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Publications (4)
Several novel lactones containing either a pyridin-3-yl or a pyridin-2-yl ring in their structure were synthesized: trans δ halolactones 6–8a,b (chloro-, bromo- and iodo-), γ iodolactone 11b and isomeric γ hydroxylactones 9–10a,b. Their structures were confirmed by NMR, IR and HR-MS and additionally by single crystal X-ray diffraction for trans δ b...
2-(2-Fluoro-4-biphenyl) propionic acid (flurbiprofen), from the phenylalkanoic acid family of nonsteroidal anti-inflammatory drugs (NSAID’s), is currently on the pharmaceutical market as a racemate. This racemic compound was tested for its propensity to undergo the self-disproportionation of enantiomers (SDE) phenomenon by various forms of chromato...
This work presents the first study of the self-disproportionation of enantiomers via chromatography (SDEvC) of β-aminophosphonic acid esters, several of which have been synthesized for the first time. Three types of structures were examined, N-acetylated, dipeptide construction with N-Cbz glycine, and a free amine. In the latter case, this is the f...
This review covers the phenomenon of the self-disproportionation of enantiomers (SDE) of amino acids and their derivatives in all its guises from phase transformations (recrystallization, sublimation, and distillation), to the application of force fields, through to chromatography including HPLC, MPLC, gravity-driven column chromatography, and SEC....
