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Magdalena Schimke

Magdalena Schimke
STRATEC Consumambles GmbH · Business Development

PhD

About

13
Publications
13,063
Reads
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211
Citations
Citations since 2017
4 Research Items
161 Citations
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2017201820192020202120222023051015202530
2017201820192020202120222023051015202530
Introduction
Business fusion and technology transfer to allow market entrance for great ideas in the microfluidic and lab-on-chip technologies.
Additional affiliations
March 2015 - present
University of Salzburg
Position
  • Senior Researcher
August 2013 - January 2015
University of Innsbruck
Position
  • PhD Student
November 2012 - present
University of Innsbruck
Position
  • Student Supervision
Description
  • supervision of undergrads internships and bachelor thesis

Publications

Publications (13)
Article
Background: Due to aging, tissue regeneration gradually declines. Contemporary strategies to promote tissue-specific regeneration, in particular in elderly patients, often include synthetic material apt for implantation primarily aiming at upholding body functions and regaining appropriate anatomical and functional integrity. Objective: Biomater...
Article
Biofunctionalization of scaffold materials can enable the healing of large bone defects. In case of minimally invasive guided-bone regeneration (GBR), limitations are however hard-to-control side effects related to the potential release of biofactors into the systemic environment. Biofactors can be stably bound to nanodiamond particles (ND) through...
Article
Full-text available
Nanoparticles, especially from carbon, have great potential in biomedicine. However, prior to clinical use, biocompatibility and biodistribution of these nanoobjects have to be assessed. Currently, particle detection is mostly based on surface‐bound labels, inevitably altering materials' properties by surface modification. Further obstacles include...
Book
• Die Autorinnen und Autoren führen interdisziplinär Wissensbestände zum Thema Altersforschung zusammen. Neben unterschiedlichen Perspektiven bieten sie in kompakten Beiträgen einen Einblick zu Prozessen des Alterns und über Erkenntnisse zu gesundem Altern. Darüber hinaus werden zentrale Ansätze und Modelle diskutiert sowie unterschiedliche diszipl...
Article
Unlabelled: Biofunctionalized scaffold facilitates complete healing of large defects. Biological constraints are induction and ingrowth of vessels. Angiogenic growth factors such as vascular endothelial growth factor or angiopoietin-1 can be bound to nano-scaled diamond particles. Corresponding bioactivities need to be examined after biofunctional...
Article
Full-text available
Multipotential mesenchymal stromal cells (MSC) are present as a rare subpopulation within any type of stroma in the body of higher animals. Prominently, MSC have been recognized to reside in perivascular locations, supposedly maintaining blood vessel integrity. During tissue damage and injury, MSC/pericytes become activated, evade from their periva...
Article
Aging is associated with an accruing emergence of non-functional tissues. Mesenchymal stem cells (MSC) bring forth progenitors with multi-lineage differentiation potential, yet, they also exhibit anti-inflammatory and tissue-protective properties. Due to aging, altered tissue microenvironments constrict controlled stem cell proliferation and progen...
Article
Excess enzyme-mediated protein O-GlcNAcylation is known to occur with diabetes mellitus. A characteristic of diabetic cardiomyopathy is the development of myocardial fibrosis. The role that enhanced protein O-GlcNAcylation plays in modulating the phenotype of cardiac fibroblasts is unknown. To address this issue, rat cardiac fibroblasts (CF) were c...
Article
Bone-derived stroma cells contain a rare subpopulation, which exhibits enhanced stemness characteristics. Therefore, this particular cell type is often attributed the mesenchymal stem cell (MSC). Due to their high proliferation potential, multipotential differentiation capacity, and immunosuppressive properties, MSCs are now widely appreciated for...
Article
Irradiation impacts on the viability and differentiation capacity of tissue-borne mesenchymal stem cells (MSC), which play a pivotal role in bone regeneration. As a consequence of radiotherapy, bones may develop osteoradionecrosis. When irradiating human bone-derived MSC in vitro with increasing doses, the cells' self-renewal capabilities were grea...

Questions

Questions (12)
Question
Dako Products work very well but are way too expensive. Alternatively I'd appreciate a self-made recipe that works very well :) I just do not have the recources to try many differnet recipes and mixtures.
Thanks for hints!
Question
I have a new material for tissue engineering however, histology is needed to evaluate it. Paraffine is too soft, diamond knife, grinder and saw not available.
Question
Can I fix cells using PFA after staining with vybrant DiO staining without losing the fluorescent signals?
Question
we are a non-immunology laboratory yet we do want a straight forward, sophisticated method to characterize cells... FACS/flow cytometers are very pricy - so any recommendations and ideas for alternatives are helpful!
Thanks!
Question
Does anyone has experience with the usage of Copper-based Cell Incubators? Causing benefits or trouble? Corrosion vs antibacterial effects?
Question
A biobank maintained with liquid nitrogen should ensure a stable low temperature.
To your experience, how low can I expect my gas phase in a storage tank to be?
I expected to reach close -196°C when the tank is accordingly filled with N2, which does not happen (says -94°C). S
So, I wonder if I need to relocate the temperature sensor? (currently it is shortly underneath the thick isolation layer of the cloding lid)
thanks for your experience and recommendations.
Question
how do you assess the level of sterility of your cell culture working bench (lamniar flow) and incubator after a long period of downtime?
Question
its used for a Messer Chronos 400 nitrogen tank (Biosafe)
thank you all for any hints! or a file ;)
Magdalena

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Projects

Projects (2)
Project
Application of Nanodiamond and MSCs in mandibular reconstruction of sheep in a pre-clinical setting