Madhu Goel

Madhu Goel
King George's Medical University | CSM · Department of Pathology

BSc, MBBS, MD, DCP

About

135
Publications
17,712
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1,955
Citations
Citations since 2016
14 Research Items
1275 Citations
2016201720182019202020212022050100150200
2016201720182019202020212022050100150200
2016201720182019202020212022050100150200
2016201720182019202020212022050100150200

Publications

Publications (135)
Article
Full-text available
Skin and Adnexal tumours are a group of benign and malignant tumours whose basic diagnosis relies on histopathology. A single tumour may show more than 1 appendageal differentiation. Morphologic distinction between benign and its malignant counterpart is of utmost importance as it affects the treatment and prognosis of patient. We have described 3...
Article
This study was designed to examine the expression and cellular distribution of homeobox (HOX) genes (HOXA10 and HOXA11) and cell adhesion molecules (E-cadherin, N-cadherin, and β-catenin) during the window of implantation in infertile women with noncavity-distorting intramural (IM) fibroids (n = 18) and in fertile controls (n = 12). Quantitative re...
Article
Full-text available
Background: Breast cancer is the commonest female cancer worldwide and its propensity to metastasize negatively impacts on therapeutic outcome. Several clinicopathological parameters with prognostic/predictive significance have been associated with metastatic suppressor expression levels. The role of metastatic suppressor gene (MSG) KiSS1 in breas...
Article
NF-κB has been implicated in mechanisms promoting inflammation in tumor microenvironment leading to breast cancer metastasis. Owing to critical role of CCL2 during metastasis, particularly in its capacity to act as a chemoattractant for macrophages and their precursors i.e monocytes, we decided to explore if pro-metastatic function of NF-κB could b...
Conference Paper
Full-text available
Abstract Background: Oral squamous cell carcinoma (OSCC) is a multistep process arising through the progressive accumulation of multiple genetic and epigenetic events. Tobacco, bidi (tobacco flakes wrapped in a tendu leaf) smoking and alcohol consumption are established risk factors associated with OSCC and premalignant oral lesions (PMOLs) in Indi...
Article
p>Background: Oral squamous cell carcinoma (OSCC) is a multistep process arising through the progressive accumulation of multiple genetic and epigenetic events. Tobacco, bidi (tobacco flakes wrapped in a tendu leaf) smoking and alcohol consumption are established risk factors associated with OSCC and premalignant oral lesions (PMOLs) in Indian popu...
Article
Background: GLUTs are a family of proteins that mediate glucose transport through the membrane, expressed in head and neck squamous cell carcinoma. GLUT-1 positivity in malignant cells indicates increased proliferative activity, energy requirements, aggressive behaviour and poor radiation response. Aim: To observe the expression of GLUT-1 protein...
Article
Background: Carcinogenesis is a multifaceted intricate cellular mechanism of transformation of the normal functions of a cell into neoplastic alterations. Metastasis may result in failure of conventional treatment and death Hence, research on metastatic suppressors in cancer is a high priority. The metastatic suppressor gene CD82, also known as KA...
Article
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Purpose: To evaluate the expression of Her2/neu and Ki-67 in benign and malignant gallbladder lesions, and to establish correlations with clinico-pathologic parameters. Materials and methods: A retrospective analysis was conducted on formalin fixed paraffin embedded (FFPE) benign (n=25) and malignant gallbladder (n=25) tissue samples. Hematoxyli...
Article
Full-text available
We came across such a diagnosis, but the presenting clinical symptom was utero-vaginal (UV) prolapse. CASE REPORT A 55-year-old postmenopausal lady, P 3+1 , presented with complaints of something coming out of vagina from past 6 months, followed by persistent pain in the lower abdomen from past 4 months and post-menopausal bleeding since 20 days. T...
Data
a. Gene-level expression (GE) track holding information about counts, length as annotated and expression values for each gene involved in Ependymoma on using one reference sequence per transcript.b. Transcript-level expression (TE) track holding information about counts, length as annotated and expression values as RPKM and relative RPKM (RPKM for...
Data
Various isoforms of the identified transcript clusters of level-2 and level-3.
Data
a. Correlation between HTA array-based transcript cluster ID identified in GO-terms level-3 and gene expression (GE) track data. b. Correlation between HTA array-based transcript cluster ID identified in GO-terms level-3 and transcript-level expression (TE) track data.
Data
a. Biological Processes related to GO terms.b. GO terms of second level in alternative splicing data obtained through HTA Array2.0.c. GO terms of second level in alternative splicing data obtained through HTA Array2.0.
Article
Full-text available
Endometrioid endometrial carcinoma (EEC), also known as type I endometrial cancer (EC), accounts for over 70-80% of all cases that are usually associated with estrogen stimulation, and often develops in a background of atypical endometrial hyperplasia. The increased incidence of EC is mainly confined to this type of cancer. Most EEC patients presen...
Article
Full-text available
Here, we sequenced and functionally annotated the long reads (1–2 kb) cDNAs library of an infratentorial ependymoma tumor tissue on PacBio RSII by Iso-Seq protocol using SMRT technology. 577 MB, data was generated from the brain tissues of ependymoma tumor patient, producing 1,19,313 high-quality reads assembled into 19,878 contigs using Celera ass...
Article
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There are several factors like angiogenesis, lymphangiogenesis, genetic alterations, mutational factors that are involved in malignant transformation of potentially malignant oral lesions (PMOLs) to oral squamous cell carcinoma (OSCC). Fibroblast growth factor-2 (FGF-2) is one of the prototypes of the large family of growth factors that bind hepari...
Article
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Background: Habit of consuming tobacco and areca-nut containing substances is in vogue in Lucknow as a part of the Nawabi culture. Hence, this study was planned with an aim to generate evidence for the prevalence of habits of substance abuse by the population of Lucknow and know their socio-demographic profile. Methodology: Population based cros...
Article
Tracheobronchopathia osteochondroplastica (TPO), a rare disorder of obscure etiology, is characterized by multiple osseous and cartilaginous nodules in the submucosa of the trachea and main bronchi. This entity commonly presents as diffuse involvement of the trachea, main bronchus or both, but a localized involvement of the airway mucosa is rare. M...
Article
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Granuloma gravidarum (GG), an inflammatory lesion, develops in the oral mucosa of pregnant women in response to chronic low-grade irritants and hormonal factors. A persistent granuloma gravidarum post partum and appropriate management strategies are discussed. Patients must be encouraged to undergo regular dental check-ups during the gestational pe...
Article
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Abstract Introduction: The extent of axillary lymph node involvement is one of the most important prognostic markers in patients of breast cancer. However, axillary dissection is associated with significant morbidity. The intra-operative sentinel node biopsy (SNB) provides a basis for omitting the routine axillary clearance however; use of in-hous...
Article
To compare the metabolic indices, lipid profile, androgens, and prostate specific antigen between prostate cancer and BPH and between grades of prostate cancer in a cross-sectional study. The study enrolled 95 cases of prostate cancer and 95 cases of benign prostatic hyperplasia (BPH). Prostate gland volume was measured using transrectal ultrasound...
Article
Both pro-inflammatory and anti-inflammatory cytokines play key roles in the pathogenesis of various forms of tuberculosis. In this study, we evaluated the role of various cytokines and matrix metalloproteinases (MMPs) in patients with spinal tuberculosis. In this prospective study, we enrolled 55 histopathologically/microbiologically confirmed pati...
Article
Aims and objectives Both pro-inflammatory and anti-inflammatory cytokines play key roles in the pathogenesis of various forms of tuberculosis. In this study, we evaluated the role of various cytokines and matrix metalloproteinases (MMPs) in patients with spinal tuberculosis. Materials and methods In this prospective study, we enrolled 55 histopatho...
Article
Full-text available
Abnormalities in ovarian function including defective oogenesis and folliculogenesis represent a key female reproductive deficiency. Accumulating evidences in literature have shown that PI3K/PTEN/Akt and TSC/mTOR signaling pathways are critical regulators of ovarian function including quiescence, activation and survival of primordial follicles (PFs...
Article
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Proton metabolic profiling of incisional biopsied cervical lymph node tissue specimens of 109 patients suffering from tubercular (CTBL) and non-specific (NSCLA) lymphadenitis were analyzed by high resolution magic angle spinning (HR-MAS) NMR spectroscopy. In the present study, 40 endogenous metabolites namely, myo-inositol (m-Ins), branched chain a...
Article
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Background & objectives: Tumour infiltrating lymphocytes (TILs) represent the host immune response against cancer cells associated with good or bad prognosis in different tumour types. This study was undertaken to evaluate the significance of CD3+, CD4+ and CD8+ TILs in breast cancer tissues in relation to clinico-pathological variables and surviva...
Article
Full-text available
Initial diagnosis of carcinoma of the urinary bladder remains to be a challenge. Urine cytology, as an adjunct to cystoscopy, is less sensitive for low-grade tumors. Urothelial cancer associated 1 (UCA1) is a novel non-coding RNA gene, which plays a pivotal role in bladder cancer progression. Our aim is to investigate the significance of urinary UC...
Article
Purpose: To identify whether CGRP and PTHrP serve as screening biomarkers for early detection of preeclampsia or even before the development of preeclampsia in early pregnancy. Methods: It was a nested case-control study. The subjects were divided into normotensive (controls) and preeclamptic (cases) groups. Serum samples of 132 cases and 132 co...
Article
Full-text available
Zygomycosis is a rare opportunistic fungal infection in immunocompetent patients. Isolated renal involvement by zygomycosis is extremely rare and diagnosed mainly during postmortem study. We report a case of a 22-year-old man with right upper quadrant pain and fever. The CT of the abdomen revealed renal cell carcinoma and subsequent nephrectomy was...
Article
Full-text available
Promoter methylation and relative gene expression of O(6)-methyguanine-DNA-methyltransferase (MGMT) and p16 genes were examined in tissue and blood samples of patients with premalignant oral lesions (PMOLs) and oral squamous cell carcinoma (OSCC). Methylation-specific PCR and reverse transcriptase PCR were performed in 146 tissue and blood samples...
Data
MSP products of MGMT and p16 genes were digested by restriction endonucleases viz. TaqI, BstU1, and FNU4H1 (supplementary fig 1a and 1b). All methylation positive samples showed presence of digestion products.
Article
The objective of this study was to evaluate the expression pattern of PDZ-Binding Kinase/T-LAK Cell-Originated Protein Kinase (PBK/TOPK) and its clinical significance in human bladder cancer (BC). We detected PBK/TOPK mRNA overexpression in BC and human normal testis tissues using RT-PCR. Using qRT-PCR revealed a higher expression of PBK/TOPK in BC...
Article
Full-text available
Early diagnosis of carcinoma of the bladder remains a challenge. Urine cytology, as an adjunct to cystoscopy, is less sensitive for low-grade tumors. X-linked inhibitor of apoptosis (XIAP), a negative regulator of apoptotic stimuli and a member of apoptosis family, is frequently activated in bladder carcinoma. Our aim is to investigate the signific...
Article
Full-text available
Purpose: The aim of this study was to investigate the prognostic significance of the CD56+NK-TIL count in infiltrating ductal carcinoma (IDC) of breast. Material and methods: Immunohistochemistry (IHC) was performed using antibodies specific for CD56 on formalin-fixed and paraffin-embedded tissue sections of 175 infiltrating ductal carcinomas (I...
Article
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Background: To evaluate serum VEGF-A levels in squamous cell carcinoma of head and neck (SCCHN) patients and relationships with response to therapy. Materials and methods: Serum VEGF-A levels in patients (n=72) treated with radiotherapy (RT) or radio-chemotherapy (RCT) and controls (n=40) were measured by ELISA. Results: Serum VEGF-A levels of...
Article
Podoplanin is a mucin-like glycoprotein that is important in lymphangiogenesis but not in blood vessel formation. The aim of this study is to determine the role of podoplanin in malignant transformation of PMOLs to oral cancer and in progression of oral cancer. In this report, LVD defined as of podoplanin detected positive lymphatic vessels and MVD...
Article
Full-text available
TGF-β1 is a multi-functional cytokine that plays an important role in breast carcinogenesis. Critical role of TGF-β1 signaling in breast cancer progression is well documented. Some TGF-β1 polymorphisms influence its expression; however, their impact on breast cancer risk is not clear. We analyzed 1222 samples in a candidate gene-based genetic assoc...
Article
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Gastrointestinal stromal tumor (GIST) is a rare mesenchymal neoplasm of the gastrointestinal tract. GIST of anal canal is very rare representing only 3% of all anorectal mesenchymal tumors. We report an extremely rare case of GIST of the anal canal in 60-years-old man with history of irregular bowel habits with dark colored stool mixed with blood a...
Article
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Pheochromocytomas are catecholamine secreting tumors of chromaffin cells. The extra adrenal pheochromocytomas are known as paragangliomas. Paragangliomas of the urinary bladder account for less than 0.06 % of all bladder tumors [1]. It commonly presents between second to fourth decades of life. Most surgeons and anesthesiologists are unfamiliar wit...
Article
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A 52-year-old postmenopausal woman presented with abdominal distension for 2 months. She had no vaginal bleeding and no relevant medical history. A physical examination showed a large palpable pelvic mass. A CT scan showed an ill-defined, heterogeneously enhancing, soft tissue attenuation lesion in the lower abdomen and pelvis involving the right a...
Article
Full-text available
Background: To assess the purpose of fungal rhinosinusitis in a University hospital and to correlate histopathological findings with culture results for accurate clinical classification of the disease. Materials and methods: One-hundred suspected patients were included in the study. Data was collected in a brief predetermined format. Samples lik...
Article
Background and objective: The present study was done to analyze the immunoexpression of diagnostic markers (MIB-1: molecular immunology borstel and PCNA: proliferating cell nuclear antigen) in grading cervical intraepithelial lesion (CIN) and squamous cell carcinoma (SCC) in cervix. Setting and design: Total 150 cervical biopsies were divided in...
Article
Full-text available
Background: Aim of this study was to investigate the prognostic significance of CD3+ TILs in infiltrating ductal carcinoma (IDC) of the breast. Materials and methods: Immuno-histochemistry was done with CD3 antibodies in tissue sections of 127 breast cancer patients, and CD3+ intra-tumoral and stromal TILs were counted in relation to clinico-pat...
Article
Full-text available
Background: Decorin is an extracellular matrix, multifunctional small proteoglycan molecule in tumor stroma that has been shown to be modulator of angiogenesis. No clinical data is available so far on decorin expression and survival outcome of oral cancer. Aim: The aim of the present study was to examine molecular and phenotypic expression of tw...