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Mahmood Khaksary

Mahmood Khaksary

Professor. Anatomical Sciences Research Center. Institute for Basic Sciences. Kashan University of Medical Sciences. Kashan. Iran;Department of Anatomy and Embryology, Faculty of Veterinary Medicine, Shahid Chamran University of Ahvaz, Ahvaz, Iran

About

80
Publications
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396
Citations
Citations since 2016
43 Research Items
325 Citations
2016201720182019202020212022020406080100120
2016201720182019202020212022020406080100120
2016201720182019202020212022020406080100120
2016201720182019202020212022020406080100120

Publications

Publications (80)
Article
Gene therapy can be used as a cancer therapy by affecting signaling networks participating in the aggressive behavior of tumors. Small interfering RNA (siRNA) is a genetic tool employed for gene silencing. The siRNA molecules have a length of 21–22 nucleotides, and are synthetic, short non-coding RNAs. The siRNA molecule should be loaded into the R...
Article
Mentha spicata L. essential oil (MsEO) is consumed in Iranian medicine for pharmaceutical and nutraceutical purposes. No reports are available on MsEO effects on gestation and exposed fetuses as the aim of this study. At gestational days (GD), thirty-five rats were divided into seven groups: control, vehicle, and five MsEO-treated groups. The MsEO...
Article
Full-text available
The identification of agents that can reverse drug resistance in cancer chemotherapy, and enhance the overall efficacy is of great interest. Paclitaxel (PTX) belongs to taxane family that exerts an antitumor effect by stabilizing microtubules and inhibiting cell cycle progression. However, PTX resistance often develops in tumors due to the overexpr...
Article
Background & Objective: The teratogenic and embryotoxic potential of Bisphenol A (BPA) has been identified in recent years. Bromelain is a natural compound of pineapple that contains different beneficial effects on the fetus. So, this study aimed to investigate the effect of bromelain against BPA-induced skeletal anomalies in the rat fetuses. Mater...
Article
Full-text available
A major terrifying ailment afflicting the humans throughout the world is brain tumor, which causes a lot of mortality among pediatric and adult solid tumors. Several major barriers to the treatment and diagnosis of the brain tumors are the specific micro-environmental and cell-intrinsic features of neural tissues. Absence of the nutrients and hypox...
Article
Although conventional drugs are widely used in the prevention and treatment of cardiovascular disease (CVD), they are being used less frequently due to concerns about possible side effects over the long term. There has been a renewed research interest in medicinal plant products, and their role in protecting the cardiovascular system and treating C...
Article
Diabetes mellitus (DM) is a chronic disease and threatening problem for world health. Allopathic medications are not efficient enough in controlling DM and its complications. Therefore, much attention has been directed towards the traditional medicine system. Plant derived-natural compounds with medicinal properties play an essential role in DM man...
Article
Curcumin is a phytochemical isolated from Curcuma longa with potent tumor‐suppressor activity, which has shown significant efficacy in pre‐clinical and clinical studies. Curcumin stimulates cell death, triggers cycle arrest, and suppresses oncogenic pathways, thereby suppressing cancer progression. Cisplatin (CP) stimulates DNA damage and apoptosis...
Article
Full-text available
Background: Diabetes mellitus can lead to histomorphometrical changes in the brain. Recent studies have shown that Aloe vera gel has antioxidant and neuroprotective effects, which is independent of glucose-lowering effects. Objectives: The present study aimed to investigate the effects of A. vera gel on histomorphometrical changes of cerebellum fol...
Article
Full-text available
Background: Diabetes mellitus can lead to histomorphometrical changes in the brain. Recent studies have shown that Aloe vera gel has antioxidant and neuroprotective effects, which is independent of glucose-lowering effects.
Article
Full-text available
Diabetes mellitus can lead to structural disorders in the brain. One of the most common complications of diabetes, diabetic neuropathy is associated with central nervous system disorders. Aloe vera has anti-diabetic, antioxidant, and neuroprotective effects. This study was designed to evaluate the effects of Aloe vera gel on the hippocampus changes...
Article
Inflammatory bowel diseases (IBDs) may result from mutations in genes encoding for innate immunity, which can lead to exacerbated inflammatory response. Although some mono-targeted treatments have developed in recent years, IBDs are caused through several pathway perturbations. Therefore, targeting all these pathways is difficult to be achieved by...
Article
Introduction Gestational diabetes mellitus (GDM) is a metabolic syndrome among pregnant mothers that increases the risk of developing growth disorders in the fetus and the placenta. Adiponectin is an adipokine, which plays a central role in the regulation of glucose and lipid metabolism, energy homeostasis, and insulin resistance in various tissues...
Article
Full-text available
Effective cancer therapy requires identification of signaling networks and investigating their potential role in proliferation and invasion of cancer cells. Among molecular pathways, signal transducer and activator of transcription 3 (STAT3) has been of importance due to its involvement in promoting proliferation, and invasion of cancer cells, and...
Article
Full-text available
Cancer is one of the life-threatening disorders that, in spite of excellent advances in medicine and technology, there is no effective cure for. Surgery, chemotherapy, and radiotherapy are extensively applied in cancer therapy, but their efficacy in eradication of cancer cells, suppressing metastasis, and improving overall survival of patients is l...
Article
Full-text available
Background: This study evaluated the effects of the maternal immune system stimulation or suppression during the pregnancy on the development of the neonate’s immune system. Methods: A total of 20 female rats were divided into four groups. The groups were treated using Leishmania major, Salmonella typhimurium, Tacrolimus, and sterilized normal s...
Article
Full-text available
Maternal diabetes is a metabolic disorder among pregnant mothers that increases the risk of developing growth disorders in the fetus and the placenta. Placenta deformity and dysfunction was reported in some studies. These changes have been related to oxidative stress. Quercetin is a component of the flavonoids group that can be found in vegetables,...
Article
Full-text available
Purpose: To investigate the prophylactic effects of quercetin on oxidative stress and damage to kidney in rat’s fetus harvested from diabetic mothers. Methods: Female Wistar rats were divided to into four experimental groups: control, quercetin, diabetic, and quercetin-treated diabetic groups (6 rats in each group). Experimental diabetes was induce...
Article
Full-text available
Immune system plays crucial role in body and lymph nodes are essential parts of this system for combating pathogens. However, no study has ever been conducted on morphometric development of sheep lymph nodes in fetal period. Thus, this study attempted to examine the morphometric characteristics of a number of important lymph nodes of some lymphocen...
Article
Full-text available
Background: There are some reports that albendazole passes placenta and causes disorders in fetus. Besides, there is some evidence that the effect apparently is related to its active metabolite, albendazole sulfoxide. So, erythromycin is the choice to inhibit metabolizing enzymes. On the other hand, free radicals have an important role in teratogen...
Article
Full-text available
Retinoic acid, an active metabolite of vitamin A, plays essential signaling roles in mammalian embryogenesis. Prenatal rat fetuse exposure to retinoid induces some malformations in various organs, the most active and teratogenic metablolite is all-transretinoic acid (atRA). The teratogenic effects of some drugs can be prevented by the application o...
Poster
Full-text available
Background: Prenatal exposure to Bisphenol A)BPA(has been associated with adverse birth outcomes. Bromelain belongs to a group of protein digesting enzymes obtained commercially from the fruit or stem of pineapple. It is known to possess antioxidant and immunomodulatory effects and protects against oxidative stress in experimental models. The aim o...
Article
Full-text available
Background: There are some reports that albendazole passes placenta and causes disorders in fetus. Besides, there is some evidence that the effect apparently is related to its active metabolite, albendazole sulfoxide. So, erythromycin is the choice to inhibit metabolizing enzymes. On the other hand, free radicals have an important role in teratogen...
Article
Full-text available
Background: Prenatal exposure to bisphenol A (BPA) has been associated with adverse birth outcomes. Bromelain belongs to a group of protein digesting enzymes obtained commercially from the fruit or stem of pineapple. It is known to possess antioxidant and immunomodulatory effects and to protect against oxidative stress in experimental models. The a...
Article
Full-text available
Background: Sodium valproate, an anticonvulsant drug, has teratogenic effects on humans’ and animals’ skeletal system via causing free radicals and oxidative stress. Carvedilol has beta-blocker, antioxidant and anti-inflammatory effects and was the benefit in diseases such as diabetes and renal failure and has protective effect in experimental oxid...
Article
Full-text available
Background: Diabetes mellitus can lead to structural disorders in the brain. Aloe vera has antidiabetic, antioxidant, and neuroprotective effects. This study was designed to evaluate the effects of Aloe vera gel on the morphometric changes in the brain of streptozotocin-induced diabetic rats. Methods: 25 male Wistar rats were randomly divided into...
Article
Full-text available
Barbus grypus is native fishes in Khuzestan province which its species with a wide distribution in the rivers that considered fisheries research in province. The fish have no stomach, space of intestine is narrow to store of food, for this reason anterior intestine dilated bowel and called intestinal bulb. Study of histological structure of intes...
Article
Full-text available
Total and regional allometric growth rates and termination sites of the spinal cord related to the respective vertebra were studied in 36 goat fetuses, from the Ahvaz slaughterhouse. These specimens were assigned to 3 groups, group 1 (CRL 10-20 cm), group 2 (CRL 21-30 cm), and group 3 (CRL 31-40 cm), each consisting of 6 male and 6 female fetuses....
Article
Full-text available
Vol. 12, No. 2, Summer, 2016 Iranian Veterinary Journal 126 Case report of a dicephalus fetus with ectopic liver in cow Khazaeel, K.1; Mazaheri, Y.2; Ranjbar R.2; Khaksary Mahabady, M.2; Nourinezhad, J.1 and Ghadiri, A.3 Received: 05.04.2015 Accepted: 03.11.2015 Abstract One apparently female dicephalus fetus of a hybrid Holstein cow have been carr...
Article
BACKGROUND AND OBJECTIVE: Cyclophosphamide is a drug widely used to treat cancer, skin diseases and immune system disorders. Since cyclophosphamide passes placenta during pregnancy and causes disorders in fetus, this study was conducted to assess the protective effects of galbanum essential oil against cyclophosphamide toxicity in rat placenta tiss...
Article
Full-text available
Although heart has been consistently considered as one of the most sensitive organs in medical basic science researches, there was not any available report about embryology and macroscopic developmental growth in sheep heart. Therefore, this study was done to investigate morphology and morphometry of shee...
Conference Paper
The results showed that after birth in carnivores, the umbilical artery remained merely the round ligament of the bladder while in the equidae in addition to round ligament of the bladder, the cranial bladder artery also occurs, which is responsible for the blood flow to the apex and of bladder. But in ruminants, in addition to the round ligament o...
Conference Paper
The results showed that after birth in carnivores, the umbilical artery remained merely the round ligament of the bladder while in the equidae in addition to round ligament of the bladder, the cranial bladder artery also occurs, which is responsible for the blood flow to the apex and of bladder. But in ruminants, in addition to the round ligament o...
Conference Paper
The results showed that after birth in carnivores, the umbilical artery remained merely the round ligament of the bladder while in the equidae in addition to round ligament of the bladder, the cranial bladder artery also occurs, which is responsible for the blood flow to the apex and of bladder. But in ruminants, in addition to the round ligament o...
Article
Full-text available
Cyclophosphamide (CP) is a drug commonly used to treat neoplastic disease and some autoimmune diseases. It is also a well-known and well-studied teratogen causing a variety of birth defects in fetuses of pregnant women treated with the drug. There are many reports that show the adverse effects of CP can be decreased by use of antioxidant drugs. It...
Article
Full-text available
In this study, a total number of 10 fish freshly prepared Barbus grypus and samples from proximal, middle and distal portions of gill arches were dissected. The 5-6 µm sections were made using paraffin embedding techniques and stained by haematoxylin & eosin (H&E) and periodic acid shiff (PAS). The results showed Barbus grypus gill has consisted fr...
Article
Full-text available
Introduction: - Significant increase in usage of silver nanoparticles (AgNPs) in consumer products, has increased its exposures to human and animals. Although there are some reports regarding the effects of AgNPs on complex organisms, no report was found as to its effects on neurobehavioral ontogeny. Methods: To investigate the effects of maternal...
Article
Introduction: - Significant increase in usage of silver nanoparticles (AgNPs) in consumer products, has increased its exposures to human and animals. Although there are some reports regarding the effects of AgNPs on complex organisms, no report was found as to its effects on neurobehavioral ontogeny. Methods: To investigate the effects of maternal...
Article
Full-text available
BACKGROUND AND OBJECTIVE: Arsenic causes congenital anomalies in humans and animals, and nanoparticles of sodium arsenite are highly capable of inducing apoptosis. Since the effects of nanoparticles of sodium arsenite on fetal malformations have not been evaluated yet, this study aims to compare the effect of sodium arsenite and nanoparticles of so...
Article
Full-text available
The aim of the present study was to evaluate the effects of different seasons on the morphometric testicular parameters and the respective epididymal sperm parameters. Total numbers of 104 scrota of pubertal buffalo bull (24-48 months) include their contents were provided from the local slaughterhouse. Scrotal circumference was measured on its plac...
Article
Cyclophosphamide (CP) is a mustard alkylating agent used in the treatment of a number of neoplastic diseases and as an immunosuppressant for the prevention of xenograft rejection. There are many reports that the teratogenic effects of cyclophosphamide can be prevented by application of antioxidant drugs and stimulation of the maternal immune system...
Article
Full-text available
The role of skin in fish is providing a physical barrier, first line of defense against pathogens, osmotic pressure, physical injury and acts as a semi-permeable osmotic barrier to maintain ionic and fluid balance in marine and fresh water fish. This study was done since, there is some reports about skin of freshwater histology information but the...
Article
Full-text available
The aim of this study was to evaluate the testicular lesions and their effects on the epididymal sperm parameters in the Iranian river buffalo (Bubalus bubalis). Total numbers of 117 scrota from the pubertal buffalo were provided from the local slaughterhouse. The samples were evaluated for morphological parameters and any macro- or microscopic les...
Article
Full-text available
Nearly completed conjoined or fused symmetrical twins are generally called diplopagus. Sheep conjoined twins have been reported less than cow. An apparently female conjoined twin lambs was examined based on external and internal features. In radiology, two vertebral columns and two pairs of the ribs were seen. Only two heads and two necks were sepa...
Article
Full-text available
The aim of the present study was to find the morphological parameters of testis-epididymis and their relationship with epididymal sperm parameters of pubertal Iranian domestic buck. Total pairs of 40 testes-epididymides were provided from local slaughterhouse and transported to the laboratory. Thirty pairs were evaluated for anatomical features and...
Data
There are many reports that show the teratogenic effects of drugs can be prevented by application of antioxidant drugs and stimulation of the maternal immune system. Therefore, in this study, the prophylactic effect of melatonin and vitamin E on teratogenic effects of arsenite sodium was studied. The study was performed on pregnant rats that were d...
Article
Full-text available
Background: There are many studies focused on long or short storage time of epididymal sperm (EPS) of different species. There are limited studies on preservation or cryopreservation of the domestic goat EPS. Objective: The aim of the present study was to evaluate the effects of ex vivo cold-storage on freezing of EPS from goat (Capra hircus). Mate...
Article
Full-text available
Background: Albendazole is utilized as an anthelmentic agent. One its side effect is teratogenicity. This effect apparently is related to its metabolites especially albendazole sulfoxid. The aim of present study was evaluation effect of erythromycin (as enzyme inhibitor in biotransformation) on albendazole biotransformation and consequently fetal m...
Article
Full-text available
Congenital defects are common in animals but there is only one report of crossbred (Iranian nativexHolstein) calf has been recorded in Iran. There were severe congenital deformities in the brain of a cyclopia calf. Forebrain structures include olfactory bulb (arrhinocephaly) and cerebral hemispheres (inepisencephaly) have not been formed. Epiphysis...
Article
Nanosilver, comprising silver nanoparticles, is attracting interest for a range of biomedical applications owing to its potent antibacterial activity. It has recently been demonstrated that nanosilver has useful anti-inflammatory effects and improves wound healing, which could be exploited in developing better dressings for wounds and burns. The te...
Article
Full-text available
Berzem; Barbus pectoralis (Cyprinidae) inhabiting Karoon River (Southwest Iran). There wasn't any available report on anatomical and histological analysis of B. pectoralis. So, in this study, the morphologic and microscopic features of spleen as the important lymphatic organ on immune system of B. pectoralis were recognized. A total number of 10 yo...
Article
Cyclophosphamide (CP) as an alkylating agent which is used for treatment of cancer and to prevent rejection of tissue transplantation. Therefore, in this study, the teratogenic effects of CP were compared. This study was performed on 11 pregnant mice that were divided into two groups. Control group received normal saline and test group received CP...
Article
Full-text available
Aim: As there was no studies available regarding the morphological structure of skin of (Barbus grypus) therefore this research work was performed to help the other studies such as histopathology of the fish. Material and Methods: Skin of the different part of the head of 20 Barbus grypus with 5mm thickness were removed and fixed in bouin solution....
Article
Full-text available
Gross anatomy of the fetlock joint of the seven male adult one- humped camels were studied. In present study, the tendinous middle interosseous muscle, interdigital intersesamoid and straight sesamoid ligaments were observed. However, there was no proximal interdigital ligament. In conclusion, we found that the gross anatomy of the ligaments in one...
Article
Cyclophosphamide (CP) as an alkylating agent is used for treatment of cancer and to prevent rejection of tissue transplantation. There are many reports that the teratogenic effects of cyclophosphamide can be prevented by application of antioxidant drugs and stimulation of the maternal immune system. Also, there is some evidence that melatonin and c...
Article
Problem statement: Some reports showed the teratogenic effects of sodium valproate can be prevented by application of antioxidant drugs and stimulation of the maternal immune system. Therefore, in this study, the prophylactic effect of melatonin on teratogenic effects of sodium valproate was compared. Approach: This study was performed on 31 pregna...
Article
Full-text available
There are many reports that show the teratogenic effects of phenobarbital can be decreased by stimulation of maternal immune system. Therefore, in this study, the prophylactic effects of levamisole and vitamin E on teratogenic effects of phenobarbital were compared. This study was performed on 20 pregnant rats that were divided into four groups. Co...
Article
Full-text available
In recent years concerns have been raised about human reproductive disorders, specially the effects of environmental factors on human fertility and pregnancy outcome. Therefore, the present study was designed to assess the effects of maternal caffeine consumption on ovarian follicles development in rat offspring. 60 pregnant female rats were random...
Article
Full-text available
There are many reports that show the teratogenic effects of drugs can be prevented by application of antioxidant drugs and stimulation of the maternal immune system. Therefore, in this study, the prophylactic effect of melatonin and vitamin E on teratogenic effects of arsenite sodium was studied. The study was performed on pregnant rats that were d...
Article
There are many reports that the teratogenic effects of cyclophosphamide (CP) can be prevented by application of antioxidant drugs and stimulation of the maternal immune system. Also, there is some evidence that vitamin E and silymarin are antioxidant. Therefore, in this study, the prophylactic effects of silymarin and vitamin E on teratogenic effec...
Article
Albendazole is utilized as an anthelmentic agent. One its side effect is teratogenicity. The aim of present study was evaluation protective effect of Sambucus extract on albendazole induced- fetal malformation. Four groups of female pregnant Wistar rats (8 rats each group) were used. One group received normal saline (as control group). A single ora...
Article
Full-text available
Albendazole is utilized as an anthelmentic agent. One its side effect is teratogenicity. The aim of present study was evaluation protective effect of Sambucus extract on albendazole induced-fetal malformation. Four groups of female pregnant Wistar rats (8 rats each group) were used. One group received normal saline (as control group). A single oral...
Article
Full-text available
The morphology of lingual papillae of 10 healthy young adult Iranian buffaloes was studied by using light microscopy. It could be divided into three areas: the lingual apex, lingual body and lingual root. Filiform, conical, fungiform and lenticular papillae were considered as mechanical papillae but circumvallate papillae were considered as gustato...
Article
Full-text available
There are reports that the teratogenic effects of cyclophosphamide can be decreased by application of antioxidant drugs and stimulation of maternal immune system. Echinacea extract has being found to be antioxidative and immunomodulatory. Mesna (Sodium 2-mercaptoethane sulfonate) is used for decreasing side effect of cyclophosphamide, especially he...
Article
In this study, the prophylactic effects of vitamin E and silymarin on teratogenic effects of phenytoin was compared. This study was performed on 32 pregnant rats that were divided into four groups. The first group (control group) received normal saline intraperitonealy and the other groups (test groups) received phenytoin (75 mg kg<sup>-1</sup> b.w...
Article
Full-text available
Objective(s) There are some reports that the teratogenic effects of cyclophosphamide (CPA) can be prevented by application of antioxidant drugs and stimulation of the maternal immune system. Echinacea purpurea extract is antioxidative and immunomodulator drug. Mesna (Sodium 2-mercaptoethane sulfonate) is used for decreasing side effects of CPA, esp...
Article
Full-text available
The objectives of this study were to investigate the effects of testis-epididymis cool storage on viability and progressive motility of buffalo epididymal sperm (EP) and to compare the influences of two basic semen extenders on post thaw EP viability and progressive motility. Abattoir collected buffalo testicles were allotted to three storage times...
Article
Full-text available
Congenital palatal defects are common in animals but there is only one report of water buffalo has been recorded in Iran. One died male water buffalo calf was examined after hysterotomy operation. At necropsy findings, brachygnathia, palate cleft and small lungs were diagnosed. It is the second report of water buffalo cleft palate in Iran.
Article
There are many reports that the teratogenic effects of phenytoin, especially cleft palate can be decreased by stimulation of maternal immune system. Also, there is some evidence that Echinacea extract and levamisole are immunomodulator drugs. So, in this study, we compared the prophylactic effects of levamisole and Echinacea extract on teratogenic...