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Pollution caused in soil and surface and groundwater by waste from mining activities is among the main environmental concerns at the Spanish, European and global levels. Between the different types of mining, metal mining is especially worrisome due to the dispersion of toxic metals such as Pb, Cd, Zn, As, Cu, etc. and the generation, from the oxidation of the pyrite waste, of the so-called acidic mine drainage (AMD). The E-BIORE2MIN Project proposes an innovative and sustainable approach to the solution of the environmental problem considered, since its objective is the development of novel combinations of biological and electrochemical technologies for the treatment of mine tailings (fine-grained mine waste) and AMD, focusing on the recovery of the resources contained therein, including metals and/or rare earth elements, reclaimed water, biomass and/or energy; that is, in line with the circular economy concept.