Madhulika Esther Prasad

• Doctor of Philosophy
• Assistant Professor at Sardar Bhagwan Singh Post Graduate Institute of Biomedical Sciences & Research

Breast cancer poses a global health challenge and requires innovative approaches for prevention and treatment. Phytochemicals have gained attention for their potential anti-cancer properties by offering promising therapeutic interventions with their many advantageous effects and activity in promoting apoptotic pathways and other molecular pathways...

Pancreatic cancer remains one of the fatal malignancies with limited treatment options and a high rate of drug resistance. Y-box binding protein 1 (YBX1) plays an essential role in pancreatic cancer by upregulating the low-density lipoprotein receptor-related protein-1 (LRP1), which promotes tumour growth through the Wnt/β-catenin pathway. Diospyro...

Millet is one of the oldest cereal grains, used for several centuries in Asia and Africa. Its ease of growth in adverse environmental conditions and with minimum agricultural inputs made it a popular choice before the advent of the green revolution. However, the green revolution's recent focus on nutritional insecurity has led to a renewed interest...

Rapid development of human civilization with increase in human population has contributed to the accumulation of hazardous pollutants in the environment. Fluorine a highly reactive element, is ubiquitously found in the world environment, mostly as inorganic compounds of fluoride. Fluoride is beneficial in trace amounts to the human body, but is ext...

Ever since the start of the Industrial Revolution, environmental pollution has significantly increased. The prominent cause of most diseases in humans, animals, and plants is the presence of toxic materials, pollutants, contaminants, and hazardous com- pounds released by industries. One of the major factors is the presence of heavy metals in the a...

Introduction: Catharanthus roseus, commonly known as Vinca Rosea or Madagascar periwinkle, is a significant plant species within the Apocynaceae family, known for its diverse medicinal properties and ornamental attri- butes, long embraced by Chinese traditional medicine practices. Methodology: Electronic records of papers published in various dat...

The continued use of crop varieties introduced by Green Revolution that focus entirely on high yield and compromise on nutritional quality, has led to the advent of diet-related diseases in recent times that need to be combated with nutraceutical food products. Nutraceuticals are foods which provide medicinal benefits along with essential nutrients...

The nutritional importance of minor millets growing in geographically and environmentally isolated semi-arid regions remains largely unexplored, which has led to it being under-utilized for diet diversification. In this study, the proximate composition of three species of minor millets, namely, Barnyard millet (Echinochloa frumentacea),Finger mille...

The enteropathogenic Escherichia coli (EPEC) multicargo chaperone CesT interacts with at least 10 effector proteins and is central to pathogenesis. CesT has been implicated in coordinating effector hierarchy although the mechanisms behind this regulation are poorly understood. To address this question, we set out to functionally characterize CesT w...

Bacterial type III secretion systems (T3SS) are complex protein assemblies that mediate the secretion of protein substrates outside the cell. Type III secretion chaperones (T3SC) are always found associated with T3SS, and they serve in multiple roles to ensure that protein substrates are efficiently targeted for secretion. Bacterial pathogens with...

The Arabidopsis RING E3 ligase, XBAT32, was previously characterized as a regulator of lateral root initiation. However, how XBAT32 function to modulate lateral root initiation was unknown. In our recent paper, we demonstrated that XBAT32 is involved in ethylene biosynthesis and it is through this function that XBAT32 is able to regulate lateral ro...

XBAT32, a member of the RING domain-containing ankyrin repeat subfamily of E3 ligases, was previously identified as a positive regulator of lateral root development. Arabidopsis (Arabidopsis thaliana) plants harboring a mutation in XBAT32 produce fewer lateral roots that wild-type plants. We found that xbat32 mutants produce significantly more ethy...