Lyudmil Antonov

Bulgarian Drug Agency

Two cDNA clones, specifically expressed in Nicotiana sylvestris anthers during uninucleate microspore development, were isolated using a subtractive hybridization approach. Sequence analysis showed that one of them, NSCHSLK, displayed a high level of similarity to several anther-specific chalcone synthase-like (CHSLK) proteins and an ORF from chrom...

The concept of biosimilarity emerged in the early 2000s, when the patents of innovative biotechnological medicinal products expired and/or when they started losing data protection, opening the door to the application for the marketing authorization of putative biological generics. With the notable exception of a European product-specific guideline...

The continuous development of biotechnology over the years has significantly changed the medical practice for the treatment of certain diseases, as well as the lives of patients and their relatives. Through advances in molecular and cellular biology applied to drug production, millions of people with cancer, rheumatoid arthritis, bone, kidney and o...

One of the most efficient methods of producing plants that are resistant to certain diseases is to select in vitro the corresponding tissues, and then grow only the most promising ones. The difficulty with this method is that too many unknown parameters influence the situations, most of which are beyond our control: e. g., what exactly will be the...

The most detailed derivation of the Landau-Lifshitz pseudotensor. Its original version is found on the author's blog https://lantonov.blogspot.com/2012/02/landau-lifshitz-pseudotensor.html This Mathematica notebook is a detailed workout of the main part of [1] (the Book). The derivation of Landau-Lifshitz pseudotensor is rightlyconsidered as one of...

We tested the possibility of using “adverse events count” (AEC) as a drug-risk indicator and side-effect severity indicator. Data from 3938 adverse event (AE) reports for COVID-19 vaccines (Comirnaty, Moderna, Vaxzevria, and Janssen) and 6869 AE reports for other medicines were collected from the Bulgarian Drug Agency database (01.01.2018–31.03.202...

Data from 6869 AE reports for other medicines collected from the Bulgarian Drug Agency database (01.01.2018--31.03.2022).

Data from 3938 adverse event (AE) reports for COVID-19 vaccines (Comirnaty, Moderna, Vaxzevria, and Janssen) collected from the Bulgarian Drug Agency database (01.01.2018--31.03.2022).

Objective: To track and analyze the dynamics of adverse drug reaction reports of authorized COVID-19 vaccines in the database of the national competent authority in Bulgaria-Bulgarian Drug Agency (BDA) and to identify the sources of ADR in our country during the considered time period. Material and methods: For the analysis of ADR reports, the spec...

I have often been asked "Do Bulgarians write in the Russian alphabet?". This question is met with a categorical answer: "No, the Russians write in a Bulgarian alphabet, the most recent one." Because, when the latest, most advanced Bulgarian alphabet was used to write numerous books in Bulgaria in the 9th century, Russia didn't exist yet. It would b...

The original paper is found on the author's blog https://lyudmilantonov.blogspot.com/2011/08/accent-in-bulgarian-dialects.html

Настоящата публикация изяснява основните термини, касаещи биологичните и биотехнологични лекарствени продукти, както и популярната напоследък тема за употребата на биоподобни лекарства. Представени са основните характеристики на биологичните лекарства, приложението на биотехнологичните методи за производство на лекарства, както и концепцията за био...

Bacteria have а great potential for agricultural applications due to their fast multiplication to great numbers,easy dispersal and survival in soil. The researches in Virginia State University laboratory are aimed at: (i) genetic alteration of phytopathogenic and saprophytic bacteria and use of the resulting strains for plant protection, and (ii) e...

Copy the link below and paste it into the browser address bar: http://www.ncbi.nlm.nih.gov/nuccore/2326771?report=graph&noslider=1&tracks=[key:sequence_track,name:Sequence,display_name:Sequence,id:STD1,category:Sequence,annots:Sequence,ShowLabel:false][key:gene_model_track,name:Genes,display_name:Genes,id:STD3,category:Genes,annots:Unnamed,Option...

Copy the link below and paste it into the browser address bar: http://www.ncbi.nlm.nih.gov/nuccore/2326773?report=graph&noslider=1&tracks=[key:sequence_track,name:Sequence,display_name:Sequence,id:STD1,category:Sequence,annots:Sequence,ShowLabel:false][key:gene_model_track,name:Genes,display_name:Genes,id:STD3,category:Genes,annots:Unnamed,Options...

Mărculeţ, Vasile. "Campania împăratului Nikephoros I în Bulgaria (811). Considerații asupra unor aspecte controversate." Tyragetia. Serie nouă 31.1 (2022): 293-309. Parcurgerea opiniilor exprimate conduce la constatarea că majoritatea autorilor se pronunță pentru localizarea confruntării în Pasul Vărbitsa sau în zone învecinate acestuia, pe râul Ti...

Original work is in the author's blog https://lyudmilantonov.blogspot.com/2011/03/bulgarian-language-and-other-slavic.html

This paper presents the comparison, in depth, of the capabilities of two Case-Based Reasoning (CBR) oriented software frameworks myCBR and jCOLIBRI for the development of predictive diagnosis and maintenance systems. Those frameworks were selected after detailed preliminary investigations [1] of the most popular noncommercial software systems for C...

A new processed pseudogene (rpL32-5C) that belongs to the mouse rpL32 multigene family has been sequenced and compared to previously characterised mammalian rpL32 family members. rpL32-5C has intact direct terminal repeats of 13 nt, a poly A tail of 10 nt and it does not contain conserved promoter elements at its 5' end. The comparison with the L32...

Six RFLP-s (restriction fragment length polymorphisms) detected in processed pseudogene sequences of the multigene family encoding human ribosomal protein S-14 were studied. The polymorphisms showed that on average one of about 250 bases in these sequences is variant, which is the case with the mutation rate in other non-coding sequences - introns,...

The soft rot bacterium Erwinia carotovora subspecies carotovora strain EC14 contains multiple pectate lyase genes. Genes pel9.5 and pel 10.5, coding for pectate lyases (pi 9.5 and 10.5), were cloned on a plasmid, transformed into Escherichia coli, and expressed catalyti-cally active products. The isoenzymes were subcloned separately and sequenced....

Resistance to bacterial soft rot in potato tubers maintained aerobically was induced by wounding tubers 4 to 24 h prior to inoculation with Erwinia carotovora subsp.carotovora. This wound-induced resistance phenomenon was blocked by hypoxic stress. An hypoxia-induced resistance mechanism also was detected: tubers acclimated to a hypoxic environment...

This paper presents the comparison, in depth, of the capabilities of two Case-Based Reasoning (CBR) oriented software frameworks myCBR and jCOLIBRI for the development of predictive diagnosis and maintenance systems. Those frameworks were selected after detailed preliminary investigations [1] of the most popular noncommercial software systems for C...