Luqman B. SafdarUniversity of Nottingham | Notts · Division of Food Nutrition and Dietetics
Luqman B. Safdar
MPhil Plant Sciences (Plant Breeding and Genetics)
Studying the genetic mechanism of grain protein regulation in wheat.
About
25
Publications
11,788
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683
Citations
Introduction
My research focuses on studying wheat grain quality traits by using cutting-edge chemo-analytical and genome sequencing technologies.
Additional affiliations
March 2018 - February 2019
Position
- Research Assistant
Description
- I worked on a project related to genomic selection for yield maximization in bread wheat. My role was to perform statistical analysis for genome-wide association study and QTL mapping.
Education
February 2016 - April 2018
Publications
Publications (25)
Cotton (Gossypium) stands as a crucial economic crop, serving as the primary source of natural fiber for the textile sector. However, the evolutionary mechanisms driving speciation within the Gossypium genus remain unresolved. In this investigation, we leveraged 25 Gossypium genomes and introduced four novel assemblies—G. harknessii, G. gossypioide...
Rising demands for protein worldwide are likely to drive increases in livestock production, as meat provides ∼40% of dietary protein. This will come at a significant environmental cost, and a shift toward plant-based protein sources would therefore provide major benefits. While legumes provide substantial amounts of plant-based protein, cereals are...
A long‐term goal of breeders and researchers is to develop crop varieties that can resist environmental stressors and produce high yields. However, prioritising yield often compromises improvement of other key traits, including grain quality, which is tedious and time‐consuming to measure because of the frequent involvement of destructive phenotypi...
The present study was designed to explore the biological potential of aerial parts of Berberis baluchistanica. HPLC analysis revealed the highest berberine content in leaves (19453.15 ppm) followed by roots (3225.12ppm) and stem (29.11ppm). Phenolics, flavonoids, tannins, DPPH inhibition activity and total antioxidant capacity are reported in root,...
The trans-Golgi network (TGN) acts as a central platform for sorting and secreting various cargoes to the cell surface, thus being essential for the full execution of plant immunity. However, the fine-tuned regulation of TGN components in plant defense and stress response has been not fully elucidated. Our study revealed that despite largely compro...
Salinity has drastic effects on plant growth and productivity and is one of the major factors responsible for crop yield losses throughout the agricultural soils of the world. The mechanisms of salinity tolerance in plants are regulated by a set of inherent multigenes and prevalent environmental factors, which bring about a myriad of metabolic chan...
In current report, nickel oxide nanoparticles (NiONPs) were synthesized using leaf extract of Berberis balochistanica (BB) an endemic medicinal plant. The BB leaves extract act as a strong reducing, stabilizing, and capping agent in the synthesis of BB@NiONPs. Further, BB@NiONPs were characterized using Uv-visible spectroscopy (UV-vis), X-ray diffr...
Oilseed rape (Brassica napus) with yellow flowers is an attractive ornamental landscape plant during the flowering period, and the development of different petal colors has become a breeding objective. Although yellowish flower color is a common variant observed in field-grown oilseed rape, the genetics behind this variation in color remains unclea...
Green synthesis of nanomaterials is advancing due to its ease of synthesis, inexpensiveness, nontoxicity and renewability. In the present study, an eco-friendly biogenic method was developed for the green synthesis of nickel oxide nanoparticles (NiONPs) using phytochemically rich Berberis balochistanica stem (BBS) extract. The BBS extract was rich...
In current report, nickel oxide nanoparticles (NiONPs) were synthesized using leaf extract of Berberis balochistanica (BB) an endemic medicinal plant. The BB leaves extract act as a strong reducing, stabilizing, and capping agent in the synthesis of BB@NiONPs. Further, BB@NiONPs were characterized using Uv–visible spectroscopy (UV–vis), X‐ray diffr...
Stripe or yellow rust, caused by Puccinia striiformis Westend. f. sp. tritici is a major threat to bread wheat production worldwide. The breakdown in resistance of certain major genes and newly emerging aggressive races of stripe rusts pose serious concerns in all main wheat growing areas of the world. To identify new sources of resistance and asso...
Background
Patients with COVID-19 can develop myocardial injury and arrhythmia during the course of their illness. However, the underlying risk factors for the development of cardiovascular related manifestations are unclear.
Methods
Using a register-based multi-center cross-sectional design, we analyzed 80 patients with myocardial injury and 401...
The organoleptic qualities of watermelon fruit are defined by the sugar and organic acid contents, which undergo considerable variations during development and maturation. The molecular mechanisms underlying these variations remain unclear. In this study, we used transcriptome profiles to investigate the coexpression patterns of gene networks assoc...
Despite the economic importance of P utilization efficiency, information on genetic factors underlying this trait remains elusive. To address that, we performed a genome-wide association study in a spring wheat diversity panel ranging from landraces to elite varieties. We evaluated the phenotype variation for P utilization efficiency in controlled...
Excess Ni intake has harmful implications on human health, which include chronic bronchitis, reduced lung function, and cancer of lung and nasal sinuses. Like other toxic metals, higher Ni accumulation in grains leads to excess intake by humans when the contaminated grains are consumed as food. There is little information about the genetic factors...
Despite the economic importance of P utilization efficiency, information on genetic factors underlying this trait remains elusive. To address that, we performed a genome-wide association study in a spring wheat diversity panel ranging from landraces to elite varieties. We evaluated the phenotype variation for P utilization efficiency in controlled...
Purpose: To examine the risk factors for Intensive Care Unit (ICU) admission, mechanical ventilation and mortality in hospitalized patients with COVID-19.
Methods: This was a retrospective cohort study including 432 patients with laboratory-confirmed COVID-19 who were admitted to three medical centers in Hubei province from January 1st to April 10t...
Chlorophyll biosynthesis and chloroplast development are crucial to photosynthesis and plant growth, but their regulatory mechanism remains elusive in many crop species. We isolated a Brassica napus yellow-virescent leaf ( yvl ) mutant, which exhibited yellow-younger-leaf and virescent-older-leaf with decreased chlorophyll accumulation and delayed...
Cadmium (Cd) toxicity is a serious threat to future food security and health safety. To identify genetic factors contributing to Cd uptake in wheat, we conducted a genome‐wide association study with genotyping from 90K SNP array. A spring wheat diversity panel was planted under normal conditions and Cd stress (50 mg Cd/kg soil). The impact of Cd st...
For global demand of high yield breeding, complex genetic regulation on plant architecture was focused by genome-wide association study (GWAS) and principal component analysis (PCA), based on 4 typical traits related to plant architecture (PA) of 373 B. napus (L.) accessions. The 4 traits included plant height, branch height, branch number and main...
Watermelon has a fleshy fruit and that is the reason sugars and organic acids play a key role in taste formulation. So far, there is no comprehensive study in watermelon regarding accumulation and regulation of sugars and organic acids. To understand the behaviour of sugars and organic acids two watermelon inbred lines "203Z" (high sugar, low acid)...
Potassium use efficiency, a complex trait, directly impacts the yield potential of crop plants. Low potassium efficiency leads to a high use of fertilizers, which is not only farmer unfriendly but also deteriorates the environment. Genome-wide association studies (GWAS) are widely used to dissect complex traits. However, most studies use single-loc...
Stripe rust, caused by Puccinia striiformis Westend. f. sp. tritici is a major threat to wheat production worldwide. The breakdown in resistance of certain major genes and new emerging aggressive races of stripe rusts are causing serious concerns in all main wheat growing areas of the world. To search for new sources of resistance genes and associa...
Salinity has drastic effects on plant growth and productivity and is one of the major factors responsible for crop yield losses throughout the agricultural soils of the world. The mechanisms of salinity tolerance in plants are regulated by a set of inherent multigenes and prevalent environmental factors, which bring about a myriad of metabolic chan...
Questions
Questions (2)
I need to do RNA extractions of a large number of samples from developing wheat grain, and plan to do them in the batches of 12. Is is sensible to keep the homogenised samples (with pestle and mortar using liquid nitrogen) on dry ice whilst the entire batch is homogenised before proceeding to the extraction protocol? Keeping in liquid nitrogen would probably be best but is dry ice also safer? The first/foremost sample will have to be on dry ice for roughly 1-hour by the time all 12 are grinded.
Is there any simple explanation of controlling background genetic variation by variance components in mixed model association tests? Any simple answers or suggested reads are highly appreciated.
