Lutz Moser

• Dr. med.
• HELIOS Klinikum Emil von Behring

Key Clinical Message Early and complete surgical resection is the most important therapeutic and diagnostic measure. Adjuvant radiation is suggested for malign phyllode tumors, phyllode tumors larger than 10 cm or those with a low distance to the resection margins. Abstract Phyllodes tumors are rare fibroepithelial tumors of the breast. Histologic...

Zusammenfassung Die 2020 veröffentlichten Ergebnisse der PET-Plan-Studie haben zum ersten Mal randomisiert kontrolliert eine Nichtunterlegenheit einer FDG-PET basierten involved-field-Bestrahlung beim lokal fortgeschrittenen nicht-kleinzelligen Lungenkarzinom im Vergleich zur elektiven Lymphabflussbestrahlung gezeigt. In Kombination mit einer isoto...

Chemoradiation is one of the therapeutic options in palliative treatment of locally advanced pancreatic adenocarcinoma, with a well-known safety profile. In this case report, we describe the treatment-related occurrence of an intrasplenic pancreatic pseudocyst which was successfully removed by gastrocystic drainage. This rare complication should be...

Background: The paradigm shift from cytological screening to Human Papillomavirus (HPV)-based screening for cervical cancer allows the introduction of new technologies in sample collection and diagnostics. The OncoE6™ Cervical Test (OncoE6 Test) is a rapid, easy-to-use lateral flow method detecting HPV16/18 E6 oncoproteins that has proven to detec...

Einfuhrung: Die Moglichkeiten zur Behandlung von Irismelanomen, welche nur 2% aller uvealen Melanome ausmachen, sind sehr heterogen und reichen von der chirurgischen Exzision uber die Radiatio mittels Brachytherapie oder Protonen bis hin zur Enukleatio bulbi bei fortgeschrittenem Befund. Die Rate von Rezidiven betragt je nach Studie und therapeutis...

To describe results after neoadjuvant proton beam irradiation followed by transscleral resection of large uveal melanoma. Retrospective interventional case series, including 106 consecutive patients. Local tumour control, enucleation and metastasis development were assessed with survival curves. Predictors of local recurrence and metastasis were in...

153 Background: Biochemical recurrence (BCR) after radical prostatectomy (RP) is usually defined at a PSA >0.2 ng/ml. BCR may precede clinical progression by years. Though salvage radiotherapy (SRT) is recommend to be initiated at PSA <0.5 ng/ml, its efficiency at PSA <0.2 ng/ml is not well documented. Methods: We relied on two independent post-RP...

Treatment modalities in iris melanoma include excision, plaque radiotherapy, photon or proton beam therapy and enucleation. In extensive tumours and diffuse seeding, radiotherapy remains as an alternative to enucleation. This study is a retrospective, consecutive, interventional, single-institutional case series. 54 patients with a diffuse and non-...

Purpose To evaluate long-term outcomes of proton beam radiotherapy in the treatment of choroidal melanoma of the intermediate zone of the fundus. Design Retrospective interventional single center study. Methods A retrospective analysis with long-term follow-up of 62 patients with a minimum tumor-to-disc and tumor-to-fovea distance of 2 mm of chor...

Purpose: The impact of neoadjuvant chemoradiation therapy (CRT) on the postoperative complication rate is discussed controversially. Thus the aim of this study was to evaluate the postoperative complication rate in our patient population. Methods: A retrospective analysis was performed to examine all patients documented online who had undergone con...

Purpose: To evaluate survival and ocular outcome in recurrent uveal melanoma treated with proton beam therapy as salvage therapy. Design: Retrospective, interventional case series. Methods: We evaluated 48 patients with local recurrence of uveal melanoma after primary treatment with brachytherapy, transpupillary thermotherapy, proton beam ther...

Purpose: To evaluate the potential benefit and risk of proton beam therapy in the treatment of symptomatic retinal papillary capillary hemangioma. Design: Retrospective interventional case series. Methods: This study included patients presenting with symptomatic exudative retinal papillary capillary hemangioma with or without association with...

The aim of this retrospective study was to determine the efficacy of proton beam irradiation in choroidal hemangioma in a long-term follow-up. A total dose of 20 Cobalt Gray equivalent (CGE) was administered to 50 eyes of 50 patients from September 1998 to September 2010. All treated patients presented with a symptomatic tumor. Nine patients were p...

To analyze the functional outcome with regard to the development of visual acuity and radiation induced optic neuropathy of patients with parapapillary choroidal melanoma treated with proton beam therapy. Clinical case series, retrospective study METHODS: We evaluated 147 consecutive patients with parapapillary choroidal melanoma who received proto...

Hintergrund: Seit 1998 werden am Helmholtz-Zentrum Berlin Augentumore mittels Protonen bestrahlt. Die vorliegende Studie analysiert die Art der Behandlungen und deren Ergebnisse uber einen Zeitraum von 15 Jahren. Methoden: Die im Zeitraum von 1998 – 2013 durchgefuhrten Patientenbehandlungen wurden hinsichtlich der Art der Tumoren, der lokalen Kontr...

Background: Prognosis evaluation of patients with choroidal and ciliary melanoma has experienced recent progress through tumour sampling and cytogenetic analysis of metastatic risk. By allocating tumor extension, height and linear basal diameter to defined TNM stages, an estimation of prognosis can also be made without invasive tissue sampling. M...

Patients with prostate cancer face the difficult decision between a wide range of therapeutic options. These men require elaborate information about their individual risk profile and the therapeutic strategies risks and benefits to choose the best possible option. In order to detect time trends and quality improvements between an early patient popu...

Objective Are 6 weekly cycles of cis-Platinum (DDP) plus one cycle of 5-FU with concurrent hyperfractionated radiotherapy (HART) superior to 2 cycles of Mitomycin C (MMC) plus one cycle of 5-FU with HART in terms of overall survival (OS), progression-free (PFS) and metastases-free survival (MFS), local (LC), regional (RC) and loco-regional control...

Histopathological regression grading has been shown to predict outcome in chemoradiated rectal cancer. Lymph node spread is still considered the most important single prognostic parameter. Therefore, we investigated the association of regression grading with tumor spread in a single center retrospective cohort. 102 consecutive patients who had unde...

Zielsetzung Trotz standardisierter operativer Techniken und multimodaler Therapiekonzepte treten kolorektale Karzinomrezidive in bis zu 20% der Fälle auf. In der kurativen Therapie dieser Patienten bildet die radikale Resektion den zentralen Bestandteil. Das Ziel dieser Arbeit war es, die Ergebnisse in der Behandlung des lokoregionären Rezidivs des...

Background We evaluated the long-term results of radiotherapy for patients with gastric marginal zone lymphoma (GMZL).Patients and methodsWe carried out a retrospective, multi-centre study of patients with low-grade GMZL treated by radiotherapy between 17 July 1981 and 25 March 2004.ResultsThere were 102 eligible patients. Fifty-eight patients were...

Purpose: Up to 20 % of colorectal cancer patients develop recurrent disease despite standardized surgical techniques and multimodal treatment strategies. Radical resection is the central component of curative therapy in these cases. The aim of this study was to evaluate treatment results in patients with locoregionally recurrent colorectal cancer....

5512 Background: Are 6 cycles of once weekly DDP plus one cycle of 5-FU with concurrent HART superior to 2 cycles of MMC plus one cycle of 5-FU in terms of overall survival (OS) and metastases-free survival (MFS)? Methods: Eligibility: Stage IV SCC of oro(OP)- and hypopharynx(HP), KFS of ≥80% stratified for sites, N-status, grading, hemoglobin and...

Proton beam irradiation is a high precision irradiation that is suitable for tumours situated at the vicinity of critical structures which need to be preserved. Choroidal melanomas lying close to the optic nerve and macula fulfil these criteria. These structures can be optimally spared from the irradiation, due to the very steep distal and lateral...

Hintergrund: Aufgrund der hohen Rezidivrate nach Bindhautmelanomexzision wird eine adjuvante lokale Chemotherapie oder eine Bestrahlung empfohlen. Als mögliche Bestrahlungsarten stehen die Röntgenoberflächenbestrahlung, die Ruthenium-106-Applikatorbestrahlung (¹⁰⁶Ru) oder die Kontaktbestrahlung mit dem Strontium-90-Applikator (⁹⁰Sr) zur Verfügung....

Because of high local recurrence rates after excision of conjunctival melanoma adjuvant local chemotherapy employing mitomycin C (MMC) or irradiation is recommended. Brachytherapy is possible with ruthenium-106-plaques ((106)Ru) or with the strontium-90-plaques ((90)Sr). Fifty-six patients received an excision and adjuvant radiotherapy of conjuncti...

Background The therapy of rectal cancer has been a matter of debate since decades, especially with regard to the benefits of neoadjuvant or adjuvant therapies. Principles of additional therapies have been established nearly two decades ago and are questioned nowadays on the basis of more recently modified operative techniques. Benefits and sequelae...

A biochemical recurrence following prostatectomy is often diagnosed in relatively young and healthy men, and hence deemed very relevant concerning life, given the generally high life expectancy of these patients. Therefore, there is a need for a therapy that offers a long-term chance of cure. Following salvage radiotherapy in large multicenter seri...

Prostate cancer progression is commonly manifested by obstructive uropathy, regional lymphatic metastases and hematogenous metastases to the axial skeleton. Radiotherapy is a mainstay in the palliation of symptomatic metastatic prostate cancer and is most often used for the palliation of painful metastatic bone lesions, resulting in a relief of pai...

Das Pankreaskarzinom ist bei stetig steigender Inzidenz die vierthufigste krebsbedingte Todesursache in der westlichen Welt. In Deutschland erkranken jhrlich mehr als 4900 Mnner und 5500 Frauen, was etwa 3% aller Krebsneuerkrankungen ausmacht. Aufgrund der unspezifischen Symptomatik wird das Pankreaskarzinom in etwa 80–90% der Flle erst im fortgesc...

In CT-based adjuvant radiotherapy of the breast, virtual simulation techniques have been developed. This paper demonstrates a simple virtual simulation of a boost field. 41 fields were planned virtually, 26 as electron beams, 15 as tangential photon beams. Depending on the user's expertise the geometric accuracy was high; possible sources of error...

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Locally released endothelin (ET)-1 has been recently identified as an important mediator of cardiac hypertrophy. It is still unclear, however, which primary stimulus specifically activates ET-dependent signaling pathways. We therefore examined in adult rats (n = 51) the effects of a selective ET(A) receptor antagonist in experimental models of card...

Autocrine release of Ang II has been shown to be essential during hypertrophic growth of cardiomyocytes in response to mechanical stretch in vitro. To define a role of the local cardiac renin-angiotensin system for pressure-induced cardiac hypertrophy in vivo, the effects of Losartan were investigated in adult Sprague-Dawley rats subjected either t...