Maddi Garmendia

• Professor (Associate) at University of the Basque Country

Background The Basque Colorectal Cancer Screening Programme has both high participation rate and high compliance rate of colonoscopy after a positive faecal occult blood test (FIT). Although, colorectal cancer (CRC) screening with biannual (FIT) has shown to reduce CRC mortality, the ultimate effectiveness of the screening programmes depends on the...

Short-term radiotherapy (STR) for rectal cancer (RC) has rarely been used in Spain. The aim of the present study is to describe oncological results after RTC and surgery for RC.

Introduction: Short-term radiotherapy (STR) for rectal cancer (RC) has rarely been used in Spain. The aim of the present study is to describe oncological results after RTC and surgery for RC. Methods: This is a retrospective analysis of a consecutive series of patients treated with STR and surgery for RC (1999-2012). Epidemiological data, stagin...

Background Intestinal metaplasia (IM) is a precursor lesion that precedes gastric cancer (GC). There are two IM histological subtypes, complete (CIM) and incomplete (IIM), the latter having higher progression rates to GC. This study was aimed at analysing gene expression and molecular processes involved in the progression from normal mucosa to IM,...

Molecular network with highest score in the IIM-GC comparison, after Ingenuity Pathway Analysis. (TIF)

Molecular network with highest score in the IM-NoGC comparison, after Ingenuity Pathway Analysis. (TIF)

Main characteristics of the samples analyzed in the expression microarray. (DOC)

Significant genes from the expression microarray selected for validation by qPCR. (DOC)

Differentially expressed genes in IIM-GC. (DOC)

Differentially expressed genes between IIM-GC and CIM-GC. (DOC)

Independent series of samples used in the validation by qPCR. (DOC)

Differentially expressed genes in CIM-GC. (DOC)

Differentially expressed genes between IIM-NoGC and CIM-NoGC. (DOC)

Differentially expressed genes in the IM-NoGC. (DOC)

GSEA analysis in IIM-GC from c2all.v5 and c3tft.v5 catalogs. (DOC)

GSEA analysis in IM-NoGC from c2all.v5 and c3tft.v5 catalogs. (DOC)

Over-expressed gene sets in IIM-GC with extreme values of Rank at max parameter. (DOC)

Gene sets composed by at least 3 leading edge genes up-regulated in the IIM-GC. (DOC)

Over-expressed gene sets in IM-NoGC with extreme values of Rank at max parameter. (DOC)

Gene sets composed by at least 3 leading edge genes overexpressed in the IM-NoGC. (DOC)

Background and aim: In high or moderate risk populations, periodic surveillance of patients at risk of progression from gastric precursor lesions (PL) to gastric cancer (GC) is the most effective strategy for reducing the burden of GC. Incomplete type of intestinal metaplasia (IIM) may be considered as the best candidate, but it is still controver...

Background: Non-alcoholic fatty liver disease (NAFLD) is caused by abnormal accumulation of lipids within liver cells. Its prevalence is increasing in developed countries in association with obesity, and it represents a risk factor for non-alcoholic steatohepatitis (NASH), cirrhosis and hepatocellular carcinoma. Since NAFLD is usually asymptomatic...

Introducción: La HL es una enfermedad multisistémica rara caracterizada por una proliferación monoclonal de células de Langerhans, de presentación uni o multisistémica. Descripción del caso: Varón de 42 años, antecedentes de pancreatectomía cefálica y BAG hepática, diagnosticado de pancreatitis crónica y colestasis crónica por obstrucción de duc...

Introducción: La localización retroperitoneal es una presentación excepcional del tumor fibroso solitario (TFS) que tiene pronóstico imprevisible, con tasa de malignidad mayor que en el TFS pleural. Descripción del caso: Varón de 37 años que presenta gran masa toracoabdominal de 10x8x9,8 cm de origen abdominal con herniación en cavidad torácica....

Background: Human papiloma virus (HPV) is a pathogenic agent in some carcinomas, like those of the uterine cervix . Some head and neck squamous cell carcinomas (SCC) have also revealed infections by HPV . In these carcinomas, p16INK4A (p16) expression has been correlated with HPV infection. We have identified koilocytosis in some infiltrating laryn...

Mature cystic teratomas of the ovary containing prostatic remnants are reported in 2 women aged 31 and 20 years. Both cases showed the expected histology of mature teratomas with a mixture of ecto- and endodermal structures lying in a fibrous stroma. In both cases, the foci of prostate tissue were composed of typical prostatic glands arranged in ac...

Plasmacytoid urothelial carcinoma is a rare and aggressive variant of bladder cancer that mimics plasmacytoma histologically and that can be confused with hemolymphoid neoplasms secondarily affecting the urinary bladder. Only single cases and short series have been described so far. Seven cases of plasmacytoid urothelial carcinoma have been found a...

Background Seminal vesicle invasion is a finding of bad prognosis in prostate cancer. Its discovery in radical prostatectomies is accidental in most cases because patients with clinical or histological evidence of extraprostatic disease are not surgically treated in most clinical protocols. Our aim is to quantify this finding in a homogeneous serie...

Case report A case of double, independent and synchronous renal epithelial neoplasms occurring in a 78 yearold man is reported. The main tumour, the one that led the patient to consult and the cause of nephrectomy, is a typical clear cell renal cell carcinoma. The secondary tumour, located 4 cm from the main tumour, was discovered in gross exam and...

Basaloid squamous cell carcinoma (BSCC) is a rare and aggressive variant of cancer that mainly arises in the upper aerodigestive tract. This study reviews the clinico-pathological features and follow-up of a series of cases occurring in the head and neck. During a 32-year period (1974-2005), a total of 40 BSCCs have been diagnosed in the head and n...

Background: Carcinomas of the pyriform sinus (PS) are rare and aggressive laryngeal tumours. This study reviews the clinicopathological features and clinical outcome of 40 cases. Design: We diagnosed 40 carcinomas of the PS during the last 9 years. Age, sex, smoking and alcohol abuse, location (L), size, histological type, node status (N), extragan...

Background: We analyse clinicopathological features of a series of carcinomas of the uvula (CU) collected in two hospitals. Design: All the CUs resected in both hospitals during 13 years period were included. Clinical and pathological data have been collected in all cases [age and sex, adjuvant therapy, follow-up, local recurrences, loco-regional e...

Background: The increase in number of prostate cancer diagnoses in the last decade is accompanied by a similar increase in the number of radical prostatectomy specimens. We analyse the histological differences between patients treated with radical surgery in 1999 and in 2006. The evolution in the indications for surgery is also evaluated. Methods:...

Introduction Lipomatous hypertrophy of the atrial septum is diagnosed more frequently after the use of noninvasive imaging techniques. Case presentation A case of lipomatous hypertrophy of the atrial septum in a 72 year-old woman who consulted because of effort-related angina is reported. The study of the excised tissue fragments showed the typica...

Background: Prostate pathology is quite heterogeneous and the diagnosis of cancer in core biopsies is not always easy. Main difficulties are related to the identification of minimal cancer and its distinction from cancer mimickers. Immunohistochemistry appears as a highly recommended tool to resolve these diagnostic dilemmas. The aim of this study...

Background: plasmacytoid urothelial carcinoma (PUC) is a very rare variant of Transitional cell carcinoma (TCC). The few previously reported cases were aggressive, high grade neoplasms, with a high stage at initial diagnosis and a poor prognosis. Its clinical presentation is frequently late due to the frequent absence of haematuria and indurated mu...

http://www.conganat.org/9congreso/trabajo.asp?id_trabajo=692&tipo=2 Las lesiones más comunes de la región sacrocoxígea detectadas durante la infancia son la espina bífida y el meningocele. Los hamartomas quísticos aparecen generalmente en adultos con un ratio mujer-hombre de 3:1. Se cree que derivan del remanente intestinal que desaparece en la oc...

http://www.conganat.org/9congreso/trabajo.asp?id_trabajo=694&tipo=2 El miofibroblastoma intraganglionar es un tumor mesenquimal, fusocelular benigno que afecta al ganglio linfático con poca frecuencia. Es un tumor de comportamiento benigno por lo que es importante distinguirlo de otros procesos malignos. Describimos un caso de miofibroblastoma intr...

Background: A wide spectrum of treatment modalities may be undertaken in prostate cancer depending upon clinical staging, PSA levels, and histological features on core biopsies (CB). We evaluate the correlation between histological data found in CBs and in their respective radical prostatectomies (RP) seeking predictive parameters that may help in...

Paciente varón de 51 años, asintomático, al que se detecta una masa retroperitoneal en el flanco izquierdo en una exploración ecográfica rutinaria. El estudio radiológico demuestra una masa de aproximadamente 10 cm de dimensiones máximas dependiente de la glándula adrenal izquierda (figura 1). La analítica de sangre y orina y el resto de la explor...