M. Ndour Mbaye

• Cheikh Anta Diop University

This proposed scientific statement is focused on providing new insights regarding challenges and opportunities for cardiovascular health (CVH) promotion in Africa. The statement includes an overview of the current state of CVH in Africa, with a particular interest in the cardiometabolic risk factors and their evaluation through metrics. The stateme...

Epidemiological data predicts that Sub-Saharan Africa will have the largest increase in type 2 diabetes (T2D) prevalence over the next two decades. Metabolomics studies have identified biomarkers that could improve T2D diagnosis and follow-up. However, no studies have characterized the metabolome of people from Sub-Saharan Africa. Plasma samples fr...

Introduction Les polyendocrinopathies auto-immunes (PEAI) sont des maladies caractérisées par la coexistence d’au moins deux affections endocrines de mécanisme auto-immun, associées parfois à une affection auto-immune non endocrinienne. Elles représentent un groupe de pathologies concomitantes, de fréquence rare, présentant une hétérogénéité cliniq...

With the growing prevalence of type 2 diabetes, particularly in emerging countries, its management in the context of available resources should be considered. International guidelines, while comprehensive and scientifically valid, may not be appropriate for regions such as Asia, Latin America or Africa, where epidemiology, patient phenotypes, cultu...

Pyoderma gangrenosum (PG) is a rare non-infectious neutrophilic dermatosis often unknowed. It usually presents with inflammatory skin ulcer, very painful, with rapid evolution. It is commonly found in a context of malignancy, inflammatory bowel disease, rheumatic and/or haematological disease. Its diagnosis is very often late after multiple therape...

Fasting glucose (FG) and glycated hemoglobin A1c (HbA1c) perform sub-optimally in people of African origin, especially in individuals with sickle-cell trait (SCT). The purpose of this study was to compare the relationships between HbA1c, FG, and fructosamine in individuals from Senegal with and without SCT. HbA1c, FG, and fructosamine were measured...

Objective: The prevalence of type 2 diabetes (T2D) is rapidly increasing in Sub-Saharan Africa, where sickle-cell trait (SCT) is also frequent. Although SCT is generally considered a benign condition, evidence suggests that SCT could exaggerate vascular dysfunction in T2D. However, it remains unclear whether SCT could increase the risk of developin...

Objective Since 2014 Senegal has benefited from regular awareness-raising Short Message Service (SMS) campaigns (Be He@lthy, Be Mobile initiative) directed at people who have signed up, for free, to the ‘mDiabète’ programme. We report on an evaluation of its impact on diabetes control. Design The clinical trial was designed to send daily SMS durin...

The Francophone (French speaking) Society of Diabetes (SFD) has been strongly involved in several actions to favor the collaboration of teams from the South and the North sharing the French language with the aim of increasing the quality of care for patients with diabetes or metabolic diseases through medical publications, e-learning, tools, exchan...

Résumé En Afrique, face à la progression exponentielle des maladies non-transmissibles et du diabète en particulier, les besoins de formation des personnels de santé sont immenses, tout comme les besoins éducatifs des patients et des populations à risque, sans oublier la population générale qui est tout autant concernée. Internet est-il une partie...

Introduction: The diagnosis of cardiothyreosis is based on the presence of the association of thyrotoxicosis and various cardiovascular disorders such as heart failure, coronary artery disease, rhythm or conduction disorders. Data are limited on this entity in Africa which a frequency of 10% to 33% among hyperthyroidism. We aimed to evaluate these...

Résumé Les infections de la main chez le diabétique, décrites sous le nom de « Syndrome de la main diabétique tropicale », sont moins courantes que les atteintes du pied, mais exposent également à des conséquences invalidantes majeures. L’objectif de notre étude était de déterminer leurs caractéristiques épidémiologiques, cliniques, étiologiques et...

Abstract: This retrospective study reproduces the correlation between glycated hemoglobin and fasting glucose in diabetic patients black Abass Ndao Hospital from 1 January 2010 to 31 December 2011 identifying the data on the register of biochemistry laboratory. We proposed glycemic intervals starting from the lowest value with increases of 0.2 g/l...

Objectives: To assess the clinical particularities and management of Graves’ disease at the Medical Clinic II of the Abass Ndao Hospital Centre in Dakar. Patients and methods: This was a retrospective, descriptive study on records of patients monitored for Graves' disease from 1 January 2010 to 31 December 2014 (5 years). Socio-demographic, clinica...

The aim of our study was to determine epidemiological, clinical and therapeutic profile of colorectal cancers in Mauritania. Patients and Methods: It was a retrospective multicentric study conducted over 5 years in Nouakchott National Hospital Centre and in private clinics of Mauritania. All cases of colorectal cancers histologically confirmed were...

It is predicted that Africa will have the greatest increase in the number of patients with type 2 diabetes mellitus (T2DM) within the next decade. T2DM patients are at risk for cardiovascular disorders. In Sub-Saharan African countries, sickle cell trait (SCT) is frequent. Despite the presence of modest abnormalities in hemorheology and oxidative s...

Résumé mDiabète est l’application au Sénégal du programme mondial « Be He@lthy, Be Mobile » lancé conjointement par l’Organisation mondiale de la Santé (OMS) et l’Union internationale des télécommunications (UIT). Il consiste en l’utilisation du téléphone mobile pour améliorer la prévention et la prise en charge des maladies non transmissibles (MNT...

We measured the glycated haemoglobin (HbA1c) levels of a total of 24 non-diabetic volunteers and diabetic patients using a point-of-care (POC) analyser in three Cameroonian cities at different altitudes. Although 12 to 25% of duplicates had more than 0.5% (8 mmol/mol) difference across the sites, HbA1c values correlated significantly (r = 0.89-0.96...

Introduction: According to the WHO, 50% of deaths worldwide (40.1% in developing countries) are due to chronic non-communicable diseases (NCDs). Of these chronic NCDs, cardiovascular diseases remain the leading cause of death and disability in developed countries. The Framingham study has shown the importance of hypercholesterolemia as a primary r...

Candida esophagitis has become a reality since the advent of endoscopy and diabetes mellitus remains a predisposing factor. The objective was to investigate the characteristics of candida esophagitis in diabetic subjects in Abass Ndao Hospital center (Dakar). This 54-month descriptive cross-sectional study included all diabetics in whom endoscopic...

The incidence of cardiovascular disease is growing worldwide and this is of major public health concern. In sub-Saharan Africa, there is a lack of epidemiological data on the prevalence and distribution of risk factors of cardiovascular disease. This study aimed at assessing the prevalence of hypertension and other cardiovascular risk factors among...

A Good Clinical Practices (GCPs) course, based on the combination of theoretical modules with a practical training in real-life conditions, was held in 2010 in Burkina Faso. It was attended by 15 trainees from nine African, Asian, and Latin American countries. There were some discrepancies between the average good results at the end of the theoreti...

Background: Cardiovascular diseases are becoming with their risk factors a real health problem in Africa. The objectives of this study were to assess the prevalence of risk factors for cardiovascular diseases in the general population in Saint-Louis, Senegal. Methodology: This is a cross-sectional, descriptive and analytical made in May 2010, in...

Introduction: The discovery of silent myocardial ischemia in a diabetic placed in a logic of secondary prevention. The objectives of this study were to investigate the echocardiographic parameters of type 2 Senegalese diabetics at high cardiovascular risk and identify those that are predictors of silent myocardial ischemia. Patients and methods:...

Objectives The purpose of this study was to investigate the prevalence of peripheral arterial disease (PAOD) and cardiovascular risk factors associated with the ankle-brachial index (ABI) in Senegalese patients aged 40 years and over. Methodology We prospectively studied a random sample of Senegalese aged 40 years and older, residing in the city o...

The purpose of this study was to investigate the prevalence of peripheral arterial disease (PAOD) and cardiovascular risk factors associated with the ankle-brachial index (ABI) in Senegalese patients aged 40 years and over. We prospectively studied a random sample of Senegalese aged 40 years and older, residing in the city of St.-Louis, Senegal. Th...

Introduction: Morbidity and mortality from diabetes are compounded by the combination of cardiovascular risk factors. For this reason, care of these risk factors is a public health goal. In this study we evaluated the level of control of cardio-vascular risk factors in black Africans with type 2 diabetes in Senegal. Methods: Between March 2007 and...

The scarcity of studies about the metabolic syndrome (MS) in Africa has motivated us to conduct a study which aim is to evaluate its frequency as well as its complications according to WHO and NCEP-ATP III criteria in a Senegalese population. A possible relationship between high-sensitivity C-reactive protein (hs-CRP) and classical atherogenic risk...

Summary Introduction: Diabetic foot ulcers represent a significant cause of morbidity. The major risk is amputation. The purpose of this study was to look at the epidemiological, clinical, and evolutionary aspects of foot ulcers as well as the main etiologies and those most prone to amputation in diabetic subjects in Dakar. Patients and method: It...

The purpose of this report is to describe four cases of nocardiosis observed over an eight-year period in medical units of Principal Hospital in Dakar, Senegal. It is a rare infection occurring mainly in people with weakened immune systems. Pulmonary forms are predominate and clinical and laboratory presentation can mimic pulmonary tuberculosis. Di...

Rheumatoid arthritis is the most common chronic inflammatory joint disease in adults. In Senegal, where biotherapy is unavailable, treatment of RA relies on a combination of glucocorticoids and disease-modifying antirheumatic drugs (DMARD). Since DMARD, particularly methotrexate, induce hepatotoxicity pretreatment assays of serum transaminase and a...

Introduction : Seul ou associé à d’autres facteurs de risque vasculaire, le diabète est responsable d’une lourde morbi-mortalité partout dans le monde. Son expansion prend des allures de pandémie, mais elle reste encore peu documentée en Afrique sub-saharienne. Ce travail fournit quelques aspects épidémiologiques du diabète parmi les autres facteur...

The Diabcare Africa project was carried out across six sub-Saharan African countries to collect standardised and comparable information for the evaluation of diabetes control, management and late complications in diabetic populations at specialist clinics. A cross-sectional, descriptive study of 2352 type-2 diabetes patients who were treated at spe...

INTRODUCTION: The discovery of silent myocardial ischemia in a diabetic placed in a logic of secondary prevention. The objectives of this study were to investigate the echocardiographic parameters of type 2 Senegalese diabetics at high cardiovascular risk and identify those that are predictors of silent myocardial ischemia. PATIENTS AND METHODS: We...

Aim: The DiabCare-Senegal project aimed to describe diabetes control and management, as well as the stage of late complications observed in diabetic patients who are under follow-up and treatment. Methods: A descriptive study has been conducted in five centers specialized in diabetes management over a period of 3 months, including all patients bei...

The follow-up of diabetes mellitus in children and teenagers remains a challenge. Ketoacidosis is the most frequent acute metabolic complication and is of bad prognosis. The objective of this study was to evaluate etiologicals factors of decompensation and evolutions in type 1 diabetes. We conducted a transversal and prospective study from January...

Lipid profile and cardiovascular risk of type 2 diabetic in Senegal. Introduction. Diabetes is most often associated with other vascular risk factors increasing the global cardiovascular risk. The diabetes' dyslipidemia is variously appreciated in the literature. The objectives of this study were to assess the prevalence of dyslipidemia in type 2 S...

Every 30 seconds, a lower limb is amputated as a result of diabetes; of all the amputations in the world, about 70% are suffered by people with diabetes – foot ulceration being a key factor in developing regions. Yet these amputations can be prevented. As well as medical factors, numerous social and socio-environmental issues affect the development...

Diabetic foot is a major complication of diabetes due to its frequency and its high risk of evolution to amputation. We report 105 cases recruited at the diabetes centre Marc Sankale. It's a prospective study including all diabetic patients who attended the diabetes centre for any foot lesion during a one year period. Besides clinical examination d...

To date no study in our country was specifically dedicated on toxic nodular goiter. They were just mentioned in generally studies about hyperthyroidism. The authors report a retrospective series of 62 cases of toxic nodular goitre collected between 1979 and 1999 at the internal medical clinic of Dakar teaching hospital. The diagnostic of toxic nodu...

Nephropathy is one of the complications occuring during diabetes and it is diagnosed via microalbuminuria. From 1992 to 1999, five hundred and eighty seven (587) diabetic patients were recruited and distributed into two groups, A (n = 270) and B (n = 317). Microalbuminuria was determined by immunonephelemetry for group A and immunoturbidimetry for...

We have studied the socio-demographic features and vascular risk factors in diabetic patients with high blood pressure. This prospective study has taken place in Centre Marc Sankale during the period 1981-1997. We selected 43 such cases out of the 258 diabetics (10 males, 33 women) received in our Department during the said period (prevalence 16.6%...

Graves' disease has for long been considered rare in children in Africa. The aim of this study is to show its increasing frequency in children and teenagers and to determine it's clinical profile, etiological and developing factors. In 10 years, 62 cases have been diagnosed with patients from 5 to 20 years among a 579 cases of Graves' disease i.e....

This study took place between January and September 1996. The inclusion criteria was a blood cholesterol concentration of at least 2.5 g/l. Thirty-three patients were included. They were aged from 37 to 77 years, with a mean age of 59 (+/- 9.4) years. Twenty-six were women and seven were men. The mean age of the women was 58.9 (+/- 10) years and th...

This study took place between January and September 1996. The inclusion criteria was a blood cholesterol concentration of at least 2.5g/l. Thirty-three patients were included. They were aged from 37 to 77 years, with a mean age of 59 (± 9.4) years. Twenty-six were women and seven were men. The mean age of the women was 58.9 (± 10) years and that of...

A case of mucormycosis (zygomycosis, phycomycosis) due to Mucor sp. was seen in a 34-year-old Senegalese man with insulin-dependent diabetes mellitus and ketoacidosis. The outcome was favorable with intravenous amphotericin B therapy, daily debridement, and optimal metabolic control. Mucormycosis is a rare disease due to a ubiquitous fungal agent....