Lutz KraushaarBielefeld University · Public Health Medicine
Lutz Kraushaar
DrPH
About
33
Publications
7,763
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128
Citations
Introduction
I work on longevity. I'm interested in extending people's life span by "chronifying" their functional health. To that end I conceived functionomics, a discipline aimed at distinguishing chronological from pathological functional changes, slowing down the former while preventing the latter. My focus is on cardiovascular function. I develop non-invasive methods for easy monitoring of arterial elasticity and aortic function, and I translate these methods into practical tools to guide interventions.
Additional affiliations
June 2011 - present
adiphea GmbH
Position
- Functionomics
Description
- Develpment of a functionomics based web-enabled platform for disease prevention.
October 2008 - June 2011
Education
August 2006 - June 2010
September 2003 - May 2005
Publications
Publications (33)
Abstract
Purpose
The systolic blood pressure/workload (SBP/MET) slope was recently reported to be a reliable parameter to identify an exaggerated blood pressure response (eBPR) in the normal population and in athletes. However, it is unclear whether an eBPR correlates with central blood pressure (CBP) and vascular function in elite athletes.
Method...
Background
Reference values for right ventricular function and pulmonary circulation coupling were recently established for the general population. However, normative values for elite athletes are missing, even though exercise-related right ventricular enlargement is frequent in competitive athletes.
Methods
We examined 497 healthy male elite athl...
SARS-CoV-2 may affect the cardiovascular system and vascular impairment has been reported in healthy young adults recovering from COVID-19. However, the impact of SARS-CoV-2 infection on the vascular function of elite athletes is unknown. We examined 30 healthy male elite athletes (age 25.8 ± 4.6 years) pre-season and at a 6-month follow-up (182 ±...
The menopausal transition might offer an easily detectable window of opportunity to identify women at increased ageing-related CVD risk, and to initiate measures that preserve vascular function and integrity for healthy ageing
Ageing is perceived to be the common culprit behind the most prevalent noncommunicable chronic diseases (NCD) such as cardiovascular disease (CVD). Treating ageing as a means to prevent its downstream pathologies has become the logical extension of this idea, and the defining criterion of anti-ageing medicine (evidence-based early detection, preven...
Purpose
Sex differences in blood pressure (BP) regulation at rest have been attributed to differences in vascular function. Further, arterial stiffness predicts an exaggerated blood pressure response to exercise (BPR) in healthy young adults. However, the relationship of vascular function to the workload-indexed BPR and potential sex differences in...
Workload-indexed blood pressure response (wiBPR) to exercise has been shown to be superior to peak systolic blood pressure (SBP) in predicting mortality in healthy men. Thus far, however, markers of wiBPR have not been evaluated for athletes and the association with vascular function is unclear. We examined 95 male professional athletes (26±5 y) an...
PurposeLow vitamin D levels have been associated with elevated blood pressure (BP) in the general population. However, whether there is an association of vitamin D insufficiency with BP changes during maximum exercise in athletes is currently unclear.
MethodsA total of 120 male professional indoor athletes (age 26 ± 5 years) were examined. BP was m...
Background
Exercise testing is performed regularly in professional athletes. However, the blood pressure response (BPR) to exercise is rarely investigated in this cohort, and normative upper thresholds are lacking. Recently, a workload-indexed BPR (increase in systolic blood pressure per increase in metabolic equivalent of task (SBP/MET slope)) was...
Purpose
Low vitamin D levels have been associated with elevated blood pressure in the general population. Prospective studies, however, have produced conflicting evidence about the blood pressure-lowering effects of vitamin D supplementation. Cardiorespiratory fitness may modulate the vitamin D–blood pressure association. We therefore examined this...
Purpose: To evaluate vascular function and its relationship to cardiorespiratory fitness in professional handball athletes. Method: We examined 30 male professional handball athletes (age 27 ± 4 y) and 10 male sedentary controls (age 26 ± 5 y) at rest. The workup included exercise testing via ergometry. To assess vascular function, a validated elec...
Background: A wealth of studies has demonstrated that parameters of vascular function are independent predictors of cardiovascular morbidity and mortality. Given the importance of these markers as benchmarks of cardiovascular health, the call has been made to develop a method that provides a non-invasive and accurate assessment of all parameters th...
Background: Elite athletes have a high cardiorespiratory fitness and a favourable cardiovascular risk profile. A few studies, however, have found an unexpectedly high incidence of atherosclerosis in athletes. Recently, new methods to investigate vascular function have emerged that might augment subclinical estimation of cardiovascular risk. The eff...
The detection of high risk for premature death of cardiovascular disease (CVD) among individuals with low-to-moderate risk factor scores is a major challenge. Systems biology suggests that the vasculature's functional robustness against risk factor challenges may serve as a novel discriminator of mortality risk under similar risk factor loads. Howe...
Undetected high risk for premature death of cardiovascular disease (CVD) among individuals with low-to-moderate risk factor scores is an acknowledged obstacle to CVD prevention. The vasculature's functional robustness against risk factor derailment may serve as a novel discriminator of mortality risk under similar risk factor loads. To test this as...
An undetected high risk for premature death of cardiovascular disease (CVD) among individuals with low-to-moderate risk factor levels is an acknowledged obstacle to CVD prevention.
In this paper, we present the hypothesis that the vasculature's robustness against risk factor load will complement conventional risk factor models as a novel stratifie...
An undetected high risk for premature death of cardiovascular disease (CVD) among individuals with low-to-moderate risk factor levels is an acknowledged obstacle to CVD prevention.
In this paper, we present the hypothesis that the vasculature's robustness against risk factor load will complement conventional risk factor models as a novel stratifier...
Eine der größten Herausforderungen für die Prävention vorzeitiger kardiovaskulärer Mortalität ist die mit verfügbaren Risikoscores verbundene Unterschätzung des Risikos bei jungen Erwachsenen und dessen Überschätzung bei älteren [1]. Hierdurch wird die Chance auf eine rechtzeitige Prävention vertan bei gleichzeitiger Inkaufnahme von Nebenwirkungen...
Objective
Evaluation of diagnostic accuracy of an oscillometry-based device (VascAssist) combining fully automated ankle-brachial index (ABI) and pulse-wave velocity (PWV) assessment for detection of peripheral arterial disease (PAD).
Subjects and methods
110 consecutive subjects including symptomatic PAD patients (n = 41) and healthy PAD-free part...
Background Endothelial dysfunction is a necessary component cause for the development of atherosclerotic vascular disease, irrespective of cholesterol levels. This view is supported by the observation that more than half of all patients hospitalized for CAD have admission levels of LDL cholesterol in the normal or ideal range1. Thus it is important...
Background Standard biomarker-based screening algorithms for atherosclerotic cardiovascular disease (cvd) are dominated by unmodifiable chronological age as the most prominent risk factor 1. Since chronological aging and cvd share the gradual arterial functional decline as their common but modifiable hallmark, the derivation of a cardiovascular age...
Background Atherosclerotic cardiovascular disease (cvd) occurs at the endothelial interface between the circulating blood and the arterial wall 1. Therefore the prediction of disease endpoints depends on measures of vascular function not just on measures of cholesterol levels. Currently applied strategies express arterial function through a single...
This study aims to investigate whether a Web-based tool will facilitate the adoption of feedback control over calorie balance in overweight individuals, thereby promoting an increase of physical activity and a reduction of body weight and cardiovascular risk factors. This is a prospective exercise intervention study, commencing with a minimum weekl...
Cardiovascular and diabetic disease are the leading and preventable causes of death worldwide. The currently prognosticated dramatic increase in disease burden over the next two decades, however, bespeaks a low confidence in our prevention ability. This conflicts with the almost enthusiastic reporting of study results, which demonstrate substantial...
Background: Cardiovascular and diabetic disease are the leading and preventable causes of death worldwide. The currently prognosticated dramatic increase in disease burden over the next two decades, however, bespeaks a low confidence in our prevention ability. This conflicts with the almost enthusiastic reporting of study results, which demonstrate...
Questions
Questions (7)
I am searching for an aid that helps to find the most relevant intervention studies for a given person's (bio)medical profile and intervention objective.
This aid should apply NLP or ACA techniques to extract from publication resources (e.g. NLM) (a) profile information (inclusion and exclusion criteria) of study participants, (b) type of intervention, (c) effect.
My extensive literature search has not thrown up any existing system that meets this description. I'd be grateful for relevant information, either about such systems or about individuals/groups with the necessary expertise/experience to develop such a system.
I am looking for comparative studies on the divergent effects of different HIIT protocols on cardiovascular and metabolic function. The vast majority of studies compare a single HIIT protocol with moderate continuous exercise protocols (in healthy and diseased subject populations). HIIT protocols which differ in intensity dose and duration (relative to the recovery intervals) should elicit different effects on vascular, cardiac and metabolic function. I am specifically interested in these differences in the context of hypertension. Does anybody work on similar questions or know studies in this area?
The Simplicity HTN-3 trial seemed to show no effect of renal denervation on ambulatory and office blood pressure. Given that peripheral blood pressure is a poor indicator of vascular function, isn’t it conceivable that (a) the study missed RD’s potential effects on vascular function and central blood pressure, and/or (b) that the benefits of RD extend exclusively to patients with a specific profile of arterial dysfunction? Both scenario necessitate the inclusion of efficacy endpoints other than peripheral blood pressure.
Our team has developed a novel technique and device for the non-invasive assessment of arterial function, with which we would like to support investigators in this area.
The system is based on an electronic model of the arterial tree which is capable of simulating oscillometrically acquired pulse pressure curves through the manipulation of the electronic equivalents of pressure, flow, resistance, compliance and inertia. Powered by artificial intelligence, this vasometrix system’s arterial model is capable of reproducing a patient’s pulse pressure curve with near perfect correlation (>99%). The better the correlation the more reliable the information about resistance, compliance and pressure. It has been validated very favorably against invasive central blood pressure measurement.
For a first impression of the system you may visit www.vasometrix.com (currently in German only) or watch a 2-minutes introductory video here: vimeo.com/162808038
If your research work might benefit from the inclusion of these easily measurable efficacy endpoints, I would love to get in touch with you to discuss a possible collaboration.
Dear All
With funding from the German government we have recently finalized the development and medical registration (EU) of the vasometrix™ System, whose integral part is arteroid™, the first medical avatar of the human arterial tree. Powered by artificial intelligence and evolutionary algorithms, this model of the human arterial tree replicates a proband’s non-invasively acquired ultra-high-resolution pulse pressure curves. With correlations of up to >99% the valiant parameters of arterial function are being derived with high accuracy: such as central pressures, compliance, TPR, augmentation pressure and index, vascular age. The very recently completed system has been validated against invasive blood pressure measurement and presented for the first time at the annual congress of the German Cardiology Association in early April this year.
I am now looking for collaborators who see the benefits of applying vasometrix in research projects or population studies, in which various parameters of arterial function are desired efficacy endpoints.
For a first impression of the system you may visit www.vasometrix.com (currently in German only) or watch a 2-minutes introductory video here: vimeo.com/162808038
In case of interest, kindly contact me directly at lutz.kraushaar@adiphea.com
Thanks and best wishes
Lutz
Specifically: Deceleration of left ventricular contraction during systole produces an expansion pressure wave (pressure drop) just before valve closure. Is it conceivable that (under possibly pathological condition) the timing of the expansion wave may modulate the radial pulse pressure wave form (incident and reflected wave) into a type-C pressure wave form (wave forms according to Murgo et al. and Nichols et al.)? Is it possible that a pathological condition may thereby produce a radial waveform which is typically associated with a healthy CV system? Has anybody made such observation in practice?
Colloquially phrased: do all animals of an experimental group get fat and diseased when exposed to an obesogenic environment which simulates contemporary human environments (i.e. ad libitum availability of high-fat food AND the availability of running wheels), or is there a percentage of animals which resist the obesity outcome, e.g. by increasing voluntary wheel running?
