M. R. Mozafari

Australasian Nanoscience and Nanotechnology Initiative · NanoBiotechnology

Reviewer Certificate

On 8 August 1984, Chuck Hull (Charles W [...]

Application of nanocarrier systems in cancer treatment has emerged as a promising strategy to overcome the limitations of conventional chemotherapy and radiotherapy, which often lead to off-target toxicity and suboptimal therapeutic outcomes. Nanocarriers, including solid lipid nanoparticles (SLNs), nanostructured lipid carriers (NLCs), lipid nanoc...

Cardiovascular Diseases (CVDs) are responsible for the highest number of deaths and disabilities globally. Although numerous therapeutic options exist for treating CVDs, most traditional strategies have proven ineffective in halting or significantly slowing disease progression, often leading to unfavorable side effects. Using nanocarriers represent...

The effective and prompt treatment of wounds remains a significant challenge in clinical settings. Consequently, recent investigations have led to the development of a novel wound dressing production designed to expedite the process of wound healing with minimal adverse complications. Chitosan, identified as a natural biopolymer, emerges as an appe...

In recent years, immunotherapy, namely immune checkpoint inhibitor therapy, has significantly transformed the approach to treating various forms of cancer. Simultaneously, the adoption of clinical oncology has been sluggish due to the exorbitant expense of therapy, the adverse effects experienced by patients, and the inconsistency in treatment resp...

Paclitaxel is one notable chemotherapy drug that is used to treat a number of cancers, including lung cancer. Nevertheless, it has drawbacks such as toxicity, low solubility in water, and the emergence of multidrug resistance (MDR). This article reviews the use of liposomal formulations to improve paclitaxel administration and efficacy for lung can...

31 years scientific achievement of Prof. Mozafari!

Contemporary nutraceutical and biomedical sectors are witnessing fast progress in efficient product development due to the advancements in nanoscience and encapsulation technology. Nutraceuticals are generally defined as food substances, or a section thereof, that provide us with health benefits such as disease prevention and therapy. Nutraceutical...

Citation: Khalid, A.; Naeem, M.; Atrooz, O.; Mozafari, M.R.; Anari, F.; Taghavi, E.; Rashid, U.; Aziz, B. State of the Art Synthesis of Ag-ZnO-Based Nanomaterials by Atmospheric Pressure Microplasma Techniques. Surfaces 2024, 7, 680-697. https:// Abstract: Atmospheric pressure microplasma is a simple, cost-effective, efficient, and eco-friendly pro...

Drug and gene carrier vesicles (also referred to as controlled release systems) are advanced dosage forms utilized for disease diagnosis, prevention, and cure. The design rationale is to supply an adequate quantity of the medicaments or diagnostic agents to the pathological sites (target cells) at the right time frame to attain maximum therapeutic...

The administration of medicinal drugs orally or systemically limits the treatment of specific central nervous system (CNS) illnesses, such as certain types of brain cancers. These methods can lead to severe adverse reactions and inadequate transport of drugs to the brain, resulting in limited effectiveness. The CNS homeostasis is maintained by vari...

Atmospheric pressure Microplasma is a simple, cost-effective, efficient, and eco-friendly procedure, which is superior to the traditional nanomaterials synthesis techniques. It generates high yields and allows for a controlled growth rate and morphology of nanomaterials. The silver (Ag) nanomaterials, with their unique physical and chemical propert...

In order to improve the treatment of lung cancer, this paper looks at the development of cisplatinbased liposomal nanocarriers. It focuses on addressing the drawbacks of conventional cisplatin therapy, including systemic toxicity, inadequate tumor targeting, and drug resistance. Liposomes, or spherical lipid vesicles, offer a potentially effective...

Background and purpose Hair loss is a prevalent problem affecting millions of people worldwide, necessitating innovative and efficient regrowth approaches. Nanostructured lipid carriers (NLCs) have become a hopeful option for transporting bioactive substances to hair follicles because of their compatibility with the body and capability to improve d...

The toxicity of systemic release in common drug delivery has irreversible effects on various tissues and organs of the body. The use of programmed biopolymers sensitive to the body's physiological conditions for targeted drug delivery has attracted extensive consideration. There are numerous benefits to this approach. The need for appropriate biopo...

Certificate

The technical phrase theragnostic (also known as theranostic) was first introduced to the scientific community in the year 1998 by John Funkhouser, to describe a methodology or procedure employed to achieve disease diagnosis and treatment simultaneously [1]. Some scholars, however, have added a third element and defined the terminology as the combi...

This extensive review highlights the different techniques used to extract chitosan, its antibacterial characteristics, and its wide range of applications across various industries. Thanks to its exceptional solubility and notable chemical and biological properties, it has been used in several applications. It is biodegradable, and biocompatible, an...

Micro- and nano-lipidic carriers used for the entrapment, encapsulation, and precise targeting of the bioactive compounds offer significant advantages to the biomedical, pharmaceutical, nutraceutical, and cosmeceutical industries. These lipid and phospholipid-based vesicles can improve the solubility, permeation, pharmacokinetics, pharmacodynamics,...

The biopolymer chitosan, which is derived from chitin, has shown great promise for tissue regeneration and regulated drug delivery. Its broad-spectrum antibacterial action, low toxicity, biocompatibility, and many other attributes make it appealing for use in biomedical applications. Crucially, chitosan may be synthesized into a range of forms that...

Breast cancer is a pervasive global health issue that disproportionately impacts the female population. Over the past few years, there has been considerable interest in nanotechnology due to its potential utility in creating drug-delivery systems designed to combat this illness. The primary aim of these devices is to enhance the delivery of targete...

Bioactive glass (BG) shows great potential as a biomaterial for bone regeneration. Chitosan enhances the biological characteristics of BG. Chitosan is the sole commonly utilized natural polysaccharide that may be chemically altered for various purposes and roles. Composite materials formed by combining chitosan bioactive glass (BG) nanoparticles an...

The complicated internal mechanical and structural qualities of normal bone tissue still prevent the development of effective therapeutic procedures for major bone lesions. It is still difficult to use tissue engineering to return damaged bones back to how they were originally intended. Due to recent advances in 3D printing, together with the intro...

The rising interest in hydrogels nowadays is due to their usefulness in physiological conditions as multi-stimuli-responsive hydrogels. To reply to the prearranged stimuli, including chemical triggers, light, magnetic field, electric field, ionic strength, temperature, pH, and glucose levels, dual/multi-stimuli-sensitive gels/hydrogels display cont...

Cancer therapy has seen significant advancements in recent years, with the emergence of RNA interference (RNAi) as a promising strategy for targeted gene silencing. However, the successful delivery of small interfering RNA (siRNA) to cancer cells remains a challenge. Chitosan nanoparticles (CSNPs) can be derived from the natural polysaccharide chit...

A quick search on "Google" or its scientific version "Google Scholar" will further prove the undeniable position and global rank of Prof. M. R. Mozafari in the area of Nanoliposomes. His hard work and extraordinary enthusiasm in this scientific field commenced several years ago in 1993 (his 1st paper was published in 1994).

Lung cancer is a significant cause of cancer-related death worldwide. It can be broadly categorised into small-cell lung cancer (SCLC) and Non-small cell lung cancer (NSCLC). Surgical intervention, radiation therapy, and the administration of chemotherapeutic medications are among the current treatment modalities. However, the application of chemot...

Chitosan-based nanoparticles have emerged as a promising tool in the realm of cancer therapy, particularly for gene delivery. With cancer being a prevalent and devastating disease, finding effective treatment options is of utmost importance. These nanoparticles provide a unique solution by encapsulating specific genes and delivering them directly t...

The usage of nanoparticles in tissue engineering applications has increased significantly in the last several years. Functional tissues are developed by regulating cell proliferation, differentiation, and migration on nanostructured scaffolds containing cells. These scaffolds provide an environment that is more structurally supportive than the micr...

Improvements in cancer treatment are largely influenced by more people knowing about it and developing new ways to diagnose and treat it. New methods such as nanotheranostics and the use of tiny particles have greatly improved the diagnosis, control and treatment of cancer. They have also helped overcome problems with traditional treatments. Nanoth...

Researchers in various fields continue to discover improved ways of local delivery of drugs to specific locations and try to increase the efficiency of these methods. Extensive research has been done on smart nano-biomaterials for drug delivery systems (DDS) in different dimensions. With the advancement of biomedical nanotechnology, conventional sm...

Quantum dots (QDs) have attracted considerable interest due to their potential applications and economic viability in various industrial sectors, such as communications, displays, and solar cells. This fascination originates from the quantum size effect-induced remarkable optical properties exhibited by QDs. In recent years, significant progress ha...

Natural polysaccharide-based nanoparticles are known for their non-toxic nature and diverse medical applications. Graphene oxide (GO) nanoparticles show potential in cancer treat-ment due to their ability to target medication delivery and influence ROS generation. These nanocomposites are versatile in gene transport, therapy, and photodynamic thera...

Photodynamic therapy (PDT) is a multidisciplinary area, which involves photophysics and photochemical sciences and plays an important role in cancer diagnosis and treatment. PDT involves a photo-activable drug called photosensitizer (PS), a specific wavelength of light and cellular compounds to produce toxic oxygen species in a much-localized way t...

3D bioprinting is a novel technology that has gained significant attention recently due to its potential applications in developing simultaneously controlled drug delivery systems (DDSs) for administering several active substances, such as growth factors, proteins, and drug molecules. This technology provides high reproducibility and precise contro...

: Lipidic carriers employed for the entrapment, encapsulation and precise targeting the bioactive compounds offer significant advantages to the biomedical, pharmaceutical, nutraceutical and cosmeceutical industries. These lipid and phospholipid‐based vesicles can improve the solubility, permeation, pharmacokinetics, pharmacodynamics and bioavailabi...

Breast cancer is a highly prevalent disease on a global scale, with a 30% incidence rate among women and a 14% mortality rate. Developing countries bear a disproportionate share of the disease burden, while countries with greater technological advancements exhibit a higher incidence. A mere 7% of women under the age of 40 are diagnosed with breast...

Citation: Alavi, M.; Ashengroph, M.; Mozafari, M.R. Interaction of Carbon Nanotubes, Capped Carbon Nanotubes, CNT 2-5 , C 60 , C 70 , HO-C 60 , [C 60 ] 2 , and [C 60 ] 3 Fullerenes with Virulence Factors of Gram-Negative and Gram-Positive Bacteria: Potential Applications for 3D-Printed Scaffolds. Inorganics 2024, 12, 77. https:// Abstract: The anti...

Drug delivery systems, also known as bioactive carriers, are currently an important contribution to the pharmaceutical and biomedical industries. A leading category of these drug carriers is lipid- and phospholipid-based systems including liposomes, nanoliposomes, solid lipid nanoparticles, nanostructured lipid vesicles, archaeosomes, and tocosomes...

Bioprinting of self-healing materials and nanostructures has gained significant attention in recent years due of its potential benefits in biomedical applications. Self-healing materials and nanostructures can enhance the mechanical stability of printed constructs by restoring their strength, stiffness, and elasticity following damage. Self-healing...

Tocosome is a novel drug delivery technology that is composed of phospholipids and tocopheryl phosphates. https://doi.org/10.1016/j.ijpharm.2017.06.037

Mozafari Method celebrated as a United Nation accredited Green Technology 2023

Mozafari Method celebrated as a United Nation accredited Green Technology

Honoured to be included in the 2022-2023 ranking list of World's Top 2% Scientists, released by Stanford University in association with Scopus, Elsevier:

Doxorubicin is one of the most effective chemotherapeutic agents; however, it has various side effects, such as cardiotoxicity. Therefore, novel methods are needed to reduce its adverse effects. Quercetin is a natural flavonoid with many biological activities. Liposomes are lipid-based carriers widely used in medicine for drug delivery. In this stu...

Immunosuppressive factors within the tumor microenvironment (TME), such as Transforming growth factor beta (TGF-β), constitute a crucial hindrance to immunotherapeutic approaches in colorectal cancer (CRC). Furthermore, immune checkpoint factors (e.g., programmed death-ligand 1 [PD-L1]) inhibit T-cell proliferation and activation. To cope with the...

The future of molecular-level therapy, efficient medical diagnosis, and drug delivery relies on the effective theragnostic function which can be achieved by the synergistic effect of fluorescent carbon dots (FCDs) liposomes (L) and nanoliposomes. FCDs act as the excipient navigation agent while liposomes play the role of the problem-solving agent,...

Nowadays, the use of lipid-based nanocarriers for the targeted and controlled delivery of a variety of hydrophobic and hydrophilic bioactive-compounds and drugs has increased significantly. However, challenges such as thermodynamic instability, oxidation, and degradation of lipid membranes, as well as the unintended release of loaded compounds, hav...

Some of the currently available encapsulation systems, including liposomes, nanoliposomes, and solid lipid nanoparticles, have already been approved to be used in the pharmaceutical, food, textile, and cosmetic markets. These systems have proven to be useful for the encapsulation, controlled release, targeting drugs, vaccines (including Covid-19 va...

World population are struggling with numerous problems related to environmental issues such as pollution, availability of food, as well as the demand and supply of energy. The pollution caused due to the inappropriate management of natural resources is raising grave concerns towards environment safety and sustainability. Certain scientific fields i...

Cancer is one of the main causes of death worldwide. There are several different types of cancer recognized thus far, which can be treated by different approaches including surgery, radiotherapy, chemotherapy or a combination thereof. However, these approaches have certain drawbacks and limitations. Photodynamic therapy (PDT) is regarded as an alte...

Polyphenolic compounds are present in different parts of plants, including the root, stem, bark, leaves, seeds and fruits. They have been reported for their various biological functions including antimicrobial, antioxidant, anti-inflammatory, anticancer, antidiabetic, cardioprotective, and neuroprotective effects to mention a few, based on their in...

Cooked and oven-dried cowpea in different four concentrations of 0%, 10%, 20%, and 30% was incorporated into nutrition bars (CNB0, CNB10, CNB20, and CNB30 respectively). The nutrition bar contained other ingredients including roasted crushed peanuts, almonds, cashew, oatmeal, raisins, date syrup, hazelnut butter, glucose syrup, sorbitol, and glycer...

Hydrocolloids are known as natural hydrophilic biopolymers that can contribute viscosity and gelation in solution, as well as nutritional benefits, thus, they are widely used in the food industry. In our work, hydrocolloid was isolated by aqueous extraction of Sesamum indicum seed at 80 °C and pH 8.0. The chemical composition and functional propert...

Severe acute respiratory syndrome (SARS)-CoV-2 from the family Coronaviridae is the cause of the outbreak of severe pneumonia, known as coronavirus disease 2019 (COVID-19), which was first recognized in 2019. Various potential antiviral drugs have been presented to hinder SARS-CoV-2 or treat COVID-19 disease. Side effects of these drugs are among t...

This study presented the optimization of synthesis experimental conditions by examining the simultaneous effects of synthesis environment and precipitating agent type on the physiochemical, morphological, and magnetization characteristics of Fe3O4 nanoparticles (FeNPs). The experimental results implied that the effect of the synthesis environment o...

Background In the present study, the effects of NaCl and CaCl 2 (0–200 mM) on the rheological properties of Lepidium perfoliatum seed gum (LPSG) as a novel potential source of hydrocolloid were investigated. Sugar composition and FTIR analysis were measured to supply more structural information. Results The results illustrated that LPSG had small...

Saffron is the commercial name of the dried stigmas of Crocus sativus flower, commonly known as the “saffron crocus.” The colorful crimson stigma and styles (called threads) are collected and dried for use, generally as an aromatic seasoning and coloring agent in food. The main ingredients of saffron include crocin, safranal, picrocrocin, and croce...

Liposomes are microscale lipid bilayer vesicles, widely employed for solubilizing drugs and delivering them to the body with precise targeting and controlled release. The nanoscale version of liposomes is known as nanoliposome. These biocompatible and biodegradable drug delivery systems have several advantages, such as the ability to be loaded with...

CERTIFICATE OF REVIEWING - Awarded to: M. R. Mozafari

MDPI is a publisher of open access, international, academic journals. We rely on active researchers, highly qualified in their field to provide review reports and support the editorial process. The criteria for selection of reviewers include: holding a doctoral degree or having an equivalent amount of research experience; a national or internationa...

Bioactive food compounds (BFCs) are micronutrients existing in small quantities in various foods. Plant, microbes, and animals are considered the main sources of bioactive components including polyphenols, flavonoids, ω-3 FAs, and so on. BFCs have many biological functions such as antioxidant, antidiabetic, antiobesity, anti-cardiovascular, antican...

Liposomes mainly comprise an aqueous core surrounded by a lipid bilayer, akin to cellular membranes. The encapsulation, loading, and release properties of therapeutic agents in both, the core and lipid bilayer can be prominently affected by the preparative processes for liposome which include hydration of lipid thin films, detergent removal, solven...

Bacterial infections can be caused by contamination of labile blood products with specific bacteria, such as Staphylococcus aureus and Staphylococcus epidermidis. Hospital equipment, bio-protective equipment, delivery systems, and medical devices can be easily contaminated by microorganisms. Multidrug-resistant bacteria can survive on various organ...

The current pandemic caused by the viral pathogen – Coronavirus – and its strains has resulted in more than 4 million deaths worldwide. Subsequent to the World Health Organisation declaration of novel coronavirus as a public health emergency on the pandemic level, the main international immunization partners developed a Global COVID-19 Vaccination...