Maciej Sopata

Szpital Kliniczny Przemienienia Panskiego · Chair and Department of Palliative Medicine

W dobie stałego postępu medycyny odleżyny stanowią istotny problem w opiece nad pacjentem z wielochorobowością, zarównohospitalizowanego, jak i objętego opieką domową. Budowanie świadomości dotyczącej stosowania najlepszych praktyk klinicznych leczenia odleżyn wśród przedstawicieli różnych zawodów medycznych jest kluczowe i powinno obejmować aspekt...

Nine soluble ligands [interleukin-6 (IL-6), interleukin-11 (IL-11), leukemia inhibitory factor (LIF), oncostatin M (OSM), ciliary neurotrophic factor (CNTF), cardiotrophin-1 (CT-1), cardiotrophin-like cytokine, interleukin-27 (IL-27), and interleukin-31] share the ubiquitously expressed transmembrane protein-glycoprotein-130 beta-subunit (gp130) an...

Background: This phase III, randomized, double-blind, placebo-controlled, parallel-group study assessed the efficacy and safety of tanezumab in subjects with cancer pain predominantly due to bone metastasis receiving background opioid therapy. Methods: Subjects were randomized (stratified by (1) tumor aggressiveness and (2) presence/absence of c...

Rationale & objective Midazolam is one of top three drugs used in palliative care. Its use increases in the last days of hospice patients’ lives while safe dosage can be challenging. Equations currently used to estimate glomerular filtration rate, e.g: the Cockroft-Gault (eGFRCR) and the Modification of Diet in Renal Disease (eGFRMDRD) ones, do not...

Artykuł jest dostępny na zasadzie dozwolonego użytku osobistego. Dalsze rozpowszechnianie (w tym druk i umieszczanie w sieci) jest zabronione i stanowi poważne naruszenie przepisów prawa autorskiego oraz grozi sankcjami prawnymi.

Artykuł jest dostępny na zasadzie dozwolonego użytku osobistego. Dalsze rozpowszechnianie (w tym druk i umieszczanie w sieci) jest zabronione i stanowi poważne naruszenie przepisów prawa autorskiego oraz grozi sankcjami prawnymi.

Tantalum (Ta) and its application in biomaterials has been attracting more and more attention recently. It can be considered as a material for hard tissue implants. This study focuses on antimicrobial and surface characterization of micro‐arc oxidized (MAO) nanocrystalline Ta compared with its microcrystalline equivalent. For the purposes of the in...

Background: The aim of the study was to analyze the dynamics of pain severity and its predictors in a group of patients with chronic venous leg ulcers. Methods: A 12-week longitudinal study included 754 patients with chronic venous leg ulcers. Subjective severity of pain was measured at weekly intervals with an 11-point visual analogue scale (VA...

The treatment of pain improves quality of life. Opioids are commonly prescribed painkillers. The side effects of opioids depend on the route of administration, dosage, drug metabolism, comorbid diseases and the patient’s general condition. Despite many beneficial effects, opioids can lead to increased mortality in heart failure, myocardial infarcti...

Spontaneous enterocutaneous fistulae are a rare complication in patients with cancer, especially following irradiation, chemotherapy or cytoreductive operations. They are associated with worse prognosis, higher costs of treatment and impaired quality of life. Proper recognition of the problem and fast implementation of selective therapy including w...

Objective:: There is a lack of literature on the characteristics and properties of fibre dressings available on the market. This study analysed the structure and absorption properties of different fibrous dressings used in wound treatment. Method:: This in vitro experiment was performed using scanning electron microscopy (SEM) and absorption tes...

Bone metastases are the most frequent cause of cancer-induced bone pain (CIBP). Although palliative radiotherapy and pharmacotherapy conducted according to World Health Organization (WHO) analgesic ladder are the treatment of choice for CIBP reduction, these methods are not always successful, especially with regard to alleviation of incidental pain...

3. Tomczyk M, Beloucif S, Sopata M, Viallard ML. « Quelle méthodologie pour une recherche qualitative internationale portant sur les dénominations, les représentations et les pratiques ? » 21st International Congress on Palliative Care, les 18-21 octobre 2016, Montréal, Canada.

Objective: To assess the impact of a two-period treatment on the clinical condition, bacteriological changes and results of treatment of venous leg ulcers (VLU) using octenidine dihydrochloride. Method: Patients with a VLU were recruited and treated with octenidine dihydrochloride for one month, after which they were randomised and treated with...

Despite considerable progress in medicine, civilization development is still associated with the increased prevalence of chronic wounds. They are characterized by etiological diversity and complex clinical courses, which complicate therapeutic process and lower its efficacy. Better understanding of molecular mechanisms underlying healing process le...

Diabetic foot ulcers (DFU) are complex, chronic wounds, which have a major long- -term impact on the morbidity, mortality and life quality of patients. The aim of the following paper strives at assessing the efficiency of the application of the foam dressing with Hydrofiber � technology, which releases silver ions, in patients with diabetic foot...

Patients with metastatic bone cancer report life-altering pain. Nerve growth factor (NGF) is involved in pain signaling. Tanezumab, an NGF monoclonal antibody, has demonstrated efficacy in chronic pain. Placebo-controlled parent (NCT00545129; study 1003) and non-controlled open-label extension (NCT00830180; study 1029) studies evaluated efficacy an...

The treatment of acute chest pain can be a challenge in palliative care. Firstly, because acute chest pain is a symptom of a paucity of diseases, which makes diagnosis difficult and time consuming, while there is also a time constraint, due to the extreme suffering of the patient. Secondly, the condition of a patient with advanced cancer disease an...

Background Unacceptable adverse effects, contraindications to and/or ineffectiveness of World Health Organization step III “pain ladder” drugs causes needless suffering among a population of cancer patients. Successful management of severe cancer pain may require invasive treatment. However, a patient’s refusal of an invasive procedure necessitates...

The aim of this article is to present selected ethical aspects concerning palliative sedation. Because there is a lack of a comprehensive terminology and universal definition of palliative sedation, it is difficult to compare the results of trials and observations and analysis of ethical aspects are often superficial, difficult or even impossible....

Neoplastic ulcers are chronic and, most often, irreversible lesions caused by proliferation of tumor cells infiltrating and damaging skin tissues. The treatment of neoplastic ulcers is a very difficult and time-consuming process. So, is very important to find methods of controlling this type of chronic wounds. To evaluate the efficiency of monitore...

This paper presents a modern concept of conservative treatment of pressure ulcers in the moist environment. Dressing types, their characteristics and a system of "colour" wound classification are presented.

This study compared wound healing efficacy of two silver dressings, AQUACEL(®) Ag and Urgotul(®) Silver, against venous ulcers at risk of infection, over 8 weeks of treatment. The primary objective was to show non inferiority of AQUACEL(®) Ag to Urgotul(®) Silver. Patients (281) were randomised into two groups. The AQUACEL(®) Ag group had 145 patie...

European Journal Palliative Care, supp. s. 228-229

Recently, a new oral prolonged-release formulation of morphine sulfate for once-daily dosing has been developed based on an injection-molded matrix (abuse-deterrent, prolonged-release erodible matrix [ADPREM]). The objective of this double-blind, randomized, exploratory crossover study was to assess the efficacy and safety of once-daily ADPREM comp...

Pressure ulcers are very common problem in chronically immobilized patients. In Poland despite of a lack of complex programme of management and treatment of pressure ulcers we observe development of modern knowledge concerning treatment of pressure ulcers. This paper presents knowledge about prevention and treatment based on "color" system which de...

Strong opioids are recommended for treating severe cancer pain in the advanced stages of the disease. Few data are available concerning the efficacy of buprenorphine in cancer pain. We compared transdermal buprenorphine 70 microg/h (BUP TDS) to placebo in an enriched design study. Opioid-tolerant patients with cancer pain requiring strong opioids i...

To assess the effect of octenidine dihydrochloride (Octenisept, Schülke & Mayr) on the clinical condition and bacterial flora in neoplastic ulcers. Twenty-one patients with advanced cancer and neoplastic ulcers were included in the study. Octenisept-moistened gauze dressings were applied to the ulcers three times daily. The clinical and bacteriolog...

The problem of malnutrition concerns most patients in the advanced stages of cancer. Nutrition and food are synonymous with the continuation of life for patients and their families and friends. In this paper, the methods of oral, enteral and parenteral nutrition are discussed, together with their advantages and the controversies connected with them...

Background. Lymphoedema is an accumulation of protein-rich fluid in the interstitial space. Long-lasting lymphoedema leads to chronic inflammation, fibrosis and tissue damage. Lymphoedema seriously affects a patient's body image, daily activities and mobility. At present, there is no curative treatment: the aim of lymphoedema management is long-ter...

This paper presents basic methods of conservative pressure ulcers treatment such: pressure reduction, irrigation, debridement, pain control, control of colonization and wound infection and using of modern dressing maintaining moist wound environment. Now there are available few new dressings for wound treatment: Granuflex Signal®, Versiva® XC™ and...

This study aimed to identify the quantitative and qualitative bacteriological status of pressure ulcers in patients with advanced cancer, and the effects on the healing process. We recruited 34 patients with advanced cancer who had 38 superficial grade II and III pressure ulcers. Patients were randomly allocated to treatment with Lyofoam/polyuretha...

This report discusses improvements in the prevention and management of pressure sores among patients with terminal illnesses

Tramal (tramadol hydrochloride) was administered to 80 cancer patients (pts) who failed to respond to nonopioid analgesics. The aim of this open study was the evaluation of the analgesic efficacy and safety of tramadol used orally as drops taken either in doses recommended by attending physicians or adjusted by pts themselves according to fixed gui...