Maël Gainche- Doctor of Chemistry
- Post-Doc at University of Clermont Auvergne
Maël Gainche
- Doctor of Chemistry
- Post-Doc at University of Clermont Auvergne
Lecturer at SIGMA Clermont
Researcher at Clermont Auvergne University
Field : Analytical chemistry, Phytochemistry
About
25
Publications
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Introduction
After a PhD in phytochemistry finished in 2020, I work mainly as researcher and teacher in university.
With chromatography techniques (from HPLC/Prep to Biobeads) and NMR, I make the elucidation of new compounds discovered in nature, in order to seek for new potential drugs for various diseases.
Nowadays, I also work on new Effect Directed Assay on HPTLC for a quicker discovery of active metabolites in complex matrixes (enzymes and microorganisms) as well as validation of analytical method.
Current institution
Additional affiliations
September 2021 - October 2021
February 2020 - July 2020
October 2021 - present
Position
- Lecturer
Description
- I work at Sigma Clermont as Lecturer for the natural substances and analytical chemistry course, and as researcher for the development of new analysis method by HPTLC.
Education
February 2017 - February 2020
September 2015 - September 2016
September 2013 - September 2016
Publications
Publications (25)
Filipendula ulmariais a plant commonly used for the treatment of several pathologies,such as diarrhoea, ulcers, pain, stomach aches, fevers, and gout. Our study focused on the use ofF. ulmariafor the treatment of gout disease. We first studied the chemical composition of a methanolicextract of the aerial parts and demonstrated its xanthine oxidase...
In recent years Bioautography has become an efficient bioassay for finding active compounds in complex matrices including extracts of; bacteria, plants or fungi. High Performance Thin Layer Chromatography (HPTLC) is a technique which allows effect-directive analysis (EDA) through the separation and identification of biologically active substances o...
Vitex madiensis Oliv. (Lamiaceae) and Crossopteryx febrifuga (Rubiaceae), two plants commonly used in traditional African medicines to treat malaria and pain, were studied either to determine their chemical profiles or to evaluate their antioxidant and anti-inflammatory activities. In this study, we investigated leaves, trunk bark, root bark and fr...
Phenanthrenoids have been widely described, in the Juncaceae family, for their
biological properties such as antitumor, anxiolytic, anti‐microbial, spasmolytic, and antiinflammatory activities. The Juncaceae family is known to contain a large variety of
phenanthrenoids possessing especially anti‐inflammatory and cytotoxic properties. Luzula sylvati...
The emergence of numerous resistance mechanisms in human pathogenic bacteria has become a major concern of medical and pharmaceutical research. The World Health Organization reckons that the number of deaths due to antibiotic resistance could reach 10 million by 2050 if new effective therapies are not rapidly developed. Only recently, pleuromutilin...
Background/Objectives: Inflammation is a vital response of the immune system, frequently linked to the development and progression of numerous chronic and autoimmune diseases. Targeting inflammation represents an attractive strategy to prevent and treat these pathologies. In this context, many pathways, including pro-inflammatory cytokines secretio...
Objective
In this study, we analyzed and investigated the antioxidant, anti-inflammatory, and antitumoral properties of methanolic (Met), dichloromethane (Dic), ethyl acetate (Ac), and diethyl ether (Et) fruit extracts of Ammodaucus leucotrichus on the MCF-7 breast cancer cell line.
Methods
The extracts of Ammodaucus leucotrichus fruits, explored...
The use of natural antioxidants as substitutes for traditional synthetic stabilizers has been investigated for the stabilization of biobased and biodegradable polymers, with the aim of designing fully biobased plastic formulations. This study focused on the thermo-and photostabilization of poly(lactic acid) (PLA) using vegetal polyphenol extracts a...
The coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has infected over 640 million people and killed more than 6 million people over the world. Most of the antivirals approved and used for the treatment of SARS COV infection consist of small synthetized compounds. Nevertheless, it has b...
High Performance Thin Layer Chromatography (HPTLC) is a method allowing an effect-directive analysis that enables separation and identification of biologically active substances on a TLC plate and allows a high throughput screening for enzymatic inhibition activity. Bioautography became, in the last decades, a very efficient way to find out new act...
(1) Interest in the Juncaceae family has risen as some members have shown anti-inflammatory properties and interesting compounds. In this regard, we decided to investigate the antioxidant and anti-inflammatory properties of Luzula sylvatica, a Juncaceae not yet extensively studied, in the context of osteoarthritis. (2) The Luzula sylvatica Ethanol...
Plante Vitex madiensis Oliv. numéro de référence T7041, récolté à 30 Km, au sud de Brazzaville, Congo • Organes récoltés Feuille, fruits, écorce de tronc, racines • Extrait méthanolique Extraction de chaque organe par macération dans le méthanol, Rapport plante/solvant 1/10. Caractérisation de métabolites secondaires antiinflammatoires extraits de...
Plants are a promising source of innovative bioactive compounds for skin treatment and some species of the Juncaceae family have been used in folk medicine for the treatment of erysipelas or bleeding. We focused on Luzula sylvatica, a Juncaceae member that has sparked growing interest for its anti-inflammatory potential Methods: The antioxidant pro...
13 different species belonging to the Geraniaceae family were collected and their phytochemical profile is currently investigate.
Background:
Some Bupleurum species, such as the Bupleurum chinense DC. or the Bupleurum scorzonerifolium Willd have been extensively studied (especially their roots) for the treatment of inflammation. In contrast, only compounds extracted from the aerial parts of Bupleurum rotundifolium have been studied and showed anti-inflammatory or antiprolife...
Meadowsweet (Filipendula ulmaria) and Harpagophytum (H. procumbens) are two medicinal herbs traditionally used for their anti-inflammatory effect. Nonetheless, if the effects of the single compounds isolated from these plants have been well described, little is known about the molecular mechanisms behind whole extracts. Methods: We studied and comp...
This is the first part of my work on Filipendula ulmaria (Meadowsweet), mainly about two ways to determine Xanthine oxydase inhibitor and the beginning of a chemoguided fractionation.
Relativement sous-exploité, le potentiel d’innovation lié aux activités biologiques des métabolites secondaires des végétaux est pourtant considérable. Aussi, nous nous sommes intéressés à la flore d’Auvergne, reconnue pour sa richesse et sa diversité, qui possède de nombreuses plantes encore peu étudiées et valorisables (projet PLANTINAUV 2017-202...
This is the very first work on the Plantinauv project.
