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Publications (228)
Hyphaene thebaica honey, commonly known as doum honey (DH), is widely utilized in the Mediterranean region due to its putative health benefits. However, the precise mechanisms underpinning these benefits remain obscure. This study sought to assess the anti-infective, anti-inflammatory, and anticancer properties of DH, and analyze its polyphenolic c...
Natural resources constitute an exhaustible source of bioactive compounds well-known for their antidiabetic properties. This study investigated the antioxidant and antidiabetic activities of Vitex agnus citratus extract against alloxan-induced metabolic disorders in an animal model. The antioxidant ability of the extract was evaluated using three c...
Background: Ethnobotanical research in the Fez-Meknes region (North-central Morocco), encompassing UNESCO cultural sites like Fez and Meknes, lacks breadth, focusing on the use of medicinal plants to treat specific diseases. This research unveils the plentiful ethnomedicinal knowledge in the region employed to address a wide array of health concern...
Background
Salvia blancoana subsp. mesatlantica (Maire) Figuerola (SBm) is a plant endemic to Morocco and is one of the less studied species of Salvia. Herbal therapy is becoming more and more popular, especially in underdeveloped nations where access to medicinal herbs is affordable. However, some plants demonstrated toxic effects in animals and h...
Background
Juniperus turbinata Guss. is a medicinal mountain plant used by the Indigenous population in the traditional pharmacopeia.
Purpose
This study aimed at investigating the phytochemical analysis, antimicrobial, antioxydant and hymolytic activities of Juniperus turbinata Guss. leaves extracts.
Materials and Methods
The essential oils of Ju...
The toxicity of a plant extract is important in the design of medicinal plant-based drugs. A test of the hemolytic effect of a substance on red blood cells (RBC) is an essential starting point. The objective of this study is the phytochemical characterization of the aqueous extract (CCA) and the ethanolic extract (CCE) from the aerial parts of Cotu...
Apricot (Prunus armeniaca L.) kernels have been widely employed in phytomedicine for treating different ailments. This study aims to unveil the phytochemical composition by HPLC-ESI-MS, in vitro antioxidant activity, and examine certain pharmacological effects of the hydro-ethanolic extract from bitter apricot kernels (BAK). Obtained results indica...
Herbs, for a long time now, have been employed to treat different ailments, such as diabetes, kidney and liver disorders, cancer, and obesity. Considering these facts, we endeavored to realize this review by enlightening the biological properties of different herbs found in the Ait Ayash region. The information is derived from different sources of...
The purpose of the current study is to assess the chemical profile, antioxidant, antimicrobial, and insecticide efficacy of essential oil derived from the leaf of Moroccan Mentha aquatica L. (MA-EO) using in vitro and in silico analysis. Using GC-MS/MS analysis, 18 components of MA-EO were identified, including linalool (42.42%), α-elemol (10.45%),...
The main purpose of our research is the evaluation of the efficacity of solvent polarity on phenolic composition, as well as the antibacterial, and antioxidant activities of extract of Moroccan Mentha aquatica L., leaves. To attempt these objectives, the HPLC-DAD was used to identify the biomolecules. The total amount of phenolic and flavonoid cont...
Introduction: Coriandrum sativum L. essential oil (CS-EO) is being evaluated in vitro for its antioxidant and antimicrobial properties, and its volatile compounds are to be identified as part of this exploratory study.
Methods: The processes underlying the in vitro biological properties were explained using in silico simulations, including drug-lik...
Anemia is a widespread global health concern necessitating effective, accessible, and natural interventions. The potential of medicinal plants to address anemia has garnered significant interest. Among these plants, parsley (Petroselinum crispum (Petroselinum crispum) L.) stands out as an edible and herbal-based option for combating anemia. Aim of...
This work intended to study differences in oil yield and co-extraction of antioxidant and antibacterial compounds of Nigella sativa L. seed oil as a function of two main extraction processes: mechanical pressing and solvent extraction, including hexane and chloroform. Next, we studied such oils’ chemical composition and antioxidant and antibacteria...
Laurus nobilis L. is one of the most interesting medicinal plants for treating different diseases. The present study was undertaken to determine the volatile profile and biological properties of Laurus nobilis L. collected from different Moroccan geographical zones. The plants investigated contained considerable amounts of antioxidants. The phytoch...
The current study used a design of experiments to evaluate the potential synergistic effects of three Moroccan bee products (honey (H), propolis (P), and bee pollen (BP)) on the free radical inhibition and antibacterial activity against clinical strains of Staphylococcus aureus and Escherichia coli. The phytochemical contents of these three bee pro...
The phenolic compounds of four Palestinian honey samples (PH1-PH4) and their antibacterial effects as well as their cytotoxic, cytostatic, and antimigration effects in human breast cancer cell line (MDA) were evaluated here. HPLC analysis of PH2 (Cornflower), PH3 (Milk thistle), and PH4 (Ziziphus) revealed 15 phenolic compounds, namely, caffeic aci...
Medicinal plants harbor numerous natural bioactive compounds with therapeutic potential, utilized in the synthesis of various drug formulations. While the diverse benefits of herbal formulations have been extensively researched, a toxicity assessment is crucial to establish a wide margin of safety for the therapeutic application of this polyherbal...
Honey is a valuable functional bee product used since ancient times for its nutritional and therapeutic properties. Microbial characteristics of honey are among the main criteria analyzed to ensure the quality and safety of this bee product. In addition, the rheological properties of honey are important physical parameters that offer essential data...
Background: Ethnobotanical studies conducted in the Fez-Meknes region, located in North-central Morocco, and home to UNESCO cultural sites such as Fez and Meknes, have been limited in scope. The existing studies primarily concentrate on the use of medicinal plants for treating particular ailments. The present study unveils the plentiful ethnomedici...
Background: COVID-19 is one of the most widely spread viruses worldwide and different conventional and traditional strategies have been tried to prevent and treat the infection. The current study was designed to document traditional knowledge on medicinal plants used to prevent and treat COVID-19 among herbalists of Azilal region, Morocco. Methods:...
Objective: The threat of immune escape and the discovery of antibiotic-resistant pathogens, as well as the failure of certain conventional drugs that are already in use for the symptomatic treatment of diseases, have prompted a re-evaluation of ancient therapeutic remedies such as phytotherapy, and aromatherapy. In this context, the present study a...
Vitex agnus cactus and Cymbopogon nardus are widely used in traditional and conventional medicine as natural anti-inflammatory agents. Within this framework, the current study was undertaken to examine in vivo the anti-inflammatory and analgesic effects of aqueous extracts of the leaves and seeds of V. agnus cactus and C. nardus. In this relation,...
Although giant fennel is recognized as a “superfood” rich in phytochemicals with antioxidant activity, research into the antibacterial properties of its fruits has been relatively limited, compared to studies involving the root and aerial parts of the plant. In this study, seven solvents—acetone, methanol, ethanol, ethyl acetate, chloroform, water,...
Introduction: The curative effects of Solanum elaeagnifolium have aroused the interest of botanical medicine researchers. However, no research has been carried out into its potential toxicity. The aim of this study was firstly to screen the secondary metabolites contained in the leaves and fruits of S. elaeagnifolium and their mineralogical composi...
This exploratory study aims to identify the volatile compounds in PC-Eo (Petroselinum crispum L. essential oil) and evaluate its antioxidant and antimicrobial properties in vitro. Molecular docking, drug-likeness prediction, and pharmacokinetics (absorption, distribution, metabolism, excretion, and toxicity—ADMET) were among the in silico simulatio...
Background: In the realms of herbal pharmacology, the Apiaceae family has long held the torch, with parsley, coriander, and celery at the forefront. They have been extensively utilized in traditional therapies, including their use as aphrodisiacs. The primary objective of this study was to evaluate the aphrodisiac potential of three Apiaceae plants...
Objectives
Fruit vinegar is one of the most famous fruit byproducts worldwide with several unique properties. There are two types of fruit vinegar, artisanal and industrial, for consumers to choose from. This review aims to assess for the first time the phytochemistry of fruit vinegar and its anti-inflammatory effects.
Method
The present work was...
The present study aimed to explore the phytochemical profile, and evaluate the antioxidant, antimicrobial, and insecticidal properties, of Moroccan Mentha longifolia L. essential oil (ML-EO) using in vitro and in silico assays. Noteworthily, as chromatography (GC-MS/MS) revealed that ML-EO is majorly composed of piperitenone oxide (53.43%), caryoph...
Bee pollen is a valuable cocktail of natural compounds with high dietary and health importance for both bees and humans. Recently, the consumption of this bee product has risen significantly because of the advanced consumer knowledge of its nutritional and health benefits. Hence, this chapter highlights the composition, physicochemical and function...
The current work attempts to explore the influence of three extraction solvents on phytochemical composition, content of polyphenols, antioxidant potential, and antibacterial capacity of hydroethanolic, acetonic, and aqueous extracts from Moroccan Mentha longifolia leaves. To achieve this goal, the chemical composition was identified using an HPLC-...
In the present investigation, the phenolic compounds of Solanum elaeagnifolium were
identified, and the plant’s anti-lipase and anti-glycation effects on hemoglobin were discovered
through in vitro experiments, as well as its short-term antihyperglycemic and anti-inflammatory
effects. The chemical compound composition was detected using HPLC-DAD, t...
To help discover a reasonable and eco-friendly insecticide, we undertook a study on the insecticidal potential of carvacrol and essential oils extracted by hydrodistillation using a Clevenger apparatus from the plant species Nigella sativa seeds essential oils of Nigella sativa (EONS) on Callosobruchus maculatus adults. Several tests including cont...
The present work aimed at characterizing the phytochemical composition of Haplophyllum tuberculatum essential oil (HTEO), assessing its antifungal activity against various fungal strains, evaluating its insecticidal and repulsive properties against Callosobruchus maculatus, and determine its antioxidant capacity. To this end, Gas chromatography-mas...
Background and Objectives: Paracetamol overdose is a significant global issue due to its widespread use, which can lead to a lack of awareness regarding its potential side effects. Parac-etamol can harm the liver, possibly resulting in liver failure. Conversely, this study employed extracts from Petroselinum crispum (PC), known for its rich content...
Background and Objectives: Paracetamol overdose is a significant global issue due to its
widespread use, which can lead to a lack of awareness regarding its potential side effects. Paracetamol can harm the liver, possibly resulting in liver failure. Conversely, this study employed
extracts from Petroselinum crispum (PC), known for its rich content...
Background
Glucose-6-phosphate-dehydrogenase (G6PD) deficiency is the most frequent enzymopathy worldwide; it is a genetic disorder that affects red blood cells and causes hemolysis. Here, we conducted a study on G6PD-deficient subjects in Mauritania to evaluate the molecular characteristics associated with a deficiency in this enzyme and the frequ...
The current work attempts to explore the influence of three extraction solvents on phytochemical composition, content of polyphenols, antioxidant potential, and antibacterial capacity of Moroccan Mentha longifolia L. leaves hydroethanolic, acetonic, and water extracts. To achieve this goal, the chemical composition was identified using an HPLC-DAD...
The Middle Atlas is a Moroccan territory that serves as an abode to plants with incredible biodiversity, of which aromatic and medicinal plants that have been of folkloric use are a significant component. However, their effective utilization in modern medicine requires the characterization of their phytochemicals to facilitate their entry into drug...
Objectives:
The authors aimed to evaluate whether blood cadmium (B-Cd), lead (B-Pb) and mercury (B-Hg) in children differ regionally in 9 countries, and to identify factors correlating with exposure.
Material and methods:
The authors performed a cross-sectional study of children aged 7-14 years, living in 2007-2008 in urban, rural, or potentiall...
Diuretic medications are widely used and can come with negative effects. Because they are effective and have fewer adverse effects than other treatments for renal illness, medicinal plants have become increasingly important. This study aimed to investigate the antioxidant ability and the impact of Laurus nobilis extract (flower) on diuresis in rats...
Ferula communis L. is thought to possess a wide range of therapeutic qualities. This plant's safety is critical regarding its potential uses as a medicine. Using the techniques outlined in the OECD recommendations, the present study aimed to assess the acute and subacute toxicity profiles of Ferula communis aqueous extract (FC-Ext) in mice. In the...
The present study was aimed at conducting phytochemical analysis and evaluating the in vitro antifungal and antioxidant activities of the essential oil obtained from the fruits of J. oxycedrus L. Hydro-distillation was used to extract the essential oil from the fruits of Juniper oxycedrus. The essential oil was analyzed using gas chromatography wit...
Juniperus phoenicea (L.) is a medicinal plant that has been used in phytotherapy as a treatment of certain pathological infections. In this context, the present work aimed to valorize the essential oil of J. phoenicea seeds (EOGP) by studying its chemical composition, and antioxidant and antimicrobial activities. The EOGP was extracted by use of hy...
Calycotome villosa subsp. intermedia is used in traditional medicine for the prevention and self-treatment of a variety of illnesses, including diabetes mellitus, obesity, and hypertension. The present study aims to investigate the in vivo, ex vivo, and in vitro hypoglycemic and hypotensive effects of the lyophilized aqueous extract of Calycotome v...
In this study, the chemical composition and the antioxidant and antidiabetic properties of S. elaeagnifolium flower (SEFl), fruit (SEFr), and leaf (SEFe) extracts were investigated in vitro and in silico. HPLC-DAD analysis was used to determine the chemical components. Colorimetric techniques were used to identify polyphenols and flavonoids. The an...
Peripheral nerve injury (PNI) is a health problem that affects many people worldwide. This study is the first to evaluate the potential effect of bee venom (BV) and its major components in a model of PNI in the mouse. For that, the BV used in this study was analyzed using UHPLC. All animals underwent a distal section-suture of facial nerve branches...
Propolis and honey possess antioxidant, hypoglycemic, and antiproteinuric effects. The study aimed to explore the effect of propolis, honey, and their combination against D-glucose-induced hyperglycemia, acute kidney injury, liver injury, dyslipidemia, and changes in the oxidants and antioxidants in renal, hepatic, and pancreatic tissues. The chemi...
Herbal medicine was used since the old time in the treatment of different types of diseases in Sefrou province, Morocco. However, few studies have been carried out to identify local medicinal flora and to scientifically document the knowledge of the traditional use of these medicinal plants by the population. This study aims to investigate the medi...
Traditional medicine is a solid background for many experimental in vivo and in vitro studies. Apple vinegar is an acidic solution with multifaceted purposes experimentally proved. This work was to document different traditional uses of apple vinegar in the two largest apple-growing Moroccan territories, accounting Deraa-Tafilalet and Fez-Meknes. T...
Abstract: Bee pollen is a hive product made up of flower pollen grains, nectar, and bee salivary secretions that beekeepers can collect without damaging the hive. Bee pollen, also called beecollected pollen, contains a wide range of nutritious elements, including proteins, carbs, lipids, and dietary fibers, as well as bioactive micronutrients inclu...
The current work was designed to evaluate the antioxidant activity and antidiabetic effect of Ficus carica L. extracts. For that, the leaves and buds of Ficus carica L. were analyzed to determine their polyphenolic and flavonoid contents and antioxidant activity. Diabetes was induced by a single dose of alloxan monohydrate (65 mg/kg body weight), t...
Cymbopogon nardus is one of the medicinal plants widely used in folk medicine to cure certain diseases. The current work aims to assess the diuretic potential of Cymbopogon nardus using animal models. Urine electrolytes (Sodium and potassium), serum electrolytes (Sodium, potassium, and chloride), blood urea, creatinine, creatinine clearance, osmola...
The Moroccan population heavily rely on herbal remedies to control diabetes mellitus. The population of the central-western region of Morocco uses a number of anti-diabetic medicinal plants, but there is a lack of good ethnobotanical information on these plants. Thus, the present survey was conducted in the Safi and Essaouira provinces to inventory...
A statistical Simplex Lattice Mixture design was applied to develop a new formulation based on a combination of three plants grown in northern Morocco: Apium graveolens L., Coriandrum sativum L., and Petroselinum crispum M. We examined the extraction yield, total polyphenol content (TPC), 2′2-diphenyl-l-picrylhydrazyl (DPPH) radical scavenging acti...