Mahaboobkhan Rasool

Mahaboobkhan Rasool
VIT University | VIT · School of Bio Sciences and Technology (SBST)

Ph.D., FRSB

About

110
Publications
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Introduction
Our immunopathology lab focuses on deciphering the less understood aspects of arthritis pathobiology and to harness the hidden potential of naturally derived compounds against the disease. Our priority theme and aim of research is to investigate the under pinning molecular mechanism of potential targets that can be translated into the development of better therapeutic interventions with more predictable, safer and cost effective outcomes.

Publications

Publications (110)
Article
Rheumatoid arthritis (RA) is a chronic immune-mediated disorder, mainly characterized by synovial inflammation and joint damage. If insufficiently treated, RA can lead to irreversible joint destruction and decreased life expectancy. While better understanding of the pathologies and the development of new antirheumatic drugs have improved the outcom...
Article
Interleukin 6 (IL-6), a pleiotropic inflammatory cytokine, is produced transiently due to tissue damage and infections. Nonetheless, IL-6 contributes to the host regenerative defense mechanism via classical signaling at the basal physiological level. Although tightly regulated transcriptional and post-transcriptional mechanism modulates its express...
Article
In search of potent and new anti-inflammatory agents, we explored a new class of isocoumarin derivatives possessing the 3-oxoalkyl moiety at C-4 position. These compounds were synthesized via the FeCl3 catalyzed construction of isocoumarin ring. The methodology involved coupling of 2-alkynyl benzamides with alkyl vinyl ketone and proceeded via a re...
Article
Disturbed Th17/Treg balance is a critical pathological event in the disease progression of rheumatoid arthritis (RA). Recently, emerging studies have demonstrated that CD4 + T helper follicular (Tfh) cells exacerbates the pathogenic manifestations of RA. Contrarily, our previous report has shown that cyanidin, a flavonoid compound, attenuates disea...
Article
Fibroblast-like synoviocytes (FLS) are the critical effector cells primarily involved in rheumatoid arthritis (RA) disease pathogenesis. Interleukin (IL)-6, a proinflammatory cytokine most abundantly expressed in the rheumatoid synovium, promotes Janus kinase (JAK)/signal transducer and transcriptional activator (STAT) signaling cascade activation...
Article
Majoon Chobchini, a polyherbal Unani compound, has been used holistically in India to treat rheumatoid arthritis. However, the potential mechanism underlying the antiarthritic efficacy of Majoon Chobchini has not been elucidated so far. This study was aimed to explore the underlying molecular mechanism and scientifically validate the therapeutic ba...
Article
While anti-inflammatory properties of isocoumarins are known their PDE4 inhibitory potential was not explored previously. In our effort the non-PDE4 inhibitor isocoumarins were transformed into the promising inhibitors via introducing an aminosulfonyl/aminocarboxamide moiety to the C-3 benzene ring attached to the isocoumarin framework. This new cl...
Article
Interleukin (IL)-17A signaling pathway plays a critical role in the initiation and progression of rheumatoid arthritis (RA) and represents a viable target for RA therapy. Cyanidin, a flavonoid compound, is a novel inhibitor of IL-17A/IL-17RA (receptor subunit A) interaction in several inflammatory diseases. However, the therapeutic efficacy of cyan...
Article
Full-text available
Inflammation is a complex biological process which alters the normal physiological function of the immune system resulting in an abnormal microenvironment that leads to several clinical complications. The process of inflammation is mediated through various intracellular signaling factors inside the cells. Apoptosis signal–regulating kinase 1 (ASK1)...
Article
Bone erosion is the major cause of deformities in autoimmune disease conditions such as osteoporosis and rheumatoid arthritis. Aberrant receptor activator of nuclear factor kappa B ligand (RANKL) secretion in bone disorders have been implicated to promote uncontrolled osteoclast differentiation through the regulation of nuclear factor of activated...
Article
Fibroblast-like synoviocytes (FLS) lining the arthritic synovial joint region have been implicated to be a key player in bone remodeling. The uncontrolled proliferation of this cell subtype is strictly regulated by various molecular elements including microRNAs (miRNAs). The Wnt1/β-catenin signaling pathway plays a crucial role in the survival of F...
Article
The hyperplastic phenotype of fibroblast-like synoviocytes (FLSs) plays an important role for synovitis, chronic inflammation and joint destruction in rheumatoid arthritis (RA). Interleukin 17A (IL-17A), a signature pro-inflammatory cytokine effectively influences the hyperplastic transformation of FLS cells and synovial pannus growth. IL-17A cytok...
Article
Bone erosion is a debilitating pathological process of osteopathic disorder like rheumatoid arthritis (RA). Current treatment strategies render low disease activity but with disease recurrence. To find an alternative, we designed this study with an aim to explore the underlying therapeutic effect of PEGylated liposomal BBR (PEG-BBR) against Wnt1/β-...
Article
Full-text available
Background: Proper blocking of toll-like receptor (TLR) activation during disease progression has been reported to have inhibitory effect on the pathogenesis of rheumatoid arthritis (RA). We tested whether the TLR4 inhibitor TAK-242 had potential as a remedy for rheumatoid arthritis. Methods: The therapeutic effect of TAK-242 was tested in vitro...
Article
Full-text available
In our previous study, we explored the therapeutic effect of berberine (BBR) against IL-21/IL-21R mediated inflammatory proliferation of adjuvant-induced arthritic fibroblast-like synoviocytes (AA-FLS) through the PI3K/Akt pathway. The current study was designed to explore the therapeutic potential of BBR (15–45 µM) against IL-21/IL-21R mediated au...
Article
Drug-induced microRNAs recently manifest significant therapeutic approaches, however, such progress in the treatment of osteopathic disorders including osteoporosis and rheumatoid arthritis remains obscure. Contrarily, non-specific drug delivery, at high doses, increases the risk of side effects and reduces drug therapeutic efficacy. Accordingly, t...
Article
Background: Arthritis is a common degenerative joint disease characterized by deterioration of articular cartilage, subchondral bone, and associated with immobility, pain and inflammation. The incessant action of reactive oxygen species (ROS) during progressive arthritis causes severe oxidative damage to vital organs and circulatory system. Purpo...
Article
A new class of PDE4 inhibitors were designed and synthesized via the InCl 3 mediated heteroarylation of indoles and their further derivatization through the Pd(II)-catalyzed C[sbnd]H activation strategy. This effort allowed us to discover a series of 2-(1H-indol-3-yl)-quinoxaline based inhibitors possessing PDE4B selectivity over PDE4D and PDE4C. O...
Chapter
Arthritis is the most prevalent autoimmune disorder, affecting 1–2% of the population worldwide and resulting in a diminished life span. Among the several classes of arthritis, rheumatoid arthritis (RA) remains the most prevalent form that lacks a definite cure due to an unknown etiology and a complex pathogenesis arising from several factors. RA i...
Article
The current study aimed to target the delivery of p-coumaric acid (CA), a dietary polyphenol to the synovial macrophages of AIA rats via mannose incorporated liposomal delivery system (ML) with reference to osteoclastogenesis and bone resorption. In vivo imaging and in vitro drug release study indicated the efficiency of mannosylated liposomes to l...
Article
The current study was designed to explore the underlying therapeutic effect of berberine (BBR), an alkaloid compound against LPS (1 μg/ml)/TNFα (10 ng/ml) mediated apoptosis signal-regulating kinase 1 (ASK1) signaling in RAW 264.7 macrophages and adjuvant-induced arthritic synovial macrophages (AA-SM) with relation to miR-23a levels. LPS and TNFα s...
Article
Interleukin 17 (IL‐17), a proinflammatory cytokine produced by T helper (Th) 17 cells, potentially controls fibroblast‐like synoviocytes (FLS)‐mediated disease activity of rheumatoid arthritis (RA) via IL‐17/ IL‐17 receptor type A (IL‐17RA)/signal transducer and activator of transcription 3 (STAT‐3) signaling cascade. This has suggested that target...
Article
Interleukin 17 (IL-17) and hypoxia have been implicated to play a key role in rheumatoid arthritis (RA). In this study, the combined treatment of IL-17 and cobalt chloride (CoCl2), a hypoxia mimetic significantly increased the osteoclast formation and the expression of TRAP and MMP-9 in RAW 264.7 macrophage cells in the presence of RANKL and M-CSF....
Article
Aims: Bone erosion induced by enhanced osteoclast formation is a debilitating pathological phenomenon in rheumatoid arthritis (RA). Recent finding has revealed that ferulic acid is associated with reduced osteoclast differentiation and bone erosion. However, the underlying mechanism through which ferulic acid inhibited osteoclast differentiation a...
Article
Rheuma­toid arthri­tis (RA) is a sys­temic and chronic au­toim­mune in­flam­ma­tory dis­or­der af­fect­ing mul­ti­ple joints. Var­i­ous cy­tokines, chemokines and growth fac­tors syn­er­gis­ti­cally mod­u­late the joint phys­i­ol­ogy lead­ing to bone ero­sion and car­ti­lage degra­da­tion. Other than these con­ven­tional me­di­a­tors that are well...
Article
The current study investigated the therapeutic effect of berberine (BBR), an alkaloid derivative against IL-21/IL-21R mediated phosphotidyl inositol 3 kinase/protein kinase B (PI3K/Akt) signaling in adjuvant induced arthritic fibroblast-like synoviocytes (AA-FLS) isolated from rats and IL-21 mediated osteoclastogenesis in bone-marrow derived monocy...
Article
Interleukin (IL)-17 predominately produced by the Th17 cells, plays a crucial role in the fibroblast-like synoviocytes (FLS) mediated disease process of rheumatoid arthritis (RA). IL-17 exerts its pathogenic effects in RA-FLS by IL-17/IL-17RA/STAT-3 signaling. Recent studies have shown that RA-FLS produces SHP-2, Cyr61, IL-23, GM-CSF and RANKL whic...
Article
Rheumatoid arthritis (RA) is a systemic autoimmune inflammatory disorder designated with hyperplastic synovium, bone destruction and cartilage degradation. Current therapies involve targeting major cytokines and inflammatory mediators involved in RA to alleviate the pain and provide a temporary relief. Interleukin 21 (IL-21), a recently identified...
Article
Rheumatoid arthritis (RA) is a chronic autoimmune mediated joint disease with severe complications affecting 1% of the population worldwide. Although the exact mechanism underlying the aggravation of RA remains unknown, its occurrence can lead to joint degradation and functional disability. Recent evidences have shown that the aberrant expression o...
Article
This study was designed to explore the underlying mechanism of p-coumaric acid (CA), a dietary polyphenol in adjuvant-induced arthritis (AIA) rat model with reference to synovitis and osteoclastogenesis. Celecoxib (COX-2 selective inhibitor) (5 mg/kg b.wt) was used as a reference drug. CA remarkably suppressed the paw edema, body weight loss and in...
Article
The current study was designed to investigate the cytotoxicity and immunomodulatory effects of sol-gel combustion based TiO2 particles (glycine and l-alanine as reducing agents) of large surface areas on RAW 264.7 macrophages. RAW 264.7 macrophages exposed to varying concentrations of TiO2 particles (0.001 to 1000 μg/ml) were assessed after 24 h an...
Article
In order to develop a better therapeutic approach for the treatment of rheumatoid arthritis (RA), withaferin-A; a steroidal lactone incorporated with mannosylated liposomes (ML-WA) was administered to adjuvant induced arthritic rats in order to target the synovial macrophages. The confocal microscopy studies showed a successful internalization of M...
Article
The purpose of the study was to develop a liposomal drug delivery system for morin, a dietary polyphenol, in order to target the synovial macrophages and investigate the remission of disease severity in the adjuvant-induced arthritic (AIA) rats. To do so, mannose decorated liposomal morin (ML-Morin) was prepared using the thin film hydration method...
Article
The current study was designed to investigate the therapeutic potential of berberine on monosodium urate (MSU) crystal stimulated RAW 264.7 macrophages and in MSU crystal induced rats. Our results indicate that berberine (25, 50 and 75μM) suppressed the levels of pro-inflammatory cytokines (interleukin-1beta (IL-1β) and tumor necrosis factor alpha...
Article
Rheumatoid arthritis (RA) is a systemic-autoimmune-mediated disease characterized by synovial hyperplasia and progressive destruction of joint. Currently available biological agents and inhibitor therapy that specifically target tumor necrosis factor-α, interleukin 1β (IL-1β), IL-6, T cells, B cells, and subcellular molecules (p38 mitogen-activated...
Article
The present study was designed to investigate the potential therapeutic effect of trikatu, an herbal compound and its underlying molecular mechanism in rats with adjuvant-induced arthritis (AIA). Our results indicate that trikatu (1000 mg/kg/b.wt. oral) administration suppressed the production of pro-inflammatory cytokines (tumor necrosis factor-α...
Article
Full-text available
Fibroblast-like synoviocytes (FLS) are inhabitant mesenchymal cells of synovial joints and have been recognized to play an imperative role in the immunopathogenesis of rheumatoid arthritis (RA). Blocking these pathological roles of FLS provides a potentially important therapeutic strategy for the treatment for RA. A recent study had confirmed that...
Article
During tumorigenesis, cancer cells generate complex, unresolved interactions with the surrounding oxystressed cellular milieu called tumor microenvironment (TM) that favors spread of cancer to other body parts. This dissemination of cancer cells from the primary tumor site is the main clinical challenge in cancer treatment. In addition, the signifi...
Article
This study sought to explore the mechanism of anti-inflammatory effect of triphala in lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophages and in adjuvant-induced arthritic rats. In stimulated RAW 264.7 cells, triphala (100-300 μg/ml) significantly suppressed production of inflammatory mediators (e.g. TNFα, IL-1β, IL-6, MCP-1, VEGF, NO, PGE2),...
Article
The anti-inflammatory effect of morin, a dietary bioflavanol was explored on monosodium urate (MSU) crystal-induced inflammation in rats, an experimental model for acute gouty arthritis. Morin treatment (30 mg/kg b.wt) significantly attenuated the ankle swelling and the levels of lipid peroxidation, nitric oxide, serum pro-inflammatory cytokines (t...
Article
Aims: The aim of this study was to investigate the anti-inflammatory effect of ferulic acid, a dietary phenol, on monosodium urate (MSU) crystal-induced inflammation in rats, an experimental model for acute gouty arthritis. For the purpose of comparison, colchicine was used as a reference drug. Main methods: Paw edema, levels/activities of elast...
Article
Full-text available
Our previous studies had reported that morin, a bioflavanoid exhibited potent anti-inflammatory effect against adjuvant-induced arthritic rats. In this current study, we investigated the anti-inflammatory mechanism of morin against monosodium urate crystal (MSU)-induced inflammation in RAW 264.7 macrophage cells, an in vitro model for acute gouty a...
Data
Effect of morin on NF-κBp65 protein expression and localization in MSU crystal induced RAW 264.7 macrophages. (TIF)
Data
Effect of morin on COX-2 protein expression in MSU crystal induced RAW 264.7 macrophages. (TIF)
Data
Effect of morin on TNF-α protein expression in MSU crystal induced RAW 264.7 macrophages. (TIF)
Article
The present study was aimed to investigate the anti-arthritic effect of majoon ushba (MU) and its underlying mechanism in adjuvant induced arthritis (AIA) rats. Arthritis was induced by intradermal injection of complete freund's adjuvant (0.1ml) into the right hind paw of the Wistar albino rats. MU (1000mg/kg/b.wt) and methotrexate (3mg/kg/b.wt) we...
Article
0 0 1 229 1311 farradilaiskandar@ymail.com 10 3 1537 14.0 Normal 0 false false false EN-US JA X-NONE The present investigation was carried out to evaluate the biochemical effect of Withania somnifera Linn. Solanaceae, commonly known as ashwagandha on adjuvant induced arthritic rats. Results were compared to Indomethacin, a non steroidal anti-inflam...
Article
The present study was aimed to investigate the anti-arthritic effect of triphala and its underlying mechanism on adjuvant-induced rat model. For comparison purpose, non-steroidal anti-inflammatory drug indomethacin was used. Arthritis was induced by intradermal injection of complete Freund’s adjuvant (0.1 ml) into the right hind paw of the Wistar a...
Article
The present study is an attempt to evaluate the hepatoprotective and anti-oxidant properties of Triphala against bromobenzene (BB) induced hepatotoxicity in rats. Hepatotoxicity was induced in rats by a single oral dose of BB (10 mmol/kg b.w) on first day of the study. Two different doses (250 mg/kg b.w and 500 mg/kg b.w) of Triphala were administe...
Article
The present study was aimed to assess the nephroprotective role of Spirulina fusiformis on bromobenzene (BB) induced toxicity in rat kidneys. Female Wistar rats were treated with a single oral dose of BB (10 mmol/kg/b.w.) following the oral administration of Spirulina fusiformis (400 and 800 mg kg/b.w.) for 8 days. The levels of serum renal functio...
Article
The purpose of the present study was to evaluate the nephroprotective and antioxidant properties of Triphala against bromobenzene-induced nephrotoxicity in female Wistar albino rats. Animals were divided into five groups of six rats and treated as follows: Group I was a normal control and received no treatment, Group II received only bromobenzene (...
Article
The present study was designed to assess the combined efficacy of morin, a dietary flavanol and non-steroidal anti-inflammatory drug indomethacin against adjuvant-induced arthritis in rats, an experimental model for rheumatoid arthritis. Arthritis was induced by intradermal injection of complete Freund's adjuvant (0.1ml) into the right hind paw of...
Article
Full-text available
The present study investigated the possible protective role of Withania somnifera (Linn.) Dunal (Solanaceae) root powder against bromobenzene-induced oxidative damage in rat liver mitochondria. Administration of bromobenzene (10. mmol/kg body weight) to rats resulted in increased levels of liver marker enzymes, lipid peroxidation, TNF-α, IL-1β and...
Article
The present study is an attempt to investigate the efficacy of Triphala in ameliorating the hepatotoxic effects of bromobenzene (BB) in experimental rats. Hepatotoxicity was induced in rats by oral administration of BB (1.57 mg/kg b.w.) and Triphala was given orally at two doses of 250 and 500 mg/kg b.w. for a period of 8 days. The antioxidant stat...
Article
AimRheumatoid arthritis is a chronic inflammatory autoimmune disorder with multi-factorial factors influencing disease alleviation in synovial joints. The aim of this study was to investigate the anti-arthritic efficacy of trikatu, a herbal compound, on biochemical and immunological complications in adjuvant-induced arthritic rats.Methods Arthritis...
Article
Context: Triphala, an Indian Ayurvedic herbal formulation which contains Terminalia chebula Retz. (Combretaceae), Terminalia bellerica (Gaertn.) Roxb. (Combretaceae) and Emblica officinalis L. (Phyllanthaceae), is used for treating bowel-related complications, inflammatory disorders, and gastritis. Objective: To determine the anti-arthritic effe...
Article
Cadmium, a well-known environmental pollutant and a toxic transitional metal causes severe damage to many organs, such as liver, kidney, lungs, heart, etc. The current study has been designed to assess the impact of p-coumaric acid, a common dietary polyphenol on cadmium chloride-induced renal toxicity in rats. Therefore, the activities of membrane...
Article
Full-text available
Background: The present study was conducted to elucidate the protective role of Withania somnifera against bromobenzene induced nephrotoxicity and mitochondrial dysfunction in rats. Methods: In this study, Wistar albino rats of either sex were divided into six groups consisting of six animals each. The first one was control, those in group II re...
Article
In the present study, the purpose was to investigate the effect of p-coumaric acid on the mRNA-expression levels of inflammatory cytokines, transcription factor, MAP kinases, and apoptotic proteins by real time reverse transcription polymerase chain reaction in the cardiac tissue of sodium arsenite exposed rats. Sodium arsenite administration (5 mg...
Article
Full-text available
The present study evaluated the efficacy of Spirulina fusiformis in protecting against chemical induced hepatotoxicity in rats using bromobenzene as the candidate toxin. A single oral dose of bromobenzene (BB) (10mmol/kg b.w.) resulted in significant (p< 0.05) decrease in antioxidant levels (catalase, superoxide dismutase, glutathione-s-transferase...
Article
Gout is an inflammatory joint disorder characterized by hyperuricaemia and precipitation of monosodium urate crystals in the joints. In the present study, we aimed to investigate the anti-inflammatory effect of trikatu, a herbal compound in monosodium urate crystal-induced inflammation in rats, an experimental model for acute gouty arthritis. Paw v...
Article
In the present study, trikatu, an herbal compound was evaluated for its immunomodulatory and anti-inflammatory properties with reference to cell mediated immune responses (delayed type hypersensitivity reaction), humoral immune response (haemagglutination titer and plaque forming assay), macrophage phagocytic index, circulating immune complex and i...
Article
The aim of the present study was to evaluate the analgesic, antipyretic and ulcerogenic effects of piperine, which is an active ingredient of pepper. Mice were administered piperine (20 and 30 mg/kg) intraperitoneally; hot plate reaction test and acetic acid test were used to determine the analgesic activity of piperine inmice. Antipyretic and ulce...
Article
Abstract The present study was conducted to elucidate the protective role of p-coumaric acid, a common dietary polyphenol against cadmium induced nephrotoxicity in rats. For the purpose of comparison, a standard reference drug silymarin (50 mg/kg b. wt) was used. In this experiment, the animals were divided into four groups, with each consisting of...
Article
Objective: The present investigation was carried out to assess the protective properties of Spirulina fusiformis against galactosamine induced toxicity in swiss albino mice. Methods: Evaluation of serum glutamate oxaloacetate transferase (SGOT), serum glutamate pyruvate transferase (SGPT), alkaline phosphatase (ALP), serum bilirubin (SBLN), antioxi...
Article
The purpose of this study was to evaluate the hepatoprotective and antioxidant properties of piperine against D- galactosamine induced hepatotoxicity in mice. Hepatotoxicity was induced in mice by a single dose of galactosamine (700 mg/kg, i.p.) activities of serum glutamate oxaloacetate transferase (SGOT), serum glutamate pyruvate transferase (SGP...
Data
Full-text available
Objective: The aim of this study was to evaluate the hepatoprotective and antioxidant effects of Withania somnifera against Paracetamol-induced liver injury in rats. Methods: In the present study, the protective effect of Withania somnifera was investigated against Paracetamol-induced hepatotoxicity and compared with Silymarin, a standard hepatopro...
Article
The aim of the present study was to investigate the hepatoprotective effects of Triphala in D-Galactosamine (D-GalN) induced hepatic toxicity in mice. The mice received a single dose of galactosamine (700mg/kg, i.p) to induce hepatotoxicity; Triphala extract (1000mg/kg, i.p) and silymarin (25 mg/kg, i.p.) were administered after the injection of ga...
Article
Liver damage can be induced by drugs or chemicals resulting from overdose or workplace exposure. Bromobenzene is an efficient model to perform studies on hepatotoxicity. After biotransformation into liver,it causes production of reactive oxygen species (ROS). Organs that have been found to be affected due to bromobenzene induced toxicity are liver,...
Article
Objective: This study was conducted to evaluate the effect of p-Coumaric acid, a common dietary phenol, on monosodium urate crystal-induced inflammation in rats-an experimental model for acute gouty arthritis. Methods: Paw edema, levels/activities of lysosomal enzymes, lipid peroxidation, enzymic antioxidants and a histopathological examination...
Article
Ocimum sanctum is a traditional herbal plant possessing numerous pharmacological and therapeutic properties. The present study was carried out to evaluate antipyretic, analgesic and antiulcerogenic properties of Ocimum sanctum (500 and 1000mg kg-1b.wt-1) in model system of rats. Drug Indomethacin (10mg kg-1b.wt-1) was used as a reference drug. Anim...
Article
Abstract The present study was performed to investigate the ameliorative role of p-coumaric acid against sodium arsenite-induced cardiotoxicity in rats. Sodium arsenite (5 mg/kg/b.wt,) was orally administered once a day for 30 days to the animals to induce cardiotoxicity. After the experimental period, cardiotoxicity was assessed by estimating the...
Article
In this study, p-coumaric acid was evaluated for its immunomodulatory and anti-inflammatory properties in vivo. The immunomodulatory effect of p-coumaric acid (100 mg/kg body weight) was assessed by evaluating its effect on cell-mediated immune responses (delayed type hypersensitivity reaction), serum immunoglobulin levels, and macrophage phagocyti...
Article
The present study was designed to investigate the antiperoxidative potential of p-coumaric acid, a common dietary phenol, in adjuvant-induced arthritis in rats. Arthritis was induced by an intradermal injection of 0.1 mL complete Freund's adjuvant in the foot pad of right hind limb of rats. p-Coumaric acid (100 mg/kg body weight, intraperitoneally)...
Article
In the present study, we aimed to investigate the hepatoprotective and antioxidant potential of ferulic acid against acetaminophen-induced liver damage in mice. Hepa-totoxicity was induced in mice by single dose of acetamino-phen (900 mg/kg body weight i.p.). Ferulic acid (80 mg/kg body weight i.p.) and silymarin (25 mg/kg/body weight i.p.) were ad...
Article
p-Coumaric acid (3-(4-hydroxyphenyl)-2-propenoic acid), a common dietary polyphenol, is widely distributed in cereals, fruits and vegetables with antioxidant property. Numerous studies have enlightened the ability of dietary phenols to be considered as potential therapeutics against arthritis. In this study, we aimed to investigate the ameliorative...
Article
The present study was undertaken to investigate the anti-inflammatory effect of piperine against adjuvant-induced arthritis in rats, an experimental model for rheumatoid arthritis and compared it with that of the non-steroidal anti-inflammatory drug indomethacin. Administration of heat-killed Mycobacterium tuberculosis (0. 1 ml) intradermally into...
Article
Full-text available
To evaluate the efficacy of boswellic acid against monosodium urate crystal-induced inflammation in mice. The mice were divided into four experimental groups. Group I served as control; mice in group II were injected with monosodium urate crystal; group III consisted of monosodium urate crystal-induced mice who were treated with boswellic acid (30...
Article
To investigate the hepatoprotective efficacy of 6-gingerol against acetaminophen-induced hepatotoxicity in mice. Mice were injected with a single dose of acetaminophen (900 mg/kg) to induce hepatotoxicity, while 6-gingerol (30 mg/kg) or the standard drug silymarin (25 mg/kg) was given 30 min after the acetaminophen administration. The mice were sac...