Magda Bucholc

Magda Bucholc
Ulster University · School of Computing, Engineering and Intelligent Systems

MSc PhD
Lecturer in Data Analytics

About

83
Publications
8,526
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196
Citations
Introduction
Dr Magda Bucholc is a Lecturer in Data Analytics at the Intelligent Systems Research Centre at Ulster University. She works on the development and implementation of statistical frameworks and computational methodologies in clinical decision making, in particular, to improve current disease risk prediction models, enable earlier diagnosis, optimize allocation of health care resources, and deliver more tailored treatments to patients.

Publications

Publications (83)
Article
Full-text available
There is currently a lack of an efficient, objective and systemic approach towards the classification of Alzheimer's disease (AD), due to its complex etiology and pathogenesis. As AD is inherently dynamic, it is also not clear how the relationships among AD indicators vary over time. To address these issues, we propose a hybrid computational approa...
Article
Full-text available
Computerized clinical decision support systems can help to provide objective, standardized, and timely dementia diagnosis. However, current computerized systems are mainly based on group analysis, discrete classification of disease stages, or expensive and not readily accessible biomarkers, while current clinical practice relies relatively heavily...
Article
Full-text available
Introduction: Hearing aid usage has been linked to improvements in cognition, communication, and socialization, but the extent to which it can affect the incidence and progression of dementia is unknown. Such research is vital given the high prevalence of dementia and hearing impairment in older adults, and the fact that both conditions often coex...
Article
Full-text available
Introduction: We assessed the association of self-reported hearing impairment and hearing aid use with cognitive decline and progression to mild cognitive impairment (MCI). Methods: We used a large referral-based cohort of 4358 participants obtained from the National Alzheimer's Coordinating Center. The standard covariate-adjusted Cox proportion...
Article
Background: Healthcare requires patient feedback to improve outcomes and experience. This study undertook a systematic review of the depth, variability, and digital suitability of current patient-reported outcome measures (PROMs) in patients undergoing laparoscopic cholecystectomy. Methods: A PROSPERO-registered (registration number CRD420212617...
Article
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Background Despite the call to enhance accuracy and value of operation records few international recommended minimal standards for operative notes documentation have been described. This study undertook a systematic review of existing operative reporting systems for laparoscopic cholecystectomy (LC) to fashion a comprehensive, synoptic operative re...
Article
Full-text available
Background Accumulated electronic data from a wide variety of clinical settings has been processed using a range of informatics methods to determine the sequence of care activities experienced by patients. The “as is” or “de facto” care pathways derived can be analysed together with other data to yield clinical and operational information. It seems...
Article
Full-text available
Accurate computational models for clinical decision support systems require clean and reliable data but, in clinical practice, data are often incomplete. Hence, missing data could arise not only from training datasets but also test datasets which could consist of a single undiagnosed case, an individual. This work addresses the problem of extreme m...
Article
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Background: Surgical Site Infections (SSI) are a major source of post-operative complications and potentially affect oncological outcomes. Reducing SSI is multi-factorial, best served by the additive affect of individual wound bundle elements. With changing strategies and novel innovations ongoing meta-analyses are needed to inform current practice...
Article
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Antimicrobial resistance has become one of the greatest threats to global health. Over 80% of antibiotics are prescribed in primary care, with many prescriptions considered to be issued inappropriately. The aim of this study was to examine the association between prescribing rates and demographic, practice, geographic, and socioeconomic characteris...
Article
There is growing evidence that alterations in the endocannabinoid system (ECS) co‐occur with dementia pathophysiology. Currently, limited literature is available on components of the peripheral ECS as diagnostic markers for dementia. In the present study we analysed the concentrations of the endocannabinoids (eCBs) anandamide (AEA) and 2‐Arachidono...
Article
Full-text available
Introduction: Umbilical hernia repair, despite its perceived simplicity, is associated with recurrence between 2.7 and 27%, in mesh repair and non mesh repair respectively. Many factors are recognized contributors to recurrence however multiple defects in the linea alba, known to occur in up to 30% of patients, appear to have been overlooked by su...
Preprint
Background: Clinical Dementia Rating Sum of Boxes (CDRSOB) scale is known to be highly indicative of cognitive-functional status, but it is unclear whether it is consistent with clinician diagnosis in evaluating drug class associations with risk of progression to mild cognitive impairment (MCI) and dementia. Methods: We employed multivariate logist...
Chapter
Dementia is one of the major causes of disability and dependency among older people worldwide. Without treatment currently available to cure dementia or to alter its progressive course, one of the principal goals for dementia care set by the World Health Organisation is the early diagnosis in order to promote early and optimal management. In recogn...
Article
Full-text available
Background: Emergency midline laparotomy is the cornerstone of survival in patients with peritonitis. While bundling of care elements has been shown to optimize outcomes, this has focused on elective rather than emergency abdominal surgery. The aim of this study was to undertake a systematic review and meta-analysis of factors affecting the develo...
Preprint
Full-text available
The increasing prevalence of dementia in older adults warrants attention to the identification of practices that can delay or reduce likelihood of progression to early forms of cognitive impairment, in particular, to mild cognitive impairment (MCI) which is often considered a transitional stage between healthy aging and dementia. In this study, we...
Article
Full-text available
Introduction: Appendicitis is one of the most common causes of acute abdominal pain requiring surgical intervention, but the variability of diagnosis and management continue to challenge the surgeons. Aim: This study assessed patients undergoing appendectomy to identify opportunities to improve diagnostic accuracy and outcomes. Methods: An ethic...
Preprint
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Background: Machine learning (ML) techniques are expected to tackle the problem of the high prevalence of Alzheimer’s disease (AD) we are facing worldwide. However, few studies of novelty detection (ND), a typical ML technique for safety-critical systems especially in healthcare, were engaged for identifying the risk of developing cognitive impairm...
Article
Full-text available
Hearing loss is the third most commonly reported chronic disease in older adults. Its prevalence ranges from 30% in individuals aged 65‐74 years to 40%‐60% in those aged 75 years or older. Evidence suggests that age‐related hearing impairment is strongly and independently associated with the decline in cognitive abilities and that individuals with...
Article
Full-text available
Background Despite some evidence of improved survival with intraoperative cholangiography (IOC) during cholecystectomy, debate has raged about its benefit, due in part to its questionable benefit, time and resources required to complete. Methods A PROSPERO-registered (ID CRD42018102154) meta-analysis following PRISMA guidelines using PubMed, Scopu...
Presentation
Background: Emergency midline laparotomy is a cornerstone to patient survival in patients with peritonitis, optimizing outcomes with the use of bundles needs to be defined. Much of the international literature and best practice mandates have focused on elective rather than emergency abdominal surgery. The aim of this study was to undertake a system...
Article
Full-text available
Background: Systems Medicine is a novel approach to medicine, i.e. an interdisciplinary field that considers the human body as a system, composed of multiple parts and of complex relationships at multiple levels, and further integrated into an environment. Exploring Systems Medicine implies understanding and combining concepts coming from diametral...
Article
Full-text available
Introduction: Conflicting results on dementia risk factors have been reported across studies.We hypothesize that variation in data preparationmethods may partially contribute to this issue. Methods: We propose a comprehensive data preparation approach comparing individuals with stable diagnosis over time to those who progress to mild cognitive impa...
Preprint
Full-text available
INTRODUCTION: Hearing aid usage has been linked to improvements in cognition, communication, and socialization, but the extent to which it can affect the incidence and progression of dementia is unknown. Such research is vital given the high prevalence of dementia and hearing impairment in older adults, and the fact that both conditions often coexi...
Chapter
Dementia is a collection of symptoms associated with impaired cognition and impedes everyday normal functioning. Dementia, with Alzheimer’s disease constituting its most common type, is highly complex in terms of etiology and pathophysiology. A more quantitative or computational attitude towards dementia research, or more generally in neurology, is...
Article
Introduction: Optimizing delivery of care to patients with appendicitis as part of an emergency general surgery care program is important. Appendicitis is one of commonest emergency surgical presentations and has significant potential morbidity and occasional mortality. Meta-analysis of reinterventions following appendicectomy has not been publishe...
Article
Full-text available
Aim To assess variables contributing to hospital conveyance for people with diabetes and the interactions between them. A secondary aim was to generate hypotheses for further research into interventions that might reduce avoidable hospital admissions. Methods A national retrospective data set including 30 999 diabetes‐related callouts from the Sco...
Article
Full-text available
Background: Despite some evidence of improved survival with intraoperative cholangiography during cholecys-tectomy, debate has raged about its benefit, in part because of its questionable benefit, time, and resources required to complete. Methods: An International Prospective Register of Systematic Reviews-registered (ID CRD42018102154) meta-analys...
Preprint
Accurate computational models for clinical decision support systems require clean and reliable data, but in clinical practice, data are often incomplete. Hence, missing data could arise not only from training datasets but also test datasets which could consist of a single undiagnosed case, an individual. Many popular methods of handling missing dat...
Article
Full-text available
Background: Cancer outcomes are complex, involving prevention, early detection and optimal multidisciplinary care. Postoperative infection and surgical site-infection (SSI) are not only uncomfortable for patients and costly, but may also be associated with poor oncological outcomes. A meta-analysis was undertaken to assess the oncological effects...
Preprint
Full-text available
Dementia is a collection of symptoms associated with impaired cognition and impedes everyday normal functioning. Dementia, with Alzheimer's disease constituting its most common type, is highly complex in terms of etiology and pathophysiology. A more quantitative or computational attitude towards dementia research, or more generally in neurology, is...
Article
Full-text available
Background: Laparoscopic cholecystectomy (LC) is one of the most commonly performed surgical procedures. Despite this, patterns of readmission following LC are not well defined. This meta-analysis aimed to determine rates and predictors of readmission. Methods: An ethically approved International Prospective Register of Systematic Reviews (PROSPERO...
Preprint
Full-text available
Background Hearing aid usage has been linked to improvements in cognition, communication, and socialization, but the extent to which it can affect the onset and progression of dementia is unknown. This study leveraged the National Alzheimer's Coordinating Center Uniform Data Set to longitudinally examine the association between the use of hearing a...
Article
Full-text available
Background: Systems Medicine is a novel approach to medicine, i.e. an interdisciplinary field that considers the human body as a system, composed of multiple parts and of complex relationships at multiple levels, and further integrated into an environment. Exploring Systems Medicine implies understanding and combining concepts coming from diametral...
Presentation
Full-text available
A meta-analysis of the use of the intraoperative cholangiography; time to revisit our approach to cholecystectomy.
Technical Report
Full-text available
This report presents the outputs of a week-long collaboration between The Alan Turing Institute and Great Ormond Street Hospital. The purpose was to scope how vital signs monitoring data can be better used to inform the removal of a breathing tube (i.e. ‘extubation’) in intensive care units (ICUs). The main objectives were evaluating the effectiven...
Presentation
Full-text available
Introduction: Despite some evidence of improved survival with intraoperative cholangiography (IOC) during cholecystectomy, debate has raged about its benefit. This meta-analysis evaluated the use and impact of IOC during cholecystectomy. Methods: An ethically approved PROSPERO-registered (ID CRD42018102154) meta-analysis following PRISMA guideline...
Conference Paper
Various epidemiological studies have shown an association between high midlife blood pressure and late-life incident dementia and cognitive decline. This study evaluated some of the commonly prescribed antihypertensive drugs and their association with progression to dementia from healthy and mild cognitive impairment (MCI) stages.
Article
Full-text available
Background: Incisional hernia (IH) occurs in approximately 25% of laparotomies. Prophylactic mesh placement (PMP) may significantly reduce IH but is not widely used. This paper will review the evidence relating to the role of PMP in laparotomy and its ability to effectively and safely have an impact on hernia reduction. Methods: An ethically app...
Technical Report
Full-text available
A central part of the biopharmaceutical manufacturing process are bioreactors, i.e. sterile containers in which genetically modified cell cultures are grown in a controlled environment to produce drugs or intermediate compounds. One of the major – and mostly unsolved –challenges is to understand how the vast array of bioreactor settings influence a...
Conference Paper
Full-text available
Introduction: Despite some evidence of improved survival with intraoperative cholangiography (IOC) during cholecystectomy, debate has raged about its benefit. This meta-analysis evaluated the use and impact of IOC during cholecystectomy. Materials & Methods: An ethically approved PROSPERO-registered (ID CRD42018102154) meta-analysis following PRISM...
Conference Paper
Full-text available
Introduction: Biliary diseae is a leading cause for surgical emergency admissions globally and despite the association of common bile duct stones (CBD) stones with increased mortality, the natural history of CBD stones is not well documented. This study undertook a meta-analysis of the significance of CBD stones in cholecystectomy patients. Materia...
Article
Full-text available
Objectives: To describe the laboratory test ordering patterns by general practitioners (GPs) in Northern Ireland Western Health and Social Care Trust (WHSCT) and explore demographic and socioeconomic associations with test requesting. Design: Cross-sectional study. Setting: WHSCT, Northern Ireland. Participants: 55 WHSCT primary care medical practi...
Presentation
Certain cardio-metabolic implications are associated with an increased risk for dementia. However, several studies have shown a degree of variability which complicate our understanding of the role of such risk factors on dementia. This study aims to further understand such risk variability by evaluating the association of these risk factors with re...
Conference Paper
Cardio-metabolic risk factors have been implicated in dementia risk but with contrasting results reported across studies. For reliable risk prediction, a comprehensive analysis of multiple risk factors is required. This is particularly important in groups that progress from normal and mild cognitive impairment (MCI) to dementia stages. This study e...
Article
Full-text available
Introduction: Laparoscopic cholecystectomy, the gold-standard approach for cholecystectomy, has surprisingly variable outcomes and conversion rates. Only recently has operative grading been reported to define disease severity and few have been validated. This multicentre, multinational study assessed an operative scoring system to assess its abilit...
Article
Full-text available
Introduction: Laparoscopic cholecystectomy, the gold-standard approach for cholecystectomy, has surprisingly variable outcomes and conversion rates. Only recently has operative grading been reported to define disease severity and few have been validated. This multicentre, multinational study assessed an operative scoring system to assess its abili...
Preprint
Computerized clinical decision support systems can help to provide objective, standardized, and timely dementia diagnosis. However, current computerized systems are mainly based on the group analysis, discrete classification of disease stages, or expensive and not readily accessible biomarkers, while current clinical practice relies relatively heav...
Conference Paper
Full-text available
The following abstracts are those that were presented at the research competition of the Student Medical Summit held in University College Dublin on the 9th February 2019. For more information about the Student Medical Summit visit www.student-medicalsummit.org or contact info@studentmedicalsummit.org.
Presentation
Introduction: Incisional hernia in occur in about 30% of patients post emergency surgery. Reinforced abdominal wall closure is gaining traction and on-lay mesh is increasingly used even in the presence of intra-abdominal sepsis. Incorporating the mesh itself with the fascial closure suture, rather than just on top has some theoretical advantages. T...
Presentation
Emergency General Surgery poses one of the great challenges in surgical outcomes; currently accounting for up to 10% of hospital admissions and has a mortality of between 5% and 30%. The pattern of re-admission to hospital following laparotomy is not well defined. This study undertook a meta-analysis to determine patterns of re-admission post emerg...
Presentation
In emergency general surgery (EGS) patients with peritonitis mortality remains ≥ 10%. Direct peritoneal resuscitation (DPR) involving instillation of peritoneal dialysis fluid in trauma patients has improved their mortality by 10% in RCTs. Its use in EGS peritonitis has not been reported. This study reports its use and novel technical options for D...
Presentation
Full-text available
Despite some evidence of improved survival with intraoperative cholangiography (IOC) during cholecystectomy, its use is variable. This meta-analysis evaluated the use and potential impact of IOC during cholecystectomy. An ethically approved PROSPERO-registered (ID CRD42018102154) meta-analysis following PRISMA guidelines using PubMed, Scopus, Web o...
Presentation
Aims & objectives: Despite increased efforts to develop prognostic models for dementia progression, current frameworks are limited mainly to methodologies that involve either single time point models or are heavily dependent on biomarkers. Our research project aims to develop a prognostic multiple time-point model for assessing the likelihood of de...
Presentation
Introduction: Biliary disease is a leading cause for surgical emergency admissions globally and despite the association of common bile duct (CBD) stones with increased mortality, the natural history of CBD stones is not well documented. Aim: This study undertook a meta- analysis of the significance of CBD stones in cholecystectomy patients. Metho...