Lukas V. F. Novak

Lukas V. F. Novak
Université Paris-Saclay · Ecology, systematics and evolution Unit

PhD

About

19
Publications
7,268
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334
Citations
Introduction
I’m currently part of the DEEM team in Orsay where I’m working on genomics of Proteorhodophytina red algae and the origin and evolution of red secondary plastids.
Additional affiliations
October 2013 - January 2020
Charles University in Prague
Position
  • PhD Student
Education
October 2011 - September 2013
Charles University in Prague
Field of study
  • Parasitology
October 2008 - September 2011
Charles University in Prague
Field of study
  • Biology

Publications

Publications (19)
Article
Full-text available
The discovery that the protist Monocercomonoides exilis completely lacks mitochondria demonstrates that these organelles are not absolutely essential to eukaryotic cells. However, the degree to which the metabolism and cellular systems of this organism have adapted to the loss of mitochondria is unknown. Here we report an extensive analysis of the...
Article
Full-text available
The discovery that the protist Monocercomonoides exilis completely lacks mitochondria demonstrates that these organelles are not absolutely essential to eukaryotic cells. However, the degree to which the metabolism and cellular systems of this organism have adapted to the loss of mitochondria is unknown. Here we report an extensive analysis of the...
Article
Full-text available
The oxymonad Monocercomonoides exilis was recently reported to be the first eukaryote that has completely lost the mitochondrial compartment. It was proposed that an important prerequisite for such a radical evolutionary step was the acquisition of the SUF Fe-S cluster assembly pathway from prokaryotes, making the mitochondrial ISC pathway dispensa...
Article
Full-text available
Background Multiple prokaryotic lineages use the arginine deiminase (ADI) pathway for anaerobic energy production by arginine degradation. The distribution of this pathway among eukaryotes has been thought to be very limited, with only two specialized groups living in low oxygen environments (Parabasalia and Diplomonadida) known to possess the comp...
Article
Full-text available
The presence of mitochondria and related organelles in every studied eukaryote supports the view that mitochondria are essential cellular components. Here, we report the genome sequence of a microbial eukaryote, the oxymonad Monocercomonoides sp., which revealed that this organism lacks all hallmark mitochondrial proteins. Crucially, the mitochondr...
Article
Full-text available
All eukaryotic organisms contain mitochondria or organelles that evolved from the same endosymbiotic event like classical mitochondria. Organisms inhabiting low oxygen environments often contain mitochondrial derivates known as hydrogenosomes, mitosomes or neutrally as mitochondrion-like organelles. The detailed investigation has shown unexpected e...
Data
Full-text available
The N-terminal parts of protein alignments demonstrating the presence of extension in Trimastix protein relatively to the prokaryotic homologues. (PDF)
Data
The probability of mitochondrial localization of selected Trimastix proteins as predicted by PSORT II, TargetP and Multiloc2 programs. (DOCX)
Data
Full-text available
Immunofluorescence microscopy of two additional Trimastix pyriformis cells. The green signal from antiH-protein (human) co-localizes with red signal from the antiH-protein (Trimastix). The DNA is stained blue with Hoechst. (PDF)

Projects

Project (1)
Project
My current research interest lies in genomics and cell biology of Preaxostyla, an understudied group of metamonads. In this project we focus on two protists, Paratrimastix pyriformis and Monocercomonoides sp. which appear to be a promising model system for the study of reductive evolution of mitochondria.