Lyle Matthew Gordon

Lyle Matthew Gordon
Nano precision medical · R&D

BASc, PhD

About

41
Publications
14,041
Reads
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1,036
Citations
Additional affiliations
September 2008 - May 2014
Northwestern University
Position
  • PhD Student
September 2007 - May 2008
University of Toronto
Position
  • Senior Thesis
Education
September 2008 - January 2014
Northwestern University
Field of study
  • Materials Science and Engineering
September 2004 - May 2008
University of Toronto
Field of study
  • Materials Science and Engineering

Publications

Publications (41)
Preprint
Full-text available
The chiton Acanthopleura granulata uses aragonitic lenses embedded in its shell to focus light onto photoreceptors. Because aragonite is biaxially birefringent, the microstructure of the lens greatly impacts the optical performance. In addition, the chiton lives in the intertidal, so lenses experience two environments with different refractive indi...
Article
Full-text available
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Article
Full-text available
Challenges and Solutions in the Characterization of Hierarchically Structured, Functionally Graded Tooth Biominerals - Karen DeRocher, Paul Smeets, Berit Goodge, Michael Zachman, Prasanna Balachandran, Linus Stegbauer, Michael Cohen, Lyle Gordon, James Rondinelli, Lena Kourkoutis, Derk Joester
Article
Full-text available
Dental enamel is a principal component of teeth1, and has evolved to bear large chewing forces, resist mechanical fatigue and withstand wear over decades2. Functional impairment and loss of dental enamel, caused by developmental defects or tooth decay (caries), affect health and quality of life, with associated costs to society3. Although the past...
Article
Full-text available
The feldspar minerals occur in a wide variety of lithologies throughout the Solar System, often containing a variety of chemical and structural features indicative of the crystallization conditions, cooling history, and deformational state of the crystal. Such phenomena are often poorly resolved in micrometre-scale analyses. Here, atom probe tomogr...
Conference Paper
The feldspar minerals occur in a wide variety of lithologies throughout the inner Solar System. These phases are often complex, containing a variety of chemical and structural features indicative of the crystallization conditions, cooling history, and deformational state of the crystal. However, these phenomena are often poorly resolved in micromet...
Article
The analysis of the atomic composition of the interface between tricalcium silicate (C3S), the main compound of Ordinary Portland Cement, and surrounding solution is still a challenging task. At the same time, that knowledge is of profound importance for describing the basic processes during hydration. By means of Scanning Electron Microscopy (SEM)...
Article
Full-text available
The development of three-dimensional (3-D), characterisation techniques with high spatial and mass resolution is crucial for understanding and developing advanced materials for many engineering applications as well as for understanding natural materials. In recent decades, atom probe tomography (APT), which combines a point projection microscope an...
Article
Three water adsorption-desorption mechanisms are common in inorganic materials: chemisorption, which can lead to the modification of the first coordination sphere; simple adsorption, which is reversible; and condensation, which is irreversible. Regardless of the sorption mechanism, all known materials exhibit an isotherm in which the quantity of wa...
Article
Full-text available
div class="title">Atom Probe of Apatites - from Single Crystals to Interphases in Tooth Enamel - Volume 21 Issue S3 - Lyle M. Gordon, Karen A. Derocher, Michael J. Cohen, Derk Joester
Article
Full-text available
div class="title">In Situ Environmental Transmission Electron Microscopy of Ice Nucleation - Volume 21 Issue S3 - Lyle M. Gordon, Libor Kovarik
Article
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div class="title">Atom Probe Tomography of Feldspars and Aluminosilicate Glasses - Volume 21 Issue S3 - Lyle M. Gordon
Article
Full-text available
div class="title">Chemical Imaging of Interfaces and in Interphases in Tooth Enamel - Volume 21 Issue S3 - Lyle M. Gordon, Michael J. Cohen, Derk Joester
Article
Full-text available
Dental enamel has evolved to resist the most grueling conditions of mechanical stress, fatigue, and wear. Adding insult to injury, it is exposed to the frequently corrosive environment of the oral cavity. While its hierarchical structure is unrivaled in its mechanical resilience, heterogeneity in the distribution of magnesium ions and the presence...
Article
Full-text available
Dental enamel, a hierarchical material composed primarily of hydroxylapatite nanowires, is susceptible to degradation by plaque biofilm-derived acids. The solubility of enamel strongly depends on the presence of Mg(2+), F(-), and CO3 (2-). However, determining the distribution of these minor ions is challenging. We show-using atom probe tomography,...
Article
Full-text available
Analysis of the detected Fe ion charge states from laser-assisted field evaporation of magnetite (Fe3O4) reveals unexpected trends as a function of laser pulse energy that break from conventional post-ionization theory for metals. For Fe ions evaporated from magnetite, the effects of post-ionization are partially offset by the increased prevalence...
Article
Metastable precursors are thought to play a major role in the ability of organisms to create mineralized tissues. Of particular interest are the hard and abrasion-resistant teeth formed by chitons, a class of rock-grazing mollusks. The formation of chiton teeth relies on the precipitation of metastable ferrihydrite (Fh) in an organic scaffold as a...
Article
Full-text available
of a paper presented at Microscopy and Microanalysis 2013 in Indianapolis, Indiana, USA, August 4 – August 8, 2013.
Article
Full-text available
of a paper presented at Microscopy and Microanalysis 2013 in Indianapolis, Indiana, USA, August 4 – August 8, 2013.
Article
Full-text available
of a paper presented at Microscopy and Microanalysis 2013 in Indianapolis, Indiana, USA, August 4 – August 8, 2013.
Article
Full-text available
of a paper presented at Microscopy and Microanalysis 2013 in Indianapolis, Indiana, USA, August 4 – August 8, 2013.
Article
The biosynthesis of magnetite in the chiton tooth begins with the formation of ferrihydrite, which is transformed into magnetite. This strategy, which employs crystallization of a precursor into the desired polymorph, is generalized across a range of organisms. However, the specific biological factors that control the transformation are not known....
Article
Nanocrystalline biological apatites constitute the mineral phase of vertebrate bone and teeth. Beyond their central importance to the mechanical function of our skeleton, their extraordinarily large surface acts as the most important ion exchanger for essential and toxic ions in our body. However, the nanoscale structural and chemical complexity of...
Article
Full-text available
of a paper presented at Microscopy and Microanalysis 2012 in Phoenix, Arizona, USA, July 29 – August 2, 2012.
Article
Full-text available
Extended abstract of a paper presented at Microscopy and Microanalysis 2012 in Phoenix, Arizona, USA, July 29 – August 2, 2012.
Article
Full-text available
Biological organisms possess an unparalleled ability to control the structure and properties of mineralized tissues. They are able, for example, to guide the formation of smoothly curving single crystals or tough, lightweight, self-repairing skeletal elements. In many biominerals, an organic matrix interacts with the mineral as it forms, controls i...
Article
Biomechanical, in vitro, and initial in vivo evaluation of a thiol-modified hyaluronan (TM-HA) and elastin-like polypeptide (ELP) composite hydrogel for nucleus pulposus (NP) tissue engineering. To investigate the utility of a TM-HA and ELP composite material as a potential tissue-engineering scaffold to reconstitute the NP in early degenerative di...
Article
Insufficiency fractures occur when physiological loads are applied to bone deficient in mechanical resistance. A better understanding of pelvic mechanics and the effect of bone density alterations could lead to improved diagnosis and treatment of insufficiency fractures. This study aimed to develop and validate a subject-specific three-dimensional...
Article
A low-density nanocrystalline material was created by electroforming nanocrystalline Ni around a rapid prototyped acrylic photopolymer micro-truss. This new hybrid material combines the structural efficiency of micro-truss architectures with the ultra-high strength that can be achieved by grain size reduction to the nanometer scale. A range of stru...
Thesis
Full-text available
A new type of mesoscale periodic cellular material was developed by electrodepositing a high strength nanocrystalline nickel sleeve over a rapid prototyped acrylic photopolymer template. Mechanical properties of the hybrid-PCM, strength and stiffness, were measured in compression. For the thickest sleeves there was approximately a twenty times incr...
Article
Quantitative assessment of metastatic disease in bone is often considered immeasurable and, as such, patients with skeletal metastases are often excluded from clinical trials. In order to effectively quantify the impact of metastatic tumor involvement in the spine, accurate segmentation of the vertebra is required. Manual segmentation can be accura...
Article
Radiological imaging is essential to the appropriate management of patients with bone metastasis; however, there have been no widely accepted guidelines as to the optimal method for quantifying the potential impact of skeletal lesions or to evaluate response to treatment. The current inability to rapidly quantify the response of bone metastases exc...

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