Lydia Krabbendam

• Head of Department at Vrije Universiteit Amsterdam

Purpose Financial problems are of influence on mental health, and vice versa. Indeed, finances are a key challenge for people with psychosis. To gain deeper insights into these challenges, a qualitative approach focusing on all perspectives within the therapeutic triad is needed. This study aims to investigate perspectives of people with psychosis,...

Human social interactions rely on the ability to reflect on one’s own and others’ internal states and traits—a psychological process known as mentalizing. Impaired or altered self- and other-related mentalizing is a hallmark of multiple psychiatric and neurodevelopmental conditions. Yet, replicable and easily testable brain markers of mentalizing h...

[PLEASE NOTE: This work is now published in Psychophysiology. Please refer to the open-access, peer-reviewed version of this work at: https://doi.org/10.1111/psyp.70004] Heart rate (HR) and heart rate variability (HRV) are two key measures with significant relevance in psychophysiological studies, and their measurement has become more convenient du...

Heart rate (HR) and heart rate variability (HRV) are two key measures with significant relevance in psychophysiological studies, and their measurement has become more convenient due to advances in wearable technology. However, photoplethysmography (PPG)-based wearables pose critical validity concerns. In this study, we validated four PPG wearables:...

While negative risk-taking behavior in adolescents is a classic topic, extant research has long spent little attention to the positive aspects of adolescents’ development. One topic that started to gain more research focus is prosocial risk-taking behavior – defined as behavior where an individual takes a risk to help someone else. However, validat...

Healthcare settings are increasingly adopting nature-based interventions (NBIs) to support users’ health and well-being, but these interventions are often underutilized. To get a grip on utilization problems, insight into factors that affect use and uptake of NBIs in routine care is needed. This scoping review aimed to provide an overview of factor...

Background. Psychotic disorders have a strong negative impact on people’s lives, including their financial situation. This study aimed to examine differences in unmet financial needs between people with psychotic disorders, parents, siblings, and controls. Secondly, we aimed to examine whether family clustering contributes to unmet financial needs....

With age, adolescents increasingly demonstrate the ability to forgo immediate, smaller rewards in favor of larger delayed rewards, indicating reduced delay discounting. Adolescence is also a time of social reorientation, where decisions not only involve weighing immediate against future outcomes, but also consequences for self versus those for othe...

Introduction Adolescence is a dynamic developmental phase in which contact with peers is crucial for socio-emotional development and wellbeing. Depression and social anxiety show patterns of high onset during this period, and more for girls than boys. Here we examine this development among Dutch adolescents, as well as how desire for more peer cont...

Trust is the glue of society. While the trust we place in close others is crucial for our wellbeing, trust in strangers is important to fulfill needs that families and friends cannot provide. Adolescence is an important phase for the development of trust in strangers, because the social world of adolescents expands tremendously. We provide an overv...

[Pleaes note: This work is now published in Psychophysiology. Please refer to the open-access, peer-reviewed version of this work at: https://doi.org/10.1111/psyp.70004]. Heart rate (HR) and heart rate variability (HRV) are two key measures with significant relevance in psychophysiological studies, and their measurement has become more convenient...

[PLEASE NOTE: This work is now published in Psychophysiology. Please refer to the open-access, peer-reviewed version of this work at: https://doi.org/10.1111/psyp.70004]Heart rate (HR) and heart rate variability (HRV) are two key measures with significant relevance in psychophysiological studies, and their measurement has become more convenient due...

Introduction Regional gray matter (GM) alterations have been reported in early-onset psychosis (EOP, onset before age 18), but previous studies have yielded conflicting results, likely due to small sample sizes and the different brain regions examined. In this study, we conducted a whole brain voxel-based morphometry (VBM) analysis in a large sampl...

Aims Depression and anxiety are the leading contributors to the global burden of disease among young people, accounting for over a third (34.8%) of years lived with disability. Yet there is limited evidence for interventions that prevent adolescent depression and anxiety in low- and middle-income countries (LMICs), where 90% of adolescents live. Th...

This Event-Related Potential (ERP) study aimed to test how habitual and short-term violent video game exposure (VVGE) may affect empathy for pain responses in adolescents. In a within-subjects design, boys (N = 56; aged 12–16 years) performed a pain judgment task before and immediately after playing a violent video game. In this task, participants...

Research has shown that adolescents – particularly girls – who mature relatively early often experience more internalizing problems. This effect is thought to be partially driven by psychosocial mechanisms, but previous research based relative pubertal maturation on complete samples or population standards, instead of considering the adolescents’ d...

Longitudinal changes in trusting behavior across adolescence and their neural correlates were examined. Neural regions of interest (ROIs) included the medial prefrontal cortex (mPFC), dorsal anterior cingulate cortex (dACC), left anterior insula (AI), bilateral ventral striatum (VS), and right dorsal striatum (DS). Participants (wave 1 age: M = 12....

Individuals with autism increasingly enroll in universities, but little is known about predictors for their success. This study developed predictive models for the academic success of autistic bachelor students (N = 101) in comparison to students with other health conditions (N = 2465) and students with no health conditions (N = 25,077). We applied...

Adolescents need to develop adequate perspective-taking skills to successfully navigate their increasingly complex social environments. This study investigated adolescents' development of the cognitive processes of egocentric and altercentric interference that influence perspective-taking abilities. Using the Dot Perspective Task, participants' (N...

Introduction The current paper undertakes interdisciplinary research on empathy in children by combining insights and methodological tools from the fields of psychology, education and anthropology. The researchers aim to map how children’s individual empathic abilities studied on a cognitive level do or do not coincide with their empathic expressio...

Neuroscience research has increased our understanding of brain development, but little is known about how parents of adolescents engage with this neuroscientific information. Dutch parents completed a digital survey on neuromyths, neuroscience literacy and views of the adolescent brain and behaviour. These parents believed 44.7% of neuromyths and s...

A painful experience affecting many children is social exclusion. The current study is a follow-up of Asscheman et al. (2020), investigating change in neural activity during social exclusion as a function of peer preference. Peer preference was defined as the degree to which children are preferred by their peers and measured using peer nominations...

Interpersonal connection is a fundamental human motivation, and the extent to which it is fulfilled is a strong predictor of symptoms of internalizing disorders such as social anxiety and depression, perhaps especially during the “social reorienting” period of adolescence. However, little is known about the contribution to this effect of the indivi...

The frequency, intensity and variability of emotional experiences increase in early adolescence, which may be partly due to adolescents’ heightened affective sensitivity to social stimuli. While this increased variability is likely intrinsic to adolescent development, greater mood variability is nevertheless associated with the risk of internalisin...

Interpersonal trust shows developmental changes during adolescence. The current study used a longitudinal design to examine the development of trust behavior, the presence of gender differences in these developmental trajectories, and the association between individual differences in these developmental trajectories and perspective-taking abilities...

Adolescence is an important developmental period for both trust behavior and personality maturation, and individual differences in trust decisions may be related to different personality traits. In the current study, a group of adolescents (n = 483, Mage = 13.5, SDage = 0.4) played two counterbalanced conditions of a multi-round trust game. In one...

Our social interactions take place within numerous social networks, in which our relationships with others define our position within these networks. In this study, we examined how the centrality of positions within social networks was associated with trust behavior and neural activity in 49 adolescents (Mage = 12.8 years, SDage = 0.4 years). Parti...

During adolescence, social cognition and the brain undergo major developments. Social interactions become more important, and adolescents must learn that not everyone can be trusted equally. Prior knowledge about the trustworthiness of an interaction partner may affect adolescents' expectations about the partner. However, the expectations based on...

Adolescence is a time of major psychological development in the cognitive, affective, and social domains. Development in these domains can also show interactions with each other. One way in which these interactions between these domains become apparent is in the form of risk-taking behavior in adolescence. Compared to children and adults, adolescen...

While research on the prevalence of co-occurring autism spectrum conditions (ASC) and trans gender modality (TGM) is available, less is known about the underlying mechanism of this association. Insight is needed to improve treatment of trans autistic people. This review provides an overview of theories on the ASC-TGM link and the available evidence...

Academic motivation represents a psychoeducational construct that is associated with the academic success of youth. For some immigrant youth, however, their academic motivation may be affected by the various challenges that they face during their settlement in a culturally diverse school that promotes different self-construal values and practices....

Individuals with autism increasingly enroll in universities, but researchers know little about how their study progresses over time towards degree completion. This exploratory population study uses structural equation modeling to examine patterns in study progression and degree completion of bachelor’s students with autism spectrum disorder ( n = 1...

During adolescence, major changes in brain mechanisms take place and differentiated representations of both the self and of others are developed. Although studies have investigated the neural mechanisms of self- and other-referential processing in adolescents, the development of these mechanisms remain largely unaddressed. Here, we report a three-y...

Developmental changes during adolescence may make youth susceptible to violent media effects. Two studies with male adolescents (N1 = 241; N2 = 161; aged 12–17) examined how habitual and short-term violent video gaming may affect emotion recognition and inhibitory control. We found that not habitual exposure to violent video games, but to antisocia...

Objectives: Social contact is known to be beneficial for humans’ mental health. Individuals with psychotic symptoms (PS) tend to show poorer social and interpersonal functioning. However, in this patient population, social contact may be crucial for their mental wellbeing and treatment success. Additionally, closeness of social contact (familiar ve...

Although good quality housing and a socially cohesive neighborhood are associated with a higher well-being in the general population, housing is a rarely studied topic in autism research. In the present study, we describe the housing situation of a large sample of adults with autism and mostly (above) average intellectual abilities (n = 1429; 17 to...

Trust is essential for establishing and maintaining cooperative behaviors between individuals and institutions in a wide variety of social, economic, and political contexts. This book explores trust through the lens of neurobiology, focusing on empirical, methodological, and theoretical aspects. Written by a distinguished group of researchers from...

Integrating fundamental science in society, with the goal to translate research findings to daily practice, comes with certain challenges. Successfully integrating research projects into society requires (1) good collaboration between scientists and societal stakeholders, (2) collaboration partners with common expectations and goals, and (3) invest...

Nature is considered to have restorative qualities that can potentially improve psychotherapy success. However, little is known about how clients experience nature during psychotherapy. The research aim of this phenomenological qualitative study was to study how clients experience nature during individual outpatient psychotherapy that took place wh...

In order to think and talk about time, people often use the ego- or time-moving representation. In the ego-moving representation, the self travels through a temporal landscape, leaving past events behind and approaching future events; in the time-moving representation, the self is stationary and temporal events pass by. Several studies contest to t...

Objectives: Psychosis is characterized by paranoid delusions, social withdrawal, and distrust towards others. Trust is essential for successful social interactions. It remains unknown which aspects of social functioning are associated with reduced trust in psychosis. Therefore, we investigated the association between social behaviour, trust, and i...

Viewing nature has restorative qualities that might help people cope with their personal struggles. Three lab experiments (N = 506) studied whether environment (nature vs. built) influences cognitive coping with psychological distress. Psychological distress was induced with an autobiographical recall task about serious regret, whereafter participa...

Previous research showed mixed evidence on how violent video game exposure (VVGE) may affect empathy for pain in the brain. This study applied an event-related potentials (ERPs) approach to improve understanding of how habitual and short-term violent gameplay may affect empathy for pain brain responses. Fifty-eight male participants with different...

Past research has linked honor to a higher tendency for retaliation. A common method is to compare groups that are either low or high in honor. While effective, this does not account for within-group variation, nor isolate honor as a distinct construct from alternative differences between groups that might affect the outcome. In the current study w...

An ability to accurately recognize negative emotions in others can initiate pro-social behavior and prevent anti-social actions. Thus, it remains of an interest of scholars studying effects of violent video games. While exposure to such games was linked to slower emotion recognition, the evidence regarding accuracy of emotion recognition among play...

An ability to accurately recognize negative emotions in others can initiate pro-social behavior and prevent anti-social actions. Thus, it remains of an interest of scholars studying effects of violent video games. While exposure to such games was linked to slower emotion recognition, the evidence regarding accuracy of emotion recognition among play...

Early adolescence may be an important period for developing sensitivity to uncooperative behavior. With this functional magnetic resonance imaging study, we examined longitudinal changes in trusting behavior and their neural correlates in regions of interest (ROIs) selected a priori: the medial prefrontal cortex (mPFC), dorsal anterior cingulate co...

Autism spectrum conditions (ASC) and schizophrenia spectrum conditions (SSC) are both characterized by changes in social-cognitive functioning. Less is known about the overlap and the differences in social-cognitive functioning when comparing individuals with subclinical levels of ASC and SSC, while studies in non-clinical samples have the benefit...

There exist large individual differences in students’ willingness to invest cognitive effort within the academic domain. In a preregistered study, we investigated whether individual differences in adolescents’ willingness to invest cognitive effort, as assessed by an experimental effort discounting task, were related to need for cognition, academic...

Introduction Social feedback can influence cognitive control during adolescence, particularly if provided by peers. The main aim of this study was to investigate if feedback given by liked or disliked peers differentially influenced adolescents' cognitive control. The second aim was to investigate if these effects could be linked to the participant...

Mentalizing is an important aspect of social cognition and people vary in their ability to mentalize. Despite initial evidence that mentalizing continues to develop throughout adolescence, it is unclear which neural mechanisms underlie individual variability in mentalizing ability in adolescents. Interactions within and between the default-mode net...

Epidemiological studies suggest that the observed association between urbanicity and psychosis may be explained in part by social deprivation, reduced social capital affecting cohesion and trust, and minority group and ethnic density effects, which in turn may represent aspects of “social defeat.” In addition, urbanicity is also associated with pol...

Important adolescents’ career-related decisions might be influenced by their beliefs about malleability of intelligence and learning (mindset). We combined quantitative and qualitative data to provide in-depth insights in the beliefs that 13- and 14-year olds hold about learning and intelligence, the factors influencing these beliefs, and the conse...

Early‐onset psychosis disorders are serious mental disorders arising before the age of 18 years. Here, we investigate the largest neuroimaging dataset, to date, of patients with early‐onset psychosis and healthy controls for differences in intracranial and subcortical brain volumes. The sample included 263 patients with early‐onset psychosis (mean...

Peer preference among classmates is a highly influential factor in children’s social development and not being preferred by peers has long-term consequences for children’s developmental outcomes. However, little is known about how a history of low peer preference during primary school is associated with neural responses to a new social exclusion ex...

Previous research suggests that individuals from individualistic and collectivistic cultures, due to different construal of the self and social groups, might have different emotional experiences and attenuate their emotional experiences differently across situations. The current research investigates the influence of these cultural orientations spe...

Background: Autistic individuals' enrollment in universities is increasing, but we know little about their study progress over time. Many of them have poor degree completion in comparison to students with other disabilities. However, longitudinal studies on study progression over time of autistic students (AS) in comparison to their peers are absen...

Everything you do requires you to exert effort. For instance, basic things like walking or cycling require physical effort and have to do with using your body. Another type of effort is cognitive effort, which has to do with thinking and using your brain. For instance, think about trying to master a Rubik’s cube. Would you want to put in your effor...

During adolescence, self-concept develops profoundly, accompanied by major changes in hormone levels. Self-evaluations become more complex, and peers and their opinions increasingly salient. Neuroimaging studies have investigated self- and other-related processing in adolescents, however, the influence of similarity of peers on these processes is s...

Background Psychosis is associated with profound problems in interpersonal functioning. One of the key elements of social relationships is trust. Previous research has shown that patients with psychotic disorders display reduced trust in others. Reduced trust may lead to paranoid ideation and (as a consequence) to social withdrawal. Patients with p...

Being able to adapt one’s trust behavior is essential for social relationships. In the current fMRI study, we first examined adolescents’ ability to adapt trust behavior and the neural mechanisms of trust. Second, we examined developmental differences by comparing young and late adolescents. Third, we examined how positions in a friendship network,...

Assessing the trustworthiness of others to learn who you can and cannot trust is important for social relationships. During early adolescence, the social environment becomes increasingly complex. The number and nature of one’s friendships may help to shape, and may be facilitated by, adequate trust behavior. In the current fMRI study, we investigat...

This study examined the sex-specific developmental trajectories of sharing behavior in the Dictator Game with an anonymous other, best friend, and disliked peer and associations with peer likeability and peer dislikeability in 1,108 children (50.5% boys) followed annually across grades 2–6 (ages 8–12) of elementary school. Results showed that shari...

Building knowledge schemas that organize information and guide future learning is of great importance in everyday life. Such knowledge building is suggested to occur through reinstatement of prior knowledge during new learning, yielding integration of new with old memories supported by the medial prefrontal cortex (mPFC) and medial temporal lobe (M...

Twenty-first century urbanization poses increasing challenges for mental health. Epidemiological studies have shown that mental health problems often accumulate in urban areas, compared to rural areas, and suggested possible underlying causes associated with the social and physical urban environments. Emerging work indicates complex urban effects t...

The number of students with Autism Spectrum Disorder (ASD) entering Universities is growing. Recent studies show an increased understanding of students with ASD in higher education. Yet, current research generally relies on small samples, lacks information about student characteristics prior to enrollment, and does not compare students with ASD to...

Patients with a disorder in the schizophrenia spectrum (SZ) demonstrate impairments in reward learning. A reduced sensitivity to social reward may impede social beyond non-social reward learning mechanisms. The aim of the current study was to investigate social and non-social reward learning in SZ by means of two interactive game-theoretical invest...

Collectivistic orientation, which entails interdependent self-construal and concern for interpersonal harmony and social adjustment, has been suggested to be associated with detecting emotional expressions that signal social threat than individualistic orientation, which entails independent self-construal. The present research tested if this detect...

How efficiently one can take the perspective of another might be influenced by individualism (I) and collectivism (C), characterized by whether the self is construed as independent or interdependent. Collectivism can be associated with more accurate and faster inference of others’ mental states because of heightened attention to others’ perspective...

Research from cultural and social psychology has identified a central role of self-construal, or the way one views themselves in relation to others, in social cognition. Accordingly, it is plausible that self-construal plays an instrumental role in important aspects of decision-making relating to fairness considerations. Prior research has shown th...

In chronic psychosis, reduced trust is associated with a neural insensitivity to social reward and reduced theory of mind (ToM). Here we investigate whether these mechanisms could underlie emerging social impairments in early psychosis. Twenty-two participants with early psychosis and 25 controls (male, 13-19 years) participated in two interactive...

Objective Elevated prevalence of non-affective psychotic disorders is often found in densely populated areas. This functional magnetic resonance imaging study investigates if reduced trust, a component of impaired social functioning in patients with psychotic disorder, is associated with urban upbringing. Methods In total, 39 patients (22 first ep...

Background Trust and reciprocity toward others have often been found to increase from childhood to adulthood. Gender differences in these social behaviors have been reported in adults. While adolescence is a key-period of change in social behavior, gender differences in trust and reciprocity during this developmental stage have rarely been investig...

Building consistent knowledge schemas that organize information and guide future learning is of great importance in everyday life. Such knowledge building is suggested to occur through reinstatement of prior knowledge during new learning in stimulus-specific brain regions. This process is proposed to yield integration of new with old memories, supp...

Research reveals that the ego- and time-moving representations, two divergent ways to talk and think about time, are psychologically meaningful: They are, for example, linked to agency. This research has, however, mainly been correlational in nature and only been conducted amongst English speakers, even though cross-linguistic differences are readi...

Background: Schizophrenia and bipolar disorder share genetic liability, and some structural brain abnormalities are common to both conditions. First-degree relatives of patients with schizophrenia (FDRs-SZ) show similar brain abnormalities to patients, albeit with smaller effect sizes. Imaging findings in first-degree relatives of patients with bi...

Peer preference among classmates is a highly influential factor in children’s social development and not being preferred by peers has long-term consequences for children’s developmental outcomes. However, little is known about how a history of low peer preference during primary school is associated with neural responses to a new social exclusion ex...

Background In chronic psychosis, the loss of trust towards others is associated with a neural insensitivity to social reward and reduced theory of mind (ToM). The aim of this study was to investigate whether these mechanisms are already present in early psychosis. Methods Twenty-two participants with early psychosis and 25 controls (male, 13–19 ye...

Background Elevated incidence rates of non-affective psychosis and psychotic symptoms in densely populated urban areas have been reported by many epidemiological studies. It has been proposed that social characteristics of the urban environment underlie the association with the development of psychotic disorders. Individuals at risk for psychosis m...

Over the past decade, important insights have been obtained into the neurocognitive development during adolescence. To better understand how these neuroscientific insights impact the real world, we investigated how neuroscience has shaped public perceptions of the “teenage brain” and if these perceptions influence adolescent behavior. When asking t...

Background: Psychosis is characterized by problems in social functioning and trust, the assumed glue to positive social relations. But what helps building trust? A prime candidate could be social mindfulness: the ability and willingness to see and consider another person’s needs and wishes during social decision making. We investigated whether firs...