Luis Serrano

• PhD
• Professor (Associate) at Public University of Navarre

Some animal fibers are considerably cheaper than others. Hence the existence of counterfeit products, which are detrimental to legitimate producers and consumers alike. Fourier-Transform Infrared (FTIR) spectroscopy can extract a characteristic waveform from fibers that can be later used for classification. However, visually inspecting such wavefor...

Ambulatory monitoring is of great interest in both clinical and domestic environments. Despite of the technological advances, few monitoring solutions are suitable for medical application and diagnosis. Here we investigate the feasibility of targeting the peri-auricular area (ear pavilion, ear canal and the surrounding skin areas) to implement a mu...

Zainketa Intentsiboetako Unitateko (ZIU) pazienteen egoera hobetzen denean beste unitate batzuetara garraiatzen dira. Horregatik, haien lokalizazioa ezagutzea estrategikoa da ospitale barruko garraioen planifikazio onerako eta baliabideak kudeatzeko. Lan honetan, pazienteen segimendua egiteko mugikor aplikazio bat aurkezten da eraikin anitzeko ospi...

Medullated fibres, due to their higher resistance to bending and pressure, constitute a problem for the textile industry. Thus, having practical instruments to identify them is essential. Therefore, the aim of this research was to develop and validate a novel, swift, automatic system (referred to as S-FiberMed) for medullation and diameter assessme...

The aim of this research is to develop and validate two computer programs based on artificial intelligence (AI) and digital image analysis (DIA) in order to determine the incidence of medullation in white alpaca fibers. Two data sets were analyzed: 76 samples of Huacaya alpaca fibers obtained from Huancavelica, Peru, and 200 samples of white alpaca...

Introducción: Son multitud los dispositivos que han ido surgiendo en los últimos años, pero en concreto, y el detonante de este proyecto en nuestro hospital, ha sido el uso del PICC, un catéter venoso central de inserción periférica. Este dispositivo ha ido surgiendo con fuerza y tomando protagonismo ya que son muy importantes y numerosas las mejor...

Co r c u e r a Ma r t í n e z , M. I. 1 ; Ma ñ e r u Or i a , A 1 ; Dí e z R e v i l l a , A 1 ; Ma a l i Ce n t e n o , S 1 ; A l d o n z a T o r r e s M1 ; I b a r r a Ma r í n B 1 ; T r i g o V i l a s e c a J D 2 , 3 ; Ma r t í n Ne v a d o L 1 ; A s t r a i n E s c o l a J. J. 2 , 3 ; Oz c o i d i B a l l a z L 1 ; F a l c o n e L a n a s F. J...

Mobile devices and social media have been used to create empowering healthcare services. However, privacy and security concerns remain. Furthermore, the integration of interoperability biomedical standards is a strategic feature. Thus, the objective of this paper is to build enhanced healthcare services by merging all these components. Methodologic...

Patients admitted to Intensive Care Units (ICU) are transported from and to other units. Knowing their location is strategic for a sound planning of intra-hospital transports as well as resources management. This is even more crucial in big hospital complexes, comprised of several buildings often connected through tunnels. In this work, a patient t...

Blockchain is currently one of the fashionable topics in many fields including, of course, healthcare. This means its indiscriminate consideration, even if it is not always useful for the expected purpose. This paper focuses on the careful analysis of the real possibilities offered by Blockchain technology, and of the limitations and deficiencies t...

Las Infecciones de transmisión sexual (ITS) se propagan de una persona a otra generalmente durante las relaciones sexuales. Entre ellas, destaca especialmente el Virus de la Inmunodeficiencia Humana (VIH), ya que hoy en día éste supone una pandemia según la Organización Mundial de la Salud (OMS). Por otro lado, la gamificación es una técnica de apr...

Es común encontrar pacientes con enfermedades crónicas que precisan numerosos fármacos. Un ejemplo son los afectados por el Virus de Inmunodeficiencia Humana (VIH), que son tratados con una amplia variedad de medicamentos antirretrovirales. Éstos pueden tener interacciones con otros medicamentos o con otras sustancias como drogas o alcohol. En este...

Los pacientes ingresados en la Unidades de Cuidados Intensivos (UCI) son trasladados desde y hacia otras unidades. Conocer su localización es clave para una buena planificación de los transportes intrahospitalarios, sobretodo en grandes complejos hospitalarios, ya que constan de varios edificios, a menudo conectados por túneles. En este trabajo se...

Los sistemas inalámbricos constituyen un elemento fundamental en la implementación de entornos de tipo contextual interactivo, cuyo paradigma es el Internet of Medical Things (IoMT). En este trabajo se analiza el comportamiento del canal radioeléctrico en diversos entornos del Complejo Hospitalario de Navarra (CHN), con el fin de poder analizar la...

El monitoreo de los diferentes signos vitales en vacunos tiene importancia desde el punto de vista productivo, sanitario y de bienestar animal; sin embargo, existen pocos equipos que tengan el potencial de uso a nivel de campo y que no sean invasivos. Por tal motivo se llevó a cabo el presente trabajo con la finalidad de diseñar, construir y evalua...

In-vehicle applications that are based on Vehicle-to-Everything (V2X) communication technologies need to be evaluated under lab-controlled conditions before performing field tests. The need for a tailored platform to perform specific research on the cooperative Advanced Driving Assistance System (ADAS) to assess the effect on driver behavior and dr...

Explica el desarrollo un monitor de signos vitales llevable, y su validación en vacunos.

In this work, the implementation of Context Aware in order to aid in the assistance of end users within the framework of e-Health and m-Health scenarios has been described. Interaction with end-users and social/medical staff is achieved by using a multi-signal input/output device. A prototype of ‘Social Sensor’ device has been designed and implemen...

In the context of hospital management and operation, Intensive Care Units (ICU) are one of the most challenging in terms of time responsiveness and criticality, in which adequate resource management and signal processing play a key role in overall system performance. In this work, a context aware Intensive Care Unit is implemented and analyzed to p...

Many different tools have been developed for traffic simulation. These tools allow the representation of complex, realistic traffic situations that can be useful in evaluating a specific traffic situation or testing new technological applications and their influence on the driver in real traffic scenarios. However, nowadays not many examples of dri...

In this work, a method to analyze the performance of Bluetooth-based Wireless Sensor Networks (WSN) deployed within hospital environments is presented. Due to the complexity that this kind of scenarios exhibit in terms of radio propagation and coexistence with other wireless communication systems and other potential interference sources, the deploy...

In this work, context aware scenarios applied to e-Health and m-Health in the framework of typical households (urban and rural) by means of deploying Social Sensors will be described. Interaction with end-users and social/medical staff is achieved using a multi-signal input/output device, capable of sensing and transmitting environmental, biomedica...

The ISO/IEEE 11073 standard for Personal Health Devices (X73PHD) aims to ensure interoperability between Personal Health Devices and aggregators —e.g. health appliances, routers— in ambulatory setups. The Integrating the Healthcare Enterprise (IHE) initiative promotes the coordinated use of different standards in healthcare systems (e.g. Personal/E...

Purpose: To evaluate a telemedicine model to follow up patients with exudative age-related macular degeneration and compare the time spent using this model with the time spent conducting office examinations. Methods: Results of office and telemedicine evaluations were compared to determine whether patients with exudative age-related macular dege...

Most healthcare services use information and communication technologies to reduce and redistribute the workload associated with follow-up of chronic conditions. However, the lack of normalization of the information handled in and exchanged between such services hinders the scalability and extendibility. The use of medical standards for modelling an...

One of the main concerns from Government Bodies, Health Authorities and the General Public is to assure the sustainability of the Health Care Systems [1]. In this context, Ambient Assisted Living is becoming an alternative to traditional methods of assistance that requires the presence of specialized medical staff. In this context, wireless technol...

In recent years important advances have been made in the development of health care systems in specific areas owing to different uses and applications. One of the foremost advancements is the so-called mobile Health (mHealth), due to its potential social and economic impact. Within this scope, several technologies – such as smart phones and ultra-s...

New use cases to extend the interoperability standard ISO/IEEE11073 (X73) were found during the development of recent specializations. These use cases expose the need of remote command and control extensions to allow managers to configure agents through the standard. This paper presents a proposal for an extension of remote control and configuratio...

The initial heterogeneity in the development of Personal Health Devices (PHDs) highlighted the lack of interoperability between agents and managers. The standardization work of the PHD Working Group (PHD-WG) has recently adapted the ISO/IEEE 11073 interoperability standard (X73), initially oriented to clinical environments, to include Personal Heal...

SUMMARY This paper describes how to analyse translinear topologies whose response is modified by the body effect by means of the general translinear principle. It proposes two different strategies for obtaining the translinear loop equations from each closed translinear set. Both strategies are tested analysing three topologies, one of them includi...

Standardized exchange of clinical information is a key factor in the provision of high quality health care systems. In this context, the openEHR specification facilitates the management of health data in electronic health records (EHRs), while the ISO/IEEE11073 (also referred to as X73PHD) family of standards provides a reference framework for medi...

The newest branch of the ISO/IEEE 11073 (X73) standard for Personal Health Devices (X73PHD), allow the development of interoperable personal health ecosystems. At the moment of this writing, more than 11 specializations have been successfully published by the Personal Health Device (PHD) Working Group (PHD WG). Nevertheless, some recent specializat...

eOphthalmology can be defined as the use of information and telecommunications technologies to provide or support a group of activities related to ophthalmic care. The same concept applied to ophthalmic care would be eOphthalmology. This paper describes the current state of eOphthalmology-based models in diabetic retinopathy screening and in the di...

This paper presents a novel generic translinear differential output stage that is useful for the implementation of rational functions with a squared denominator. As a proof of concept, such output stage is used to implement the first derivative of a rational activation function. Simulated results are presented for an implementation on a 0.35 µm CMO...

In this work, a novel ambulatory ECG monitoring device developed in-house called HOLTIN is analyzed when operating in complex indoor scenarios. The HOLTIN system is described, from the technological platform level to its functional model. In addition, by using in-house 3D ray launching simulation code, the wireless channel behavior, which enables u...

This project aimed at designing and developing a system for following-up cardiovascular patients integrating a social media (Twitter) and a healthcare communications standard (HL7 v2.x). Two applications - an android-based tool for gathering and tweeting vital cardiovascular signs and a Java-based desktop tool for receiving and parsing the informat...

The evolution of the Point-of-Care (POC) to home hospitalization brings the Mobile POC approach consisting of several portable medical devices and a mobile system with 3rd Generation (3G) connectivity. Plug-and-play is a desired feature in Mobile POC applications. This paper presents a new interoperable plug-and-play Electrocardiogram (ECG) recorde...

Hospitals and health care systems usually need to install appropriate, ad-hoc software in every computer that requires access to an electrocardiogram (ECG). Other solutions provide the ECGs as images, hindering thereby advanced features. One step beyond is the use of applets, which provide a richer web environment, but this still requires additiona...

e-Ophthalmology is the use of information and telecommunications technologies to provide or support a group of activities related to ophthalmic care. Chronic glaucoma is an ocular disease characterized by optic neuropathy that leads to progressive loss of the visual fields and often is associated with elevated intraocular pressure levels. Glaucoma...

Diabetic retinopathy (DR) is the leading cause of visual loss in people aged 30 to 69 years. Most authorities recommend screening of the ocular fundus to prevent severe visual loss. The increasing incidence of diabetes mellitus and fewer ophthalmologists in many countries is leading to inadequate screening. Establishing an adequate system for DR sc...

Traditional fields in health delivery such as chronic diseases or independent aging are evolving to novel healthcare applications like intra-hospital ecosystems and Neonatal Intensive Care Units (NICUs). Furthermore, emerging trends in Information and Communication Technologies (ICTs) and evolution of the Medical Devices (MDs) to Personal Health De...

As health care becomes distributed and wireless (home monitoring, M-Health, AmI), system interoperability becomes a challenge. The solution seems to be to use international health informatics standards. Among these, ISO/IEEE 11073 (X73PHD) is the best suited for interoperability of Personal Health Devices (PHDs). Nevertheless, given that low cost,...

Emerging technologies enable new health delivery services based on Ambient Intelligence (AmI) concepts, Ubiquitous Health (U-Health) paradigm, and patient empowerment. However, these services show several drawbacks, being the lack of standardization one of the most important. The under development ISO/IEEE 11073 for Personal Health Devices (X73PHD)...

Diabetic retinopathy (DR) is the leading cause of visual loss in people aged 30 to 69 years. Most authorities recommend screening of the ocular fundus to prevent severe visual loss. The increasing incidence of diabetes mellitus and fewer ophthalmologists in many countries are leading to inadequate screening. Establishing an adequate system for DR s...

The aim of this chapter is to describe the establishment of, and our 3-year experience with, a model of diabetic retinopathy (DR) screening by general practitioners (GPs) using nonmydriatic retinography. We describe the training program developed to instruct the participating GPs in the interpretation of digital retinographies of patients with diab...

To ascertain in real practice the diagnosis rate of diabetic retinopathy (DR) in patients considered to have positive screening test by general practitioners (GPs) and what are the reasons for the false positive diagnosis. Four GPs previously instructed in the interpretation of retinal photographs evaluated the digital retinography images of patien...

Traditional fields in health delivery such as chronic diseases or independent aging are evolving to novel healthcare applications like intra-hospital ecosystems and Neonatal Intensive Care Units (NICUs). Furthermore, emerging trends in Information and Communication Technologies (ICTs) and evolution of the Medical Devices (MDs) to Personal Health De...

Traditionally, e-Health solutions were located at the point of care (PoC), while the new ubiquitous user-centered paradigm draws on standard-based personal health devices (PHDs). Such devices place strict constraints on computation and battery efficiency that encouraged the International Organization for Standardization/IEEE11073 (X73) standard for...

Recent advances and continuous innovations in Information and Communication Technologies (ICTs) are bringing new opportunities to biomedical engineering and healthcare applications. Their most interesting advantages are being achieved to interoperability of Medical Devices (MDs) and Personal Health Devices (PHDs), and standard-based design focused...

This paper presents the solution to the mathematical problem of obtaining maximally flat transconductances with transconductors of multiple coupled asymmetric differential pairs. This problem has remained unresolved until now and this solution provides an extremely fast an easy way to obtain the transistor asymmetries and tail current factors. Gene...

In this paper several approaches to implement the ISO/IEEE11073 interoperability standard into personal health devices using low-voltage low-power (LV-LP) microcontrollers are proposed. The patterns methodology previously suggested by the authors is followed in all of the approaches which include an 1-process implementation using non-blocking funct...

Resumen En este artículo se presentan diferentes formas de implementar el estándar ISO/IEEE11073 en dispositivos de salud personal con requerimientos de bajo consumo de potencia. Para ello se aplica la metodología de patrones planteada por los autores previamente proponiendo cuatro posibilidades de implementación: una implementación basada en un so...

We evaluated tele-ophthalmology for diabetic retinopathy screening in a primary care setting. Four general practitioners (GPs) were taught to assess non-mydriatic retinography images of patients with diabetes. After training, a total of 1223 patients were screened using this method: 926 (76%) did not have diabetic retinopathy and 297 (24%) were ref...

The ISO/IEEE 11073 (x73) family of standards is a reference frame for medical device interoperability. A draft for an ECG device specialization (ISO/IEEE 11073-10406-d02) has already been presented to the Personal Health Device (PHD) Working Group, and the Standard Communications Protocol for Computer-Assisted ElectroCardioGraphy (SCP-ECG) Standard...

The ISO/IEEE 11073 (x73) family of standards is a reference frame for medical device interoperability. A draft for an ECG device specialization (ISO/IEEE 11073-10406-d02) has already been presented to the Personal Health Device (PHD) Working Group, and the Standard Communications Protocol for Computer-Assisted ElectroCardioGraphy (SCP-ECG) Standard...

The new paradigm of personal health demands open standards and middleware components that permit transparent integration and end-to-end interoperability from new personal health devices to healthcare information system. The use of standards seems to be the internationally accepted way to face this challenge. In this article, the implementation of a...

The new paradigm of e-Health demands open sensors and middleware components that permit transparent integration and end-to-end interoperability of new personal health devices. The use of standards seems to be the internationally adopted way to solve these problems. This paper presents the implementation of an end-to-end standards-based e-Health sol...

La eSalud se puede definir como el uso de las tecnologías de la información y las comunicaciones para proporcionar o apoyar un diverso grupo de actividades relacionadas con la atención en salud. Si este concepto se traslada a la atención oftalmológica sería lo que denominamos como eOftalmología. En este artículo se describe el estado actual de los...

This paper presents a novel implementation methodology of ISO/IEEE11073 standards for use in real monitoring platforms based on patterns paradigm. These monitoring platforms include several medical devices based on low voltage-low power microprocessors. As a proof of the concept, INTENSA project which aims to develop and evaluate a heart failure fo...

The storage and retrieval of digital ECGs in a standard-compliant way has been a key issue during the last decades. The SCP-ECG standard, one of the top efforts in this area, has been recently approved as part of the ISO/IEEE 11073 (x73) family of standards, a reference standard for medical device interoperability. For the Personal Health Device (P...

Resumen Hoy en día, en el diseño de los nuevos sistemas de información aplicados a la salud resultan aspectos clave los paradigmas de interoperabilidad y estandarización. Para los dispositivos médicos, esto puede conseguirse mediante los estándares internacionales de interoperabilidad. En ese campo, la familia de estándares ISO/IEEE 11073 (x73) es...

Resumen Durante las últimas décadas se han desarrollado y estandarizado una amplia variedad de protocolos de almacenamiento y transmisión de señales electrocardiográficas. El estándar SCP-ECG, que representa uno de los esfuerzos más importantes en este ámbito, ha sido incorporado recientemente a la familia de estándares ISO/IEEE 11073 (x73), estánd...

Interoperability among medical devices and compute engines in the personal environment of the patient, and with healthcare information systems in the remote monitoring and management process is a key need that requires developments supported on standard-based design. Even though there have been some international initiatives to combine different st...

Recent advances in biomedical engineering and continuous technological innovations in last decade are promoting new challenges, especially in e-Health environments. In this context, the medical devices interoperability is one of the interest fields wherein these improvements require a standard-based design in order to achieve homogeneous solutions....

This paper presents a novel non-linear neural activation function architecture that approximates the tanh(nx) function accurately. The purpose of this realization is the description of a circuit that can be designed to obtain different slopes at the origin of the activation function. The special features of transistors working in the subthreshold r...

This brief presents two novel architectures, i.e., a nonlinear neural activation function and its derivative. Both are suitable for implementations of neurons in multilayer perceptron networks with an on-chip backpropagation learning algorithm. The activation function proposed shows minimal area and power consumption, can be considered as an approx...

Advances in Information and Communication Technologies, ICT, are bringing new opportunities in the field of interoperable and standard-based systems oriented to ubiquitous environments and wearable devices used for digital homecare patient telemonitoring. It is hoped that these advances are able to increase the quality and the efficiency of the car...

There is a need to develop open sensors and middleware components that allow transparent integration and plug-and-play interoperability of Medical Devices (MDs) and Computer Engines (CEs). The use of standards seems to be the internationally adopted way to solve these problems and allow implementing ubiquitous solutions, including wearable devices,...

Continuous technological innovations are bringing new opportunities to healthcare applications. Although these improvements apply to most of its different fields, outstanding results are being achieved in medical devices interoperability, oriented to ubiquitous solutions including wearable devices, focused to the new paradigm of Personal Health (p-...

To assess the extent of agreement in the evaluation of non-mydriatic retinographies of diabetic patients among ophthalmologists and a group of primary care physicians with previous training. The study was divided in two phases. In the first phase, the four participants were instructed in the interpretation of retinographies. The second phase involv...

Purpose: To assess the extent of agreement in the evaluation of non-mydriatic retinographies of diabetic patients among ophthalmologists and a group of primary care physicians with previous training. Methods: The study was divided in two phases. In the first phase, the four participants were instructed in the interpretation of retinographies. The s...

Advances in information and communication technologies, ICT, are bringing new opportunities in the field of middleware systems oriented to ubiquitous environments and wearable devices used for patient telemonitoring. At a time of such challenges, this paper arises from the need to identify robust technical telemonitoring solutions that are both ope...

This paper explains the challenges encountered during the ISO/IEEE 11073 standard implementation process. The complexity of the standard and the consequent heavy requirements, which have not encouraged software engineers to adopt the standard. The developing complexity evaluation drives us to propose two possible implementation strategies that cove...

This paper presents a novel topology that implements an accurate approximation to the tanh (x) function. This approximation works in current mode and uses transistors in the subthreshold region of operation minimising power consumption and occupied area. Moreover, it has been designed with fully differential and balanced topologies so that the exte...

A proof-of-concept design of a patient monitoring solution for intensive care unit environments has been presented. It is end-to-end standard-based, using ISO/IEEE 11073 (X73) in the bedside environment and EN13606 to communicate the information to an electronic healthcare record (EHR) server. At the bedside end, the system is a plug-and-play senso...

This article describes the optimization of a patient telemonitoring platform based on the ISO/IEEE11073 (X73) standard to enable medical device interoperability. In order to achieve this, principal advantages and remaining improvements are evaluated to include in further upgrades towards the new profile evolution, oriented to ubiquitous environment...

Advances in Information and Communication Technologies, ICT, are bringing new opportunities and use cases in the field of systems and Personal Health Devices used for the telemonitoring of citizens in Home or Mobile scenarios. At a time of such challenges, this review arises from the need to identify robust technical telemonitoring solutions that a...

Remote patient monitoring in e-Health is everyday closer to be a mature technology / service. However, there is still a lack of development in areas such as standardization of the sensor's communication interface, integration into Electronic Healthcare Record systems or incorporation in ambient-intelligent scenarios. This work identifies a set of u...

This paper presents a proof-of-concept design of a patient monitoring solution for Intensive Care Unit (ICU). It is end-to-end standards-based, using ISO/IEEE 11073 (X73) in the bedside environment and EN13606 to communicate the information to an Electronic Healthcare Record (EHR) server. At the bedside end a plug-and-play sensor network is impleme...