Maël Gainche

Maël Gainche
Université Clermont Auvergne | Univ BPC · Institut de Chimie de Clermont-Ferrand

Doctor of Chemistry
Post-Doc and Lecturer in Phytochemistry SIGMA Clermont Chemistry Institute of Clermont-Ferrand (ICCF)

About

13
Publications
2,899
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14
Citations
Introduction
After a PhD in phytochemistry finished in 2020, I work mainly as researcher and teacher in university. With chromatography techniques (from HPLC to Biobeads) and NMR, I make the elucidation of new compounds discovered in nature, in order to seek for new potential drugs for various diseases. Nowadays, I also work on new Effect Directed Assay on HPTLC for a quicker discovery of active metabolites in complex matrixes (enzymes and microorganisms).
Additional affiliations
October 2021 - present
SIGMA Clermont
Position
  • Lecturer
Description
  • I work at Sigma Clermont as Lecturer for the natural substances and analytical chemistry course, and as researcher for the development of new analysis method by HPTLC.
September 2021 - October 2021
Université Clermont Auvergne
Position
  • Researcher
September 2020 - August 2021
University of Strasbourg
Position
  • ATER
Description
  • Working as learner and researcher at the Faculty of Pharmacy of Strasbourg University in Dominique Bonnet's laboratory, in Departement of Pharmacognosy
Education
February 2017 - February 2020
Université Clermont Auvergne
Field of study
  • Organic chemistry
September 2015 - September 2016
Université Clermont Auvergne
Field of study
  • Organic chemistry
September 2013 - September 2016
SIGMA Clermont
Field of study
  • Organic chemistry

Publications

Publications (13)
Article
Full-text available
Plants are a promising source of innovative bioactive compounds for skin treatment and some species of the Juncaceae family have been used in folk medicine for the treatment of erysipelas or bleeding. We focused on Luzula sylvatica, a Juncaceae member that has sparked growing interest for its anti-inflammatory potential Methods: The antioxidant pro...
Poster
Full-text available
The emergence of numerous resistance mechanisms in human pathogenic bacteria has become a major concern of medical and pharmaceutical research. The World Health Organization reckons that the number of deaths due to antibiotic resistance could reach 10 million by 2050 if new effective therapies are not rapidly developed. Only recently, pleuromutilin...
Article
Full-text available
Filipendula ulmariais a plant commonly used for the treatment of several pathologies,such as diarrhoea, ulcers, pain, stomach aches, fevers, and gout. Our study focused on the use ofF. ulmariafor the treatment of gout disease. We first studied the chemical composition of a methanolicextract of the aerial parts and demonstrated its xanthine oxidase...
Experiment Findings
13 different species belonging to the Geraniaceae family were collected and their phytochemical profile is currently investigate.
Article
Full-text available
Phenanthrenoids have been widely described, in the Juncaceae family, for their biological properties such as antitumor, anxiolytic, anti‐microbial, spasmolytic, and antiinflammatory activities. The Juncaceae family is known to contain a large variety of phenanthrenoids possessing especially anti‐inflammatory and cytotoxic properties. Luzula sylvati...
Article
Full-text available
Background: Some Bupleurum species, such as the Bupleurum chinense DC. or the Bupleurum scorzonerifolium Willd have been extensively studied (especially their roots) for the treatment of inflammation. In contrast, only compounds extracted from the aerial parts of Bupleurum rotundifolium have been studied and showed anti-inflammatory or antiprolife...
Article
Full-text available
Meadowsweet (Filipendula ulmaria) and Harpagophytum (H. procumbens) are two medicinal herbs traditionally used for their anti-inflammatory effect. Nonetheless, if the effects of the single compounds isolated from these plants have been well described, little is known about the molecular mechanisms behind whole extracts. Methods: We studied and comp...
Presentation
This is the first part of my work on Filipendula ulmaria (Meadowsweet), mainly about two ways to determine Xanthine oxydase inhibitor and the beginning of a chemoguided fractionation.
Poster
Relativement sous-exploité, le potentiel d’innovation lié aux activités biologiques des métabolites secondaires des végétaux est pourtant considérable. Aussi, nous nous sommes intéressés à la flore d’Auvergne, reconnue pour sa richesse et sa diversité, qui possède de nombreuses plantes encore peu étudiées et valorisables (projet PLANTINAUV 2017-202...

Network

Cited By

Projects

Projects (3)
Project
The aim of this project is to investigate chemically the biggest number of plant in a family (for example the Geraniaceae) in order to improve the knowledge of the phytochemistry of all the plants in Europe. Moreover, describing the chemical profile of plants could help for further investigation.
Project
Finding interesting molecules in local plants from the Auvergne region (FRANCE), particularly for the treatment of inflammatory diseases.