Maël Gainche

Université Clermont Auvergne | Univ BPC · Institut de Chimie de Clermont-Ferrand

Plants are a promising source of innovative bioactive compounds for skin treatment and some species of the Juncaceae family have been used in folk medicine for the treatment of erysipelas or bleeding. We focused on Luzula sylvatica, a Juncaceae member that has sparked growing interest for its anti-inflammatory potential Methods: The antioxidant pro...

The emergence of numerous resistance mechanisms in human pathogenic bacteria has become a major concern of medical and pharmaceutical research. The World Health Organization reckons that the number of deaths due to antibiotic resistance could reach 10 million by 2050 if new effective therapies are not rapidly developed. Only recently, pleuromutilin...

Filipendula ulmariais a plant commonly used for the treatment of several pathologies,such as diarrhoea, ulcers, pain, stomach aches, fevers, and gout. Our study focused on the use ofF. ulmariafor the treatment of gout disease. We first studied the chemical composition of a methanolicextract of the aerial parts and demonstrated its xanthine oxidase...

13 different species belonging to the Geraniaceae family were collected and their phytochemical profile is currently investigate.

Phenanthrenoids have been widely described, in the Juncaceae family, for their biological properties such as antitumor, anxiolytic, anti‐microbial, spasmolytic, and antiinflammatory activities. The Juncaceae family is known to contain a large variety of phenanthrenoids possessing especially anti‐inflammatory and cytotoxic properties. Luzula sylvati...

Background: Some Bupleurum species, such as the Bupleurum chinense DC. or the Bupleurum scorzonerifolium Willd have been extensively studied (especially their roots) for the treatment of inflammation. In contrast, only compounds extracted from the aerial parts of Bupleurum rotundifolium have been studied and showed anti-inflammatory or antiprolife...

Meadowsweet (Filipendula ulmaria) and Harpagophytum (H. procumbens) are two medicinal herbs traditionally used for their anti-inflammatory effect. Nonetheless, if the effects of the single compounds isolated from these plants have been well described, little is known about the molecular mechanisms behind whole extracts. Methods: We studied and comp...

This is the first part of my work on Filipendula ulmaria (Meadowsweet), mainly about two ways to determine Xanthine oxydase inhibitor and the beginning of a chemoguided fractionation.

Relativement sous-exploité, le potentiel d’innovation lié aux activités biologiques des métabolites secondaires des végétaux est pourtant considérable. Aussi, nous nous sommes intéressés à la flore d’Auvergne, reconnue pour sa richesse et sa diversité, qui possède de nombreuses plantes encore peu étudiées et valorisables (projet PLANTINAUV 2017-202...

This is the very first work on the Plantinauv project.