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Publications
Publications (38)
Sickle cell anemia (SCA) causes a long-standing vascular inflammation state, leading to endothelial dysfunction and chronic overexpression of several adhesion molecules, which contributes to acute and constant vaso-occlusive (VOC) episodes. It has been demonstrated that hydroxyurea (HU) can reduce VOC events, organ damage, blood transfusions, and e...
Background
Depressive symptomatology is prevalent among female university students with adverse effects on their quality of life and academic performance. Previous research suggested associations between depressive symptomatology and oxytocin levels and between depressive symptomatology and Temperament Traits. Despite this evidence, to the best of...
Obesity is a major public health problem, which has a strong genetic component that interplays with environmental factors. Several genes are known to be implicated in the regulation of body weight. The identification of alleles that can be associated with obesity is a key element to control this pandemic. On the basis of a Portuguese population, 65...
Introduction
Unacylated ghrelin (UAG) is the major form of circulating ghrelin. Initially considered as a nonfunctional peptide, soon after, UAG has been associated to an insulin sensitizing action and to a negative action on energy balance. The aim of this study was to analyze the association between the serum levels of UAG and glucose metabolism...
BACKGROUND: Obesity is frequently referred to as an independent risk factor for high blood pressure and hypertension is very prevalent among obese people. The aims of this study were: to compare office-based and 24 h blood pressure (BP) and its circadian pattern between lean and obese women; to study correlations between BP, insulin resistance (IR)...
Among all aflatoxins, aflatoxin B1 (AFB1) is normally predominant in food cultures and products and is also the one with highest toxicity. It is the most potent hepatocarcinogen known in mammals and due to that is classified by the International Agency of Research on Cancer as Group 1 carcinogen. Although dietary exposure to AFB1 has been extensive...
Background/aim:
Formaldehyde is classified as carcinogenic to humans, making it a major concern, particularly in occupational settings. Fat-soluble vitamins, such as vitamins A, D, and E, are documented as antigenotoxic and antimutagenic and also correlate with the cell antioxidant potential. This study investigates the influence of these vitamins...
Aflatoxin B1 (AFB1) is a secondary metabolite produced by the fungi Aspergillus flavus and is the most potent hepatocarcinogen known in mammals and has been classified by the International Agency of Research on Cancer as Group 1 carcinogen. Although dietary exposure to AFB1 has been extensively documented, there are still few studies dedicated to t...
Occupational exposure to aflatoxin B1 in poultry slaughterhouses
Susana Viegas, Luísa Veiga, Ana Almeida, Mateus dos Santos
Exposure to mycotoxins is not usually identified as a risk factor present in occupational settings. This is probably due to the inexistence of limits regarding concentration of airborne mycotoxins and, also, due to the fact...
Background: Obesity is associated with increased atherogenesis through alterations in lipids, among other potential factors. Some of those abnormalities might be mediated by insulin resistance (IR).
Aims: To compare lipid and apolipoprotein profile between lean and obese women; to evaluate the influence of IR on lipid and apolipoprotein profile, in...
Occupational co-exposure to several mycotoxins in the waste management setting
Contrary to fungi, exposure to mycotoxins is not usually identified as a risk factor present in occupational settings. This is probably due to the inexistence of limits regarding concentration of airborne mycotoxins, and also due to the fact that these compounds are rare...
Aflatoxin B1 (AFB1) is considered by different International Agencies as a genotoxic and potent hepatocarcinogen. However,
despite the fact that the fungi producing this compound are detected in some work environments, AFB1 is rarely monitored in
occupational settings. The aim of the present investigation was to assess exposure to AFB1 of workers f...
Existirá ou não relação entre a obesidade e os nossos genes? É possível que o nosso peso seja determinado pelos nossos genes? A obesidade é uma doença multifactorial que resulta da combinação de diversos factores - ambientais, comportamentais e genéticos. Até à data, pouco foi feito em Portugal para compreender o envolvimento da genética na obesida...
Although the adverse health consequences of ingestion of food contaminated with aflatoxin
B1 (AFB1) are known, relatively few studies are available on the adverse effects of exposure in
occupational settings. Taking this into consideration, our study was developed aiming to elucidate
the possible effects of occupational exposure to AFB1 in Portugue...
Although the adverse health consequences of ingestion of food contaminated with aflatoxin B1 (AFB1) are known, relatively few studies are available on the adverse effects of exposure in occupational settings. Taking this into consideration, our study was developed aiming to elucidate the possible effects of occupational exposure to AFB1 in Portugue...
Purpose
We evaluated the association between risk of obesity in the Portuguese population and two obesity-related single-nucleotide gene polymorphisms: fat-mass and obesity-associated (FTO) rs9939609 and peroxisome proliferator-activated receptor gamma (PPARG) rs1801282.
Patients and methods
A total of 194 Portuguese premenopausal female Caucasian...
Background: Obesity is a medical condition developed from the excessive accumulation of fat mass that may increase health problems and decreased life expectancy, which may result from the combination of different genetic, environment and lifestyle factors[1]. Excess of body weight and physical inactivity is largely associated with type 2 diabetes t...
In 1987, the International Agency for Research on Cancer concluded that there was sufficient evidence for carcinogenicity of naturally occurring aflatoxins in humans. Regarding occupational exposure to this chemical agent, farmers and other agricultural workers present a higher risk due to airborne aflatoxin via inhalation of dust. This study was c...
Objective:
To assess different factors influencing adiponectinemia in obese and normal-weight women; to identify factors associated with the variation (Δ) in adiponectinemia in obese women following a 6-month weight loss program, according to surgical/non-surgical interventions.
Methods:
We studied 100 normal-weight women and 112 obese premenopa...
Although there is an abundance of literature concerning the ingestion of food contaminated with aflatoxin B1
(AFB1), only a small number of studies explore mycotoxin exposure in occupational settings. Taking this into
consideration, our study was developed with the intention of elucidating whether there is occupational exposure to AFB1 in Portugue...
Background: Obesity represents a cardiovascular risk factor. Monocyte chemoattractant protein-1 (MCP-1) is a known regulator of monocyte recruitment to sites of inflammation, and participates at the early phases of atherogenesis. Apolipoproteins, as part of the lipoprotein particles, are classically coupled with cardiovascular risk distinction.
Aim...
Aflatoxin B(1) (AFB(1)) has been recognized to produce cancer in human liver. In addition, epidemiological and laboratory studies demonstrated that the respiratory system was a target for AFB(1). Exposure occurs predominantly through the food chain, but inhalation represents an additional route of exposure. The present study aimed to examine AFB(1)...
INTRODUCTION • Obesity attendance rate has increased in the last century, and is considered by WHO as the epidemic of the XXI century 1. Several important genes/Single Nucleotide Polymorphisms (SNPs) have been associated to obesity and overweight 2 , such as Fat mass and obesity associated-gene (FTO) rs9939609 and Peroxisome proliferator-activated...
Obesity became a major public health problem as a result of its increasing prevalence worldwide. Paraoxonase-1 (PON1) is an esterase able to protect membranes and lipoproteins from oxidative modifications. At the PON1 gene, several polymorphisms in the promoter and coding regions have been identified. The aims of this study were i) to assess PON1 L...
This study was conducted to determine the association between magnesium (Mg), body composition and insulin resistance in 136 sedentary postmenopausal women, 50 to 77 years of age.
Diabetics, hypertensives and women on hormonal replacement therapy were excluded and the remaining 74 were divided according to BMI> or =25 (obese: OG) and BMI<25 kg/m(2)...
