Lynn Valérie Fehlbaum

Jacobs Center for Productive Youth Development · Developmental Neuroscience

Background Substantial evidence acknowledges the complex gene-environment interplay impacting brain development and learning. Intergenerational neuroimaging allows the assessment of familial transfer effects on brain structure, function and behavior by investigating neural similarity in caregiver-child dyads. Methods Neural similarity in the human...

The ability to understand mental states of others is referred to as mentalizing and enabled by our Theory of Mind. This social skill relies on brain regions comprising the mentalizing network, as robustly observed in adults, but also in a growing number of developmental studies. We summarized and compared neuroimaging evidence in children/adolescen...

Background: Substantial evidence acknowledges the complex gene-environment interplay impacting brain development and learning. Intergenerational neuroimaging allows the assessment of familial transfer effects on brain structure, function and behavior by investigating neural similarity in caregiver-child dyads. Methods: Neural similarity in the huma...

Theory of Mind (ToM) or mentalizing is a basic social skill which is characterized by our ability of perspective-taking and the understanding of cognitive and emotional states of others. ToM development is essential to successfully navigate in various social contexts. The neural basis of mentalizing is well-studied in adults, however, less evidence...

Background. Covid-19 and associated restrictions have been linked to negative mental health outcomes across the globe. Cognitive emotion regulation strategies constitute means to mitigating negative affect and are associated with prefrontal and limbic brain regions. Methods. Variations in cognitive emotion regulation strategy use, anxiety and depre...

Abstract Background Conduct disorder (CD) is characterized by severe aggressive and antisocial behavior. Initial evidence suggests neural deficits and aberrant eye gaze pattern during emotion processing in CD; both concepts, however, have not yet been studied simultaneously. The present study assessed the functional brain correlates of emotional fa...

Reduced responsiveness to emotions is hypothesized to contribute to the development of conduct disorder (CD) in children and adolescents. Accordingly, blunted psychophysiological responses to emotions have been observed in boys with CD, but this has never been tested in girls. Therefore, this study compared psychophysiological responses to sadness...

The ability to understand mental states of others is known as Theory of Mind or mentalizing. Neuroimaging studies in adults have reported activation increases in medial prefrontal, inferior frontal, temporoparietal cortices and precuneus during mentalizing. In children/youths, activation in some areas of this social brain network are suggested to d...

Theory of Mind (ToM) or mentalizing is a basic social skill which is characterized by our ability of perspective-taking and the understanding of cognitive and emotional states of others. ToM development is essential to successfully navigate in various social contexts. The neural basis of mentalizing is well-studied in adult populations, however, li...

Background: Conduct disorder (CD), which is characterized by severe aggressive and antisocial behavior, is linked to emotion processing and regulation deficits. However, the neural correlates of emotion regulation are yet to be investigated in adolescents with CD. Furthermore, it remains unclear whether CD is associated with deficits in emotional...

p>Objective: studies using diffusion tensor imaging (DTI) to investigate white matter (WM) microstructure in youths with conduct disorder (CD) have reported disparate findings. We investigated WM alterations in a large sample of youths with CD, and examined the influence of sex and callous-unemotional (CU) traits. Method: DTI data were acquired f...

Background Previous studies of conduct disorder (CD) have reported structural and functional alterations in the limbic system. However, the white matter tracts that connect limbic regions have not been comprehensively studied. The uncinate fasciculus (UF), a tract connecting limbic to prefrontal regions, has been implicated in CD. However, CD-relat...

Conduct disorder (CD) is a psychiatric disorder of childhood and adolescence which has been linked to deficient emotion processing and regulation. The behavioral and neuronal correlates targeting the interaction of emotion processing and response inhibition are still under investigation. Whole-brain event-related fMRI was applied during an affectiv...

Purpose: Autonomic nervous system (ANS) functioning has been widely studied in relation to antisocial behavior, such as Conduct Disorder (CD). However, research in females is scarce and findings are inconsistent. This study investigated baseline ANS activity in CD children and adolescents and tested for sex differences. Furthermore, subgroups of CD...

Purpose: Autonomic nervous system (ANS) functioning has long been studied in relation to antisocial behaviour, but relevant measures (heart rate, heart rate variability, pre-ejection period, respiration rate) have rarely been considered together. This study investigated the relationship between these measures and antisocial behaviour. Methods: Usin...

Distribution of the delinquency and aggression subscale from the CBCL (left: raw scores; right T-scores).

Distribution of callous-unemotional traits, for girls and boys respectively.

Characteristics and usefulness of the newly built composite score reflecting CU traits.

Site-specific acquisition parameters and numbers of subjects tested.

Callous-unemotional traits are characterized by a lack of empathy, a disregard for others' feelings and shallow or deficient affect, such as a lack of remorse or guilt. Neuroanatomical correlates of callous-unemotional traits have been demonstrated in clinical samples (i.e., adolescents with disruptive behavior disorders). However, it is unknown wh...

The human brain has the capacity to integrate various sources of information and continuously adapts our behavior according to situational needs in order to allow a healthy functioning. Emotion–cognition interactions are a key example for such integrative processing. However, the neuronal correlates investigating the effects of emotion on cognition...

Objective: Diffusion tensor imaging (DTI) studies in adolescent conduct disorder (CD) have demonstrated white matter alterations of tracts connecting functionally distinct fronto-limbic regions, but only in boys or mixed-gender samples. So far, no study has investigated white matter integrity in girls with CD on a whole-brain level. Therefore, our...

In the course of reading development children become familiar with letter strings and learn to distinguish between lexical and non-lexical items. In previous studies, the N1 component of the ERP was shown to reflect print tuning but also to be sensitive to lexical effects. It remains unclear, however, whether these two aspects of orthographic proce...

Do you like science fiction? Have you heard of, or are you even a fan of, the famous “Star Wars” series? To summarize, there are rebels, emperors, princesses, robots, and many more fabulous creatures. There is also a power source called “The Force.” It is used by the Jedi (the good ones) but also by the dark side (the evil ones). Only the dark side...

Early language delay has often been associated with atypical language/literacy development. Neuroimaging studies further indicate functional disruptions during language and print processing in school-age children with a retrospective report of early language delay. Behavioral data of 114 5-year-olds with a retrospective report of early language del...

Recent neuroimaging work has suggested that aggressive behaviour (AB) is associated with structural and functional brain abnormalities in processes subserving emotion processing and regulation. However, most neuroimaging studies on AB to date only contain relatively small sample sizes. To objectively investigate the consistency of previous structur...