M. Magdalena Echezarreta Lopez

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M. Magdalena verified their affiliation via an institutional email.

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• PhD. Associate Professor
• Professor (Associate) at University of La Laguna

Background: The manufacture of biologics is a complex, controlled, and reproducible process that results in a product that meets specifications. This should be based on data from batches used to demonstrate manufacturing consistency. Ten batches of originator product (Avastin®) were analyzed over a 10-year period. Methods: The β-expectation toleran...

The quality of drug products may be affected from manufacture to dispensing, particularly at high temperature and humidity as in Mauritania. This country is not included in the World Health Organization reports on poor quality products due to the lack of a qualified laboratory and monitoring system. Ensuring the quality of medicine is even more rel...

(1) Background: First-line antituberculosis treatment in paediatrics entails the administration of Isoniazid, Pyrazinamide, and Rifampicin. This study examines the possibility of developing a combined dose liquid formulation for oral use that would facilitate dose adjustment and adherence to treatment for younger children. (2) Methods: The active p...

The search for an ideal bone tissue replacement has led to the development of new composite materials designed to simulate the complex inorganic/organic structure of bone. The present work is focused on the development of mineralized calcium alginate hydrogels by the addition of marine derived calcium carbonate biomineral particles. Following a nov...

The morphology and dimensions of bioactive materials are essential attributes to promote tissue culture. Bioactive materials with nanofibrous structure have excellent potential to be used as bone-defect fillers, since they mimic the collagen in the extracellular matrix. On the other hand, bioactive glasses with applications in regenerative medicine...

Background and objectives: β-Lapachone (βLAP) is a promising, poorly soluble, antitumoral drug. βLAP combination with cyclodextrins (CDs) improves its solubility and dissolution but there is not enough information about the impact of cyclodextrins on βLAP intestinal permeability. The objectives of this work were to characterize βLAP intestinal per...

A laser-spinning technique has been used to produce amorphous, dense and flexible glass nanofibers of two different compositions with potential utility as reinforcement materials in composites, fillers in bone defects or scaffolds (3D structures) for tissue engineering. Morphological and microstructural analyses have been carried out using SEM–EDX,...

The purpose of this work was to study the chemical stability of the new antitumoral β-lapachone (βLAP) to determine the degradation pathway/s of the molecule and the degradation kinetics in addition to identifying several degradation products. Samples of βLAP in solution were stored under conditions of darkness and illumination at 40°C at which the...

The aim of this work is to analyze the effect of cyclodextrin (CD) complexation on the solubilization and stabilization of sodium dicloxacillin in acid aqueous solutions. The effect of four cyclodextrins α-, β-,γ- and hydroxypropyl-β-CD was studied. Phase solubility diagrams obtained are AL or BS type, depending on the cyclodextrin used and on the...

The interaction between dexamethasone sodium phosphate (DSP) and four cyclodextrin (CyD) derivatives [2,6-di-O-beta-cyclodextrin (DIMEB), gamma-cyclodextrin (gamma-CyD), and hydroxypropyl-beta-cyclodextrin with either 2.7 or 4.6 degrees of substitution (HPbetaCyD 2.7 and HPbetaCyD 4.6, respectively)] was investigated by proton nuclear magnetic reso...

The aim of this study was to increase the solubility of sulfamethizole in water by complexing it with beta-cyclodextrin (BCD) and hydroxypropyl-beta-cyclodextrin (HPBCD). The interaction of sulfamethizole with the cyclodextrins was evaluated by the solubility, 1H NMR spectrometry and molecular modelling. The stability constants calculated from the...

Bropirimine (ABPP) is an orally active immunomodulator that increases endogenous alpha-interferon and other cytokines used clinically against carcinoma in situ of the bladder. The oral absorption of ABPP is poor because its low solubility in water. The purpose of this study is to develop a technological procedure useful to increase the water solubi...

The formation of inclusion compounds of diclofenac sodium with β- and hydroxypropyl-β-cyclodextrins was studied in solution by phase solubility techniques and by 1H-NMR spectroscopy. Phase solubility diagrams revealed the formation of a 1/1 complex with both cyclodextrin derivatives in simulated gastric juice pH 1.2, with a similar stability consta...

The formation of inclusion compounds of diclofenac sodium with beta- and hydroxypropyl-beta-cyclodextrins was studied in solution by phase solubility techniques and by H-1-NMR spectroscopy. Phase solubility diagrams revealed the formation of a 1/1 complex with both cyclodextrin derivatives in simulated gastric juice pH 1.2, with a similar stability...

Pilocarpine hydrochloride is a widely used drug for the treatment of primary (open-angle) glaucoma. It is also used as a model drug in studies aimed at developing controlled-release ocular drug delivery systems. In such applications, pilocarpine is typically formulated in an aqueous system (Desai y col., 1992). In aqueous medium, pilocarpine can hy...

The inclusion complex formation of dexamethasone sodium phosphate with dimethyl-β-cyclodextrin and hydroxypropyl-β-cyclodextrin was studied by nuclear magnetic resonance technique. The structure of both inclusion complexes was found to be similar. Polymyxin B sulphate does not affect the formation of these inclusion complexes. This fact was found u...