Mahdi Adabi

• PhD
• Professor (Associate) at Tehran University of Medical Sciences

Aims: In this study, carbon quantum dot (CQD)-loaded poly(lactic-co-glycolic acid) (PLGA) nanoparticles (NPs) were prepared, and their surfaces were modified with tween 20, tween 80, poloxamer 188, or poloxamer 407. The physicochemical properties, cytotoxicity, and cellular uptake of the NPs were subsequently evaluated using the C6 glioblastoma ce...

Nanotechnology has revolutionized cancer treatment by providing innovative solutions through nanocancer therapies, nanovaccines, and nanoparticles. This review focuses on the application of these technologies in colorectal cancer (CRC), highlighting their progression from preclinical studies to clinical trials. Nanoparticles, including liposomes, s...

Hyperlipidemia, a critical risk factor for various health conditions, necessitates innovative therapeutic strategies. Investigating the effectiveness of liposomal formulations in managing hyperlipidemia is essential. Resveratrol (RES)-loaded nanoliposomes present a promising new approach for hyperlipidemia treatment. In this study, we investigated...

Epigallocatechin-3-gallate (EGCG), the primary polyphenol in green tea, is renowned for its potent antioxidant properties. EGCG interacts with various cellular targets, inhibiting cancer cell proliferation through apoptosis and cell cycle arrest induction, while also modulating metabolic pathways. Studies have demonstrated its potential in addressi...

Wound management is a critical aspect of healthcare, necessitating effective and innovative wound dressing materials. Many existing wound dressings lack effectiveness and exhibit limitations, including poor antimicrobial activity, toxicity, inadequate moisture regulation, and weak mechanical performance. The aim of this study is to develop a natura...

The effect of chemotherapy for anti-glioblastoma is limited due to insufficient drug delivery across the blood–brain–barrier. Poloxamer 188-coated nanoparticles can enhance the delivery of nanoparticles across the blood–brain–barrier. This study presents the design, preparation, and evaluation of a combination of PLGA nanoparticles (PLGA NPs) loade...

Inflammatory responses play a crucial role in the pathophysiology of spinal cord injury (SCI) and developing new approaches to establish an anti-inflammatory environment for the promotion of neuroregeneration holds promise as a potential approach. In this study, our aim was to investigate the potential of combining an acellular spinal cord scaffold...

In the context of treating spinal cord injury (SCI), the modulation of inflammatory responses, and the creation of a suitable region for tissue regeneration may present a promising approach. This study aimed to evaluate the effects of curcumin (Cur)‐loaded bovine serum albumin nanoparticles (Cur‐BSA NPs) cross‐linked with an acellular spinal cord s...

The effect of anti-glioblastoma therapies is dwindling due to insufficient delivery across the blood-brain-barrier. It has been stated that poloxamer 188-coated nanoparticles are able to circumvent the blood-brain-barrier. Building off of such success, this study presents the design, preparation, and evaluation of a combination of PLGA nanoparticle...

Iron fortification in food is considered as an important way to prevent and treat iron deficiency. However, adding iron in food can affect flavor, color, and oxidation of fat components. Encapsulation of iron can solve the drawbacks of taste, color, and reactivity of iron in oral iron consumption without adverse effect on food quality. The aim of t...

Aptasensors are amazing among many currently formed procedures due to their excellent particularity, selectivity and responsiveness. These biosensors get more popular in combination with gold nanoparticles (AuNPs) to detect chemical and biological molecules. The response of AuNPs by changing color provides a simple explanation of outcomes. The auth...

The aim of this study was to prepare folate-targeted Erlotinib loaded human serum albumin nanoparticles (FA-ERL-HSA NPs) and investigate in vitro cytotoxic and apoptotic effects using cell lines (U87MG and C6 cells) and an in vivo rat bearing C6 glioma model. The mean size of the FA-ERL-HSA NPs prepared using a desolvation method was 135 nm. In vit...

Human immunodeficiency virus (HIV) is the aetiological factor of acquired immunodeficiency disease syndrome (AIDS). A noticeable public health worry is associated with the fast growth of drug resistance to the present treatments and also the drugs with negative side effects because of their long-term use. Lately, there has been quick progress in us...

Glioblastoma (GBM) is an aggressive, fatal and malignant primary brain tumor. Despite the current standard treatment for glioblastoma patients including neurosurgical resection, followed by concomitant radiation and chemotherapy, the median survival rate is about 15 months. An unresolved challenge for current therapies is related to getting drugs t...

Aim: Cell-free DNA in the plasma is known to be a potential biomarker for noninvasive diagnosis of oncogenic mutations. The authors aimed to design an optimized padlock probe-based hyperbranched rolling circle amplification biosensor to detect the KRAS G12D mutation using fluorescence and colorimetric methods. Methods: Single-factor experiments, Pl...

Flaxseed oil as a natural ingredient has many health benefits due to the rich contents of omega-3 fatty acids. However, its use in food formulations is limited because of low aqueous solubility, easy oxidation owing to the unsaturated nature of the fatty acids such as omega-3. The aim of this study was to prepare a stable nanoemulsion containing fl...

The aim of this work is to co-load paclitaxel (PTX) and etoposide (ETP) in methoxy poly(ethylene glycol)-poly(lactic-co-glycolic acid) nanoparticles (mPEG-PLGA NPs) to overcome the pharmacokinetics and physiological limitations and enhance the therapeutic efficacy for treating intracranial glioblastoma. Both drugs were loaded into mPEG-PLGA NPs by...

The aim of this work was to design and develop an electrochemical immunosensor based on electrospun carbon nanofiber (ECNF) mat for the detection of human epidermal growth factor receptor 2 (Her-2). First, ECNF mat was fabricated by electrospinning method and heat-treatment and used directly as a novel electrode. To determine Her-2, this ECNF mat e...

In this research, a novel electrochemical aptasensor for the detection of Penicillin in a milk sample was designed using a Penicillin aptamer as the specific recognition element and an electrospun carbon nanofiber (ECNF) mat electrodeposited gold nanoparticles (AuNPs) as the platform. Firstly, the ECNF mat electrode was fabricated by means of elect...

In this study, the actinidin enzyme that was extracted from kiwi fruit was immobilized on a scaffold based on electrospun chitosan nanofibers, and its ability to treat burn wounds was investigated. Afterward, cytotoxicity of the nanofibrous patch and nanofibers with actinidin enzyme was evaluated by MTT test separately on skin fibroblast cells (AGO...

Salmonella enterica is considered one of the most common bacterial agent causes of acute gastroenteritis and foodborne illness in humans worldwide. Antibiotic-resistant is considered as a major problem in Salmonella enterica Serovar. This study introduces a new simple and sensitive aptasensor based on chitosan (Chi)-electrospun carbon nanofibers (C...

Aim The aim of this study was to improve the therapeutic index of chemotherapeutic drugs on glioblastoma cells through an improved co-drug delivery system. Materials and methods Methotrexate (MTX) and paclitaxel (PTX) were co-loaded into poly (lactic-co-glycolic acid) nanoparticles (PLGA NPs) coated with polyvinyl alcohol (PVA) and Poloxamer188 (P...

Tissue engineering makes it possible to fabricate scaffolds that can help the function of defective tissues or even the most complex organs such as the heart. Carbon nanofibers (CNFs), because of their high mechanical strength and electrical properties, can improve the functional coupling of cardiomyocytes and their electrophysiological properties....

Purpose The main purpose of this study was to develop etoposide (ETP) and paclitaxel (PTX) co-loaded methoxy poly(ethylene glycol)-poly(lactic-co-glycolic acid) (mPEG-PLGA) nanoparticles (NPs) with optimized size to achieve co-delivery of ETP and PTX. In addition, the effect of defined parameters including the amount of aqueous to organic phase, th...

In this study, a novel non-enzymatic glucose sensor was successfully produced using nickel electrodeposition on an oil free carbon nanofiber (CNF) mat prepared by electrospinning method. The as-prepared Ni/CNF mat electrode was studied by means of scanning electron microscopy (SEM), energy dispersive spectroscopy (EDS) and X-ray diffraction (XRD)....

Purpose Nanoformulations for co-delivery of multiple therapeutics and combinational therapies are expected to provide improved pharmacokinetics, reduced drug toxicities, and avert drug resistance. Methotrexate (MTX) and curcumin (CUR) were chosen as model drugs for this study primarily due to their anticancer activities in different phases of the c...

Curcumin, an herbal derivative, could be used as anticancer agent in drug delivery. Due to hydrophobic properties of curcumin, its bioavailability decreases to cancer cells. The aim of this study was to prepare curcumin loaded poly (lactic-co-glycolic acid) nanoparticles (CUR-PLGA-NPs) as a drug delivery system to overcome the limitation of hydroph...

In this work we prepared curcumin loaded mPEG-PLGA nanoparticles using precipitation technique and investigated the effect of various parameters such as polyvinyl alcohol (PVA), curcumin concentrations and stirrer time on encapsulation efficiency (EE) of curcumin into mPEG-PLGA nanoparticles. Artificial neural networks (ANN) were used to model the...

Purpose: The size of polymeric nanoparticles is considered as an effective factor in cancer therapy due to enterance into tumor tissue via the EPR effect. The purpose of this work was to investigate the effective parameters on poly(lactic-co-glycolic acid)-paclitaxel (PLGA –PTX) nanoparticles size. Methods: We prepared PLGA-PTX nanoparticles via si...

Objective(s): Nanoparticles offer an attractive platform for drug delivery through a wide variety of the body's physiological barriers. Furthermore, modification of nanoparticle surface with moeites such as Poloxamer188 can enhance their accumulation and localization at disease site. In this work, we investigated the physiochemical effect of a scav...

The aim of this work was to prepare gelatin nanofibers and investigate their medical applications such as nanofibrous scaffolding for skin regeneration, and skin wound dressing in tissue engineering. First, gelatin nanofibers were prepared via electrospinning method. The morphology and diameter of the nanofibers were characterized by scanning elect...

The purpose of the current study was to prepare Methotrexate (MTX) loaded Poly Lactic-Co-Glycolic Acid (PLGA) Nanoparticles (NPs) and investigates their toxicity effect on human glioblastoma cells. The influence of different experimental parameters including polymer concentration, Polyvinyl Alcohol (PVA) concentration in the external phase and drug...

Cancer is known as a dangerous disease at cellular and molecular level of organism which necessitates its detection and treatment in early stages. With the development of nanomedicine, the fabrication of structures/materials at the range of 1 to 100 nm offers good advantage to clinical applications. Among nanostructure, nanobubbles (NBs) have recei...

Objective(s): This paper investigates the validity of Artificial Neural Networks (ANN) model in the prediction of electrospun kefiran nanofibers diameter using 4 effective parameters involved in electrospinning process. Polymer concentration, applied voltage, flow rate and nozzle to collector distance were used as variable parameters to design vari...

Chitosan/polyethylene oxide (PEO) solution makes electrospun nanofibers with decreased beads and diameters in comparison with lonely chitosan (CS). The aim of this work was to find an artificial neural network (ANN) model for predicting the chitosan/PEO blend electrospun nanofiber diameter. Chitosan/PEO concentration ratio, distance between nozzle...

In this research, the polyvinyl alcohol (PVA) nanofibers through forcespinning process were successfully produced and the effective parameters for predicting nanofibers diameter using artificial neural network (ANN) were investigated. The various parameters of forcespinning process including rotational speed, orifice, distance to the collector, and...

The aim of this study was to predict the effects of different parameters on the conductivity of mineralized PAN-based carbon nanofibers by the artificial neural network (ANN) method. The conductivity of CNFs was investigated as a function of various parameters, including simulated body fluid (SBF) concentration, immersion time and CNFs diameter. In...

Glioblastoma is a malignant brain tumor and leads to death in most patients. Chemotherapy is a common method for brain cancer in clinics. However, the recent advancements in the chemotherapy of brain tumors have not been efficient enough. With the advancement of nanotechnology, the used drugs can enhance chemotherapy efficiency and increase the acc...

Among polymers, polyaniline (PANi) has been introduced as a good candidate for muscle regeneration due to high conductivity and also biocompatibility. Herein, for the first time, we report the use of electrospun nanofibrous membrane of PAN-PANi as efficient scaffold for muscle regeneration. The prepared PAN-PANi electrospun nanofibrous membrane was...

There has been huge interest in applications of nanomaterials in biomedical science, including diagnosis, drug delivery, and development of human organs. Number of these nanomaterials has been already studied in human or at pre-clinical trial. There is a growing concern on potential toxicity and adverse effects of nanomaterials on human health, inc...

The aim of this work was to investigate the effective parameters for predicting the cathodic current in a polyacrylonitrile-based carbon nanofiber (CNF) electrode using an artificial neural network (ANN) method. The various factors including CNF diameter, CNF layer thickness, electrodeposition time of Pt on the CNF electrode, and pH of a phosphate...

Imatinib is a useful drug to inhibit some receptors such as c-kit and PDGFRs which are overexpressed in glioblastoma. However, Imatinib is easily effluxed by the proteins of the endothelial cells. The aim of this work was to synthesize imatinib base (IMTb) in nanoscale and also investigate the amount of its loading into the human serum albumin (HSA...

The purpose of this work was to investigate the performance of electrodes synthesized with Polyacrylonitrile-based carbon nanofibers (PAN-based CNFs). The homogenous PAN solutions with different concentrations were prepared and electrospun to acquire PAN nanofibers and then CNFs were fabricated by heat treatment. The effective parameters for the pr...

The purpose of this study was to investigate the validity of an artificial neural network (ANN) method in the prediction of nanofiber diameter to assess the parameters involved in controlling fiber form and thickness. A mixture of polymers including poly(vinyl alcohol) (PVA) and chitosan (CS) at different ratios was chosen as the nanofiber base mat...

The purpose of this work was to fabricate an electrochemical DNA biosensor for detecting hepatitis B virus. Gold nanorods (GNRs), which are known for their conductivity, were used to increase surface area and consequently increase the immobilization of single-stranded DNA (ss-DNA) on the modified gold electrode. The GNRs were characterized via tran...

The restoration of defective bone tissue and complications related to surgery and fracture site infection are major concerns in orthopedic surgeries. However, it is crucial to develop osteoconductive and bacteriostatic composites. Chitosan/nano hydroxyapatite (CT/n-HAp) powder containing of Ag and Si were prepared by an in situ hybridization method...

The aim of this work was to evaluate the effective parameters for prediction of the electrospun gelatin nanofibers diameter using artificial neural network (ANN) technique. The various sets of electrospinning process including temperature, applied voltage and polymer and solvent concentrations were designed to produce pure gelatin nanofibers. The o...

A cysteamine (CysAm) nanostructure was generated to act as an intermediate layer between gold electrode and carbon nanotubes. A bare gold electrode was placed in a solution of CysAm to create a self-assembled monolayer on its surface. The modified electrode was then incubated with a solution of multi-walled carbon nanotubes. Cyclic voltammetry and...