Magdalena Cuevas

Magdalena Cuevas
University of Concepción · Departamento de Fisiología

PhD

About

10
Publications
2,508
Reads
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119
Citations
Additional affiliations
August 2013 - December 2016
Universidad de La Frontera
Position
  • Professor (Assistant)
March 2012 - May 2016
Universidad de La Frontera
Position
  • PhD Student
January 2005 - December 2011

Publications

Publications (10)
Article
Full-text available
After the discovery of prion phenomenon, the physiological role of the cellular prion protein (PrP C ) remained elusive. In the past decades, molecular and cellular analysis has shed some light regarding interactions and functions of PrP C in health and disease. PrP C , which is located mainly at the plasma membrane of neuronal cells attached by a...
Article
Full-text available
Since the early studies of William J. McCormick in the 1950s, vitamin C has been proposed as a candidate for the treatment of cancer. A number of reports have shown that pharmacological concentrations of vitamin C selectively kill cancer cells in vitro and decrease the growth rates of a number of human tumor xenografts in immunodeficient mice. Howe...
Article
Full-text available
The production of reactive oxygen species (ROS) in boar spermatozoa increases in refrigeration; this can have an impact on sperm quality and fertilization capacity. We evaluated the effect of polyphenol-rich aqueous extract of murtilla ( Ugni molinae Turcz) on boar sperm stored at 17°C in order to reduce oxidative stress and improve sperm quality i...
Article
Full-text available
Hypertension is a systemic condition with high morbidity and mortality rates worldwide, which poses an increased risk for cardiovascular diseases. In this study, we demonstrated the antioxidant and vasodilator activity of Ugni molinae Turcz. (Murtilla) fruit, a berry native to Chile and proposed models to explain its modulatory mechanism in hypoten...
Article
Full-text available
Studies have indicated that excessive production of reactive oxygen species (ROS) can affect cellular signalling pathways. In reproductive health, the biotechnological manipulation of sperm used for human and animal reproduction can induce thermal and biochemical changes that increase ROS generation, causing effects such as decreased motility and a...
Article
Full-text available
Studies had indicate that excessive production of re-active oxygen species (ROS) affect cellular signaling pathways, which is associated with pathological and physiological conditions such as cancer, diabetes and neurodegenerative diseases In this context, our la-boratory has obtained the Bios-p, a ROS modulator, peptide analogue by sequencing from...
Article
Full-text available
It is believed that amyloid-β peptide (Aβ), in its aggregated-oligomeric state, constitutes one of the neurotoxic factors involved in the pathogenesis of Alzheimer's disease. With the objective of studying a potential role of the peptide on synaptic transmission, we studied the effect of soluble Aβ(1-40) on synaptic transmission in rat hippocampal...
Article
In this study, we describe a novel form of anti-homeostatic plasticity produced after culturing spinal neurons with strychnine, but not bicuculline or 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX). Strychnine caused a large increase in network excitability, detected as spontaneous synaptic currents and calcium transients. The calcium transients were...
Article
Previous studies, using electrophysiological and fluorimetric analysis with a calcium sensitive dye, have shown that 5-7 DIV developing spinal cord neurons displayed high levels of glycinergic transmission. GABAergic and AMPAergic neurotransmission contributed much less to the overall transmission. Here, we show that culturing neurons in absence of...

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Projects

Project (1)
Project
Evaluate the effect of boxing training in motor and non-motor symptoms of Parkinson Disease patients