Łukasz Małek

Łukasz Małek
Cardinal Wyszynski National Institute of Cardiology · Department of Epidemiology, Cardiovascular Disease Prevention and Health Promotion Institute of Cardiology

Professor
Sports cardiology, Cardiac magnetic resonance

About

197
Publications
15,705
Reads
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2,046
Citations
Introduction
Research interest: sports cardiology, epidemiology, prevention and health promotion in cardiac diseases Methods: cardiac magnetic resonance and other non-invasive cardiology tests Current research: adaptation and maladaptation to exercise in amateur middle age athletes, influence of various types of sports on life duration, risk of cardiac events during sport events
Additional affiliations
July 2019 - present
Cardinal Wyszynski National Institute of Cardiology
Position
  • Professor (Full)
Description
  • Sport Cardiology Outpatient Clinic dedicated to amateur and professional athletes with a suspicion of a cardiac condition, who require additional advanced diagnostic procedures/treatment, sports cardiology consultation or monitoring (under construction).
March 2017 - September 2020
Józef Piłsudski University of Physical Education in Warsaw
Position
  • Professor (Associate)
Description
  • academic teacher, researcher
October 2016 - February 2017
Collegium Masoviense
Position
  • Professor
Education
September 2018 - September 2020
St George's, University of London
Field of study
  • Sports cardiology
May 2009 - February 2014
Institute of Cardiology
Field of study
  • cardiology
February 2007 - April 2009
Institute of Cardiology
Field of study
  • cardiology

Publications

Publications (197)
Article
Full-text available
Background. Cytokines soluble tumor necrosis factor-like weak inducer of apoptosis (sTWEAK) and interleukin 6 (IL-6) are involved in immune response, proliferation, apoptosis, and cardiovascular pathologies. We have previously confirmed that changes of their platelet or plasma contents are associated with pulmonary arterial hypertension (PAH). The...
Article
Full-text available
Cardiac magnetic resonance (CMR) is a second-line imaging test in cardiology. Balanced enlargement of heart chambers called athlete's heart (AH) is a part of physiological adaptation to regular physical activity. The aim of this study was to evaluate the diagnostic utility of CMR in athletes with suspected structural heart disease (SHD) and to anal...
Article
Isolated myocardial edema not accompanied by late gadolinium enhancement (LGE) may be occasionally found on cardiac magnetic resonance (CMR). This type of picture may be encountered in patients with suspected myocarditis, post some acute cardiac events, with cardiac allograft rejection or even in athletes after an extreme exercise. Currently, there...
Article
Full-text available
Background: Despite the positive effects of endurance training on the cardiovascular (CV) system, excessive exercise induces not only physiological adaptations but also adverse changes in CV system, including the heart. We aimed to evaluate the selected miRNAs expression based on bioinformatic analysis and their changes before and after an ultramar...
Article
Full-text available
Clinically silent cardiac disease is frequently observed in rheumatoid arthritis (RA), and cardiovascular complications are the leading cause of mortality in RA. We sought to evaluate the myocardium of young RA patients without known cardiac disease using cardiac magnetic resonance (CMR), including T1/T2 mapping sequences. Eighteen RA patients (med...
Article
Full-text available
Background In pulmonary arterial hypertension (PAH) increased afterload leads to adaptive processes of the right ventricle (RV) that help to maintain arterio-ventricular coupling of RV and preserve cardiac output, but with time the adaptive mechanisms fail. In this study, we propose a multimodal approach which allows to estimate prognostic value of...
Conference Paper
Background Self-monitoring is a cornerstone of many complex physical activity interventions and is a powerful behaviour change technique leading to substantial physical activity increases. Whether additional intervention components, such as counselling or incentives, yield further benefits over self-monitoring is not known. We aimed to determine wh...
Article
Background and aim Characterized by prolonged, highly dynamic exercise that is low-to-high power in nature, endurance training has proven beneficial in cardiovascular disease prevention. Several miRNAs have been reported to be regulated in response to exercise in healthy humans. Our aim was to determine the miRNA expression changes before and after...
Article
Full-text available
The impact of long-term training on cardiovascular disease (CVD) is not clear. Carotid intima–media thickness (CIMT) test is recommended as a useful measure to diagnose the early stages of atherosclerosis. MicroRNAs (miRNAs) are altered due to endurance exercise and can be promising biomarkers of pathophysiological changes. We aimed to evaluate the...
Article
Full-text available
In response to an increased afterload in pulmonary arterial hypertension (PAH), the right ventricle (RV) adapts by remodeling and increasing contractility. The idea of coupling refers to maintaining a relatively constant relationship between ventricular contractility and afterload. Twenty-eight stable PAH patients (mean age 49.5 ± 15.5 years) were...
Article
Full-text available
Objectives The aim of the study was to identify predictors determining the course of COVID-19 and antibody response in elite athletes. Design Observational study. Methods Routine medical screening with physical examination, resting ECG, and laboratory tests including antibody response was performed 12-68 days after the diagnosis of COVID-19 in 11...
Article
Full-text available
Background Pediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2 (PIMS-TS) is an inflammatory disease occurring in a small minority of children a few weeks after acute infection. Cardiac manifestations are common, but little is known about the potentially persistent heart changes after PIMS-TS. Purpose To analyze the fr...
Article
Full-text available
The aim of the study was to assess the role of cardiovascular magnetic resonance (CMR) in the diagnosis of idiopathic VA in children. This retrospective single-centre study included a total of 80 patients with idiopathic ventricular arrhythmia that underwent routine CMR imaging between 2016 and 2020 at our institution. All patients underwent a 3.0...
Article
Full-text available
Epicardial adipose tissue (EAT) volume is associated with cardiovascular disease (CVD). Data regarding the influence of extremely intensive training on CVD are scarce. We compared EAT volume among ultra-marathon runners and in the sedentary control group, and assessed the correlations between EAT and risk factors of coronary artery disease (CAD). E...
Article
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The foundations of sports cardiology include promoting physical activity and an ability to provide a safe environment for training and competition for all athletes at all levels, from professional to recreational [...]
Article
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Galectin-3 (G3) is a biomarker known as an inflammatory state exponent. The aim of this paper was to analyze the G3 in adolescents with ventricular arrhythmia (VES) in order to evaluate its impact on myocardial tissue preservation. The study group (SG) consisted of 25 VES adolescents. The control group (CG) was 21 healthy children. G3 was assessed...
Article
Full-text available
A better understanding of the left ventricle (LV) and right ventricle (RV) functioning would help with the differentiation between athlete's heart and dilated cardiomyopathy (DCM). We aimed to analyse deformation parameters in endurance athletes relative to patients with DCM using cardiac magnetic resonance feature tracking (CMR-FT). The study incl...
Article
Full-text available
Several performance-enhancing or ergogenic drugs have been linked to both significant adverse cardiovascular effects and increased cardiovascular risk. Even with increased scrutiny on the governance of performance-enhancing drugs (PEDs) in professional sport and heightened awareness of the associated cardiovascular risk, there are some who are prep...
Article
Full-text available
Magnetic resonance (MR) studies suggested cardiac involvement post-Covid-19 in a significant subset of affected individuals, including athletes. This brings serious clinical concerns regarding the potential need for in-depth cardiac screening in athletes after Covid-19 before return to play. The aim of this study was to gain further insight into th...
Article
Full-text available
Study aim : The aim of the study was to analyse the lifespan of Polish male Olympic medallists in comparison to the general male population. Material and methods : The study included 238 Polish male Olympic medallists who participated in the Olympic games in 1924–1992. Duration of life in relation to the general Polish population was assessed. The...
Preprint
Full-text available
ACCEPTED FOR PUBLICATION IN THE JOURNAL OF MAGNETIC RESONANCE IMAGING ON THE 12/21/2020 Background. MR studies suggested cardiac involvement post-Covid-19 in a significant subset of affected individuals, including athletes. This brings serious clinical concerns regarding the potential need for in-depth cardiac screening in athletes after COVID-19...
Preprint
Full-text available
Several performance-enhancing or ergogenic drugs have been linked to both significant adverse cardiovascular effects and increased cardiovascular risk. Even with increased scrutiny on the governance of performance-enhancing drugs (PEDs) in professional sport and heightened awareness of the associated cardiovascular risk, there are some who are prep...
Article
Full-text available
Monitoring of markers reflecting cardiac autonomic activity before and during stressful situations may be useful for identifying the physiological state of an athlete and may have medical or performance implications. The study aimed to determine group and individual changes in short-term (5 min) and ultra-short-term (1 min) heart rate (HR), respira...
Article
Introduction: Right ventricular (RV) function is a major determinant of survival in patients with pulmonary arterial hypertension (PAH). In our previous study, we confirmed that increased RV fluorodeoxyglucose (FDG) uptake in positron emission tomography (PET) (presented as higher ratio of FDG uptake of RV to LV) was associated with progressive RV...
Article
Full-text available
Purpose Dysfunction of the right ventricle (RV) is an important determinant of survival in patients with pulmonary arterial hypertension (PAH). The presence of late gadolinium enhancement (LGE) in cardiac magnetic resonance (CMR) at RV insertion points (RVIPs) has been found in majority of PAH patients and was associated with parameters of RV dysf...
Article
Full-text available
Introduction Cardiovascular diseases are the leading cause of death worldwide. According to the World Health Organization data, they are responsible for approximately 31% of deaths annually. It is estimated that nearly 80% of premature CVDs are preventable by modification of lifestyle including regular physical activity. Endurance training can be d...
Article
Background Right ventricular (RV) function is a major determinant of survival in patients with pulmonary arterial hypertension (PAH). In our previous study, we confirmed that increased RV fluorodeoxyglucose (FDG) uptake in positron emission tomography (PET) (presented as higher ratio of FDG uptake of RV to LV) was associated with progressive RV dys...
Article
A 30-year-old female patient was referred to our centre due to an abnormal ECG showing left ventricular hypertrophy. The physical examination was normal, and the patient was asymptomatic. Echocardiography was performed, revealing an atypical pattern of left ventricular hypertrophy with heterogeneous echogenicity of the left ventricular walls. A car...
Article
Background Endurance training can be described as long-time activity characterized by high dynamic and low to high power and was proven beneficial in CVD prevention. Nevertheless, studies reported that excessive endurance training can act as double-edged sword inducing the inflammatory response and cell apoptosis. This negative effect can be the re...
Article
Full-text available
Endurance sports have an unarguably beneficial influence on cardiovascular health and general fitness. Regular physical activity is considered one of the most powerful tools in the prevention of cardiovascular disease. MicroRNAs are small particles that regulate the post-transcription gene expression. Previous studies have shown that miRNAs might b...
Article
Full-text available
Background: The status of football spectatorship-induced emotional stress as a risk factor for acute cardiovascular (CV) events remains in dispute. Aims: To examine the relation between football spectatorship and the incidence of selected acute CV events across the Polish male population. Methods: Events occurring in male patients aged 35 and ol...
Article
Full-text available
The purpose of the article is to study whether the position occupied on the pitch influences 15 life duration of the football players. It is known that various types of sport activity (endurance, 16 resistance or mixed) may influence the lifespan in a different way. However, there is a paucity of 17 data regarding the role of different positions pl...
Article
Full-text available
Background To assess left ventricular hypertrophy, actual left ventricular mass (LVM) normalized for body size has to be compared to the LVM normative data. However, only some published normative echocardiographic data have been produced separately for girls and boys; numerous normative data for the pediatric population are not sex-specific. Thus,...
Article
Full-text available
Pro-inflammatory adipokines have a multifunctional role in adipogenesis, angiogenesis, glucose homeostasis, and inflammation. The aim of the present study is to evaluate the effect of running a 100 km ultra-marathon on serum levels of two adipokines: resistin and chemerin. Fifteen male participants complete a medical questionnaire and their body co...
Article
Objective Right ventricular (RV) function is a major determinant of survival in patients with pulmonary arterial hypertension (PAH). Metabolic alterations may precede haemodynamic and clinical deterioration. Increased RV fluorodeoxyglucose (FDG) uptake in positron emission tomography (PET) was recently associated with progressive RV dysfunction in...
Article
Background Regular physical activity should constitute the essence of treatment in patients with cardiovascular risk factors. We sought to determine the benefits of nurse-led intervention to promote physical activity in sedentary older adults in a primary care setting. Methods A group of 199 sedentary older adults (mean age 62.7±6.9, 34.2% male) w...
Article
Full-text available
Background: Intensive and prolonged exercise leads to a rise of troponin concentration in blood. The mechanism responsible for troponin release during exercise remains ill-defined. The study aim was to search for risk factors of troponin increase after a prolonged endurance competition. Methods: The study included a group of 18 amateurs, healthy...
Article
Full-text available
Background: Intensive and prolonged exercise leads to a rise of troponin concentration in blood. The mechanism responsible for troponin release during exercise remains ill-defined. The study aim was to search for risk factors of troponin increase after a prolonged endurance competition. Methods: The study included a group of 18 amateurs, healthy vo...
Article
Full-text available
Several previous studies suggested that prolonged and extensive physical activity might lead to increased prevalence of myocardial fibrosis in athletes. The review summarizes these studies focusing on common patterns of myocardial fibrosis observed in athletes, their potential causes and significance. It also presents recent research on parametric...
Article
Background Many children presenting with myocarditis may not fully recover and have long‐term complications, including dilated cardiomyopathy. Magnetic resonance imaging (MRI) has a potential for early detection of persistent changes with long‐term implications, but is not performed routinely in the monitoring of myocarditis. Purpose To monitor ad...
Article
Full-text available
Background Normalization for body size is required for reliable left ventricular mass (LVM) evaluation, especially in children due to the large variability of body size. In clinical practice, the allometrically adjusted ratio of LVM to height raised to the power of 2.7 is often used. However, studies presenting normative LVM data for children recom...
Article
Background The concept of coupling mainly refers to the relationship between ventricular contractility and afterload. Together, strictly related parameters may provide a more accurate estimation of the RV performance status. Indexing RV function, assessed by CMR feature tracking analysis, with a pulmonary artery systolic pressure (PASP) obtained fr...
Article
Background: Native myocardial T1 and T2 relaxation times are diagnostic tools used in clinical practice for adult and pediatric populations. Use of a mapping technique requires accurate knowledge of normal ranges in healthy patients, which is lacking in pediatric populations. Purpose: To establish normal values for native T1 and T2 mapping in he...
Article
PURPOSE: There is a direct reverse dose-effect relationship between the amount of physical activity and cardiovascular risk. It is unknown whether this is true for extreme, persistent endurance training. The aim of the study was to assess structural changes of the heart in long-time ultra-marathon runners with special focus on myocardial fibrosis u...
Article
Full-text available
Background Left ventricular mass normalization for body size is recommended, but a question remains: what is the best body size variable for this normalization—body surface area, height or lean body mass computed based on a predictive equation? Since body surface area and computed lean body mass are derivatives of body mass, normalizing for them ma...
Article
Purpose: The aim of the study was to analyze the accuracy of impedance cardiography (ICG) for hemodynamic assessment in wheelchair rugby players during rest and exercise. Method: The study included 21 players (mean age 33.0 ± 5.4, 86% male) with posttraumatic tetraplegia. ECG, echocardiography, and gas exchange analysis during rest and exercise wer...
Article
Purpose: The aim of the study was to analyze the accuracy of impedance cardiography (ICG) for hemodynamic assessment in wheelchair rugby players during rest and exercise. Method: The study included 21 players (mean age 33.0 ± 5.4, 86% male) with posttraumatic tetraplegia. ECG, echocardiography, and gas exchange analysis during rest and exercise wer...
Article
Full-text available
Introduction The role of three-dimensional echocardiography (3D-ECHO) chamber quantification in children is still underestimated. Material and methods In 43 children 3D-ECHO measurements of end-diastolic (EDV) and end-systolic ventricular volumes (ESV) were compared to cardiac magnetic resonance (CMR) using Bland-Altman analysis and linear regress...
Article
Both regular physical activity and hypertension may be related to increased myocardial thickness, but the interplay between these two factors in causing cardiac remodeling in athletes is still a matter of debate. The aim of this study was to analyze the relation between resting and peak exercise blood pressure (BP) and myocardial hypertrophy in hea...
Article
Full-text available
Background: Focusing on patients with arrhythmia, the aims of this study was to assess ventricular function in children using three-dimensional echocardiography (3D-ECHO) and to compare the results to those obtained with cardiac magnetic resonance (CMR). Methods: The study group consisted of 43 children in whom 3D-ECHO and CMR were performed. Twen...
Article
Full-text available
Background: Cardiac magnetic resonance (CMR) is the gold standard for heart size, volume and mass calculation, however, dedicated software is needed to perform the segmentation process. The aim of the study was to validate the performance of an open-source CMR segmentation tool against the latest version of vendor-validated CMR42 software. Materia...
Article
Full-text available
It has been demonstrated that regular sport activity in children leads to physiological changes in the heart including increased left ventricular (LV) myocardial thickness and mass (LVM). The aim of the study was to establish the first specific normal values of LVM for child and adolescent athletes. Parasternal long-axis, 2D-guided echocardiographi...
Article
Full-text available
This is a case of initially 15 years of age, white, male from junior football team. He was completely asymptomatic, with no previous medical history or family history of sudden cardiac death and cardiac diseases. He has been playing football for 8 years. On periodic preparticipation screening, he presented T-wave inversions (TWIs) in leads V4–V6 an...
Article
Full-text available
Cardiac haemangioma in children is a very rare benign tumour, which can lead to life-threating complications such as stroke or sudden death. There is no obvious correlation with age, sex, or family history. Symptoms depend on the location of the mass and can be non-specific. The tumour may be detected by echocardiography, but cardiac magnetic reson...
Article
Full-text available
Background Application of normative data for echocardiographic measurements to children practicing sports may lead to false positive findings. The aim of the study was to define the normative data of basic echocardiographic measurements for this group and to compare them to the previously published normative data for the pediatric population. Met...
Data
Linear dimensions comparison study_database. (CSV)
Data
Coefficients for regression equations relating echocardiographic measurements and body surface area, mean squared error, and adjusted coefficient of determination which appeared optimal in terms of utilized input variables. (DOCX)
Article
Introduction: Myocarditis is an inflammatory disease of the myocardium. Paediatric myocarditis is frequently overlooked due a misleading presentation when characteristic symptoms are lacking. Aim of the study: The aim of our study was to assess the clinical presentation of myocarditis in children, and the sensitivity and usefulness of chosen tests...