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Introduction
Lusine Sahakyan currently works at the Biomedicine Chair of Pharmacy institute of Yerevan State University.
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Publications (10)
An approach to the synthesis of a series of novel, enantiomerically pure analogs of β-hydroxy-α-amino acids is reported. The method involves the introduction of the acetylene group into their side chain, followed by further elaboration of the terminal alkyne moiety. The asymmetric synthesis of alkyl- and aryl-substituted derivatives of (S)-O-propar...
This study delves into the impact of two synthetic non-natural amino acids, 7 and 8, on the structural dynamics of serum albumin and their potential significance in anticancer drug delivery systems. Crucially, the dihydrofuran-containing compound 7 has been identified to bind to the G-quadruplex (G4) DNA sequence 22-mer Pu22, a mimic of the proto-o...
The present study investigated the anion composition of drinking water from various cities and villages in Armenia, including spring water and tap water samples. The simultaneous separation was achieved for fluoride, chloride, bromide, nitrite, nitrate, sulfate, and phosphate anions with the correlation coefficients >0.998. Validation of the method...
Ni(II) complex of the Schiff base of the chiral auxiliary (S)-2-N-(N'-benzylprolyl)aminobenzophenone (BPB) and dehydroalanine as the initial complex in the addition reaction was investigated. The obtained four new derivatives of -alanine were investigated as inhibitors of aldose reductase. Only one of them: (S)-2-amino-3-((4-methylbenzyl)amino)pro...
An isocratic, high-performance liquid chromatography (HPLC) quantitation method was developed for the quantitative determination of metformin, glibenclamide, gliclazide, glimepiride in some antidiabetic biologically active additives. A Nucleosil C 18 , 5 μm, 4.6 mm × 150 mm, column with mobile phase containing buffer (10 mm Na 2 HPO 4 , 10 mm sodiu...
The optimal conditions of the method, applicable during forensic chemical examinations, were elaborated. Particularly, the investigation of the conditions for the isolation of Nifedipine from liver and skeletal muscle tissues, the identification of the isolated Nifedipine by TLC method and checking the accuracy of the method using HPLC was carried...
New enantiomerically enriched unsaturated tailor-made amino acids have been obtained. As a starting amino acid synthon for the asymmetric synthesis of tailor-made unsaturated amino acids, Ni(II) square-planar complexes of Schiff’s bases of propargylglycine, allylglycine and glycine with chiral auxiliary (S)-2-N-(N’-benzylprolyl)-aminobenzophenone (...
Разработан метод асимметрического синтеза энантиомерно обогащенных β-гетероцик-лически замещенных производных (2S, 3S)-allo-α-аминомасляной кислоты, содержащих 5-тиоксо-1,2,4-триазольные группы с различными заместителями в положениях 3 и 4 путем при-соединения соответствующих нуклеофилов триазольного ряда к С=С связи (E)- и (Z)-дегид-роаминомасляно...
ryра и (мягкм сила> РАЗДЕЛ II. ЯЗЫК И ИДЕНТИЧНОСТЪ С К. Гаспарян, Л. С. Саакян (Ереванс Kui) zocydap сrпв eHHblil унuверс um еп,-фменuя) УДК 81'27:39' ББк ш100.63 НАЦИОНАЛЬНАЯ ЦНДВ НТИЧНОСТЬ-б iшркдлЕ языкА и культуры л\ннотация, Язык,-главIIое орудие этнического сопротивления и са-, _.-охранения. ооновные характеристики национальной идентиrIности...
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