Maha Hassan

Cairo University | CU · business management

Background Several environmental and genetic factors are associated with high levels of lipids in obese patients. Apolipoprotein B (ApoB) is the major protein component of low-density lipoproteins (LDL), very-low density lipoproteins (VLDL) and chylomicrons and plays a central role in lipid metabolism. Several apoB restriction fragment length polym...

In the present scenario, the people's esthetic requirements and expectations have increased substantially. Hence, the dentists are faced with ever increasing demands to provide their patients with highly esthetic, durable tooth-colored restorations while maintaining a conservative approach to tooth reduction. Over the past 25 years, porcelain venee...

Purpose: to evaluate the efficacy of the polarized light therapy in accelerating pressure ulcers healing. Methods of evaluation (wound surface area and wound volume). Methods:-Thirty patients (18 males and 12 females) with complete or incomplete spinal cord injury patients and complain from pressure ulcers were randomly divided into two groups. Gro...

This study has been conducted to evaluate the efficacy of the Gallium Aluminum Arsenide (Ga-As) laser in accelerating pressure ulcers healing. Methods of evaluation (wound surface area and wound volume). Methods:-Thirty patients (16 males and 14 females) with complete or incomplete spinal cord injury patients and complain from pressure ulcers were...

Etodolac (ET) (poorly soluble drug) nanosuspensions were prepared by both pH shift method and antisolvent techniques in order to increase its dissolution rate. Various stabilizers were used, namely, Tween 20 and 80, HPMC, PVP K44, PVA, PEG 400, NaCMC, and β-cyclodextrin. The prepared nanosuspensions were characterized by Fourier transform infrared...

Objectives: The efficacy of ketorolac tromethamine (KT) floating alginate beads as a drug delivery system for better control of KT release was investigated. The formulation with the highest drug loading, entrapment efficiency, swelling, buoyancy, and in vitro release would be selected for further in vivo analgesic effect in the mice and pharmacoki...

The present study aimed to formulate orodispersible tablets of flutamide (FTM) to increase its bioavailability. Orodispersible tablets were prepared by direct compression technique using three different approaches namely; super-disintegration, effervescence and sublimation. Different combined approaches were proposed and evaluated to optimize table...

A solid dispersion (SD) approach has been performed to enhance the dissolution rate of insoluble drugs by improving their aqueous solubility. An insoluble drug, nimesulide (Nims), was chosen as a model for non-steroidal anti-inflammatory drugs. It was dispersed in a water-soluble carrier poloxamer 407. Different methods were employed to prepare suc...

Background: Acanthosis nigricans (AN) is characterized by hyperpigmented velvety plaques of the skin. AN is caused by hyperinsulinemia, a result of insulin resistance that is associated with obesity. Objective: To detect the relation between the severity of AN skin lesions and metabolic syndrome components in obese patients not fulfilling the crite...

The aim of this work was to evaluate the efficacy of Helium Neon (He–Ne) laser therapy on post mastectomy lymphedema and shoulder mobility. Thirty female patients with axillary lymph node dissection (ALND), with or without radiotherapy had been participated in this study. The patients were randomly divided into two groups of equal numbers. Group A...

The floating beads have been employed to make a sustained release of the drug in the stomach and to decrease the dose of the drug and hence overcome its side effects. The common benefits of the floating beads were it is easy preparation, without the need of a high temperature, and high percentage of the drug entrapment. In the present work, the Ket...

This article continues to explore some crucial differences between group analysis (as a western approach to group therapy) and the Minia integrative dynamic model (an approach that was developed in Egypt in the last decade). The article re-emphasizes the assumption that certain socio-cultural factors can grossly affect both the theory and practice...

A series of amino acid esters (3a-e) have been synthesized and evaluated as potential prodrugs of metronidazole with the aim of improving aqueous solubility and therapeutic efficacy. The aqueous solubility and the lipophilicity (expressed as the log P value) of metronidazole and its esters were investigated. In general the prodrugs revealed enhance...

The main aim of pharmacotherapeutics, is the attainment of an effective drug concentration at the intended site of action for a sufficient period of time to elicit the response. In this study a trial was made to formulate atenolol, which is a beta-adrenergic blocker in a topical ophthalmic gel. Two polymers were used in this study, carboxymethylcel...

A keratinase enzyme was isolated and purified from a feather-degrading culture of Aspergillus oryzae. Fractional precipitation of the crude enzyme with ethanol, acetone and ammonium sulfate yielded 21 fractions. The fraction obtained at 75–85% ammonium sulfate saturation showed the highest activity and about 3.3-fold purification. This fraction was...

The production of an antibiotic by free and immobilized cells of Streptomyces violatus through entrapment or adsorption on different materials was investigated. S. violatus entrapped in Ca-alginate beads gave low antibiotic activity compared to the free cell or adsorbed cell, while the adsorption of S. violatus on sponge cubes yielded the highest a...

A survey was carried out to select an antibiotic producing Streptomyces strain isolated from garden soil in Alexandria, Egypt. Streptomyces violatus showed the highest antimicrobial activity in static cultures after 7 days incubation at 30°C. The antibacterial substance was more active against Bacillus subtilis and Staphyllococcus aureus than Esche...

Streptomyces violatus produced an antimicrobial substance (268 µg/ml) after 7 days incubation at 30°C in static cultures. Fifteen litres of the culture filtrate were extracted with ethyl acetate and concentrated till dryness. The oily extract was subjected to silica gel column chromatography. Gradient elution was carried out using n-hexane-ethyl ac...