Lynn Dennany

Lynn Dennany
University of Strathclyde · Department of Pure and Applied Chemistry

About

86
Publications
10,644
Reads
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1,720
Citations
Additional affiliations
June 2010 - present
University of Strathclyde
Position
  • Lecturer
August 2004 - December 2009
Dublin City University
Position
  • Posdoctoral Researcher

Publications

Publications (86)
Article
With a rise in the development and subsequent employment of precision medicine, their lies an immediate necessity for the development of technology to enable the implementation of such treatment plans into the healthcare environment. Electrochemistry stands to offer one of the most viable techniques for such technologies given its success within cu...
Article
Pseudomonas Aeruginosa (P. Aeruginosa) is a prevalent and opportunistic bacterium which frequently causes severe nosocomial infection. Current clinical detection methods are limited in terms of necessary time and equipment. Increasingly, P. Aeruginosa’s electrochemically active virulence factor pyocyanin has facilitated its rapid detection, primari...
Article
Veterinary science or veterinary medicine is a diverse and significant field. Concerned not only with the diagnosis and treatment of domestic animals and livestock, but it also places focus upon zoonotic diseases, the development and effectiveness of potential vaccines and the possibility of transmission of veterinary medication or viruses into ani...
Article
Novel psychoactive substances (NPS) are today considered one of the major ticking public health time bombs in regard to drug abuse. The inability to identify these substances with current screening methods, sees their distribution remain uninterrupted and contributes to the high death rates amongst users. To tackle this problem, it is vital that ne...
Article
Synthetic cannabinoids (SC) are one of the most prevalent classes of novel psychoactive substances (NPS) which have emerged onto the drug market in recent years. The incompatibility of traditional colorimetric screening methodologies with these new compounds has left a significant gap in the forensic tool kit available to tackle the importation and...
Article
Electrochemical based sensors have become increasing popular within biomedical applications. Their low cost, high portability and flexibility in regard to manufacturing materials makes them ideal candidates for point of care sensors. The virulence factor pyocyanin is a useful diagnostic biomarker for the detection of Pseudomonas aeruginosa bacteriu...
Article
With advances in medical understanding and pharmaceutical drug development a shift away from the traditional “one size fits all” approaches common place in today's treatment plans have been witnessed. Instead greater emphasis has been placed upon the development of personalised precision medicine, tailored to the individual and their disease charac...
Article
Synthetic Cannabinoids (SC) are amongst the most prevalent class of novel psychoactive substances (NPS) which have emerged. The increase in hospitalisation and fatalities as a result of the prevalence of these SC and their abuse, highlights the necessity for the rapid and reliable screening for the substance within toxicological samples. Being able...
Article
Full-text available
A point-of-care blood test for the detection of an emerging biomarker, CCL17/TARC, could prove transformative for the clinical management of classic Hodgkin lymphoma (cHL). Primary care diagnosis is challenging due to nonspecific clinical presentation and lack of a diagnostic test, leading to significant diagnostic delays. Treatment monitoring enco...
Article
Full-text available
We present a new approach to explore the potential-dependent multi-colour co-reactant electrochemiluminescence (ECL) from multiple luminophores. The potentials at both the working and counter electrodes, the current between these electrodes, and the emission over cyclic voltammetric scans were simultaneously measured for the ECL reaction of Ir(ppy)...
Article
The abuse of methamphetamine (MA) is to date detected and subsequently verified through the monitoring of MA and its metabolites within biological specimens. Current approaches require complex sample purification strategies alongside significant analysis time. Given the high prevalence of MA within the global drug market, there remains a need for r...
Article
Due to severe consequences of potential overdoses from paracetamol (PCM) on the human body, the measurement of PCM in the pharmaceutical and the biological samples is essential. Therefore, presenting a simple and rapid technique with high detection limit and wide linear range plays a crucial role in detecting the PCM’s overdose leading to drug pois...
Article
The incorporation of counterions into a variety of substances to control a number of their physiochemical properties is vital within a range of fields. Electrochemiluminescence (ECL) based sensors have grown in popularity in recent years with their employment observed across analytical and bioanalytical applications. ECL is typically concerned with...
Chapter
This article focuses upon new challenges faced by analytical chemists for sensing applications addressed through the development of novel materials. This contribution will focus on the development of novel materials for sensor applications. Although only a small scope of materials research present is covered within this article the principles discu...
Chapter
This article focuses upon new challenges faced by today's society which electrochemical sensors maybe able to address. Focusing primarily upon two of the major challenges faced at the time of writing; the opioid crisis caused by fentanyl and the deadly Covid-19 pandemic, the employment of electrochemical sensors is assessed to determine the contrib...
Article
The rapid and continued appearance of novel psychoactive substances onto the global drug market continues to highlight the need for the introduction of novel screening methodologies. Here we discuss the potential of electrochemiluminescence (ECL)-based sensors as viable alternatives to address this current gap within forensic practices. By utilizin...
Article
Full-text available
While debates have raged over the relationship between trance and rock art, unambiguous evidence of the consumption of hallucinogens has not been reported from any rock art site in the world. A painting possibly representing the flowers of Datura on the ceiling of a Californian rock art site called Pinwheel Cave was discovered alongside fibrous qui...
Article
The detection of extracellular vesicles, or exosomes are important mediators in intercellular communication and often play a role in cancer progression. CD63 is a key exosomal protein due to its distinctive cellular functions and association with many cancers. This describes a label-free electrochemiluminescence (ECL) nanoimmunosensor for the detec...
Article
Rapid, periodic monitoring and detection of ethanol (EtOH) after consumption via a non-invasive measurement has been an area of increased research in recent years. Current point-of-care or on-site detection strategies rely on single use sensors which are inadequate for monitoring during a longer period. A low cost, portable and novel approach is de...
Article
Full-text available
Abstract Herein, the efficient serotonin (5-HT) sensing studies have been conducted using the (ZnO NRs)1−x(CNs)x nanocomposites (NCs) having appropriate structural and electrochemical properties. Initially, the different compositions of ZnO nanorods (NRs), with varying content of carbon nanostructures (CNs=MWCNTs and RGO), are prepared using simple...
Article
With the rapid growth and appearance of novel psychoactive substances (NPS) onto the global drug market, the need for alternative screening methodologies for implementation within clinical enviroments is substantial. The immunoassay methods currently in use are inadequate for this new drug trend with the potential for misdiagnosis and subsequent ad...
Article
Electrochemiluminescence (ECL) has increased in popularity as a result of its inherent advantages, including but not limited to portability, simplicity of use and low reagent consumption. However, its significant advantages are often over shadowed as a result of its limited specificity. ECL emissions are intrinsically broad and lack the definition...
Article
Full-text available
This study consisted of three parts to evaluate the performance of Lumicyano™ on a variety of fabrics. One part assessed the impact of dye percentage (8%, 9% and 10%) on visualisation of fingermark detail and luminescent brightness in split grab marks. A 9% dye produced the highest quality detail of grab impressions with least interference from bac...
Article
Full-text available
A major challenge within forensic science is the development of accurate and robust methodologies which can be utilised on site for detection at crime scenes and can be used for analysing multiple sample types. The recent expansion of electro-chemical sensors to tackle this hurdle requires sensors that can undergo analysis without any pre-treatment...
Chapter
This chapter covers the range of electrochemical approaches for a variety of chemical sensing utilised within forensic analysis. Electrochemical-based sensors are powerful analytical tools which can be exploited by the forensic community and they have found widespread applications within the fields of illicit drug detection, toxicological analysis,...
Article
A new approach to examine electrochemiluminescence (ECL), in which the potentials at both the working and counter electrodes are measured and the emitted light is detected by photomultiplier tube, camera...
Article
The expansion of electrochemical sensors to biomedical applications at point of care requires these sensors to undergo analysis without any pre-treatment of extraction. This poses a major challenge for all electrochemical sensors including electrochemiluminescent (ECL) based sensors. ECL offers many advantages for biomedical applications however; o...
Conference Paper
As the result of CV and EIS of the modified electrode, we could accomplishedly fulfill the immobilization of the aptamer with Ru(bpy)2(cbpy)NHS and the ECL results of the bare gold electrode, our ECL system is working well. As the future work, initially, the ECL properties of the modified electrode will be explored and then the characterization of...
Article
The electrochemiluminescent (ECL) performance of three ruthenium-based metallopolymer platforms with different homogeneous charge transfer diffusion coefficients (DCT) is reported. Significantly, simultaneous detection of light and current in tandem with steady-state photoluminescence studies demonstrate that increasing the rate of Ru3 + production...
Research
A new ECL aptamer-based biosensor for highly sensitive detection of a small molecule drug, methamphetamine, will be developed employing an aptamer as a molecular reorganization element and ruthenium complex as an ECL label. This work aims that ECL-AB biosensor designed by the combination of a highly binding aptamer to methamphetamine with a highly...
Article
Potential forensic use of tissue-specific DNA methylation markers has recently been discussed for the identification of the biological source of a stain. In this study 13 promising markers were evaluated to identify suitable candidate markers for the development of a robust and reliable multiplex assay. The results of this study suggest that a comb...
Article
Electrochemical based sensors are a powerful analytical tool which can be exploited by the forensic community particularly for the analysis of illicit substances from street and biological samples. This report presents a brief overview on selected recent publications related to the application of electrochemical sensors to forensic drug analysis an...
Article
Full-text available
Sexual assault samples are some of the most common samples encountered in forensic analysis. These samples can require a significant time investment due to differential extraction processes. We report on the first record of successful direct amplification of semen for STR analysis. Neat seminal fluid, dilutions ranging from 1:5 to 1:160 and GEDNAP...
Article
Full-text available
We demonstrate that for quantum dot (QD) based electrochemiluminescence (ECL), the commonly used co-reactant does not perform as effectively as potassium persulfate. By exploiting this small change in co-reactant, ECL intensity can be enhanced dramatically in a cathodic-based ECL system. However, TPA remains the preferential co-reactant-based syste...
Article
Direct detection of amphetamine type stimulants (ATS) including methylamphetamine (MA) in street samples and biological matrices without the need for pretreatment or extraction is a great challenge for forensic drug analysis. Electrochemical techniques, such as electrochemiluminescence (ECL), are promising tools for this area of analysis. This cont...
Article
Full-text available
Mammalian ageing features biological attrition evident at cellular, genetic and epigenetic levels. Mutation of mitochondrial DNA, and nuclear DNA methylation changes are well established correlates of ageing. The methylation of mitochondrial DNA (mtDNA) is a new and incompletely described phenomenon with unknown biological control and significance....
Article
Direct detection of medically relevant biomarkers in whole blood without the need for pretreatment or extraction is a great challenge for biomedical analysis and diagnosis. Electrochemical techniques, such as electrochemiluminescence (ECL), are promising tools for this area of analysis. ECL offers high sensitivities together with the ability to obt...
Article
Despite the high profile of amphetamine, there have been relatively few structural studies of its salt forms. The lack of any halide salt forms is surprising as the typical synthetic route for amphetamine initially produces the chloride salt. (S)-Amphetamine hydrochloride [systematic name: (2S)-1-phenylpropan-2-aminium chloride], C9H14N(+)·Cl(-), h...
Article
Full-text available
DNA analysis has been widely accepted as providing valuable evidence concerning the identity of the source of biological traces. Our work has showed that DNA samples can survive on cartridges even after firing. The study also raised the possibility of determining other information such as the age of the donor. Such information may be invaluable in...
Article
Full-text available
This work exploits the high-affinity of recombinant antibodies and low background electrochemiluminescence (ECL) for cardiac-biomarker detection. The developed assay is capable of fg mL-1 detection limits as well as the detection of C-Reactive Protein (CRP) over a clinically relevant range. The assay demonstrated robust reproducibility, selectivity...
Article
Full-text available
Current histological investigation of vaginal swabs after alleged sexual assault includes the scoring of spermatozoa (0, + to ++++) and the recording of visible tails. It is a method that is universally employed. Despite this method being used for 40 years, there has never been a study investigating its suitability for forensic science. Here, we in...
Article
This contribution examines the application of near infra-red (NIR) quantum dot (QD) containing films for cholesterol detection. Water-soluble, 2-(dimethylamino) ethanthiol (DAET) protected 800 nm CdSeTe/ZnS core-shell QDs were prepared and incorporated into a chitosan film. The NIR electrogenerated chemiluminescence (ECL) of the QD/chitosan films u...
Article
Full-text available
The incorporation of 2,1,3-benzothiadiazole units within the arms of trigonal quarterfluorene – truxene star-shaped system leads to a monodisperse material with stable multi-electron p- and n-doped states and highly efficient yellow electrogenerated chemiluminescence (ECL). The quantum yield for ECL is 7 times greater than that of the common blue E...
Article
Full-text available
Electrochemiluminescence (ECL) uses redox reactions to generate light at an electrode surface, and is gaining increasing attention for biosensor development due to its high sensitivity and excellent signal-to-noise ratio. ECL studies of monodisperse oligofluorene–truxenes (T4 series) have been reported previously, showing the production of stable r...
Article
Proton transfer to the sulfa drug sulfadiazine [systematic name: 4-amino-N-(pyrimidin-2-yl)benzenesulfonamide] gave eight salt forms. These are the monohydrate and methanol hemisolvate forms of the chloride (2-{[(4-azaniumylphenyl)sulfonyl]azanidyl}pyrimidin-1-ium chloride monohydrate, C10H11N4O2S+·Cl−·H2O, (I), and 2-{[(4-azaniumylphenyl)sulfonyl]...
Article
Full-text available
This critical review covers the use of carbon nanomaterials (single-wall carbon nanotubes, multi-wall carbon nanotubes, graphene, and carbon quantum dots), semiconductor quantum dots, and composite materials based on the combination of the aforementioned materials, for analytical applications using electrogenerated chemiluminescence. The recent dis...
Article
This work explores the differences between two GCMS instruments for the determination of amphetamine and methylamphetamine extracted from water samples (ultra pure water and river water) without the necessity for derivatization. The instruments contained different generations of gas chromatograph and mass selective detector components and revealed...
Article
Full-text available
The electrochemiluminescent (ECL) properties of a luminescent metal centre, [Ru(bpy)(3)](2+), can be significantly modulated through its electronic interaction with neighbouring centres and the polymer backbone used to confine it on an electrode surface. From the perspective of ECL based sensing devices, an increase in the ECL efficiency of a metal...
Article
Electrodes, modified with [Ru(bpy)2PVP10]n(ClO4)2 metallopolymer:gold nanoparticle composites, are used for the high sensitivity detection of nicotinamide adenine dinucleotide, NADH, using electrochemiluminescence, ECL; bpy is 2,2′-bipyridyl and PVP is poly (4-vinylpyridine). Incorporation of 12.5 nm gold nanoparticles protected with 4-dimethylamin...
Article
Full-text available
Water soluble positively charged 2-(dimethylamino)ethanethiol (DAET)-protected core-shell CdSe/ZnS quantum dots (QDs) were synthesized and incorporated within negatively charged Nafionpolymer films. The water soluble QDs were characterized using UV-visible and fluorescence spectroscopies. Nafion/QDs composite films were deposited on glassy carbon e...
Article
Full-text available
Emission spectroscopy and electrochemistry has been used to probe the electronic communication between adjacent metal centres and the conjugated backbone within a family of imidazole based metallopolymers, [Ru(bpy)(2)(PPyBBIM)(n)](2+), in the ground and excited states, bpy is 2,2'-bipyridyl, PPyBBIM is poly[2-(2-pyridyl)-bibenzimidazole] and n = 3,...
Article
Full-text available
An electroactive nitrospiropyran-substituted polyterthiophene, poly(2-(3,3''-dimethylindoline-6'-nitrobenzospiropyranyl)ethyl 4,4''-didecyloxy-2,2':5',2''-terthiophene-3'-acetate), has been synthesized for the first time. The spiropyran, incorporated into the polymer backbone by covalent attachment to the alkoxyterthiophene monomer units, leads to...
Article
Full-text available
The properties of two forms of polyaniline (PAni) synthesised under acidic and basic conditions have been investigated both individually and as combined complexes. The PAni polymerised within alkaline media was redox inactive and non-conducting while the PAni emeraldine salt (ES) was electroactive and conducting. Raman, electron spin resonance, UV-...
Article
Full-text available
Water soluble positively charged 2-(dimethylamino) ethanethiol (DAET)-protected core-shell CdSe/ZnS quantum dots (QDs) were synthesized and incorporated within negatively charged Nafion polymer films. The water soluble QDs were characterized using UV-visible and fluorescence spectroscopies. Nafion/QDs composite films were deposited on glassy carbon...
Article
In this work, two significant advances in photolithographic patterning of polyaniline (PANI) films are reported. Firstly, flash welding was enhanced through the use of polymeric substrates, enabling complete penetration of the welding of PANI films with thicknesses ranging from 5 to over 14 mu m, significantly thicker than reported previously. Mask...
Article
Full-text available
The use of nanostructured carbon materials as electrodes for energy storage and conversion is an expanding area of research in recent years. Herein, platinum nanoparticles have been deposited onto both multi-walled and single-walled carbon nanotubes (CNTs) via a microwave assisted polyol reduction method. This interaction has been probed with elect...
Article
Synthesis methods used to produce poly(2-methoxyaniline-5-sulfonic acid) (PMAS), a water-soluble, self-doped conducting polymer, have been shown to form two distinctly different polymer fractions with molecular weights of approximately 2 kDa and 8-10 kDa. The low molecular weight (LMWT) PMAS fraction is redox inactive and nonconducting, while the h...
Article
Full-text available
Chemical surface treatment of porphyrin-sensitised titania films using bis-(4-methoxyphenyl) phosphinic acid after dye adsorption, results in large improvements in DSSC efficiencies which originate primarily from higher short circuit currents. The result was attributed to a positive shift in the TiO(2) quasi-Fermi level with simultaneous retardatio...
Article
The electrochemical and photophysical properties of a luminescent metal center, [Os(bpy)(3)](2+), are significantly modified by encapsulation within a conducting polymer composite film. Cyclic voltammetry reveals that the encapsulation in an inherently conducting polymer, polyaniline (Pani) or polypyrrole (PPy), can dramatically influence the charg...
Article
Steady state luminescence and measurements of the luminescent lifetime as well as cyclic voltammetry have been used to elucidate the mechanism and dynamics of interaction between a luminescent ruthenium metal center and two different fractions of poly(2-methoxyaniline-5-sulfonic acid) (PMAS). The two fractions, high molecular weight (HMWT) PMAS and...
Article
The oxidative electropolymerization of [Ru(aphen)3](PF6)2 from an ionic liquid, 1-butyl-2,3-dimethylimidazolium bis[(trifluoromethyl)sulfonyl]imide (BDMITFSI), is reported; aphen is 5-amino-1,10-phenanthroline. The deposition rate in the ionic liquid is more than an order of magnitude faster than in conventional solvents such as anhydrous acetonitr...