Magda Elhenawee

The ecological impact of routine quality control activities in the pharmaceutical industry is crucial, producing large amounts of dangerous organic waste. For that, the use of mixed-micellar LC was found beneficial. When sodium dodecyl sulfate (SDS) is mixed with Brij-35 as surfactants in the mobile phase, no organic modifier was needed for enhanci...

Angiotensin-converting enzyme inhibitors are one of the most widely used anti-hypertensive drugs which are used to reduce hypertension. In 2018, the United States Food and Drug Administration together with the European Medicine Agency declared the presence of carcinogenic nitrosamine impurities such as nitrosodiethylamine (NDEA) in some of the prod...

This literature mini-review focuses on chromatography and its application for separation of proteomics, Factors affecting RP-HPLC of proteins and their peptide mapping. Only two drugs are cited in the mini-review, which are erythropoietin hormone and carbetocin where mode of action and analytical techniques used for their determination were describ...

This literature review is dealing with Hepatitis C, treatment strategy, and different analytical techniques for determination of recently used anti-HCV drugs specifically Sofosbuvir, Simeprevir, Ledipasvir, Daclatasvir and Velpatasvir in different pharmaceutical and biological samples.

In this literature review, we will introduce most of the up-to-date reported methods that have been developed for the determination of Ombitasvir, Paritaprevir and Ritonavir in their pure form, combined form with other drugs combined form with degradation products, and in biological samples. Most of reported methods includes spectrophotometric and...

In this literature review, we will introduce most of up-to-date reported methods that have been developed for determination of lamivudine in its pure form, combined form with other drugs, combined form with degradation products, and in biological samples.

This literature review focuses on drugs used for erectile dysfunction and premature ejaculation, in respect of mode of action and different analytical techniques used for their determination either alone or in combination with other drugs in different pharmaceutical and biological matrices. The cited drugs are Sildenafil, Avanafil, Apomormphine, Yo...

Chromatographic application of two recent HPLC stationary phases for protein analysis was demonstrated. These two stationary phases are namely monolithic rods and core-shell particles. Monolithic rods have higher permeability and larger porous structure allowing faster elution, while smaller core-shell particles have narrower particle size distribu...

By 2025, it's estimated that 322 million males worldwide will suffer from sexual disorders. This can give an estimation for the size of the pharmaceutical and counterfeit products industry for the next few years. Meanwhile, green analytical chemistry forced itself to decrease the massive environmental pollution and hence new analytical methodologie...

Background: Silver nanoparticles synthesis is now widely applicable as a method for sensitive spectrophotometric determination of many pharmaceuticals. Objective: A highly sensitive, cheap, green, nonextractive, and accurate spectrophotometric method was developed for the determination of three important antiviral drugs. Methods: The method de...

The discovery of new direct-acting antiviral drugs gave rise to a leap forward in the treatment of hepatitis C viral infections. For the first time since 1998, the Food and Drug Administration (FDA) approved interferon-free oral treatment paradigms. Among the new treatment regimens, the combinations of sofosbuvir/daclatasvir and sofosbuvir/velpatas...

The therapeutic combination of ondansetron (OND) and pantoprazole (PAN) is widely prescribed for the treatment of many gastrointestinal tract (GIT) disorders. For this reason, a new, simple, very sensitive, accurate and precise HPTLC method was proposed for the determination of OND and PAN in pure forms, normal saline infusion solution, and spiked...

Ombitasvir, ritonavir and paritaprevir are three recently discovered directly acting antiviral drugs (DAADs) used in combined single dose tablet dosage form for treatment of hepatitis-C viral infections (HCV). The methods of analysis followed by quality control and research laboratories are required to be economic and fast; however, these methods c...

Impurity profiling of active pharmaceutical ingredients is a crucial step in assessing their quality. In this study, a green stability indicating method for simultaneous determination of latanoprost (LTN)and timolol (TIM)was validated and assessed for greenness. TIM & LTN are two anti-glaucoma drugs manufactured as combination therapy. Their separa...

The combination of sofosbuvir and daclatasvir or sofosbuvir and ledipasvir are now widely used as an ideal treatment of hepatitis C virus infection. For that purpose, a simple, sensitive, accurate, economic, and precise high‐performance thin‐layer chromatography was developed and validated for the determination of sofosbuvir, daclatasvir, and ledip...

Background: The introduction of monolithic rods and core-shell particles as new morphologies of packing materials different from the conventional totally porous particles resulted in a leap forward for performance in LC. Meanwhile, environmental safety has become increasingly important in many areas, especially in industry and research laboratories...

The performances of core–shell 2.7 μm and fully porous sub-2 μm particles packed in narrow diameter columns were compared under the same chromatographic conditions. The stationary phases were compared for fast separation and determination of five new antiviral drugs; daclatasvir, sofosbuvir, velpatasvir, simeprevir and ledipasvir. The gradient elut...

A simple, rapid and accurate, routine-LC method is described for simultaneous determination of four antihypertensive drugs, hydrochlorothiazide, losartan potassium, valsartan and irbesartan in bulk powders and pharmaceutical preparations. The chromatographic separation of the four pharmaceuticals was achieved on a reversed phase C18 "Intersil® ODS-...

In this study, the effect of change in chromatographic process variables on the retention behavior of four drugs employed in erectile dysfunction therapy on a calixarene stationary phase was described. Three of these drugs are known to treat erectile dysfunction, namely, sildenafil citrate, tadalafil and apomorphine hydrochloride, and one drug that...

In this article, the effect of changes in different process variables such as pH, buffer type and concentration, column temperature, injection volume, as well as type and contents of organic modifier on retention behavior of seven antihypertensive drugs from two different categories (Angiotensin II receptor blockers and Diuretics) was investigated....

This study reports for the first time about a stability indicating RP-HPLC method for quantitative determination of Praziquantel (PZQ) in bulk powder and dosage form and in presence of its pharmacopoeial impurities. The chromatographic separation was carried out on (Caltrex AI®) calixarene column, a relatively new packing material. Chromatography w...

A simple spectrophorometric method for the determination of secnidazole, niclosamide, nifuroxazide and sulphasalzine is described. The method is based on reduction of the nitro group present in secnidazole and niclosamide molecule using zinc powder and dilute hydrochloric acid followed by reaction with fast red B salt in presence of ammonium chlori...