation method. The prepared ketorolac tromethamine microparticles were evaluated for their production yiel...
Article
Full-text available
The purpose of this study was to prepare and characterize controlled release ketorolac tromethamine microspheres. To achieve this goal, cellulose acetate butyrate microspheres loaded by ketorolac tromethamine were prepared by the emulsion solvent evaporation method. The prepared ketorolac tromethamine microspheres were evaluated for their productio...
Article
Full-text available
In a trial to delay the release rate of diclofenac sodium from alginate coated microcapsules, the use of a copolymer was suggested. Mixtures of polymers can have a significant properties than that of individual polymer to achieve sustained release microcapsules. On considering the negative charge of alginate and its ability to form polyionic comple...
Article
Full-text available
Piroxicam is a potent nonsteroidal anti-inflammatory drug associated with many side effects when taken orally. An attention was paid in this work to formulate and characterize piroxicam containing polymer films for dermal use. The used polymers were Eudragit types namely Eudragit RL100, RS100, L100 and Eudragit S100. In this study, medicated films...
Article
Full-text available
The aim of this study was the preparation of diclofenac sodium microcapsules using cellulose acetate as a polymer and polyvinyl acohol as an emulsifying agent by solvent evaporation technique. Preliminary experiments were carried out to determine practically the volume range of both the external phase, the internal organic phase, the concentration...

Network

Cited By

Projects

Projects (3)
Project
Design and Optimization of new Nanomedicines for treatment of different cancer types