Mahendran Subramanian

Mahendran Subramanian
Imperial College London | Imperial · Department of Bioengineering and Department of Computing

Master of Engineering

About

30
Publications
6,692
Reads
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200
Citations
Introduction
Mahendran does research in Biomedical Engineering and Bioengineering. He is currently associated with the 'Brain & Behaviour Lab, Department of Bioengineering and Department of Computing, Imperial College London'.

Publications

Publications (30)
Article
Full-text available
Heat dissipation during magnetization reversal processes in magnetic nanoparticles (MNP), upon exposure to alternating magnetic fields (AMF), has been extensively studied in relation to applications in magnetic fluid hyperthermia (MFH). This current paper demonstrates the design, fabrication, and evaluation of three innovative advances in bioinstru...
Article
Full-text available
This paper aims to apply a proposed, based on calorimetric measurements, a reliable numerical model for magnetic fluid hyperthermia (MFH) treatment planning of breast cancer. Furthermore, we perform a comparative analysis of magnetic nanoparticles (MNPs) and tumour tissue interactions by means of the magnetic-field-dependent Néel and Brownian relax...
Article
Full-text available
Purpose: The localized heating of magnetic nanoparticles (MNPs) via the application of time-varying magnetic fields – a process known as magnetic field hyperthermia (MFH) – can greatly enhance existing options for cancer treatment; but for broad clinical uptake its optimization, reproducibility and safety must be comprehensively proven. As part of...
Preprint
Full-text available
Functional Electrical Stimulation (FES) can restore motion to a paralysed person's muscles. Yet, control stimulating many muscles to restore the practical function of entire limbs is an unsolved problem. Current neurostimulation engineering still relies on 20th Century control approaches and correspondingly shows only modest results that require da...
Preprint
We have pioneered the Where-You-Look-Is Where-You-Go approach to controlling mobility platforms by decoding how the user looks at the environment to understand where they want to navigate their mobility device. However, many natural eye-movements are not relevant for action intention decoding, only some are, which places a challenge on decoding, th...
Article
Full-text available
Copepods are the dominant members of the zooplankton community and the most abundant form of life. It is imperative to obtain insights into the copepod-associated bacteriobiomes (CAB) in order to identify specific bacterial taxa associated within a copepod, and to understand how they vary between different copepods. Analysing the potential genes wi...
Article
Full-text available
Electromagnetic hyperthermia as a potent adjuvant for conventional cancer therapies can be considered valuable in modern oncology, as its task is to thermally destroy cancer cells exposed to high-frequency electromagnetic fields. Hyperthermia treatment planning based on computer in silico simulations has the potential to improve the localized heati...
Article
Full-text available
Marine pollution is a significant issue in recent decades, with the increase in industries and their waste harming the environment and ecosystems. Notably, the rise in shellfish industries contributes to tons of shellfish waste composed of up to 58% chitin. Chitin, the second most ample polymer next to cellulose, is insoluble and resistant to degra...
Article
Full-text available
Antarctica holds about 70% of all the freshwater on the planet in the form of ice. The seawater, it chills, affect the currents and temperature everywhere. Global warming risks the melting of the icecaps as it has already increased the ocean temperature by 1 °C to the West Antarctic peninsula since 1955. A better understanding of the microbial comm...
Conference Paper
Full-text available
Existing wheelchair control interfaces, such as sip & puff or screen based gaze-controlled cursors, are challenging for the severely disabled to navigate safely and independently as users continuously need to interact with an interface during navigation. This puts a significant cognitive load on users and prevents them from interacting with the env...
Conference Paper
Full-text available
In vitro and in vivo evaluation of magnetic nanoparticles in relation to magnetic fluid hyperthermia (MFH) treatment is an on-going quest. This current paper demonstrates the design, fabrication, and evaluation of an in vivo coil setup for real-time, whole body thermal imaging. Numerical calculations estimating the flux densities, and in silico ana...
Article
Full-text available
The manipulation of magnetic nanoparticles (MNPs) using an external magnetic field, has been successfully demonstrated in various biomedical applications. Some have utilised this non-invasive external stimulus and there is an potential to build on this platform. The focus of this study is to understand the manipulation of MNPs by a time-varying sta...
Article
Full-text available
The manipulation of magnetic nanoparticles (MNPs) using an external magnetic field, has been demonstrated to be useful in various biomedical applications. Some techniques have evolved utilizing this non-invasive external stimulus but the scientific community widely adopts few, and there is an excellent potential for more novel methods. The primary...
Article
Full-text available
Bacterial diversity studies in hypersaline soil often yield novel organisms and contribute to our understanding of this extreme environment. Soil from Mad Boon is previously uncharacterized, with dense mangrove forest in one side and hypersaline soil in another side of backwater located in Southeast coast of Tamil Nadu, India. We surveyed to charac...
Article
Full-text available
The purpose of this study was to establish a numerical model for calorimetric measurements of magnetic fluids under an alternating magnetic field (AMF). The modified linear response theory (LRT) and Stoner-Wohlfarth theory were applied to investigate heat dissipation from the ferrofluid. The hysteresis area was calculated once the magnetic field va...
Preprint
Functional Electrical Stimulation (FES) systems are successful in restoring motor function and supporting paralyzed users. Commercially available FES products are open loop, meaning that the system is unable to adapt to changing conditions with the user and their muscles which results in muscle fatigue and poor stimulation protocols. This is becaus...
Preprint
Full-text available
Natural eye movements during navigation have long been considered to reflect planning processes and link to future action intention. We investigate here whether natural eye movements during joystick-based navigation of wheel-chairs follow identifiable patterns that are predictive of joystick actions. To place eye movements in context with driving i...
Article
To develop treatments for neurodegenerative disorders, it is critical to understand the biology and function of neurons in both normal and diseased states. Molecular studies of neurons involve the delivery of small biomolecules into cultured neurons via transfection to study genetic variants. However, as cultured primary neurons are sensitive to te...
Article
Full-text available
To develop treatments for neurodegenerative disorders, it is critical to understand the biology and function of neurons in both normal and diseased states. Molecular studies of neurons involve the delivery of small biomolecules into cultured neurons via transfection to study genetic variants. However, as cultured primary neurons are sensitive to te...
Conference Paper
Full-text available
The article concerns the heat flow problem during magnetic field excitation of superparamagnetic fluid. Precise determination of the energy converted into the heat is important issue defining applicability of the phenomena in the Magnetic Fluid Hyperthermia therapy. However it can be done only when all other heat transfer parameters are known, whic...
Article
Full-text available
Herein, we present a pilot study concerning the use of fluorodeoxy glucose conjugated magnetite nanoparticles (FDG-mNP ) as a potential agent in magnetic nanoparticle mediated neuroblastoma cancer cell hyperthermia. This approach makes use of the 'Warburg effect', utilising the fact that cancer cells have a higher metabolic rate than normal cells....
Article
Purpose: We describe the design and application of a new apparatus for applying Radiofrequency (RF) electromagnetic fields to cells in culture on a microscope stage. This new design enables real-time studies of the actuation of magnetic nanoparticles bound to membrane receptors or internalised within cells together with the study of magnetic fluid...
Article
Full-text available
Purpose: We describe the design and application of a new apparatus for applying Radiofrequency (RF) electromagnetic fields to cells in culture on a microscope stage. This new design enables real-time studies of the actuation of magnetic nanoparticles bound to membrane receptors or internalized within cells together with the study of Magnetic Fluid...
Conference Paper
The use of magnetic nanoparticles (MNPs) as gene delivery vehicles is emerging as a promising tool to enhance transfection rates in neural transplant cells. Magnetic assistive technology significantly enhances MNP mediated biomolecule delivery in oligodendrocytes & neural stem cells, however the impact of a biaxial magnetic field on transfection ou...
Article
Full-text available
Magnetic nanoparticle-based gene transfection has been shown to be an effective, non-viral technique for delivery of both plasmid DNA and siRNA into cells in culture. It has several advantages over other non-viral delivery techniques, such as short transfection times and high cell viability. These advantages have been demonstrated in a number of pr...

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Projects

Projects (5)
Archived project
Preparation of magnetic nanoparticles and testing the SAR efficiency and bio-compatibility to further utilization in Magnetic Hyperthermia
Project
Oscillating Magnet Array mediated Cytotoxicity in Cancer Cells. Gradient Magnetic Field. Cell Labelling. Novel Magnetic Nanoparticles.