Maciej Grzybek

Maciej Grzybek
Medical University of Gdansk | MUG · Department of Tropical Parasitology

Professor

About

73
Publications
43,627
Reads
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474
Citations
Introduction
I am a parasitologist with an enthusiastic approach towards gaining new experiences and facing difficult challenges. I enjoy working with people as well as on my own and solving problems logically and systematically. Participation in various biological research projects made me feel self-confident as well as comfortable with any laboratory work.
Additional affiliations
December 2020 - present
Medical University of Gdansk
Position
  • Professor (Associate)
December 2017 - April 2021
Medical University of Gdansk
Position
  • Professor (Assistant)
October 2016 - November 2017
University of Life Sciences in Lublin
Position
  • Professor (Assistant)
Education
May 2013 - June 2016
University of Life Sciences in Lublin
Field of study
  • Veterinary Parasitology
October 2010 - July 2013
University of Life Sciences in Lublin
Field of study
  • Analytical Biology
September 2010 - September 2011
University of Nottingham
Field of study
  • Parasitology

Publications

Publications (73)
Article
Full-text available
Major histocompatibility complex (MHC) genes encode proteins crucial for adaptive immunity of vertebrates. Negative frequency‐dependent selection (NFDS), resulting from adaptation of parasites to common MHC types, has been hypothesized to maintain high, functionally relevant polymorphism of MHC, but demonstration of this relationship has remained e...
Article
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The proteolytic and antioxidant systems are important components of humoral immunity, and these biomarkers indicate the immune status. These compounds are synthesized in the bees' fat body and released into the hemolymph. Their functions maintain the organism's homeostasis and protect it against adverse environmental factors (including pathogens)....
Article
Objectives This work aimed to analyse possible zoonotic spillover of SARS-CoV-2. We report the spillover of mink-adapted SARS-CoV-2 from farmed mink to humans after adaptation that lasted at least three months. Methods Next –Generation Sequencing and bioinformatic approach were applied to analyse the data. Results In an isolate obtained from an a...
Article
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Astrovirus infections pose a significant problem in the poultry industry, leading to multiple adverse effects such as a decreased egg production, breeding disorders, poor weight gain, and even increased mortality. The commonly observed chicken astrovirus (CAstV) was recently reported to be responsible for the “white chicks syndrome” associated with...
Article
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Routine genomic surveillance on samples from COVID-19 patients collected in Poland during summer 2021 revealed the emergence of a SARS-CoV-2 Delta variant with a large 872 nt deletion. This change, confirmed by Sanger and deep sequencing, causes complete loss of ORF7a , ORF7b , and ORF8 genes. The index case carrying the deletion is unknown. The st...
Article
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Toxoplasma gondii is an intracellular Apicomplexan parasite with a broad range of intermediate hosts, including humans and rodents. Rodents are considered to be reservoirs of infection for their predators, including cats, felids, pigs, and wild boars. We conducted a multi-site, long-term study on T. gondii in northeastern Poland. The study aimed to...
Preprint
Full-text available
The COVID-19 pandemic caused by SARS-CoV-2 started in fall 2019. A range of different mammalian species, including farmed mink, have been confirmed as susceptible to infection with this virus. We report here the spillover of mink-adapted SARS-CoV-2 from farmed mink to humans after extensive adaptation that lasted at least 3 months. We found the pre...
Preprint
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Toxoplasma gondii is a significant pathogen affecting humans and animals. We conducted seromonitoring for T. gondii in four sylvatic rodent species in Poland. We report an overall seroprevalence of 5.5% (3.6% for Myodes glareolus and 20% for other vole species). Seroprevalence in bank voles varied significantly between host age and sex.
Article
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Rodents are known to be reservoir hosts for a plethora of zoonotic viruses and therefore play a significant role in the dissemination of these pathogens. We trapped three vole species (Microtus arvalis, Alexandromys oeconomus and Microtus agrestis) in northeastern Poland, all of which are widely distributed species in Europe. Using immunofluorescen...
Preprint
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Rodents are known to be reservoir hosts for a plethora of zoonotic viruses and therefore play a significant role in the dissemination of these pathogens. We trapped three vole species (Microtus arvalis, M. oeconomus and M. agrestis) in N.E. Poland, all of which are widely distributed species in Europe, and, using immunofluorescence assays, we asses...
Article
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Blastocystis is an enteric microorganism commonly found in humans and animals worldwide. Its pathogenic role in humans and transmission patterns has not been fully explained. However, nine subtypes (ST1–8, ST12) are considered as potentially zoonotic. Studies from various regions of the world show that pigs are mainly infected with ST5. Although pi...
Article
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Safe and efficient techniques for the live capture of carnivores are limited. In this study, we identified some of the factors that could affect the success of capturing red fox cubs with live capture traps (also known as cage traps). During a three-year period, we analysed 32 captures of 25 fox cubs (1.3 captures/fox). We assessed the impact of th...
Article
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Background: Rodents constitute an important part of the diet of many carnivore species. This predator-prey food chain is exploited by helminth parasites, such as cestodes, whose larval stages develop in rodents and then mature to the adult stage in predators. The main aim of our study was to use molecular techniques for identification of cestode s...
Conference Paper
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Rodents are known to be reservoir hosts of zoonotic viruses and therefore play a significant role in the dissemination of these pathogens. Using immunofluorescence assays, we carried out the first long-term seromonitoring programme for hantavirus, arenavirus and cowpox virus infections in bank voles from three ecologically similar, but separate, si...
Article
Rodents play a role as reservoir hosts for tick-borne encephalitis virus (TBEV). We trapped voles of the genus Microtus and tested their blood for the presence of antibodies against TBEV. We detected TBEV antibodies in three adult individuals (3.9%). Voles may play a role in the circulation of TBEV.
Article
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In this study we screened for the presence of antibodies against hantavirus, arenavirus and cowpox virus in Polish bank voles over a 9 year period. Cowpox virus was most prevalent and its prevalence was affected by both extrinsic and intrinsic factors.
Article
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Lactate is produced by active skeletal muscles. H+ is produced during lactate neutralization in the Cori cycle, which leads to muscle acidosis and sores (so called Delayed Onset Muscle Soreness – DOMS) in vertebrates. The aim of the study was to determine the activities/concentrations of compounds which may be involved in the Cori cycle in bee work...
Article
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Rodents play an important role as reservoir hosts of zoonotic diseases. As a component of our long-term programme of monitoring parasitic infections in bank vole populations in three ecologically similar sites in NE Poland, we screened blood samples for signs of a serological response to the presence of Trichinella spp. The overall seroprevalence o...
Article
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Many factors, including pathogens, environmental change and breeding techniques, affect honeybee immunity/resistance, so substances and natural supplements that enhance it are desired. To eliminate the impact of unknown external factors, in 2016 a cage experiment was conducted under constant laboratory conditions (35 °C, 65% relative humidity). Bee...
Article
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The Apicystis bombi neogregarines parasitize bumblebees. Apis mellifera is its accidental host but, in the future, it might become its ultimate host. Using PCR and microscopic analysis we found A. bombi in 1 of 10 apiaries in Central Europe. The colony was queenless, with rebel workers. The parasite was detected in the hemolymph and digestive tract...
Article
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Background: Bartonella spp. cause persistent bacterial infections in mammals. Although these bacteria are transmitted by blood-feeding arthropods, there is also evidence for vertical transmission in their mammalian hosts. We aimed to determine: (i) the prevalence and diversity of Bartonella spp. in a Microtus spp. community; (ii) whether vertical...
Article
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The attenuated total reflectance-Fourier transform infrared (ATR-FTIR) fingerprinting of some selected cucurbits was performed on three types of seed extracts (alcoholic, cold-water, and hot-water) in order to elaborate a characteristic FTIR profile of their family representatives and to determine their biochemical content. Cluster analysis and pri...
Article
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Reptiles are becoming increasingly popular animals in amateur husbandry in Poland and worldwide. The world literature, however, does not provide data on the actual causes of radiological and ultrasound consultations in certain groups of animals, including reptiles. The aim of the study was the analysis of causes and results of diagnostic imaging ex...
Article
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The aim of the study was to investigate the state of parasitic invasions in flocks of carrier and fancy pigeons in south-western Poland. Coproscopic methods (flotation with saturated NaCl and saccharose, as well as the McMaster method) were used to examine 42 pigeon flocks (18 flocks of fancy pigeons and 24 flocks of carrier pigeons). A total of 21...
Article
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The aim of the study was to analyze endoparasitic fauna in roe deer of a selected area of south-western Poland using coproscopic studies and postmortem studies of internal organs (lungs, livers and digestive tracts). Microscopic methods included flotation and the McMaster method. In May and June 2015, 53 culled male roe deer were examined. Parasite...
Article
Equine Anoplocephalosis constitute a significant problem in horses worldwide. The aim of this study was to analyse intrinsic (host age and sex) and extrinsic (management type, pasture type and moisture) factors that influence the prevalence and FEC of A. perfoliata infections. Faecal samples were collected from 994 horses managed in studs or indivi...
Article
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2017): Effect of dietary supplementation with preparation comprising the blend of essential oil from Origanum vulgare (lamiaceae) and Citrus spp. (citraceae) on coccidia invasion and lamb growth, ABSTRACT The objective of this research was to assess the effectiveness of dietary supplementation with oils extracted from Origanum vulgare (Lamiaceae) a...
Conference Paper
Parasites are considered to be an important selective force in host evolution but ecological studies of host-parasite systems are usually short-term providing only snap-shots of what may be dynamic systems. We have performed a long term monitoring of helminths of bank voles at three ecologically similar woodland sites in NE Poland, spaced over a pe...
Conference Paper
Small rodents represent ideal model species to investigate dynamics of parasite infections, thanks to their abundance, ease of manipulation and to the availability of a large scientific knowledge gathered through laboratory experiments. Laboratory investigations in controlled environments allow indeed to examine in depth complex biological mechani...
Article
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We examined age-related biochemical and histological changes in the fat bodies and hemolymph of Osmia rufa males and females. We analysed solitary bees during diapause, in October and in April; as well as the flying insects following diapause, in May and June. The trophocyte sizes, as well as the numbers of lipid droplets were the greatest at the b...
Article
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Background Vertical transmission is one of the transmission routes for Babesia microti, the causative agent of the zoonotic disease, babesiosis. Congenital Babesia invasions have been recorded in laboratory mice, dogs and humans. The aim of our study was to determine if vertical transmission of B. microti occurs in naturally-infected reservoir host...
Article
The reprogramming of human induced pluripotent stem cells (hiPSCs) proceeds in a stepwise manner with reprogramming factors binding and epigenetic composition changes during transition to maintain the epigenetic landscape, important for pluripotency. There arises a question as to whether the aberrant epigenetic state after reprogramming leads to ep...
Conference Paper
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Zarażenia pasożytami są głownie kontrolowane przy użyciu syntetycznych środków przeciwpasożytniczych. Rosnąca lekooporność pasożytów jest stwierdzana u ludzi i zwierząt . Rośliny z rodziny Cucurbitaceae, a w szczególności dynia (np. Cucurbita moschata) i jej pestki zostały wskazane jako gatunki charakteryzujące się działaniem przeciwpasożytniczym u...
Article
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A significant number of studies report growing resistance in nematodes thriving in both humans and livestock. This study was conducted to evaluate the in vitro and in vivo anthelmintic efficiency of Curcubita pepo (C. pepo) L. hot water extract (HWE), cold water extract (CWE) or ethanol extract (ETE) on two model nematodes: Caenorhabditis elegans (...
Article
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Gastrointestinal parasites are responsible for high economic losses to sheep production. Infected animals show developmental problems, reduced weight and a low quality of meat and wool. This study takes into consideration two different sheep management systems, indoor (n = 50) and outdoor (n = 50) ones, and their impact on the occurrence of gastroi...
Conference Paper
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Introduction: The most prevalent cardiopulmonary nematodes in domestic cats in Europe is Aelurostrongylus abstrusus [1]. Clinical sings of diseases range from asymptomatic to severe respiratory symptoms, dependent on the intensity of invasions, co-infections, host age, conditions and immune status. Early and correct diagnosis improves the prognosis...
Conference Paper
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Introduction Blood transfusions are routinely performed in small animal veterinary hospitals. However, in many practices a screening of blood donors for canine vector-borne diseases (CVBDs) is not a mandatory procedure. So far dogs have been not tested for the occurrence of microfilariae in most Polish canine blood banks, which indicates lack of a...
Article
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Vector-borne infection constitutes a significant health issue in dogs worldwide. Recent reports point to an increasing number of canine vector-borne disease cases in European countries, including Poland. Canine babesiosis caused by various Babesia species is a protozoal tick-borne disease with worldwide distribution and significant veterinary impor...
Conference Paper
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Szop pracz (Procyon lotor), to inwazyjny gatunek pochodzący z Ameryki Północnej występujący w na terenie Europy i Polski. Ocenia się, że w kraju największa populacja zamieszkuje zachodnie województwa. Wraz z innymi obcymi przedstawicieli mięsożernych takimi jak norka amerykańska i jenot stanowią poważny problem ekologiczny dla rodzimych gatunków ss...
Conference Paper
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Vector­borne infections constitute a significant health problem in dogs worldwide. Recent reports suggest an increasing number of CVBD in European countries including Poland. Babesia canis is responsible for most canine babesiosis cases in Central and Eastern Europe. It causes mild to severe symptoms, however it should be stressed that a wide range...
Article
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Bank voles (Myodes glareolus) and house mice (Mus musculus musculus; M. m. domesticus) in Europe are each parasitized by their own distinct species of Aspiculuris (Nematoda, Oxyurida) The molecular phylogeny and morphology of the oxyuroid nematode genus Aspiculuris from voles and house mice has been examined. Worms collected from Myodes glareolus i...
Article
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For this study, 724 gastrointestinal tracts of slaughter horses were investigated to determine the prevalence, intensity of Anoplocephala perfoliata and tapeworm development stages over the second, third and fourth quarter of 2012 and the first quarter of 2013. For each positive horse, faecal samples were collected from the rectum or small colon fo...
Article
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Abundance and prevalence of helminth infections often differ between host sexes, and are usually biased in favor of males. Relatively few cases of female-biased parasitism have been reported. We sampled bank voles in three woodland sites in N.E. Poland over 11 years at 3–4-year intervals, and assessed their parasite burdens. Prevalence and abundanc...
Article
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Gastro-intestinal parasites are extremely important pathogens of humans, domestic livestock, and wild animals. Parasitological prevention in wild ruminants was conducted in forests of eastern Poland in early spring from 2009 to 2013. Fenbendazol in a single-dose (5 mg/kg BW) mixed with feed was distributed through forest feeders. Fecal material was...