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Publications
Publications (81)
Introduction: Cannibidiol (CBD) is one of the two primary phytocannabinoids found in cannabis. Its diverse pharmacological properties suggest potential benefits for a wide range of medical conditions. The primary objective of this study was to estimate the prevalence of CBD use among patients being treated for substance use disorder. Additionally,...
Background
Although renal damage is increasingly reported among the most undernourished patients with Anorexia Nervosa (AN), it remains underestimated in current practice, and often associated with acute dehydration. The purpose of our study was to evaluate the frequency, the extent, and the risk factors of renal involvement among adolescents and a...
Background
Chronic use of cannabis is associated with an increased risk of psychosocial, mental and physical health impairments. Sociohealth institutions reach a very limited proportion of cannabis users in need of treatment. Using data collected from festival attendees, this study aimed to estimate the prevalence of dependent cannabis users and to...
Background
In many countries, nitrous oxide is used in a gas mixture (EMONO) for short-term analgesia. Cases of addiction, with significant misuse, have been reported in hospitalized patients. Patients suffering from sickle cell disease (SCD) could represent a high-risk population for substance use disorder (SUD) due to their significant pain crisi...
Background
Opioid-related mortality is a rising public health concern in France, where opioids were in 2021 implicated in 75% of overdose deaths. Opioid substitution treatment (OST) was implicated in almost half of deaths related to substance and drug abuse. Although naloxone could prevent 80% of these deaths, there are a number of barriers to the...
Zopiclone, like zolpidem, is under surveillance in France due to its potential for dependence, abuse and misuse. However, part of the narcotics regulation was implemented in 2017 in France for zolpidem only, which has led to an increase in the number of zopiclone consumers. The objective of this article is to present French addictovigilance data re...
Background:
Since the appearance of zolpidem on the market, the occurrence of serious cases of abuse, misuse and dependence have come to the attention of authorities. In view of the increase in the number and severity of cases among zolpidem users and the predominant presence of zolpidem in falsified prescriptions, the French Health Authorities im...
Abstarct:
PURPOSE: Anorexia Nervosa (AN) is a severe chronic disorder and parents' experience of caregiving is usually marked by emotional distress and burden. Severe chronic psychiatric disorders are known to be linked with the concept of grief. Grief has not been investigated in AN. The aim of this study was to explore parents' and adolescents'...
Background:
In recent years, many studies have explored the associations among impulsivity, history of abuse, the emergence of eating disorders with episodes of binge eating (EDBE) and their severity. Nevertheless, factors associated with successful clinical outcomes of EDBE are still unknown. Our study aimed to test the hypothesis that a history...
EMONO is an equimolar mixture of oxygen and nitrous oxide and is considered a reference for dental care in children. Completion of dental treatment has usually been used as a criterion to assess EMONO treatment. However, patient-reported outcomes are needed because i) we treat vulnerable subjects, and ii) effects felt can impact dental care prognos...
Background:
The French national drug regulatory authority stated, in 2017, that a secured prescription pad must be used for zolpidem prescriptions. This study aimed to evaluate the evolution of the problematic consumption of zolpidem at the individual level since the new regulation.
Methods:
Two nationwide populations of at-risk users of zolpide...
Background:
In recent years, zolpidem has been the subject of numerous reports of misuse, abuse and dependence. In view of these risks, the French drug agency decreed the implementation of secure prescription pads in April, 2017. The objective of this study was to characterize the impact of this regulatory change on the patterns of zolpidem use....
The article describes the diverse modalities of inpatient care for anorexia nervosa in France (11 specialized centers). The impact of this diversity on patient outcome will be studied as a result of this work.
Résumé
Le recours à l’hospitalisation dans l’anorexie mentale se fait dans des situations extrêmes dont les critères sont codifiés internationalement et nationalement. Néanmoins il existe sur le terrain de multiples modalités d’application de ces principes. Aucun travail n’a été réalisé afin d’évaluer si les différentes modalités de prise en charge...
PurposeThe cognitive profiles of patients suffering from anorexia nervosa (AN) are currently explored as potential facilitating and/or maintenance factors. Specific data in restrictive AN (AN-R) remain contradictory. This study focused on women with AN-R to evaluate their cognitive functions to develop a more specific cognitive remediation program....
Introduction
Ces dernières années, le zolpidem a été le médicament hypnotique le plus prescrit en France et a également fait l’objet de multiples rapports de mésusage, d’abus et de dépendance. Devant ces risques, les médecins ont été informés en janvier 2017 qu’à partir d’avril 2017 la prescription du zolpidem devait obligatoirement être réalisée s...
Objective
Anorexia nervosa (AN) is a complex disease in which obsessive thoughts about body image, shape, or weight are expressed. The intensity of these concerns varies among individuals, and only a few studies have focused on their impact on patients’ clinical course when patients are treated on an outpatient basis. Our study aimed to determine w...
Background
Sickle cell disease (SCD) induces chronic haemolytic anaemia and intermittent vaso-occlusion that results in tissue ischaemia causing acute, severe pain episodes that can lead to frequent hospitalizations. These consequences can have repercussions on family, social, school and/or professional life. Here, we present some of the results of...
Introduction
Ces dernières années, le zolpidem a été le médicament hypnotique le plus prescrit en France et a également fait l’objet de multiples rapports de mésusage, d’abus et de dépendance. Devant ces risques, les médecins ont été informés en janvier 2017 qu’à partir d’avril 2017 la prescription du zolpidem devait obligatoirement être réalisée s...
Introduction
Les antihistaminiques (antiH1) de première génération disponibles sans prescription sont approuvés dans de nombreuses indications telles que l’insomnie, la toux, l’écoulement nasal, la cinétose. Leurs propriétés pharmacologiques antihistaminiques et atropiniques en font des substances susceptibles d’être mésusées, c’est-à-dire avec une...
Introduction
Le zolpidem est un des médicaments hypnotiques les plus prescrits en France et son potentiel d’abus et de dépendance a été montré dans plusieurs études. En janvier 2017, une information a été communiquée aux médecins sur l’obligation à partir d’avril 2017 de prescription du zolpidem sur ordonnance sécurisée. L’étude ZORRO (ZOlpidem et...
Aims
In recent years, zolpidem has been the subject of numerous reports of misuse, abuse and dependence. In view of these risks, the French drug agency (ANSM) decreed in April 2017 the implementation of secure prescription pads. The objective of this study was to evaluate the impact of this regulatory measure on the prescription of zolpidem and oth...
Purpose:
Benzodiazepines (BZDs) and related drugs (Z-drugs) are mainly taken chronically, and older people are much more likely to take them on a chronic basis despite recommendations. Withdrawal symptoms could be an obstacle to stopping BZD/Z-drug administration. The main objective of this study is to estimate the prevalence of withdrawal symptom...
Benzodiazepines and related drugs (BZD/Z) are used longer than recommended in the elderly population. However, to date, very few attempts have been made to evaluate dependence on BDZ/Z among the elderly population. We conducted a national multicentric observational prospective study aimed at evaluating the prevalence of and risk factors for depende...
The concept of “food addiction” (FA) has aroused much focus because of evidence for similarities between overeating and substance use disorders (SUDs). However, few studies have explored this concept among the broad spectrum of eating disorders (ED), especially in anorexia nervosa (AN). This study aimed to assess FA prevalence in ED female patients...
Objectives:
Benzodiazepines and non-benzodiazepine hypnotics (or Z-drugs) (BZD/Z) are widely prescribed for older patients despite major side effects and risks when chronically used. The patient's understanding of the treatment is one of the keys to good adherence. The purpose of the study was to assess the knowledge of BZD/Z treatment among older...
Our objective was to quantify the impact on the use of zolpidem of the obligation implemented in France in 2017 to use secure prescription pads to prescribe it. We conducted a cohort study within the French SNDS healthcare database. Patients aged over 18 years of age were considered for inclusion. The number of prevalent users and incident episodes...
Background
Few studies have examined the consumption trajectories of inmates after entry to prison. The aim of this study was to assess the changes in the consumption of psychoactive substance between the period before detention and during incarceration and to characterize the profiles of prisoners with similar consumption trajectories during incar...
Contexte : Les troubles périnéosphinctériens (TPS) survenant chez les patients souffrant de trouble du comportement alimentaire (TCA) sont des complications sous-abord ées dans la littérature. Le but de cette revue de la littérature était de faire le point sur l’état des connaissances actuelles pour aider le clinicien prenant en charge les TPS à le...
Introduction
In recent years, data collected by the French Addictovigilance Network have shown the potential for abuse and addiction associated with zolpidem (the most sold hypnotic drug in France). Since 10 April 2017, new regulations have come into force that require zolpidem to be prescribed on special secure prescription pads, in order to reduc...
Background
Many studies were conducted to assess the benefit/risk ratio of EMONO (Equimolar Mixture of Oxygen and Nitrous Oxide) in France before it was authorized for use outside the hospital setting in 2009. The main objective of this project is to evaluate the effects sought and felt by children when EMONO is used in paediatric dentistry. The se...
Background: Many studies were conducted to assess the benefit/risk of equimolar mixture of oxygen and nitrous oxide (EMONO), but evaluating the appetite associated to its use is now getting very little attention in the literature. The purpose of this study was to investigate the effects present, felt, and sought during care by the child related wit...
Introduction
La consommation de substances psychoactives en prison existe même si elle est réglementairement interdite. Plusieurs études effectuées en France dans des populations carcérales ont évalué la prévalence de cette consommation. Cependant, l’évolution des consommations et des modalités de consommation entre le moment de l’entrée en établis...
Introduction
Les poppers, autrefois utilisés en médecine pour leurs propriétés vasodilatatrices dans l’angor, font aujourd’hui l’objet d’abus. Après avoir été réglementée, leur vente est aujourd’hui libre. Utilisés à des fins sexuelles ou récréatives, on assiste aujourd’hui à une explosion de l’utilisation des poppers chez les jeunes, notamment pou...
History of intensive sports practice: comparison between patients with substance use disorders and eating disorders
Several authors have noted the frequent association between excessive sport and the consumption of psychoactive substances or the presence of an eating disorder, however no study has compared these two types of patients with respect t...
Objectives
Addictions are not restricted to substance-use disorders, and it is now widely recognized that they also include behavioral addictions. Certain individuals with eating disorders also experiment their disorder as an addiction. The objective was to identify typologies of patients presenting with various behavioral addictions or eating diso...
Graphic representations of the latent trajectories obtained for the 2 ASRS dimensions after the Growth Mixture Models analysis.
(DOCX)
Graphic representations of the latent trajectories obtained for the 3 damage scores after the Growth Mixture Models analysis.
(DOCX)
Graphic representations of the latent trajectories obtained for the 4 UPPS-P dimensions after the Growth Mixture Models analysis.
(DOCX)
Graphic representations of the latent trajectories obtained for the 3 character dimensions of the TCI after the Growth Mixture Models analysis.
(DOCX)
Le terme de « Food addiction », ou addiction à l’alimentation (AA), a été introduit en 1956 par Randolph. Il repose sur l’idée que certains aliments pourraient avoir un potentiel addictif et que la suralimentation pourrait constituer une forme de comportement addictif. Pour diagnostiquer une AA, il est donc tentant d’appliquer des critères déjà exi...
Plusieurs auteurs ont remarqué la fréquente association entre une pratique sportive excessive et la consommation de substances psychoactives ou la présence d’un trouble du comportement alimentaire. Cependant, aucune étude ne s’est intéressée à comparer ces deux types de patients vis-à-vis de leur pratique sportive. L’objectif de cette étude était d...
Introduction L’anorexie mentale restrictive (AMR) concerne, en France, à peu près 1,5 % de la population féminine, entre 15 à 35 ans. L’AMR est fréquemment associée à des comorbidités psychiatriques et présente un taux élevé de décès. La remédiation cognitive est une technique thérapeutique prometteuse en cours d’évaluation [1]. L’objectif de cette...
Aim:
Poppers have become legal in France since June 2013. Is their liberalisation associated with an increase of severe side effects observed?
Methods:
To identify elevated methaemoglobinaemia related to poppers abuse, we reviewed all methaemoglobin concentrations measured in Nantes university hospital, during 12 months.
Results:
Methaemoglobi...
Impulse control disorders (ICDs) are a well-known adverse effect of dopamine agonists (DAAs). This critical review aims to summarize data on the prevalence and factors associated with the development of an ICD simultaneous to DAA use. A search of two electronic databases was completed from inception to July 2017. The search terms were medical subje...
We assumed that, as in the case of addiction disorders, former cult members exhibit vulnerability and protective factors for cult commitment and membership. Thus, the aim of our study was to identify vulnerability factors that are involved in the commitment and in the retention in the group, as well as protective factors that are involved in the de...
Introduction. In France, an addictovigilance network is responsible for evaluating drug dependence, by drawing on pharmacoepidemiological studies, clinical studies and by assessing healthcare professionals’ reports on problematic consumption.
Methods. The aim of this study was to determine whether zolpidem and zopiclone have different dependence pr...
Purpose:
Over the last few years, disordered eating in athletes has received increasing attention. According to several studies, athletes could be more vulnerable to disordered eating and some characteristics specific to the athletic community could be in favour of an increased risk of poor body image and disturbed eating habits in athletes. Howev...
Introduction
Les patients souffrant de syndrome drepanocytaire majeur (SDM) sont particulierement exposes a des douleurs aigues liees aux crises vaso-occlusives, de facon parfois repetee et imprevisible. Il existe dans cette population un risque de pseudo-addiction, d’abus et de dependance aux antalgiques peu evalue. L’objectif de l’etude Phedre es...
Introduction
L’adolescence représente une période charnière du développement cérébral avec une vulnérabilité accrue à la prise de risque. Le nombre de déclarations reçues au CEIP-A de Nantes rapportant des conséquences graves avérées ou potentielles liées à des consommations occasionnelles de substances psychoactives (SPA) chez des sujets de moins...
Background
Gamma-hydroxybutyrate (GHB) is a synthetic drug increasingly used by consumers of psychoactive substances. The sought after psychoactive effects of GHB have resulted in an increase in recreational use in Europe. GHB is considered to have a high dependence potential, and abrupt discontinuation after long-term use can result in a severe wi...
Concerns about body shape and weight are core diagnostic criteria for eating disorders although intensity varies between patients. Few studies have focused on the clinical differences relative to the intensity of these concerns. Nonetheless, they might have a prognostic value. This study was aimed at identifying the characteristics associated with...
Diagnostic criteria for Anorexia Nervosa and Bulimia Nervosa according to American Psychiatric Association.
Diagnostic and statistical manual of mental health disorders: DSM-5 5th ed. Washington DC: American Psychiatric Publishing; 2013.
(DOC)
Objectifs
En France, le réseau des Centres d’évaluation et d’information sur la pharmacodépendance-addictovigilance” (CEIP-A) est responsable de la collecte et de l’évaluation des notifications rapportant une dépendance à des substances psychoactives médicamenteuses ou non. Ces notifications sont évaluées à l’aide d’un score qui permet d’évaluer le...
Aims:
The French health authority (ANSM) is responsible for monitoring medicinal and other drug dependencies. To support these activities, the ANSM manages a network of 13 drug dependence evaluation and information centres (Centres d'Evaluation et d'Information sur la Pharmacodépendance - Addictovigilance - CEIP-A) throughout France. In 2006, the...
Background:
Methadone and buprenorphine are the two opiate maintenance treatments (OMT) available in France. According to the good clinical practices, a full clinical and biological assessment is required before deciding to initiate or renew an OMT. For methadone, this assessment includes psychoactive drug consumption investigation, through an ini...
Background:
The use of analgesics can lead to cases of drug abuse and dependence. It can also cause pseudo-addiction in patients suffering from pain. What is the actual situation in patients suffering from severe sickle-cell disease, exposed to acute pain during vaso-occlusive crises? Evaluation of the use of analgesics, on the basis of Diagnostic...
Introduction
Les troubles du comportement alimentaire (TCA) sont des pathologies fréquentes qui touchent principalement les femmes et dont le pronostic reste réservé. Les patientes souffrant de TCA sont beaucoup plus préoccupées par leur image corporelle et leur poids que le reste de la population [1]. De surcroît, les préoccupations corporelles se...
L’objectif de l’étude était d’évaluer si l’attachement insécure était associé à des symptômes plus sévères dans l’anorexie mentale.
Introduction
En France, le réseau des Centres d’évaluation et d’information sur la pharmacodépendance (CEIP) a pour mission d’évaluer le potentiel de dépendance des médicaments et substances. Ils disposent pour cela d’un outil permettant de recueillir les notifications des cas d’abus et de dépendance émanant des professionnels de santé. Un score, r...
Abstract In 2004, the health authorities modified the summary of zolpidem characteristics. The present paper aims at showing that, in spite of this modification, zolpidem remains considered as a drug associated with problematic use, as the official system providing information on abuse and/or dependence potential of drugs informs us. Methods The au...
Eating disorders are complex troubles with a psychological, behavioural or physical expression. Care must therefore be both diverse and organised in order to help the patient to recover an healthy development without these disorders often symptoms of a failure of adolescence. Authors describe the different type of care generally provided, recalling...
