Magdalena Tarnacka

• PhD
• University of Silesia in Katowice

Solvent evaporation techniques are widely used for the formation of amorphous-like solid forms of active pharmaceutical ingredients. This study investigates the effect of solvent evaporation on the structure of itraconazole (ITZ) – an antifungal drug and a model thermotropic liquid crystal that exhibits nematic and smectic phases when supercooled f...

This study presents a novel approach by utilizing poly(vinylpyrrolidone)s (PVPs) with various topologies as potential matrices for the liquid crystalline (LC) active pharmaceutical ingredient itraconazole (ITZ). We examined amorphous solid dispersions (ASDs) composed of ITZ and (i) self-synthesized linear PVP, (ii) self-synthesized star-shaped PVP,...

The properties of confined materials are assumed to be governed by the phenomena occurring at the interface, especially the formation of an irreversible adsorption layer (IAL), which was widely discussed...

In this paper, we propose one-step synthetic strategies for obtaining well-defined linear and star-shaped polyvinylpyrrolidone (linPVP and starPVP). The produced macromolecules and a commercial PVP K30 with linear topology were investigated as potential matrices for suppressing metronidazole (MTZ) crystallization. Interestingly, during the formatio...

The enhancement of the properties (i.e., poor solubility and low bioavailability) of currently available active pharmaceutical ingredients (APIs) is one of the major goals of modern pharmaceutical sciences. Among different strategies, a novel and innovative route to reach this milestone seems to be the application of nanotechnology, especially the...

In this paper, we investigated the annealing experiments of poly(mercaptopropylmethylsiloxane, PMMS) confined within two types of porous templates (anodic aluminium oxide, AAO, and silica) characterized by different pore diameter, d= 8-120nm, using different thermal protocols (varying significantly in cooling/heating rate) by means of Broadband Die...

Phenyl alcohols (PhAs) are an interesting class of materials, for which the dielectric response reveals only the presence of single prominent Debye-like (D) relaxation, interpreted as a genuine structural (α) process. Herein, we have performed dielectric and mechanical measurements on a series of PhAs characterized by the varying length of the alky...

In this paper, we have examined a series of phenyl-substituted primary monohydroxy alcohols (phenyl alcohols, PhAs), from ethanol to hexanol by means of dielectric and Fourier transform infrared (FTIR) spectroscopies supported by the mechanical investigations. The combination of both dielectric and mechanical data allows calculation of the energy b...

In this paper, several experimental techniques, i.e., differential scanning calorimetry, X-ray diffraction, Fourier transform infrared, Raman, and broadband dielectric spectroscopy were applied to study the nature of the phase transitions in 1-adamantylamine (1-NH2-ADM, C10H17N) and 1-adamantanol (1-OH-ADM, C10H16O). Calorimetric measurements showe...

In the present study, the behavior of the calcium channel blocker cilnidipine (CLN) infiltrated into silica (SiO2) and anodic aluminum oxide (AAO) porous membranes characterized by a similar pore size (d = 8 nm and d = 10 nm, respectively) as well as the bulk sample has been investigated using differential scanning calorimetry, broadband dielectric...

Herein, the annealing of highly polar (S)-(-)-4-methoxymethyl-1,3-dioxolan-2-one (S-methoxy-PC) within alumina and silica porous membranes characterized by different pore diameters was studied by means of dielectric spectroscopy. We found a significant slowing down of the structural dynamics of confined S-methoxy-PC with annealing time below and, s...

Herein, we studied the impact of surface roughness on the molecular dynamics of a series of phenyl-terminated monohydroxyalcohols under spatial confinement provided by nanoporous anodic aluminum oxide (AAO) membranes of constant (const-AAO) and modulated (modul-AAO) pore diameter using Broadband Dielectric Spectroscopy and Differential Scanning Cal...

In this paper, efficient MMA photo O-ATRP protocols conducted inside nanoreactors varying in nanostructured interfaces are reported for the first time. We showed that the microstructure of recovered polymers could...

In this paper, thermal properties, atomic-scale structure, and molecular dynamics (at ambient and high pressure) of native melatonin (MLT) and its partially-deuterated derivative (MLT-d2) have been investigated. Based on infrared spectroscopy, it was shown that treating MLT with D2O causes the replacement of hydrogen atoms attached to the nitrogen...

The nature of hydrogen bond (HB) interactions is still far from being understood despite intense experimental and theoretical studies on this subject carried out by the leading research centers. In this paper, by a combination of unique high-pressure infrared, dielectric and volumetric data, the intramolecular dynamics of hydroxyl moieties (which p...

Modified oligosaccharides with cyclic topology seem to be promising excipients for the preparation of Amorphous Solid Dispersions (ASDs), especially with those Active Pharmaceutical Ingredients (APIs), which have a strong crystallization tendency from the amorphous/glassy state. Herein, the usefulness of two acetylated cyclodextrins (ac-α-CD and ac...

We study the molecular origin of a prepeak (PP) observed at low q values in the structure factors of three oligomers in a bulk (poly(mercaptopropyl)methylsiloxane, PMMS, poly(methylmercaptopropyl)-grafted-hexylmethacrylate, PMMS-g-HMA, and poly(methylphenyl)siloxane, PMPS) in order to understand the lowering of the PP intensity detected for oligome...

In this paper, the steric hindrance effect related to the presence of either an aromatic or cyclic ring on the self-association process in the series of monohydroxy alcohols (MAs), from cyclohexanemethanol to 4-cyclohexyl-1-butanol and from benzyl alcohol to 4-phenyl-1-butanol, was studied using X-Ray Diffraction (XRD), Differential Scanning Calori...

In this paper, high-pressure (HP) dielectric studies on H-bonded active pharmaceutical ingredient - ritonavir indicated the narrowing of α-dispersion with compression, and consequently, a breakdown of the temperature-pressure superpositioning rule. To understand such peculiar behavior, reported so far only for a few van der Waals compounds, we perf...

Star-shaped glycopolymers due to the attractive combination of the physicochemical, morphological, self-assembly properties along with biological activity have gained increased attention as innovative agents in novel cancer therapies. Unfortunately, the production of these highly desirable biomaterials remains a challenge in modern macromolecular c...

In this study, we report the acid-catalyzed and high pressure assisted ring-opening polymerization (ROP) of γ-butyrolactone (GBL). The use of a dually-catalyzed approach combining an external physical factor and internal catalyst (trifluoromethanesulfonic acid (TfOH) or p-toluenesulfonic acid (PTSA)) enforced ROP of GBL, which is considered as hard...

In this work, we examined the effect of the length of alkyl chain attached to the benzene ring on the self-assembling phenomena for a series of phenyl alcohol (PhA) derivatives, from phenylmethanol (benzyl alcohol) to 7-phenyl-1-heptanol, by means of X-Ray Diffraction (XRD), Differential Scanning Calorimetry (DSC), Fourier Transform Infrared (FTIR)...

In this paper, we report 1,5,7-Triazabicyclo[4.4.0]dec-5-ene (TBD) supported high-pressure approach enforcing Ring-Opening Polymerization (ROP) of γ-butyrolactone (GBL), that due to unfavorable thermodynamics and low ring strain, is considered as a hardly polymerizable monomer. Application of Broadband Dielectric Spectroscopy (BDS) allowed us to fi...

Herein, we investigated the molecular dynamics as well as intramolecular interactions in two primary monohydroxy alcohols (MA), 2-ethyl-1-hexanol (2EHOH) and n-butanol (nBOH), by means of broad-band dielectric (BDS) and Fourier transform infrared (FTIR) spectroscopy. The modeling data obtained from dielectric studies within the Rubinstein approach...

Poly(1-vinyl-2-pyrrolidone) (Povidone, PVP) is one of the most interesting and versatile synthetic polymers utilised in the pharmaceutical and cosmetic industries. Its large-scale commercial production offers an assortment of products in a wide range of molecular weights but poorly-controlled (macro)structural parameters (i.e., dispersity, function...

Herein, broadband dielectric (BDS) and Fourier transform infrared spectroscopy (FTIR), together with differential scanning calorimetry (DSC) and X-ray diffraction (XRD), were applied to study the molecular dynamics, molecular interactions as well as physical stability of an amorphous Active Pharmaceutical Ingredient (API)—probucol (PRO)—infiltrated...

Herein, we examined the effect of finite size and wettability on the structural dynamics and the molecular arrangement of the propylene carbonate derivative, (S)-(−)-4-methoxymethyl-1,3-dioxolan-2-one (assigned as s-methoxy-PC), incorporated into alumina and silica porous templates of pore diameters d = 4 nm–10 nm using Raman and broadband dielectr...

The subject of the invention is a method of pressure polymerization of γ-butyrolactone (GBL), enabling the production of chemically pure poly(γ-butyrolactone) PGBL, consisting in mixing the monomer in the form of γ-butyrolactone with a catalyst in the form of 1,5,7-triazabicyclo[ 4.4.0]dec-5-ene, preferably dried, in a catalyst to monomer ratio ran...

This work highlights the development of a robust and universal route towards gaining control over macromolecule molecular weight, molecular weight distribution, and more importantly, morphology through the implementation of photoiniferter-mediated RAFT (photo-RAFT) carried out in mesoporous materials varying in the composition, pore arrangement, an...

The innovative combination of light and high-pressure allowed us to effectively polymerize for the first time challenging ionic 1,2,4-triazolium-based ionic liquid (IL) with fluorinate anion (MetTRI/NTF) and non-ionic vinyl acetate...

The invention relates to a method for producing poly(N-vinylpyrrolidone) through pressure-induced free-radical polymerization of N-vinylpyrrolidone (NVP) initiated by light, either in bulk or in a solvent, under favorable pressure and temperature conditions (p and T). The method involves adding a radical photoinitiator to the monomer in the form of...

The impact of the chain length or dispersity of polymers in controlling the crystallization of amorphous active pharmaceutical ingredients (APIs) has been discussed for a long time. However, because of the weak control of these parameters in the majority of macromolecules used in pharmaceutical formulations, the abovementioned topic is poorly under...

We examined the behavior of poly(mercaptopropyl)methyl-siloxane (PMMS), characterized by a polymer chain backbone of alternate silicon and oxygen atoms substituted by a polar pendant group able to form hydrogen bonds (−SH moiety), by means of infrared (FTIR) and dielectric (BDS) spectroscopy, differential scanning calorimetry (DSC), X-ray diffracti...

In this paper, we have analyzed structural, thermal, and dynamical properties of four azole antifungals: itraconazole (ITZ), posaconazole (POS), terconazole (TER) and ketoconazole (KET), differing mainly in the length of the rod-like backbone and slightly in side groups. Our investigations clearly demonstrated that the changes in the chemical struc...

We investigated the influence of anion type (salicylate, [(MOB)MIm][Sal], vs chloride, [(MOB)MIm][Cl]) of imidazolium-based ionic liquid (IL) and its content on the curing kinetics of bisphenol A diglicydyl ether (DGEBA of molecular weight Mn = 340 g/mol). Further physicochemical properties (i.e., glass transition temperature, Tg, and conductivity,...

Herein we explored thermal properties, dynamics wettability and H-bonding pattern in various poly(propylene glycols) (PPG) of Mn = 400 g/mol confined into two types of nanoporous templates: silica (d=4 nm) and alumina (d=18 nm). Unexpectedly it was found that mobility of the interfacial layer and depression of the glass transition temperature weakl...

Herein, we show that the nanostructured interface, via modulation of pore size, has a strong impact on the segmental and chain dynamics of two poly(propylene glycols) (PPG) derivatives of two various molecular weights, Mn = 4000 g/mol and Mn = 2000 g/mol. In fact, a significant acceleration of dynamics was observed for PPG infiltrated into ordinary...

In this work, we developed a fast, highly efficient, and environmentally friendly catalytic system for classical free-radical polymerization (FRP) utilizing a high-pressure (HP) approach. The application of HP for thermally-induced, bulk FRP of 1-vinyl-2-pyrrolidone (VP) allowed to eliminate the current limitation of ambient-pressure polymerization...

Broadband dielectric spectroscopy (BDS) has been used to study the molecular dynamics and aging process in neat probucol (PRO) as well as its binary mixtures with selected acetylated saccharides. In particular, we applied the Casalini and Roland approach to determine structural relaxation times in the glassy state of the examined systems (so-called...

In this paper, the molecular dynamics, H-bonding pattern and wettability of the primary and secondary monohydroxyalcohols, 2-ethyl-1-hexanol (2E1H), 2-ethyl-1-butanol (2E1B) and 5-methyl-3-heptanol (5M3H) infiltrated into native and functionalized silica and alumina pores having pore diameters, d = 4 nm and d = 10 nm, have been studied with the use...

Herein, we report the pioneering high-pressure dielectric studies on a dynamics of a model van der Waals glass-forming liquid bisphenol-A diglycidyl ether (DGEBA) infiltrated into anodic aluminum oxide (AAO) templates of the mean pore sizes d=150 and d=18 nm. It was found that the shape of the structural process, although it varies with the confine...

Star‐shaped 1‐vinyl‐2‐pyrrolidone (VP)‐based polymers having four pendant arms were produced via high‐pressure RAFT using the trithiocarbonate‐functionalized core. The use of compression (p = 250 MPa) significantly reduced or eliminated star‐star/star‐chain coupling side reactions and termination process characteristics the for “core‐first” R‐type...

In this paper, thermal and structural properties, as well as molecular dynamics of co-amorphous binary mixtures composed of itraconazole (ITZ) and four other active pharmaceutical ingredients (APIs) with antifungal activity (posaconazole (POS), ketoconazole (KET), fluconazole (FLU), and voriconazole (VOR)), have been investigated. Calorimetric meas...

In this paper, we present facile synthetic strategies enabling production of well-defined poly(ionic liquids) PILs based on 1-vinyl-4-benzyl-3-methylimidazolium- (VBIm) and 1-vinyl-4-benzyl-3-methylpyrrolidium (VBPy) ionic liquids (IL) possessing different counterions (chloride Cl􀀀 vs. bis(trifluoromethanesulfonyl)imide NTf2 - ) (VBIm/NTf2,VBIm/Cl,...

In this paper, Broadband dielectric spectroscopy (BDS) has been applied to study molecular dynamics and crystallization kinetics of antihyperlipidemic active pharmaceutical ingredient (API) – gemfibrozil (GEM), as well as its deuterated (dGEM) and methylated (metGEM) derivatives, characterized with different type and strength of intermolecular inte...

In this paper, Broadband Dielectric Spectroscopy (BDS) has been applied to study the molecular dynamics of the two active pharmaceutical ingredients (APIs), probucol (PRO) and droperidol (DRO), above and below the glass transition temperature, at varying thermodynamic conditions. We found that the structural (α)-relaxation process in both compounds...

In this paper, catalyzed and non-catalyzed water-initiated Ring-Opening Polymerization (ROP) of ε-caprolactone (ε-CL) at varying thermodynamic conditions (T=293-393 K and p=0.1-500 MPa) was carried out. As organocatalysts, two non-nucleophilic bases characterized by a different mode of action, i.e. 1,8-Diazabicyclo(5.4.0)undec-7-ene (DBU) and 1,5,7...

Currently, a great effort is put on the understanding of the effect of the nanometrical constraint on the dynamics of the soft materials. Recent studies by Alexandris et al. [Macromolecules, 2016, 49, 7400–7414] and some of us [J. Phys. Chem. C, 2019, 123, 5549–5556] revealed that the enhancement of the molecular mobility and depression in the glas...

In this paper, we studied the impact of saccharides having a similar backbone but differing in the degree of freedom, local molecular mobility, flexibility of the ring and intermolecular interactions on the glass-forming ability (GFA) of naproxen (NAP) in binary mixtures. For this purpose, a series of methyl and acetyl derivatives of glucose (GLS)...

The vitrification process is usually preceded by the significant change (around 6-8 decades) in the viscosity, structural relaxation times, or diffusion that occurs in a relatively small range of temperatures in fragile liquids. Along with this phenomenon, also conformations of the molecules vary as well. In fact, this process is studied in bulk po...

The subject of the invention is a method of pressure polymerization of 1-vinyl-2-pyrrolidone (VP), enabling the production of chemically pure poly(1-vinyl-2-pyrrolidone) PVP, consisting in the monomer in the form of 1-vinyl-2-pyrrolidone (VP ) with a purity preferably above 99%, is mixed with a thermoinitiator in the form of azobis(isobutyronitrile...

The uniform thin films with variable thicknesses (d = 49, 120, 220 nm) of active pharmaceutical ingredient (API) glibenclamide (GCM) was spin-coated and investigated using broadband dielectric, grazing incident FTIR spectroscopies, atomic force microscopy, and ellipsometry. Data analysis revealed that nanoconfined systems consist of a mixture of am...

We report, for the first time, the metal-free green synthesis of linear poly(vinyl pyrrolidone) (PVP) homopolymers of molecular weight higher than 100 kg/mol and narrow dispersities via thermal and photo-induced...

In this paper, we explored the influence of both the variation in the molecular weight (M n = 400, 2000, 4000 g/mol) and the terminal groups (hydroxyl, amino, and methoxy) on the molecular dynamics of poly(propylene glycols) confined within anodic aluminum oxide membranes of different pore diameters. All confined samples revealed the presence of tw...

In this paper, comprehensive calorimetric, structural, inter- and intramolecular dynamics measurements with the use of Differential Scanning Calorimetry (DSC), X-ray diffraction (XRD), Broadband Dielectric and Fourier Transform Infrared (FTIR) spectroscopies have been applied to investigate properties of itraconazole (ITZ) glasses obtained via slow...

Different experimental techniques were applied to study thermal and structural properties, strength of H-bonds, possible keto-enol tautomerism and molecular dynamics at various thermodynamic conditions in the H-bonded active substance, curcumin (CRM). Dielectric measurements revealed dynamical features of examined compound that are uncharacteristic...

In this paper, the high-pressure calorimetry was used to monitor the heat of the polymerization of bisphenol-A diglycidyl ether (DGEBA) mixed with a stoichiometric amount of aniline over a wide range of pressure (p = 0.1–350 MPa at T = 298.15 K). To the best of our knowledge, this is the first high-pressure calorimetric study of the reaction kineti...

The effect of hard confinement and high pressure on the progress of free-radical and reversible addition-fragmentation chain transfer polymerizations of sterically hindered 1-octyl-3-vinylimidazolium bis(trifluoromethanesulfonyl)imide ([OVIM][NTf2]) has been investigated.

The behavior of the low and high molecular weight glass formers confined in nanoporous templates remains an unsolved puzzle despite the intensive long-term studies in this matter. The special effort is put to understand the enhancement of the segmental or structural dynamics and the depression of the glass transition temperatures in materials infil...

Herein, we tested the validity of the thermodynamic scaling of two (α and δ) relaxation processes observed in the isotropic and nematic phases of itraconazole, that is classified as a liquid crystal (LC). As illustrated, relaxation times of both processes obtained at various thermodynamic conditions can be successfully superposed over 1/TV^γ with d...

In this paper, the crystal growth of three active pharmaceutical ingredients (APIs): griseofulvin, nifedipine and naproxen from the single component systems and the solid dispersions composed of APIs and acetylated maltose, has been investigated in a wide temperature range using optical microscopy. Additionally, complementary calorimetric and diele...

Method of pressure polymerization of ε-caprolactone The subject of the invention is a method of pressure polymerization of ε-caprolactone (ε-CL), enabling the production of linear polycaprolactone (PCL), in which an initiator in the form of water is added to the ε-caprolactone (ε-CL) monomer with a purity preferably above 90%. or anhydrous alcohol...

Broadband dielectric and Raman spectroscopies combined with calorimetric measurements and DFT calculations have been used to investigate the molecular dynamics of the benzyl derivative of ibuprofen (Ben-IBU) incorporated into aluminum oxide (AAO) templates of various pore diameters (d=20 nm and d=80 nm). Time-dependent experiments on the material c...

In this paper, we have investigated the molecular dynamics above and below the glass-transition temperature of bisphenol-A diglycidyl ether (known as DGEBA, Mn = 340 g/mol) infiltrated in nanoporous alumina (AAO) templates of various pore sizes by means of dielectric and Raman spectroscopies. It was found that the temperature dependence of the stru...

The synthesis of tailored [2‐(methacryloyloxy)ethyl]‐trimethylammonium chloride (ChMA/Cl⁻) and bis(trifluoromethanesulfonate) imide (ChMA/NTf2⁻)‐based ionic homopolymers by sustainable activators generated by electron transfer atom transfer radical polymerization (ATRP) method has been demonstrated. Linear and four‐arm star‐shaped macromolecules we...

In this paper, thermal properties, molecular dynamics, crystallization kinetics and intermolecular interactions in pure naproxen (NAP), its amide (NH2-NAP) and four esters (methyl – Met-NAP, isopropyl – Iso-NAP, hexyl – Hex-NAP, benzyl – Ben-NAP), have been investigated using Differential Scanning Calorimetry (DSC), Broadband Dielectric (BD) and Fo...

Broadband Dielectric Spectroscopy (BDS) was applied to monitor Z–E isomerization in a fulgide-type photochromic compound, Aberchrome 670 (Ab670).

The effect of the chemical modification of poly(propylene glycol) (PPG) end groups on the molecular dynamics under 2D confinement and the polymer/matrix interactions (including interfacial energies) was investigated by a combination of differential scanning calorimetry (DSC), broadband dielectric spectroscopy (BDS), surface tension and contact angl...

In this paper, the molecular dynamics of a series of ester derivatives of ibuprofen (IBU), in which the hydrogen atom from the hydroxyl group was substituted by the methyl, isopropyl, hexyl, and benzyl moieties, has been investigated using Broadband dielectric (BD), Nuclear magnetic resonance (NMR), and Raman spectroscopies. We found that except fo...

Efficient ROP polymerization of ϵ-caprolactone, resulting in products characterized by high molecular weight of low dispersities, remains a challenging task and is currently an important matter of ongoing research, mostly due to the accompanying side reactions, i.e., hydrolysis and transesterification. Herein, we studied in detail the impact of 2D...

Broadband Dielectric Spectroscopy was applied to investigate molecular dynamics of two anhydrosaccharides, i.e., 1,6-anhydro-β-D-mannopyranose, anhMAN (hydrogen-bonded system) and 2,3,4-tri-O-acetyl-1,6-anhydro-β-D-glucopyranose, ac-anhGLU (van der Waals material), at different thermodynamic conditions. Moreover, the reported data were compared wit...

Intra- and intermolecular studies on the molten L-sorbose have been carried out at variable temperature conditions to determine the crosover temperature (Tc). In addition, isothermal time-dependent FTIR and Raman measurements were performed to probe the pace of mutarotation and activation energy of this reaction in the studied saccharide, which var...

In this paper, 1,6-anhydro-β-D-glucopyranose (anhGLU), 1,6-anhydro-β-D-mannopyranose (anhMAN), and 1,6-anhydro-β-D-galactopyranose (anhGAL), three new materials that form the Orientationally Disordered Crystal (ODIC) phase, have been thoroughly investigated using various experimental techniques. All measurements clearly indicated that these compoun...

Here, we have studied the effect of spatial restrictions on the molecular dynamics and crystallization behavior of modeled lipophilic drug fenofibrate incorporated into nanoporous aluminum oxide membranes of different pore size. Our measurements demonstrate that on subsequent cooling dynamics of confined liquid split up into two distinct fractions,...

For the first time, RAFT polymerization of monomeric ionic liquid under hard confinement was successfully carried out. Consequently, macromolecules of well-defined chemical structure and narrow molecular weight distribution were obtained. Additionally, we reported the unique possibility of triggering RAFT polymerization at 30oC. This novel strategy...

In this paper, broadband dielectric spectroscopy was applied to investigate molecular dynamics of 1,2,3,4,6-penta-O-(trimethylsilyl)-D-glucopyranose (S-GLU) at ambient and elevated pressures. Our studies showed that apart from the structural relaxation, one well resolved asymmetric secondary process (initially labeled as β) is observed in the spect...

The effect of nanoscale confinement on the formation of glacial phase in triphenyl phosphite (TPP), usually assigned to liquid-liquid transition (LLT), was investigated by a combination of differential scanning calorimetry (DSC), broadband dielectric (BDS) and Raman spectroscopy. Although the application of micronscale confinement revealed the prese...

The synthesis of well-defined imidazolium-based poly(ionic liquid)s (PILs) by Reversible Addition-Fragmentation Chain Transfer (RAFT) polymerization is demonstrated. Two specially designed monomeric ionic liquids (MILs), such as 1-methyl-3-vinylimidazolium bis(trifluoromethanesulfonyl)imide [MVIM][NTf2] and 1-ethyl-3-vinylimidazolium bis(trifluorom...

Comprehensive FTIR studies on the progress of mutarotation in D-fructose mixed with maltitol have been carried out over a wide range of temperatures, both above and below the glass transition temperature (Tg). Except for the analysis of single bands enabling monitoring selective pathways of mutarotation (α→β), we developed completely new approach t...

Development of green ε-caprolactone (CL) polymerization method is the most important challenge of modern polymer chemistry. Herein, we propose a novel way to produce polyesters of well-defined chemical structure, narrow molecular weight distributions by using combination of high pressure, temperature and water. We found two competitive phenomena: p...

The annealing behavior of poly(propylene glycol) (PPG, Mw = 4000 g/mol) incorporated into the nanoporous aluminum oxide (AAO) membranes of different pore diameter was investigated by broadband dielectric spectroscopy (BDS) and differential scanning calorimetry (DSC). The presence of two subsets of molecules of different dynamics (interfacial and co...

In this paper the crystal growth of nifedipine from pure system and from binary mixtures composed of active substance (API) and two acetylated disaccharides: maltose and sucrose (NIF-acMAL, NIF-acSUC, 5:1 weight ratio) was investigated. Optical snapshots supported by X-Ray diffraction (XRD) and Fourier Transform Infrared Spectroscopy (FTIR) measure...

The kinetics of polymerization of Bisphenol-A diglycidyl ether (DGEBA), a well-known epoxy resin, with two ionic amines 1-(3-aminopropyl)-3-butylimidazolium bis(trifluoromethylsulfonyl)imide ([apbim][NTf2]) and the tetrabutylammonium leucine ([N4444][Leu]) have been studied with the use of differential scanning calorimetry (DSC) and broadband diele...