
Luis Gonzalo Sequeda-CastañedaPontifical Xavierian University · Department of Chemistry
Luis Gonzalo Sequeda-Castañeda
Chemist. MSc. PhD Candidate
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71
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Introduction
Additional affiliations
Education
January 2014 - December 2019
January 2010 - January 2010
September 2007 - September 2007
Publications
Publications (71)
Essential oils (EOs) have unique properties, such as antibacterial, antioxidant, and antiviral activities, which are beneficial in various industries, including cosmetics, food, and pharmaceuticals. In this study, the antioxidant and antimicrobial activities of Pentacalia vaccinioides EOs obtained from leaves and flowers (fresh and dried plant mate...
Essential oils (EOs) have unique properties, such as antibacterial, antioxidant, and antiviral activities, which are beneficial in various industries, including cosmetics, food, and pharmaceuticals. In this study, the antioxidant and antimicrobial activities of Pentacalia vaccinioides EOs obtained from leaves and flowers (fresh and dried plant mate...
Background: Amelogenesis imperfecta is a hereditary disorder affecting dental enamel. Among its phenotypes, Hypocalcified AI is characterized by mineral deficiency, leading to tissue wear and consequently dental sensitivity. Excessive fluoride intake (through drinking water, fluoride supplements, toothpaste, or by ingesting products such as pestici...
The genus Ocotea of the Lauraceae family has species whose wood is employed in construction and for other purposes including as biofuel, for disinfection, cosmetics, and in the treatment of various diseases. Studies regarding Ocotea caudata’s phytochemical and pharmacognostic uses are scarce, thus, this work is the first to study its fruits. O. cau...
Background: Conventional periodontal therapy relies on bone regeneration strategies utilizing scaffolds made of diverse materials, among which collagen, to promote cell adhesion and growth. Objective: To evaluate periodontal ligament fibroblast (HPdLF) cell adhesion and viability for periodontal regeneration purposes on hydroxyapatite scaffolds con...
Dental caries is an infectious process that results in tooth decay, where Streptococcus mutans is considered the main causing agent. An alternative which might prevent or control this disease is to identify microorganisms with S. mutans antagonistic potential. This study, encompassed within an Oral Microbial Ecology approach had as an objective to...
Lipid peroxidation, protein oxidation, and mutations in mitochondrial DNA generate reactive oxygen species (ROS) that are involved in cell death and inflammatory response syndrome. ROS can also act as a signal in the intracellular pathways involved in normal cell growth and homeostasis, as well as in response to metabolic adaptations, autophagy, im...
Objective
To determine if native Colombian Piper marginatum Jacq. and Ilex guayusa Loes plant extracts have a remineralizing effect on teeth with Amelogenesis imperfecta in comparison with the commercial products Clinpro-3M and Recaldent™.
Material and Methods
An in vitro study was carried out with 128 human teeth slices (64 healthy and 64 with Am...
Anacardium excelsum is a tree between 15 and 50 meters high, with a thick trunk and is present in some departments of Colombia. Its nut-shaped fruits were used in the old Upar Valley by natives (Valledupar) to make Caracolí bread. Most research has been done at the forest level, but there are few phytochemical and biological activity studies. This...
Hydroxyapatite (HAp) is the most commonly used biomaterial in modern bone regeneration studies because of its chemical similarity to bone, biocompatibility with different polymers, osteoconductivity, low cost, and lack of immune response. However, to overcome the disadvantages of HAp, which include fragility and low mechanical strength, current stu...
Ginger is a plant that is native to southern China. In the last decade and research on the components of ginger has significantly increased; of these components, 6-shogaol exhibits the greatest potential antitumor capacity. However, the molecular mechanism through which 6-shogaol exerts its effects has not yet been elucidated. In this study, the ef...
One of the main focuses of tissue engineering is to search for tridimensional scaffold materials, complying with nature's properties for tissue regeneration. Determining material biocompatibility is a fundamental step in considering its use. erefore, the purpose of this study was to analyze osteoblast cell adhesion and viability on different materi...
The graphic abstract is included and is titled “SEM micrographs of structure and the CFM (confocal fluorescent Microscopy) images of cell viability, on different scaffolds after 7 days of osteoblastic cells culture.”
Berberis goudotii is an endemic Colombian plant found in the paramo ecosystem. It has been used in food preparation and as a medicinal plant for diverse treatments. Additionally, it is used as a mouthwash to strengthen the gums and combat throat irritations and periodontitis. The present research evaluated Berberis goudotii aerial parts extract and...
Debido al aumento de los defectos óseos en la población mundial por causas como accidentes, cáncer y enfermedades congénitas, entre otras, las investigaciones de nuevos materiales y técnicas para la recuperación del tejido óseo perdido apuntan al uso de la ingeniería de tejidos. El éxito de esta técnica radica, principalmente, en la elaboración, el...
Background:
Chronic periodontitis is a multifactorial infectious disease, where multiple bacteria, such as Porphyromonas gingivalis, Prevotella intermedia, and Fusobacterium nucleatum are implicated. The main purpose of researching natural products is to find substances or compounds with antimicrobial activity.
Aim:
The objective of this work wa...
The bio-flocculants used in this study were synthesised by the Mannich reaction, which includes three reagents: a substrate (tannin extracts of Acacia, Quebracho, and Castanea), formaldehyde, and an amine derivative (ethanolamine, diethanolamine, ammonium chloride). Nine natural flocculants were prepared by combining extracts and amines; these prod...
The use of hen egg-shell as calcium biogenic source for hydroxyapatite obtention (Egg-Shell-Hydroxyapatite ES-HAp) has become relevant for development of biomaterials for tissue engineering. Platelet-rich fibrin (PRF) and platelet-rich plasma (PRP) have also been used as growth factors sources to enhance regenerative processes. Even though the comb...
Context: Essential oils (EO) are commonly extracted from plants by steam distillation in which an aqueous phase called hydrosol (HD) is obtained. Unlike EO, hydrosol studies have been limited despite the interest of the food, cosmetic and phytotherapeutic industries to find natural preservative alternatives to synthetic ones. Aims: To evaluate the...
Zingiber officinale is a type of Ginger used for the treatment of reactive oxygen species (ROS) associated diseases. Reports describe its use in cellular models, such as pancreatic and intestinal cancer cell lines. However, the biochemical bases of antitumor, anti-inflammatory and antioxidant activities have not yet been fully elucidated. The aim o...
Foods, medicines and cosmetics, among other industrial products, require additives type antioxidants to maintain the useful life and thereby prevent oxidative deterioration. Currently the development of new products requires natural additives from fruits, herbs and vegetables [1]. In this work the antioxidant capacity was evaluated and preliminary...
The increase in resistance to antibiotics by some bacteria, can look for other alternatives in the treatment of diseases caused by some pathogenic commensal organisms These alternatives have increased in recent years with studies of different plants with therapeutic and anti microbial properties Taking into account that there are few studies of the...
Neurodegenerative conditions such as Alzheimer's disease, Parkinson's disease and amyotrophic lateral sclerosis are characterized by having a significant increase in oxidative stress that can lead to the cellular damage of both neurons and astrocytes. Therefore, the search for molecules that can modulate oxidative stress in these diseases has recen...
Leukemia is one of the most common malignancies in children and represents a challenge to increase life
expectancy. Many studies have been conducted with the aim to find natural compounds to fight cancer;
however, chemotherapy is still the most widely used treatment despite side effects as harmful to patients. In this paper the antioxidant and cyto...
Hybrid palm oil obtained from interspecific hybrid Elaeis oleifera x Elaeis guineensis palm (HPO) has been recently proved to have a favorable impact on human plasma lipids related to cardiovascular disease risk factors. In the present work, we describe for the first time, the functional effect of crude HPO supplementation on human antioxidant plas...
Given the lack of knowledge in Cecropia mutisiana Mildbr phytochemical and pharmacological properties, the objective of this work was to determine the plants antioxidant and antimicrobial capabilities, taking into account its wide use by Colombian communities. For this study Rosmarinus officinalis Govaerts extracts were used as experimental standar...
Ilex guayusa Loes (Aquifoliaceae) is native to the Andean Amazon (Colombia, Ecuador, and Perù) commonly known as guayusa. From ancestral times up to today Guayusa has been employed by indigenous and urban communities as a herbal infusion, for the treatment of diabetes, infertility, or venereal diseases. As an antiinflammatory, diuretic or energizin...
Cancer stem cells (CSC) are the primary cell type responsible for metastasis and relapse. ABC-transporters are integral membrane proteins involved in the translocation of substrates across membranes protecting CSC from chemotherapeutic agents. A plant extract derived from C. spinosa (P2Et) previously investigated for its antitumor activity has been...
Pentacalia nitida and Pentacalia corymbosa are plant species present in the Colombian páramo regions moorland areas of the Andes Mountains. These plants are employed in popular medicine as an alexiteric, in
edemas or to treat lesions, pharyngitis, sore throat, as a disinfectant, as a scar forming agent, and to alleviate other affections of the skin...
Resumen: La capacidad antioxidante y la actividad antimicrobiana que presentan algunas especies botánicas, permiten ser ampliamente aplicadas en la industria; ya que las sustancias químicas derivadas de estas pueden brindar la oportunidad de encontrar principios activos [1]. La búsqueda de alternativas antimicrobianas contra bacterias aerobias y an...
The consumption of foods high in natural antioxidants, like fruits and vegetables, is associated with a lower risk of oxidative stress-related diseases. The aim of this study was to establish the relationship between the plasma antioxidant capacity in adults over fifty and their intake of vitamin A, C, and E. We evaluated 118 24-hour recalls of int...
Berberis rigidifolia is a plant commonly known as espino, espuelo, espino de oro and tachuelo in Colombia. Berberis rigidifolia is known for various medicinal properties in traditional medicinal and use to cure a variety of diseases. The plant is reported to treat amebiasis, diarrhea, uterine bleeding, mouth irritations, sore throats, laxative, cut...
En la actualidad la enfermedad periodontal es considerada la segunda enfermedad oral con mayor prevalencia en la población mundial y la principal causa de perdida de las estructuras de soporte dental que en algunos casos conduce a pérdidas dentales en la población adulta 1. Esta patología infecciosa es producida principalmente por bacterias Gram-ne...
Hombres, animales y plantas están expuestos a microorganismos patógenos causando enfermedades en todo el mundo. Medicamentos sintéticos son usados contra patógenos, sin embargo éstos pueden tener efectos secundarios negativos en los organismos hospederos. Por otro lado, los microorganismos, por su rápido y constante ciclo de vida, tienen gran capac...
Polyphenol compounds from plants have antioxidant activity because of their capacity of decrease the reactive oxidative species (ROS). Therefore, the search of new plant extracts containing polyphenols has been a priority of pharmaceuticals and research institutions. In this work we assessed the antioxidant activity and total phenol content in meth...
Piper marginatum is a neotropical native plant found from Guatemala to Brazil including the Caribbean. This
species is known for its healing properties in traditional medicine. It is employed for treating inflammation,
malaria, wound healing, snakebites, pathologies related to bile or liver, dental caries, as a diurectic,
sudoriferous agent, haemos...
Baccharis latifolia is a plant commonly known in South America as " Chilca ". B. latifolia has several curative properties reported in traditional medicinal such as analgesic, treat diarrhea, vulnerary, resolvent, flatulence, heartburn, antidiabetic and in the treatment of inflammation, stomach pain and insomnia. The medicinal properties of this pl...
Two procedures of steam distillation of Rosmarinus officinalis and Thymus vulgaris were
compared by phytochemical, antioxidant and antimicrobial analysis of their respective essential
oils and hydrosols using respectively GCFID and GCMS analysis, free radical scavenging activity
on ABTS and dilution and diffusion method against 3 bacteria and 2 fun...
Two procedures of steam distillation of Rosmarinus officinalis and Thymus vulgaris were
compared by phytochemical, antioxidant and antimicrobial analysis of their respective essential
oils and hydrosols using respectively GCFID and GCMS analysis, free radical scavenging activity
on ABTS and dilution and diffusion method against 3 bacteria and 2 fun...
Cecropia mutisiana is known in traditional medicine for its diverse medicinal properties. Thus, it is used to cure a varied gamut of diseases. In Colombia Cecropia mutisiana is a plant commonly known as agrumo, calentano, guarumo, orumo, or yarumo. Among its different medicinal properties this plant is used to treat mild respiratory diseases includ...
Piper calceolarium is a plant traditionally used in different country such as Colombia for the treatment of pain
(Bernal et al., 2011). Despite its extensive use in traditional medicine, the mechanism by which Piper calceolarium
exerts its anti-nociceptive action has not been fully characterized. One of the pathways involved in
nociception, compris...
Post-harvest losses in tomato crops can be accredited to a number of causes, which include biological causes that produce physiological deterioration; infection caused by diseases and pests that cause rotting. In this study, we assayed, in vitro and in vivo, the yeast Candida guilliermondii to determine its effectiveness as a biocontrol to reduce t...
Mortars from Bogotá, Villa de Leyva and Barichara were compared chemically and microbiologically. We analyzed the samples using atomic absorption and emission spectrometry, Fourier-transform infrared spectroscopy, X-ray diffraction, scanning electron microscopy and energy dispersive spectroscopy. Oxides of silicon, aluminum, calcium, iron, magnesiu...
Diversity of pathogenic microorganisms overcomes the defenses of animals, plants, and humans, causing severe diseases. The use of traditional antibiotics may have negative secondary effects on organisms and the environment. Therefore, we must search for new alternatives in plants that contain antimicrobial compounds, such as flavonoids, bioflavonoi...
The method by which to obtain Hydroxyapatite to be used as bone substitute should offer specific qualities such as, high purity, performance, low cost and has to be the following, bioactive, biocompatible, it has to have osteoconductivity and it has to bond directly to the bone. In this paper, synthetic HAp was prepared using 3 different methods re...
The search for elaborate tridimensional scaffolds materials with high mechanical stability, which can adapt to the surgical site, allow oseointegration and degrade rapidly, are more often needed factors for the regeneration of bone tissue. Objective: Analyze the osteoblastic growth capability over different materials to determine which of all is th...
Anacardium excelsum is a plant native to the tropics which belongs to the Anacardiaceae family, known in Colombia under the name Caracolí and used widely in the forestry industry. Secondary metabolites have been reported primarily phenolic compounds with biological activities as antioxidant. In this study, were obtained ethanol extracts of three...
Polyphenols are secondary metabolites with antioxidant properties and are abundant in the diet. Fruits, vegetables, herbs, and various drinks (tea, wine, and juices) are all sources of these molecules. Despite their abundance, investigations into the benefits of polyphenols in human health have only recently begun. Phenolic compounds have received...
Frutos de interés comercial como la uva isabella (Vitis labrusca) y el agraz (Vaccinium meridionale) son ricos en polihidroxifenoles conocidas moléculas con potencial antioxidante. El consumo
de estas frutas se ha relacionado con efectos benéficos a nivel celular y por tanto en la prevención de diversas patologías como el cáncer y las neurodegenera...
In this study, we evaluated the antimicrobial activity of secondary metabolites presents in extracts and fractions of Anacardium excelsum (Anacardeaceae), using agar well diffusion assay and bioautography. As a general result was determined that Anacardium excelsum has good antimicrobial activity against gram positive microorganisms. Regarding the...
Tradicionalmente, los pañetes son recubrimientos del muro cuya función principal es la de
protegerlo contra los efectos del clima u otros elementos externos que pueden ocasionar el
deterioro. Estos revestimientos han tenido una variada aplicación en arquitectura. Se han
empleado tanto en interiores como exteriores, en mamposterías expuestas al air...
High-resolution gas chromatography (HRGC) with electron-capture detection (ECD), nitrogen-phosphorus detection (NPD), flame ionization detection (FID) or with mass spectrometry-selected ion monitoring (MS-SIM) was used in the analysis of volatile carbonyl compounds. Eighteen carbonyl compounds that are typically produced during lipid peroxidation w...