M. Coulibaly Traore

M. Coulibaly Traore
Research Institute of Health Sciences | IRSS · MEPHATRA

PhD
Senior Researcher at IRSS

About

57
Publications
4,839
Reads
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411
Citations
Citations since 2016
49 Research Items
375 Citations
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20162017201820192020202120220204060
Additional affiliations
July 2018 - present
Research Institute of Health Sciences
Position
  • Managing Director
Description
  • Preclinical evaluations and characterisation of active chemical compounds from plants, clinical evaluations of modernes medicines and phytomedicines
Education
January 2004 - June 2008
Faculty of Pharmaceutical Sciences University of Copenhagen
Field of study
  • Natural Products Chemistry
October 1985 - September 1996
University of Ouagadougou
Field of study
  • Biochemistry and Microbiology

Publications

Publications (57)
Article
Full-text available
Background Malaria infection during pregnancy (MIP) is not only deleterious to the woman, but it also puts her fetus at increased risk of adverse outcomes, such as preterm delivery, low birth weight, and intrauterine growth retardation. Additionally, all-cause mortality during the first year of life in babies born to women with malaria during pregn...
Article
Full-text available
Background Malaria in pregnancy remains a major health threat in sub-Saharan Africa to both expectant mothers and their unborn children. To date, there have been very few studies focused on the out of pocket costs associated with seeking treatment for malaria during pregnancy. Methods A cross-sectional survey was undertaken in Burkina Faso and The...
Article
Full-text available
The assessment in real‐life conditions of the safety and efficacy of new antimalarial drugs is of greatest interest. This study aimed to monitor and evaluate both clinical and biological safety of pyronaridine‐artesunate (PA) in real‐life conditions in Burkina Faso's health system. This was a single‐arm, open‐label study, where patients attending N...
Article
Full-text available
Background Malaria in pregnancy can result in placental infection with fetal implications. This study aimed at assessing placental malaria (PM) prevalence and its associated factors in a cohort of pregnant women with peripheral malaria and their offspring. Method The data were collected in the framework of a clinical trial on treatments for malari...
Article
Full-text available
Background: Some ergogenic medicinal plants are used in exercise and sport in Africa in order to increase sport performance. However, data on their composition and their possible impacts on health are limited. This study was initiated to provide ethnobotanical data on plants traditionally used to optimize physical performance and to perform a quali...
Article
Full-text available
Background Malaria and malnutrition represent major public health concerns worldwide especially in Sub-Sahara Africa. Despite implementation of seasonal malaria chemoprophylaxis (SMC), an intervention aimed at reducing malaria incidence among children aged 3–59 months, the burden of malaria and associated mortality among children below age 5 years...
Article
Full-text available
Background: Genetic polymorphisms in the human immune system modulate susceptibility to malaria. However, there is a paucity of data on the contribution of immunogenetic variants to malaria susceptibility in infants, who present differential biological features related to the immaturity of their adaptive immune system, the protective effect of mat...
Article
Full-text available
Background Single nucleotide polymorphisms occurring in the Plasmodium falciparum multidrug resistant gene 1 (pfmdr1) are known to be associated with aminoquinoline resistance and, therefore, represent key P. falciparum markers for monitoring resistance both in susceptible groups (children under 5 years old and pregnant women) and in the general po...
Article
Full-text available
Background: Ultrasound scanning during the 2nd or the 3rd trimester of pregnancy for fetal size disturbances screening is heavily dependent of the choice of the reference chart. This study aimed to assess the agreement of Salomon and the Intergrowth 21st equations in evaluating fetal biometric measurements in a rural area of Burkina Faso, and to m...
Preprint
Full-text available
Background To date, there have been few studies on the roles and challenges that community health workers (CHWs) face when encouraging pregnant women to attend health facilities and provide community-based interventions including scheduled screening and treatment (CSST) for malaria. This study investigates the characteristics, daily activities and...
Preprint
Full-text available
Background: Malaria in pregnancy remains a major health threat in sub-Saharan Africa to both expectant mothers and their unborn children. To date, there have been very few studies focused on the costs associated with seeking treatment for malaria during pregnancy. Methods . A cross-sectional survey was undertaken in Burkina Faso and The Gambia to e...
Article
Full-text available
Background : Malaria during pregnancy is a major health risk for both the mother and the foetus. Pregnancy has been shown to influence the pharmacokinetics of a number of different antimalarial drugs. This might lead to an under-exposure in these patients which could increase the risk of treatment failure and the development of drug resistance. The...
Article
Full-text available
Background : Malaria during pregnancy is a major health risk for both the mother and the foetus. Pregnancy has been shown to influence the pharmacokinetics of a number of different antimalarial drugs. This might lead to an under-exposure in these patients which could increase the risk of treatment failure and the development of drug resistance. The...
Article
The roots and leaves of Cochlospermum planchonii and C. tinctorium are widely used in Burkina Faso as medication for malaria treatment. The cochloxanthins, carotenoids, are - at least partially - responsible for the antimalarial activity of Cochlospermum spp.. Because of large variation of cochloxanthin contents in rhizomes and leaves of Cochlosper...
Article
Full-text available
Purpose: In 2005, Burkina Faso changed its first-line treatment for uncomplicated malaria from chloroquine to artemisinin-based combination therapies (ACTs). Patient adherence to ACTs regimen is a keystone to achieve the expected therapeutic outcome and prevent the emergence and spread of parasite resistance. Eleven years after the introduction of...
Conference Paper
Full-text available
Introduction Although the deleterious effects of malaria in pregnancy to both the mother and the child are well documented, the mechanisms involved are still relatively unknown. This applies also to the increased susceptibility to malaria infection during the postpartum. To improve our knowledges on this topic, it is relevant to investigate on what...
Article
Full-text available
Abstract Background: We investigated whether adding community scheduled malaria screening and treatment (CSST) with artemether-lumefantrine by community health workers (CHWs) to standard intermittent preventive treatment in pregnancy with sulfadoxine-pyrimethamine (IPTp-SP) would improve maternal and infant health. Methods: In this 2-arm cluster-...
Article
Full-text available
Background Factors driving inter-individual differences in immune responses upon different types of prenatal malaria exposure (PME) and subsequent risk of malaria in infancy remain poorly understood. In this study, we examined the impact of four types of PME (i.e., maternal peripheral infection and placental acute, chronic, and past infections) on...
Article
Full-text available
Up to now, the control of malaria remains a challenge. The World Health Organization (WHO) recommends the use of artemisinin-based combination therapies (ACTs) for uncomplicated malaria treatment. Despite this guideline, many people in Burkina Faso use herbal medicine as primary treatment against malaria. The aim of this study was to assess the in...
Article
Full-text available
Background: Infants are thought to be protected against malaria during the first months of life mainly due to passage of maternal antibodies. However, in high transmission settings, malaria in early infancy is not uncommon and susceptibility to the infections varies between individuals. This study aimed to determine malaria morbidity and infection...
Article
Full-text available
Background: Although consensus exists that malaria in pregnancy (MiP) increases the risk of malaria in infancy, and eventually nonmalarial fevers (NMFs), there is a lack of conclusive evidence of benefits of MiP preventive strategies in infants. Methods: In Burkina Faso, a birth cohort study was nested to a clinical trial assessing the effective...
Article
Full-text available
Objective: In malaria endemic area, women acquire throughout successive pregnancies, increasing protection against Plasmodium falciparum malaria infections by having increased levels of antibodies to the Variant 2 Cell Surface antigen- Chondroitin Sulphate A. Primigravidae are more susceptible to placental malaria due to the lack of these specific...
Article
Full-text available
Background: Diagnosis of malaria in pregnancy is problematic due to the low sensitivity of conventional diagnostic tests (rapid diagnostic test and microscopy), which is exacerbated due to low peripheral parasite densities, and lack of clinical symptoms. In this study, six potential biomarkers to support malaria diagnosis in pregnancy were evaluat...
Article
Full-text available
Sulphadoxine-pyrimethamine (SP) is only used for intermittent preventive treatment during pregnancy (IPTp) in most Sub-Saharan African countries. However, there are concerns about the efficacy of IPTp-SP because of increasing resistance. Combinations of point mutations in the dhps and dhfr genes of Plasmodium falciparum are associated with SP resis...
Article
One of the current strategies to prevent malaria in pregnancy is intermittent preventive treatment with sulfadoxine-pyrimethamine (IPTp-SP). However, in order for pregnant women to receive an adequate number of SP doses, they should attend a health facility on a regular basis. In addition, SP resistance may decrease IPTp-SP efficacy. New or additio...
Article
Full-text available
Congenital malaria diagnosis is challenging due to frequently observed low parasite density infections, while their clinical relevance during early infancy is not well characterized. In Nanoro health district (Burkina Faso), we determined the prevalence of congenital malaria by real-time quantitative PCR and we assessed the performance of rapid dia...
Article
Full-text available
Background Pregnant women are a high-risk group for Plasmodium falciparum infections, which may result in maternal anaemia and low birth weight newborns, among other adverse birth outcomes. Intermittent preventive treatment with sulfadoxine–pyrimethamine during pregnancy (IPTp-SP) is widely implemented to prevent these negative effects of malaria....
Article
Full-text available
Background: Adolescence is associated with adverse fetal outcome, particularly in resources limited settings. We assessed the association between mother’s age and low birth weight or prematurity in Nanoro, a rural health district of Burkina Faso. Methods: We collected data on mothers and their newborns in the framework of the “Safe and Efficacious...
Article
Full-text available
Background: Information regarding the safety and efficacy of artemisinin combination treatments for malaria in pregnant women is limited, particularly among women who live in sub-Saharan Africa. Methods: We conducted a multicenter, randomized, open-label trial of treatments for malaria in pregnant women in four African countries. A total of 3428...
Article
Full-text available
phytochemical assay was conducted to establish the chemical profile of “Saye”, a mixture of leaf of Cassia alata, root of Cochlospermum planchonii and whole plant of Phyllantus amarus, used as antimarial remedy. Water and organic extracts were prepared. Characterization of phytoconstituents using specific chemical reagents was performed in tubes, b...
Article
Full-text available
Background and Objective: Pterocarpus erinaceus Poir. (Fabaceae) is used in folk medicine in Burkina Faso to treat inflammatory diseases including malaria, ulcer, rheumatism and infectious disease. The aim of this study was to carry out the evaluation of the safety and efficacy of methanol extract of Pterocarpus erinaceus leaves studying anti-infla...
Article
Full-text available
Background Information regarding the safety and efficacy of artemisinin combination treatments for malaria in pregnant women is limited, particularly among women who live in sub-Saharan Africa. Methods We conducted a multicenter, randomized, open-label trial of treatments for malaria in pregnant women in four African countries. A total of 3428 pre...
Conference Paper
Full-text available
Ex vivo assays are usually carried out on parasite isolates collected from patients with uncomplicated Plasmodium falciparum malaria, from which pregnant women are usually excluded as they are often asymptomatic and with relatively low parasite densities. Nevertheless, P. falciparum parasites infecting pregnant women selectively sequester in the pl...
Article
Full-text available
BACKGROUND: Ex vivo assays are usually carried out on parasite isolates collected from patients with uncomplicated Plasmodium falciparum malaria, from which pregnant women are usually excluded as they are often asymptomatic and with relatively low parasite densities. Nevertheless, P. falciparum parasites infecting pregnant women selectively sequest...
Article
Full-text available
Objectives: Mefloquine/artesunate has recently been developed as a fixed-dose combination, providing a promising rescue/alternative treatment for malaria during pregnancy. However, limited data are available on the effect of pregnancy on its pharmacokinetic properties. This study was conducted to assess the pharmacokinetic properties of mefloquine/...
Article
Saye is an antimalarial recipe containing Cochlospermum planchonìì Hook. F. (Cochlospermaceae), Phyllanthus amarus Schumach and Thonn (Euphorbiaceae) and Cassia alata h. (Fabaceae). This study assessed the antiplasmodial and antioxidant activity of the aqueous extracts of the individual plants and their combinations. Extracts were assessed on Plasm...
Article
Objectives: To evaluate persistence of several Plasmodium antigens in pregnant women after treatment and compare diagnostics during treatment follow-up. Methods: Thirty-two pregnant women (N = 32) with confirmed malaria infection by a histidine-rich protein 2 (HRP2)-based rapid diagnostic test (RDT) and microscopy were followed for 28 days after...
Article
Fractionation of an ethanol extract of roots of Cochlospermum tinctorium afforded five compounds: 3-O-E-p-coumaroylalphitolic acid (1), cochloxanthin (2), dihydrocochloxanthin (3), alphitolic acid (4), and 1-hydroxytetradecan-3-one (5). This is the first example of a 1-hydroxyalkan-3-one obtained from plant material after gentle workup. The antipla...

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Projects

Projects (8)
Project
Develop OPIC-based pharmaceutical formulations for the management of infectious dermatoses
Project
To determine efficacy, safety, and tolerability of pyronaridine-artesunate (PA) as compared to either artemether-lumefantrine (AL) or dihydroartemisinin-piperaquine (DP) when administered to pregnant women with P. falciparum infection during the 2nd or 3rd trimester. The primary hypothesis is the clinical pair-wise non-inferiority of PA as compared to either AL and DP. Non-inferiority is defined as a difference in treatment success (PCR-adjusted Adequate Clinical and Parasitological Response, ACPR) of 5% or less.
Project
Contribuer à la lutte contre la Covid-19 par le développement de formulations pharmaceutiques à base de OPIC destinées à la prise en charge des dermatoses infectieuses