M. M. H. Arief

Benha University · Department of Chemistry

This study was conducted to access the extraction yield of antioxidant and their activity from Egyptian tomato waste. Conventional and novel assisted extraction methods (ultrasound and microwave) using different hydrophilic and lipophilic solvents at different times and temperatures for optimizing extraction conditions were used. Total phenolics, f...

Saccharine is classified as a pharmacologically significant active scaffold for various biological activities, including antibacterial and anticancer. Herein, saccharinyl hydrazide (1) was synthesized and converted into 2-[(2Z)-2-(1,1-dioxo-1,2-dihydro-3H-1λ6,2- benzothiazole-3-ylidene) hydrazinyl] acetohydrazide (5), which was employed as a key pr...

Six novel fluorescent disperse dyes were synthesized by diazo-coupling reaction. As dye intermediates, two diazo components having 5-amino-4-arylazo-3-methyl-1H-pyrazoles moieties were initially prepared, diazotized and coupled with three pyrrolinone esters (PES) derivatives to give azo-hydrazone pyrazolo/pyrrolinone derivatives. The dye structures...

Word count: 177 Selenium containing heterocyclic compounds gained great interest as bioactive molecules as of late. This report explores the design, synthesis, characterization, and antimicrobial screening of new pyridine derivatives endowed with selenium moieties. A one-pot multicomponent system with a solvent-free, microwave irradiation environme...

In this study, we used oxazinethione as a perfect precursor to synthesize new pyrimidine and pyrazole derivatives with potent biological activities. Biological activities were determined for all compounds against A. flavus, E. coli, S. aureus, and F. moniliform. Compounds 3, 4a-b, and 5 exhibited higher activities toward A. flavus, E. coli, S. aure...

Selenium containing heterocyclic compounds gained great interest as bioactive molecules as of late. This report explores the design, synthesis, characterization, and antimicrobial screening of new pyridine derivatives endowed with selenium moieties. A one-pot multicomponent system with a solvent-free, microwave irradiation environment was employed...

Selenium containing heterocyclic compounds gained great interest as bioactive molecules as of late. This report explores the design, synthesis, characterization, and antimicrobial screening of new pyridine derivatives endowed with selenium moieties. A one-pot multicomponent system with a solvent-free, microwave irradiation environment was employed...

Selenium containing heterocyclic compounds gained great interest as bioactivemolecules as of late. This report explores the design, synthesis, characterization, andantimicrobial screening of new pyridine derivatives endowed with selenium moieties. Aone-pot multicomponent system with a solvent-free, microwave irradiation environmentwas employed to a...

Selenium containing heterocyclic compounds gained great interest as bioactive molecules as of late. This report explores the design, synthesis, characterization, and antimicrobial screening of new pyridine derivatives endowed with selenium moieties. A one-pot multicomponent system with a solvent-free, microwave irradiation environment was employed...

The objective of the present study has focused on the phytochemical analysis of Cinnamon cassia bark for determination of bioactive components, which have been associated with antioxidative stress induced by difenoconazole treatment in hepatic tissue of male albino rats. Ninety rats were assigned randomly to 9 groups, each group comprised of 10 ani...

Background The synthesis of a novel series of oxadiazine-4-thiaone biological molecules was executed through the incorporation of the ortho-, meta-, and para-benzoyl isocyanates to the tetrabromophethalimide nucleus. Objectives A one-pot multicomponent methodology in a solvent-free microwave irradiation environment was employed to afford this seri...

A new series of solid state fluorescent disperse dyes based on hybrid structure of pyrrolinone ester (PES)/coumarin moiety was prepared and fully characterized using spectroscopic analysis such as 1HNMR, MS and IR spectra. The coumarin derivative (7- amino-4- methyl coumarin) was initially prepared from amino phenol via multi steps condensation rea...

3-Hydrazinylidene-2,3-dihydro1H,2-benzothiazole 1 was synthesized as reported before. Compound 1 was allowed to react with different electrophilic reagents (aldehyde-sugars, aldehydes, and anhydride). Structures of all synthesized compounds were elucidated from (IR, Mass spectrum) and elemental analysis. Some of the resulting compounds were screene...

Abstract Acetylation of isatin with acetic anhydride lead to the formation of N-acetyl isatin 1 which then reacted with semicarbazide in acetic acid to give semicarbazone derivative 2. Which then reacted with different monosaccharide such as glucose, galactose and mannose to give the corresponding azomethine sugar derivatives 3a-c. Reaction of sem...

Liver X Receptor (LXR) agonists have been reported as a potential treatment for atherosclerosis, Alzheimer’s disease and hepatitis C virus (HCV) infection. We have designed and synthesized a series of potent compounds based on a 1,2,4-triazole scaffold as novel LXR modulators. In cell-based cotransfection assays these compounds generally functioned...

Nuclear hormone receptors represent a large family of ligand-activated transcription factors that include steroid receptors, thyroid/retinoid receptors, and orphan receptors. Among nuclear hormone receptors, the liver X receptors have emerged as very important drug targets. These receptors regulate some of the most important metabolic functions, an...

Re-investigation of the phytochemical constituents of Salvia africana-lutea L. methanolc extract, led to the purification and identification of six abietane diterpene (7 -methoxyrosmanol (1), rosmadial (2), rosmanol (3), carnosol (4), epiisorosmanol (5), epirosmanol (6)) and rosmarinic acid methyl ester (7). The compounds 1 and 3-5 showed significa...

The objective of this study is to perform a safety assessment of chromafenozide residue level on tomato at the Egyptian national level. An open field decline study of chromafenozide on tomato was performed. The theoretical maximum daily intake (TMDI) of chromafenozide was calculated for assessing the chronic dietary exposure indicating that the ADI...

YDROCRACKING technique was applied here for producing petroleum- like fractions from waste frying oil. The experiments were performed in a fixed bed flow reactor system, under high pressure using zeolite catalyst. The operating conditions were optimized and found to be 400°C, 2.5 MPa hydrogen pressure and 5 h- 1 LHSV. The obtained biofuel was fract...

A series of monomeric and dimeric cyanine dyes belonging to the thiazole orange family have been prepared via an improved synthetic procedure, by the reaction of the monomethine dye containing an iodoalkyl group with tertiary diamine linkers under microwave irradiation. The effects of microwave power and irradiation time on yield were examined. The...

Introduction: A green protocol will be used to synthesize a novel series of 3-cyano-5- arylazo-pyridones (9a-c) and (10d-i). Methodology: Structures of the new products will be confirmed on the basis of spectroscopic data (FT-IR, 1D, NMR) as well as alternative synthetic routes, anticancer cell-line will be investigated and also molecular docking s...

6-AMINOURACIL-2-THIONE (1) and its 5-bromo derivative 2 underwent alkylation yielding their respective S-alkyl products 4a-j. The reaction of compound 1 and aldehydes in the presence of chloroacetic acid afforded the respective thiazolopyrimidinyl acetamides 7a-d. The C-glycosides 8a, b and 9c-e were successfully prepared through condensing compoun...

This study presents a method validation for extraction and quantitative analysis of azoxystrobin residues in green beans and peas using HPLC-UV and the results confirmed by GC–MS. The employed method involved initial extraction with acetonitrile after the addition of salts (magnesium sulfate and sodium chloride), followed by a cleanup step by activ...

The fast depletion of petroleum crude oil reserves and the serious consideration of environmental issues make the implementation of sustainable energy sources a crucial issue worldwide. Biofuel derived from vegetable oils is receiving a great attention as one of the most suitable and logical alternatives of fossil fuels. Therefore, the production o...

In this work, three commercial diazinon emulsifiable concentrate (EC) formulations 60% were collected from the Egyptian market (manufactured from three different companies ) to investigate the degradation of diazinon after storage at 54 ±2 oC for 70 days , at room temperature for 12 months, and exposure to sunlight for 6 months, also identification...

A series of monomethine cyanine dyes belonging to the thiazole orange family have been prepared via an improved synthetic procedure, by the condensation of benzothiazolium salts with quaternary salt of quinolines having reactive methyl group in the presence of triethyl-amine under solvent-free microwave irradiation. The effects of microwave power a...

Several azo acid dyes with built-in UV-absorber residues (resorcinol, 2, 4-dihydroxy benzophenone, 1-hydroxy benzotriazol sulfonic acid) were synthesised. The structure of the synthesized dyes was fully elucidated by using FTIR, 1 H-NMR. In this paper we report the synthesis and application of the anti-UV dyes on wool fabrics aiming to these new dy...

OPTIMIZING THE BIOFUEL PRODUCTION BY HYDROTREATING JOJOBA OIL. Source: International Journal of Academic Research . May2014, Vol. 6 Issue 3, p194-201. 8p. Author(s): El khatib, S. A.; Hanafi, S. A.; Arief, M. M. H.; Al-Amrousi, E. F. Abstract: Hydroprocessing of vegetable oils is a prominent technology that using the existing infrastructure of petr...

4-(Isatin-3-ylideneamino)benzoic acid, was synthesized and converted into 4-(isatin-3-ylideneamino)benzoyl chloride. Hydrazinolysis of the acid chloride afforded4-(isatin-3-ylideneamino)benzohydrazide. The latter compound was used as a key precursor for the synthesis of pyrazole, triazole, phthalazine, thiadiazole, and oxadiazole derivatives via...

Excessive use of pesticides in grape cultivation could lead to impact on environment and health. Dissipation rate, half-live (t0.5) and the preharvest interval (PHI) of acaridae chlorfenapyr (challenger 36% SC) and a fungicide difenoconazole (Score 25% EC) which two widely used pesticides in growing grape, were evaluated in grape fruits and leaves....

The main objective of this study was to understand the residue and persistence behavior of Penconazole fungicide in grape fruit samples. The residues were analyzed by GC. The average initial deposit of in grape fruit was observed to be 1.04 mg kg-1 at single application rate. The recoveries of Penconazole on grape fruit were observed from 91.04% to...

The main objective of this study was to understand the residue and persistence behavior of lufenuron insecticide in grape fruit samples. The residues were analyzed by HPLC and it dissipated in grape fruit following first order kinetics. The average initial deposit of in grape fruit was observed to be 1.85mg kg-1 at single application rate. The reco...

Reactions of isatinNacetylchloride 2 with equivalent amount of hydrazine hydrate gave 2-(2, 3-dioxo-2, 3-dihydro-1H-indol-1-yl) acetohydrazide 3 which was then cyclized to give [1, 2, 4] triazino [4, 3-a] indole-3, 10 (2H, 4H)-dione 5 but when 2 reacted with excess of hydrazine hydrate it give 2[(2, 3-bishydrazono)-2, 3-dihydro-1H-indol-1-yl] aceto...

Reactions of isatin–N–acetylchloride 2 with equivalent amount of hydrazine hydrate gave 2-(2, 3-dioxo-2, 3-dihydro-1H-indol-1-yl) acetohydrazide 3 which was then cyclized to give [1, 2, 4] triazino [4, 3-a] indole-3, 10 (2H, 4H)-dione 5 but when 2 reacted with excess of hydrazine hydrate it give 2[(2, 3-bishydrazono)-2, 3-dihydro-1H-indol-1-yl] ace...

NINE novel azo dyes containing UV absorber (anti-UV dyes) were synthesized by diazotization of primary aromatic amines (p.NO2, p.Cl, p.Br aniline) and then coupling with J- acid coupler. The resultant intermediates were also diazotized and coupled with anti-UV functional finishing groups (resorcinol, 2, 4- dihydroxy benzophenone, 1- hydroxy benzotr...

Several azo acid dyes with built-in UV-absorber residues (resorcinol, 2, 4- dihydroxy benzophenone, 1- hydroxy benzotriazol sulfonic acid) were synthesised. The structure of the synthesized dyes was fully elucidated by using FTIR, 1 H-NMR. In this paper we report the synthesis and application of the anti-UV dyes on wool fabrics aiming to these new...

One field experiment was conducted with lufenuron (Match(®) 5 % EC) on tomato crop during August 2011. The main objective was to understand the residue and dissipation behavior of insecticide lufenuron in tomato fruit samples. The dissipation behavior of lufenuron insecticide followed first-order rate kinetics at standard recommended dose applicati...

The reaction of nucleophilic phosphacumulene ylides with visnaginone and khellinone afforded the corresponding phosphanylidene and furochromene derivatives. Moreover, pyranochromenes were obtained from the reaction of chromene carbaldehydes with phosphacumulenes. On the other hand, the phosphanylidene-cyclobutylidenes and their dimers were produced...

Two models of temporarily anionic sulphatoethylsulphone reactive disperse dyes were applied to wool, polyester and wool/polyester blend fabrics at different dyeing pH. Maximum exhaustion values and colour yield were observed at pH 7. The results showed that reactive disperse dyes containing bis‐sulphatoethylsulphone reactive groups were more conven...

Series of nonionic surfactants were constructed in the following sequence preparation of fatty alkyl alcohols ethoxylated (R= C8, C12,C16 and C18) (Ia-d) with different moles of ethylene oxide (n = 2, 4,6 and 8 moles) (Ia-d) i-iv, then the chlorides of these ethoxylated were prepared to give the corresponding fatty alcohols chlorides (IIa-d i-iv),...

alpha-Benzylamino-beta-(5,5-dioxodibenzothiophen-2-carbonyl)propionic acid (1) has been synthesized by treating the corresponding beta-aroylacrylic acid with benzylamine in dry benzene. On treatment with hydrazine hydrate the keto acid I furnishes the corresponding pyridazinone derivative 2. The behaviour of 2 towards carbon electrophiles, namely,...

The residual behavior of abamectin (Vertemic 1.8% EC), diniconazole (Sumi-eight 5%EC) and methomyl (Lannate 90%SP) in strawberry fruits under the environmental condition of Egypt was studied. The tested pesticides were sprayed at recommended dose of 60, 25 cm 3 in 100 liter water and 300g per feddan for abamectin, diniconazole and methomyl, respect...

The concentrations of 13 polycyclic aromatic hydrocarbons (PAHs) in water, sediment and fish samples collected from 6 locations in El-Menofiya governorate, Egypt were analyzed. Concentrations of total 13 PAHs in water samples ranged from 226.9 ng l at El Sarsawia canal to 1492.2 ng l at El -1 -1 Menofi drain, which were predominated by three-and fo...

The concentration of organochlorine pesticides (OCPs) and polychlorinated biphenyl (PCBs) in aquatic environment at El Menofiya Governorate were assessed to explore the effect of sampling area and different matrix. Water, sediment and fish samples were collected from El Menofiya, canal water supplies (El Sarsawia, El Bagoria and Bahr Shebin), in ad...

The synthesis of N-acryloyloxy- and N-methacryloyloxyphthalimides were accomplished in fair yield by reaction of acryloyl and methacryloyl chlorides with N-hydroxyphthalimide in the presence of triethylamine. The resulting monomers were polymerized. The ability of the prepared activated polymers to enter exchange reactions with hydroxylated compoun...

α-Benzylamino-β-(5,5-dioxodibenzothiophen-2-carbonyl)propionic acid (1) has been synthesized by treating the corresponding β-aroylacrylic acid with benzylamine in dry benzene. On treatment with hydrazine hydrate the keto acid 1 furnishes the corresponding pyridazinone derivative 2. The behaviour of 2 towards carbon electrophiles, namely, ethyl chlo...

4-(5,5-Dioxodibenzothiophen-2-yl)-4-oxo-2-butenoic acid ( 1 ) was condensed with compounds containing active methylene groups under Michael reaction conditions to form the Michael adducts 2a-c , 3a-c , and 4a-b . The behavior of Michael adduct towards the action of hydrazine hydrate was investigated. The compounds were tested for biological propert...

3-(1,1-Dioxadibenzothien-4-oyl)acrylic acid (1) was condensed with compounds containing active methylene groups under Michael reaction conditions to furnish the Michael adducts (lactones,2a–c, lactams,3a–c, ketones4a, b). The behavior of these adducts toward the action of hydrazine hydrate were investigated. The compounds were tested for their biol...

3-(1,1-Dioxadibenzothien-4-oyl)acrylic acid (1) was condensed with compounds containing active methylene groups under Michael reaction conditions to furnish the Michael adducts (lactones 2a-c, lactams 3a-c, ketones 4a,b). The behavior of these adducts toward the action of hydrazine hydrate were investigated. The compounds were tested for their biol...