Maarten Otter- MD
- PostDoc Position at Maastricht University
Maarten Otter
- MD
- PostDoc Position at Maastricht University
About
34
Publications
29,191
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348
Citations
Introduction
Women with TXS are exciting from a scientific point of view. They have several physical characteristics, such as early menopause. My PhD research project revealed that women with TXS are more vulnerable to developing impaired social functioning, psychiatric disorders and neurocognitive dysfunction.
Current institution
Additional affiliations
September 2021 - present
SIZA
Position
- Psychiatrist/researcher
Description
- At Siza I function as a consultant psychiatrist with a patient group with all kinds of chronic neuropsychiatric disorders. This group consists of people with chronisc traumatic injury, (mild) intellectual disabilities, cerebral palsy, autism and neurological disorders.
Publications
Publications (34)
The developmental and clinical aspects in the literature on triple X syndrome are reviewed. Prenatal diagnosis depends on karyotyping. The incidence is 1 of 1000 females. At birth, 47,XXX girls have a lower mean birth weight and a smaller head circumference. Triple X diagnosis was not suspected at birth. The maternal age seems to be increased. Todd...
Background
Triple X syndrome (TXS) is caused by aneuploidy of the X chromosome and is associated with impaired social functioning in children; however, its effect on social functioning and emotion recognition in adults is poorly understood.
Aims
The aim of this study was to investigate social functioning and emotion recognition in adults with TXS....
Background: Triple X syndrome (TXS, also known as trisomy X or 47,XXX) has been associated with impaired overall neurocognitive functioning in children and relatively young adults. However, neurocognitive functioning in adults with TXS is poorly understood. The aim of this study was, therefore, to examine cognitive functioning in adults with TXS. M...
Background
Women with Triple X syndrome (TXS) have an extra X chromosome. TXS appeared to be associated with psychiatric disorders in biased or underpowered studies.
Aims
This study aims to describe the prevalence of psychiatric disorders in adults with TXS in a relatively large and less biased group of participants.
Method
In this cross-sectional...
Triple X syndrome (47,XXX or trisomy X) is a relatively frequent cytogenetic condition with a large variety of physical and behavioural phenotypes.
Two adult patients with a triple X karyotype are described.
Their karyotype was unknown until some years ago. What these patients have in common is that they were diagnosed with a broader autism phenoty...
My doctoral thesis, Triple X Syndrome in Adults: cognitive, psychiatric and Neuroanatomical Profile, revealed new data on the behavioural phenotype in adults with Triple X syndrome. Women typically have 2 X chromosomes. Women with triple X syndrome have 3 X chromosomes. And those women are less intelligent than would be expected based on family dat...
47,XXX (Triple X syndrome) is a sex chromosome aneuploidy characterized by the presence of a supernumerary X chromosome in affected females, and has been associated with a variable cognitive, behavioral, and psychiatric phenotype. Alterations in brain gray matter structure and function have been reported, but less is known about white matter (WM) o...
47,XXX (Triple X syndrome) is a sex chromosome aneuploidy characterized by the presence of a supernumerary X chromosome in affected females and is associated with a variable cognitive, behavioral, and psychiatric phenotype. The effect of a supernumerary X chromosome in affected females on intracortical microstructure is currently unknown. Therefore...
Background
Triple X syndrome (47,XXX) is a relatively common sex chromosomal aneuploidy characterized by the presence of a supernumerary X chromosome in females and has been associated with a variable cognitive, behavioural and psychiatric phenotype. 47,XXX may serve as a suitable model for studying the effect of genetic architecture on brain morph...
Triple X syndrome is a sex chromosomal aneuploidy characterized by the presence of a supernumerary X chromosome, resulting in a karyotype of 47,XXX in affected females. It has been associated with a variable cognitive, behavioral, and psychiatric phenotype, but little is known about its effects on brain function. We therefore conducted 7 T resting-...
Reactie op 'Suïcide bij mensen met een lichte verstandelijke beperking' suïcidale gedachten en suïcidaal gedrag bij patiënten met LVB staat hierbij voorop. Een strategie die leidt tot meer en betere toepassing van de multidisciplinaire richtlijn kan levens van patiënten met LVB redden. Dit geldt temeer daar de literatuur aanknopingspunten biedt om...
The phenotype of triple X syndrome comprises a variety of physical, psychiatric, and cognitive features. Recent evidence suggests that patients are prone to severe language impairments. However, it remains unclear whether verbal impairments are pervasive at all levels of language, or whether one domain is relatively more spared than others. Here we...
Artsen voor Verstandelijk Gehandicapten (AVG), huisartsen, artsen voor verstandelijk gehandicapten (AVG) en uiteraard psychiaters schrijven regelmatig psychofarmaca voor. Eén van de aanbevelingen van de meest recente richtlijn (2016) ‘Voorschrijven van Psychofarmaca’ van de Nederlandse Vereniging van Artsen voor Verstandelijke Gehandicapten (NVAVG)...
Purpose
The purpose of this paper is to establish the value of clinical genetic diagnostics in the lives of people with an intellectual disability (ID), their families, and their primary and professional caregivers. It has been shown that psychologists are more likely to make use of the opportunities offered by clinical genetic diagnostics if they...
Key Clinical Message
Clinical geneticists, neurologists, psychiatrists, and other healthcare providers can learn from this case report that patients with a behavioral phenotype that includes a mild learning disability may also require a thorough examination, including brain MRI and whole‐exome sequencing.
In the psychiatric treatment of patients with mild learning disabilities or borderline intellectual functioning, signs and symptoms of psychiatric disorders are sometimes misinterpreted as behaviour that reflects problems that are known to patients with mental retardation. We report on two case studies in which lithium therapy made a substantial co...
Background:
There is a good chance that you, as a psychiatrist, will come in to contact with patients who have a borderline or mild intellectual disability (50 > iq < 85). Referral to specialised care is not always an option and may not always be necessary. However, diagnosing psychiatric disorders in these patients can present challenges.
Aim:...
Clozapine is effectiever dan andere antipsychotica bij de behandeling van therapieresistente psychotische stoornissen, de bekendste indicatie voor clozapine. De bijwerkingen van clozapine vragen kennis van en ervaring met het voorschrijven van clozapine. Artsen, ook specialisten, artsen voor verstandelijk gehandicapten en psychiaters, ervaren een d...
Dit hoofdstuk gaat over de psychiatrische diagnostiek en psychofarmacologische behandeling van psychiatrische patiënten met een lichte verstandelijke beperking en mensen met een lichte verstandelijke beperking met een psychiatrische ziekte. Deze bijdrage is bedoeld voor gedragswetenschappers, groepsleiders, activiteitenbegeleiders – niet-medici dus...
Mannen hebben als geslachtschromosomen een X- en een Y-chromosoom, vrouwen twee X-chromosomen. Ongeveer 0,5 procent van alle kinderen wordt geboren met een chromosoomafwijking. In 0,4 procent betreft het een afwijking van de autosomen. Bij ongeveer 0,1 procent van alle pasgeborenen echter bestaat een numerieke afwijking in de geslachtschromosomen....
