Łukasz Mazurkiewicz

Łukasz Mazurkiewicz
Institute of Cardiology · Cardiomyopathy Department

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120
Publications
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Publications

Publications (120)
Article
Cardiomyopathies (CMs) are a very broad group of diseases, including genetically determined and acquired, and their classification is based on phenotypic characteristics. There is always a need to search for the etiology (often also to try to identify the genetic cause), which may determine the appropriate choice of clinical management. The geograp...
Article
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This paper presents the development of a novel microvehicle concept under the H2020 LEONARDO project, which targets the limitations of current micromobility solutions. By combining the features of a monowheel and a kick scooter, the vehicle is designed to enhance safety, comfort, and convenience for urban transport. It employs an innovative control...
Article
Modeling the knee is an important factor in increasing the quality of life of both healthy individuals and patients. Nevertheless, the intricate nature of the knee makes this problem complicated. In this study, an extension to an established planar knee joint model with Hertzian contact pairs is proposed with contact mechanics based on polynomial c...
Article
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The aim of this study was to assess the impact of cardiac magnetic resonance (CMR) on the diagnosis in patients with known or suspected left ventricular noncompaction (LVNC). We retrospectively reviewed the medical charts of 12,811 consecutive patients who had CMR studies between 2008 and 2022 in a large tertiary center. We included patients referr...
Article
Background: Numerous prognostic factors have been proposed for cardiac amyloidosis (CA). The knowledge about other subtypes of restrictive cardiomyopathy (RCM) is scant. Aims: This study aimed to elucidate the etiology and prognostic factors of RCM as well as assess cardiac biomarkers: high-sensitive troponin T (hs-TnT), growth differentiation f...
Article
Considering the rare incidence of transthyretin amyloidosis cardiomyopathy (ATTR-CM) in Poland, patients encounter difficulties at the stage of diagnosis and treatment. For a successful diagnosis, it is vital to raise the suspicion of ATTR-CM, that is, to identify the typical clinical scenarios such as heart failure with preserved ejection fraction...
Article
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Background: Left ventricular noncompaction (LVNC) is a distinct cardiomyopathy characterized by the presence of a two-layer myocardium with prominent trabeculation and deep intertrabecular recesses. The diagnosis of LVNC can be challenging because the diagnostic criteria are not uniform. The aim of our study was to evaluate echocardiographic and CM...
Preprint
Background: Left ventricular noncompaction (LVNC) is a distinct cardiomyopathy characterized by the presence of a two-layer myocardium with prominent trabeculation and deep intertrabecular recesses. The diagnosis of LVNC can be challenging because the diagnostic criteria are not uniform. The aim of our study was to evaluate echocardiographic and CM...
Article
Full-text available
Purpose: The aim of this study was to develop a method to implement muscle forces to a numerical model of a dummy and to evaluate the effect of muscle activation on driver behavior during a frontal collision. The authors focused on the forces acting at the knee, hip, and elbow joints. Methods: The authors carried out torque measurements in joint...
Article
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Background: The heart failure (HF) population is estimated to be 64.3 million people worldwide and continues to grow. Identifying the underlying cause of HF is crucial for patient management and prognosis. Aims: We sought to evaluate the role of cardiac magnetic resonance (CMR) imaging to identify the etiology of HF and to evaluate the impact on...
Article
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Background: Left ventricular noncompaction (LVNC) is a genetically determined cardiomyopathy that occurs following a disruption of endomyocardial morphogenesis. The purpose of this study was to identify the clinical characteristics and genetic profile of children with LVNC. Methods: From February 2008 to July 2020, a total of 32 children (median 11...
Article
Introduction Restrictive cardiomyopathy (RCM) is considered to have a genetic background in approximately 50–60% of patients (pts) [1,2,3]. Purpose The aim of the study was to assess the frequency of pathogenic gene variants in Polish patients with RCM. Methods Restrictive cardiomyopathy was diagnosed by transthoracic echocardiography. The analys...
Article
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Mitral regurgitation (MR), which is one of the factors responsible for heart failure symptoms and the development of atrial fibrillation, is an important feature of hypertrophic cardiomyopathy (HCM), and its presence affects which treatment options are chosen. Although cardiac magnetic resonance imaging (MRI) is considered the reference standard fo...
Article
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Background: Peripartum (PPCM) and dilated (DCM) cardiomyopathies are distinct forms of cardiac disease that share certain aspects in clinical presentation. Aim: We hypothesized that different cardiac structural changes underlie PPCM and DCM, and we aimed to investigate them with cardiovascular magnetic resonance (CMR). Methods: We included 21...
Preprint
Background: Left ventricular noncompaction (LVNC) is a genetically determined cardiomyopathy, that occurs following a disruption of endomyocardial morphogenesis. The purpose of this study was to identify the clinical characteristics and genetic profile of children with LVNC. Methods: From February 2008 to July 2020, a total of 32 children (median 1...
Article
Full-text available
Myocardial ischemia caused by microvascular dysfunction is an important pathophysiologic component of hypertrophic cardiomyopathy (HCM), promoting myocardial fibrosis, adverse left ventricular remodeling, and impacting on clinical course and outcome in HCM patients. The aim of study was to assess the prevalence and clinical significance of myocardi...
Article
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In hypertrophic cardiomyopathy (HCM) patients, left ventricular (LV) maximal wall thickness (MWT) is one of the most important factors determining sudden cardiac death (SCD) risk. In a large unselected sample of HCM patients, we aimed to simulate what changes would occur in the calculated SCD risk according to the European HCM Risk-SCD calculator w...
Article
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Background Although hypertrophic cardiomyopathy (HCM) is considered a disease of the left ventricle (LV), right ventricular (RV) abnormalities have also been reported on. Cardiovascular magnetic resonance feature tracking (CMR-FT) accurately and reproducibly quantifies RV myocardial deformation. Aim To investigate RV deformation disorders in child...
Article
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A better understanding of the left ventricle (LV) and right ventricle (RV) functioning would help with the differentiation between athlete's heart and dilated cardiomyopathy (DCM). We aimed to analyse deformation parameters in endurance athletes relative to patients with DCM using cardiac magnetic resonance feature tracking (CMR-FT). The study incl...
Article
Funding Acknowledgements Type of funding sources: None. Background Heart failure (HF) is a clinical syndrome caused by structural or functional cardiac abnormality and is diagnosed on the basis of typical symptoms. It is associated with significant morbidity and mortality and affects more than 25 million people worldwide. HF of unknown aetiology i...
Article
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Introduction: The most efficient risk stratification algorithms are expected to deliver robust and indefectible identification of high-risk children with hypertrophic cardiomyopathy (HCM). Here we compare algorithms for risk stratification in primary prevention in HCM children and investigate whether novel indices of biatrial performance improve t...
Article
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We investigated factors associated with right ventricular (RV) function and size in hypertrophic cardiomyopathy (HCM) patients. Two hundred fifty-three consecutive HCM patients and 20 healthy volunteers underwent cardiac magnetic resonance examination. In addition to measuring RV function (ejection fraction—RVEF) and size (end-diastolic volume—RVED...
Article
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Purpose: Right ventricular (RV) outflow tract obstruction (RVOTO) was demonstrated to be protective against RV dilatation in patients with repaired tetralogy of Fallot and chronic pulmonary regurgitation (PR). We hypothesised that the presence of additional haemodynamic abnormalities (more than mild tricuspid regurgitation, residual ventricular se...
Article
Background Lambda (λ) and kappa (κ) types of light-chain amyloidosis (AL amyloidosis) are believed to have a similar prognosis. Data on the comparison of these two types of cardiac amyloidosis is scanty. Objectives The aim of the study was to investigate wether lambda light-chain cardiac amyloidosis indicates worse prognosis than the kappa variety...
Article
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Objectives: To assess the value of cardiac MRI in comparison to echocardiography in consecutive patients with previously diagnosed and new suspected hypertrophic cardiomyopathy (HCM). Methods: All MRI studies of patients with HCM or suspected disease performed at our centre within a 10-year time period were evaluated. Initial diagnoses (echocard...
Article
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The paper presents modelling and simulation of a local blast wave interaction with a tire of a logistic truck supporting military operations. In the military industry, it is desired to improve effectiveness and strength of vehicle components and simultaneously to minimize the risk of crew injuries. Therefore, the main goal of this paper is to prese...
Article
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Background: Pulmonary regurgitation (PR) is the most common late complication in patients after repair of tetralogy of Fallot (TOF). The majority of patients remain asymptomatic over years but eventually the compensatory mechanisms fail leading to right ventricular (RV) dilatation and dysfunction, limited exercise capacity, ventricular arrhythmia,...
Article
Objectives: The objective of this meta-analysis was to assess the predictive value of late gadolinium enhancement (LGE) and global systolic impairment for future major adverse cardiovascular events in left ventricular noncompaction (LVNC). Background: The prognosis of patients with LVNC, with and without left ventricular dysfunction and LGE, is...
Chapter
Bioresorbable stents (BRSs) represent a promising technological development within the field of cardiovascular angioplasty because of their ability to avoid long-term side effects of conventional stents such as in-stent restenosis, late stent thrombosis and fatigue induced strut fracture. However polymer materials used for production of some of the...
Article
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The article presents a new solution of child-resistant systems to improve the safety of children transported in motor vehicles subjected to a side impact during a vehicle crash. The proposed concept works by means of implementation of an energy dissipation mechanism acting between a child restraint system anchorage and a restraint system seat. The...
Article
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Objectives: To investigate biatrial mechanics and their relation with left ventricular outflow tract (LVOT) obstruction (LVOTO), the degree of hypertrophy, indices of ventricular diastolic function and fibrosis in children with hypertrophic cardiomyopathy (HCM). Methods: Fifty-five consecutive, prospectively recruited children with HCM (mean age...
Article
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Objective: This article discusses differences between a side impact procedure described in UN/ECE Regulation 129 and scenarios observed in real world cases. Methods: Numerical simulations of side impact tests utilizing different boundary conditions are used to compare the severity of the Regulation 129 test and the other tests with different kinem...
Article
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Abstract Background Cardiovascular magnetic resonance (CMR) imaging in patients with hypertrophic cardiomyopathy (HCM) enables the assessment of not only left ventricular (LV) hypertrophy and scarring but also the severity of mitral regurgitation. CMR assessment of mitral regurgitation is primarily based on the difference between LV stroke volume (...
Conference Paper
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Development of new polymer based bioabsorbable drug-eluting scaffolds (BVS) requires a new geometry of the device which is made of material characterized by a substantially lower stiffness than the stiffness of the metallic alloy. It is essential to provide sufficient radial strength of the stent. The optimization procedure based on 3D parametric F...
Article
Objectives To assess the magnitude of myocardial displacement abnormalities and their alterations with the fibrosis, left-ventricular (LV) outflow tract obstruction (LVOTO) and hypertrophy in juveniles with hypertrophic cardiomyopathy (HCM). Study design. Fifty-five children [age 12,5 ± 4.6 years, 38 (69,1%) males, 19 (34,5%) with LVOTO] with HCM a...
Article
Purpose The purpose of this study was to compare the ability of various parameters of myocardial mechanics to predict large amounts of biventricular fibrosis assessed via T1 mapping in patients with dilated cardiomyopathy (DCM). Material Cardiovascular magnetic resonance feature tracking analysis and T1 mapping were performed in 26 patients with D...
Data
Composite materials, especially those fibre reinforced, thanks to their advantages, are being used in a growing number of industries. However, the complex structure of these materials results in many analytical problems. One such problematic field is to model failure of a composite, and especially the delamination process. The aim of this paper is...
Article
The main goal of gas grid maintenance is to avoid leaks and raptures that may result in a fire of flammable clouds and lead to environmental consequences in the surrounding area. High pressure gas pipeline failure may also cause injuries and human fatalities. To reduce a failure probability and at the same time keep gas transmission system design c...
Article
Aim: To investigate changes in myocardial tissue volume during the cardiac cycle to verify the hypothesis of non-compressibility of the myocardium in healthy individuals (HI) as well as in patients with hypertrophic cardiomyopathy (HCM), dilated cardiomyopathy (DCM), and aortic stenosis (AS). Materials and methods: The study group included 30 HI...
Article
The paper presents numerical and experimental burst pressure evaluation of the gas seamless hot-rolled steel pipe. The main goal was to estimate mechanical toughness of pipe wrapped with composite sleeve and verify selected sleeve thickness. The authors used a nonlinear explicit FE code with constitutive models which allows for steel and composite...
Chapter
In this paper a practical modeling methodology and obtained results are presented for a series of finite element method numerical analyses of Child Restraint System (CRS) operation during frontal impact car accident, with particular emphasis on Built-in Belts Pretensioner (BBP) modeling in terms of child’s body response. Built-in belts pretensioner...
Article
Background: The survival in adults with congenitally corrected transposition of the great arteries (ccTGA) might be reduced due to dysfunction of the systemic right ventricle (sRV). The quantitative echocardiographic assessment of sRV function and tricuspid (systemic atrioventricular valve) regurgitation (TR) is still a diagnostic challenge. Thus,...
Article
Purpose: To investigate whether magnetic resonance imaging (MRI) cine-derived dyssynchrony indices provide additional information compared to conventional tagged MRI (tMRI) acquisitions in heart failure patients undergoing cardiac resynchronization therapy (CRT). Materials and methods: Patients scheduled for CRT (n = 52) underwent preprocedure M...
Article
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The paper presented shows a part of investigations covering the contact problem in nu- merical modelling using an explicit code. The authors have outlined the parameters and factors that have a direct impact on a proper contact definition, which, as is known, has much importance in finite element analyses. For the purpose of the study, a test model...
Conference Paper
Full-text available
One of the crucial factors determining the effective burden is an appropriate selection of geometry of cut-holes. Furthermore, leaving empty (uncharged) blasting holes may lead to enlargement of the fractured zone, and thus – improvement of the mining faces blasting effectiveness by means of reducing the number of blasting holes and/or extending th...
Conference Paper
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Nowadays, one can see that the risk of terrorist attacks is at high level. Bombing attacks are the most common of terrorist activities and its number is still growing. The problem of blast wave interaction with structure and its destructive effect was already presented in many papers. The numerical studies of such problems seems to be the most popu...
Article
Myocardial fibrosis was shown to influence prognosis in hypertrophic cardiomyopathy (HCM). It is typically assessed by late gadolinium enhancement (LGE) on cardiac magnetic resonance (CMR). Native T1-mapping has been proposed, as a contrast-free method of fibrosis assessment. The aim of the study was to define a cut-off value for native T1 relaxati...
Article
Full-text available
Dynamic response of an I-beam supporting structure subjected to shock wave produced by the detonation of high explosive materials is presented in this paper. Dynamic response of structural components in different load cases – with multimaterial panel protection and without protection, subjected to blast wave from various charge weight and various d...
Article
The main objective of drill-and-blast technology utilized in underground mines is the effective burden development which volume determines ore production. One of the crucial factor affecting the volume of burden is the appropriate selection of geometry of the cut-holes. Because till today there were no available effective analytical tools which wou...
Article
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PL:Podstawowym celem stosowania technologii strzałowej przy urabianiu złoża w kopalniach podziemnych jest uzyskanie odpowiedniego zabioru, którego objętość determinuje wprost poziom produkcji. Jednym z kluczowych czynników, decydujących o uzyskaniu właściwego zabioru, jest odpowiedni dobór metryki strzelania, a w tym przede wszystkim geometrii otwo...
Article
Full-text available
Impaired right ventricular (RV) mechanics is a common problem in patients after repair of tetralogy of Fallot (TOF). Moreover, also impaired left ventricular (LV) systolic function has been demonstrated in this population. There are no studies evaluating patients after TOF repair with impaired both RV and LV ejection fractions (RVEF, LVEF). We hypo...
Chapter
Full-text available
Dynamic response of a column made of steel I-beam with and without protective cover subjected to the shock wave produced by the detonation of high explosive (HE) material is presented in this paper. This column represents the supporting structure used in many critical facilities exposed to possible terrorist attacks. The 3D explicit, finite element...
Chapter
Full-text available
The following paper presents the possibility of numerical modelling of interaction between a net similar to net-gun and chosen rigid object with relatively small geometric dimensions and low weight. Both, net and object had rotational and translational velocity applied. In order to simulate the breach process of the net fibre a failure criterion wa...
Article
Background and aim: We sought to search for factors that are associated with the magnitude of trabeculation by cardiac magnetic resonance (CMR), and evaluate the impact of trabeculations on outcomes in patients with dilated cardiomyopathy (DCM). Methods: We evaluated clinical profiles and outcomes of 276 subjects with DCM (age - 33,2+/-13,3 years,...
Article
Background: Estimation of sudden cardiac death (SCD) risk is an integral part of clinical management of patients with hypertrophic cardiomyopathy (HCM). Identification of novel biomarkers of this disease can provide additional criteria for SCD risk stratification. Soluble suppression of tumourigenicity (sST2) and galectin-3 (Gal-3) are useful biom...
Article
Background: Alcohol septal ablation (ASA) is an alternative to surgical treatment in patients with hypertrophic obstructive cardiomyopathy (HOCM). Through alcohol-induced necrosis, ASA leads to an increase in left ventricular outflow tract (LVOT) diameter and a decrease in LVOT pressure gradient. Aim: We sought to assess the effect of ASA on lef...
Article
Full-text available
Split Hopkinson pressure bar (SHPB) is one of the most important and recognisable apparatus used for characterizing the dy-namic behaviour of various materials. Incident pulse generated one the incident bar usually have a rectangular shape, which is proper for some materials but for others is not. Therefore, several methods of shaping the incident...
Conference Paper
Full-text available
The object of analysis was an I-beam steel structure subjected to pressure waves generated by TNT charge detonation. This column represents the supporting structure used in many critical facilities exposed to possible terrorist attacks. The computational methods were used to study the influence of explosive shape and its FE representation. Coupled...
Conference Paper
Full-text available
The problem of high explosive materials and the development of structures resistant to shock waves have become important as a result of increasing terrorist activities in recent years. The principal objective of the research presented in this paper was to develop energy absorption protective covers for I-beam supporting structures. The dynamic resp...
Article
Full-text available
The main objective of the study is to develop experimentally validated FE model and perform numerical analysis of layered composites made by hand lay-up techniques during tension and bending test. The research object is glass - polyester laminate made of four unidirectional layers. In order to validate the numerical models experimental test were pe...