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Luís Pereira-da-Silva

Luís Pereira-da-Silva
NOVA Medical School | Faculdade de Ciências Médicas, Universidade NOVA de Lisboa

MD, PhD
- Pediatrician and Neonatologist - Professor of Pediatrics - Professor of Pediatric Nutrition

About

183
Publications
64,462
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889
Citations
Introduction
Associate Professor of Pediatrics, NOVA Medical School, Universidade NOVA de Lisboa; Pediatrician and Neonatologist, Hospital Dona Estefânia, Centro Hospitalar Universitário Lisboa Central (CHULC); Coordinator of the Nutrition Lab, Hospital Dona Estefânia, CHULC; Invited Coordinator Professor of Dietetics and Nutrition, Lisbon School of Health Technology, Portugal; Leader of the Nutrition and Health Promotion group of the Comprehensive Health Research Center.
Additional affiliations
September 2015 - present
NOVA Medical School | Universidade NOVA de Lisboa
Position
  • Professor (Associate)
Description
  • Regent Professor of "Introduction to Pediatrics and Health in Adolescence" of the Integrated Master's degree in Medicine Regent Professor of "Maternal and Pediatric Nutrition" of the Bachelor's degree in Nutrition Sciences
September 2010 - May 2021
Lisbon School of Health Technology | Lisbon Polytechnic Institute
Position
  • Professor (Associate)
Description
  • Professor of Dietetics and Nutrition
September 2009 - April 2021
Centro Hospitalar Universitário de Lisboa Central
Position
  • Manager
Description
  • Research unit assisting six tertiary hospitals belonging to Centro Hospitalar Universitário de Lisboa Central
Education
August 2020 - January 2021
Universidade NOVA de Lisboa
Field of study
  • Pediatrics
June 2007 - June 2007
NOVA Medical School, NOVA University of Lisbon, Portugal
Field of study
  • Ph.D.
June 2006 - June 2006
NOVA Medical School, NOVA University of Lisbon, Portugal
Field of study
  • Educational and Scientific Qualification (Aptidão Pedagógica e Capacidade Científica)

Publications

Publications (183)
Article
Full-text available
Intrauterine growth restriction (IUGR) may predispose metabolic diseases in later life. Changes in fat-free mass (FFM) and fat mass (FM) may explain this metabolic risk. This review studied the effect of IUGR on body composition in early infancy. Five databases and included studies from all countries published from 2000 until August 2021 were searc...
Article
Full-text available
The first 1000 days of life are very sensitive to any event that alters health programming, and they represent a window for intervention to improve population health. Pregnant women, fetuses, and infants are particularly vulnerable to exposure to food contaminated with mycotoxins. This review aimed to gather data from the literature on mycotoxins e...
Chapter
Full-text available
Mesmo que as estratégias ventilatória e antimicrobiana praticadas numa unidade de cuidados intensivos neonatais sejam de excelência, a qualidade assistencial praticada nestas pode considerar-se de citária se não for dada a devida atenção ao suporte nutricional. MENU
Article
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Bronchopulmonary dysplasia (BPD) remains the most common severe complication of preterm birth, and nutrition plays a crucial role in lung growth and repair. A practical nutritional approach for infants at risk of BPD or with established BPD is provided based on a comprehensive literature review. Ideally, infants with BPD should receive a fluid inta...
Article
Full-text available
Objective The study aimed to assess the association between intrauterine growth of preterm infants and energy and macronutrient contents in their mothers' milk. Study Design A historical cohort of mothers of preterm infants was assessed according to offspring's intrauterine growth. Fetal growth restriction (FGR) was defined as small-for-gestational...
Article
Full-text available
Adequate nutrition of very preterm infants comprises fortification of human milk (HM), which helps to improve their nutrition and health. Standard HM fortification involves a fixed dose of a multi-nutrient HM fortifier, regardless of the composition of HM. This fortification method requires regular measurements of HM composition and has been sugges...
Article
Context Mitchell Riley syndrome (MRS) due to RFX6 gene mutations is characterized by neonatal diabetes and protracted diarrhea. RFX6 gene encodes a transcription factor involved in enteroendocrine cell differentiation required for beta-cell maturation. In contrast to the pathway by which RFX6 mutations leads to diabetes, the mechanisms underlying p...
Article
Full-text available
This cohort study describes the evolution of resting energy expenditure (REE), respiratory quotient (RQ), and adiposity in infants recovering from corrective surgery of major congenital gastrointestinal tract anomalies. Energy and macronutrient intakes were assessed. The REE and RQ were assessed by indirect calorimetry, and fat mass index (FMI) was...
Article
Full-text available
The growth charts and reference values for preterm infants are revisited and recommendations for their use updated by the Portuguese Neonatal Society. To assess intrauterine growth: The cross-sectional sex specific Fenton 2013 charts, based on birth weight, length and head circumference, are the most appropriate. Neonates born with weight < 3rd pe...
Article
Full-text available
Introduction: The gut microbiota plays a main role in the maintenance of host's health. Exposure to different conditions in early life contributes to distinct 'pioneer' bacterial communities in the intestine, which shape the newborn infant development. Newborn infants with congenital malformations of the gastrointestinal tract (CMGIT), necrotising...
Article
Full-text available
A practical approach for nutritional assessment in preterm infants under intensive care, based on anthropometric measurements and commonly used biochemical markers, is suggested. The choice of anthropometric charts depends on the purpose: Fenton 2013 charts to assess intrauterine growth, an online growth calculator to monitor intra-hospital weight...
Article
Full-text available
This update of guidelines for neonatal PN prescription is divided in two parts: - Part I, included in the same issue of the journal, in which general aspects and criteria for fluids, energy, and macronutrients prescriptions, particularly for very and extremely preterm infants, are reviewed. - Part II, herein included, in which criteria for micronu...
Article
Full-text available
Objective: To determine associations between sex and neurodevelopmental outcomes in human milk-fed very preterm infants, adjusted to early measured nutrient intakes and other neonatal cofactors. Methods: Consecutive inborn human milk-fed infants, with gestational age <33 weeks, were eligible. In-hospital energy and protein intakes have relied on...
Article
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This birth cohort study compared the infant growth curve estimates in São Tomé Island to the WHO growth standards. Despite this island belonging to a lower-middle-income country, there were several factors favorable for growth that were present. Four-hundred and seventy-five full-term singleton appropriate for-gestational-age infants were enrolled...
Article
Full-text available
Introduction: Breastfeeding has unique health benefits. Exclusive breastfeeding is recommended during the first six months of life and should be maintained during complementary feeding. Alternatively, infant formulas, which are designed to mimic human breastmilk to promote similar metabolic and growth profiles, can be used. This study aimed to ass...
Thesis
This primary objective of this study was to determine the evolution of resting energy expenditure (REE) and respiratory quotient (RQ) in term and preterm newborn infants undergoing corrective surgery of congenital malformations of the gastrointestinal tract. The secondary objective was to determine factors associated with the evolution of REE and R...
Article
Full-text available
Background To achieve recommended nutrient intakes in preterm infants, the target fortification method of human milk (HM) was proposed as an alternative to standard fortification method. We aimed to compare assumed energy and macronutrient intakes based on standard fortified HM with actual intakes relying on measured composition of human milk (HM),...
Thesis
Background In very preterm infants, adequate early nutritional support is of utmost importance for the quality of growth and neurodevelopmental outcomes in the short-, medium- and long-term. Human milk (HM) has well-known advantages over infant formulas, including for brain development. Objectives To determine, in a homogeneous sample of HM-fed ver...
Article
Full-text available
The associations between enteric pathogenic parasites and growth in infants in São Tomé were explored using a refined anthropometric approach to recognize early growth faltering. A birth cohort study was conducted with follow-up to 24 months of age. Microscopic examination for protozoa and soil-transmitted helminths was performed. Anthropometric as...
Thesis
Background Giardia lamblia, Cryptosporidium and Entamoeba hystolitica are prevalent etiologic agents of enteric infections in infants from low- and middle-income countries. Host-parasite interactions may lead to mucosal inflammatory response and increased intestinal permeability. Clinically this can result in a negative impact on growth and neurode...
Article
Full-text available
Objective To determine the associations of measured protein, energy, and protein-to-energy (PER) intakes with body composition in human milk (HM)-fed preterm infants. Study Design Neonates born at < 33 gestational weeks were eligible. Standard fortification method with modular supplements was used and the HM composition was measured. The weight gai...
Article
Full-text available
The prevalence of childhood overweight and obesity has increased in most countries the last decades. Considering this in a simplistic way, we can say that obesity is the result of an imbalance between energy intake and energy expenditure. Moreover, the environment from conception to childhood could influence the child’s future health. The first 100...
Article
Full-text available
Observational cross-sectional study carried out in a pediatric neurodevelopment unit of a tertiary-care hospital. A sample of 355 children with median ((min.-max.) 1.0-17.3) years with intellectual disability (30.4% borderline, 43.1% mild, 19.7% moderate, 5.1% severe, and 1.7% profound disability) was seen over a period of 3 years. Based on clinica...
Article
Full-text available
Introduction: The resting energy expenditure (REE) evolution after liver transplantation is not fully understood. Objective: To assess longitudinally the REE evolution in adults undergoing liver transplantation, in association with other nutritional measurements that characterize the metabolic profile. Methods: A single-center cohort of consec...
Article
Background Cholestasis is a common complication in infants receiving prolonged parenteral nutrition (PN). We studied the effects of two intravenous lipid emulsions composed with either 30% soybean oil, 30% medium-chain triglycerides (MCT), 25% olive oil, and 15% fish oil (SMOF) or with 50% MCT and 50% soybean oil n-6 (MCT/SOY) on the incidence of c...
Article
The cumulative effect of repeated asymptomatic enteric infections on intestinal barrier is not fully understood in infants. We aimed to evaluate the association between previous enteric parasitic infections and intestinal inflammation and permeability at 24-months of age, in asymptomatic infants of São Tomé Island. A subset of infants from a birth...
Article
Full-text available
Growth and development are key characteristics of childhood and sensitive markers of health and adequate nutrition. The first 1000 days of life—conception through 24 months of age—represent a fundamental period for development and thus the prevention of childhood obesity and its adverse consequences is mandatory. There are many growth drivers durin...
Article
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Introduction: Portuguese population is drifting away from the Mediterranean diet-like pattern. In this context, the current nutritionalstatus of women of childbearing age and of pregnant Portuguese women and their growing fetuses is critically reviewed. Material and methods: A narrative critical review was performed on recent published high qual...
Article
Full-text available
Objective: An early and accurate recognition of success in treating obesity may increase the compliance of obese children and their families to intervention programs. This observational, prospective study aimed to evaluate the ability and the time to detect a significant reduction of adiposity estimated by body mass index (BMI), percentage of fat m...
Article
Full-text available
http://www.mdpi.com/journal/ijerph/special_issues/prevent_obesity_1000_days The Mediterranean Nutrition (MeNu) Group are initiating a Project Collection on the pediatric obesity prevention in the first 1000 days of life. We have invited Prof. Dr. María M. Morales Suárez-Varela to serve as the Guest Editor of this Collection. The venue is a peer-rev...
Article
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Table of contents A1 Preterm and low birth weight nutrition in the first month life: implications for the outcome Massimo Agosti A2 Behind human milk and breastfeeding: not only food, not only growth Carlo Agostoni A3 To prevent obesity: importance and issues of cultural adaptation from weaning to 3 years of age Serge Chalons A4 Diet before and dur...
Article
Full-text available
Background: This study aimed to determine factors associated with body composition changes shortly after liver transplantation (LTx), including the influence of immunosuppressive agents. The combined resting energy expenditure (REE) and handgrip strength provided a valuable assessment in data interpretation of body composition. Methods: This obs...
Thesis
Background: The assessment of nutritional status in patients undergoing liver transplantation (LTx) should be comprehensive, accounting for the wide spectrum of the clinical and metabolic conditions. The metabolic disturbances related to liver disease may limit the precision and accuracy of traditional nutritional assessment methods underestimating...
Article
Full-text available
Objective: An early and accurate recognition of success in treating obesity may increase the compliance of obese children and their families to intervention programs. This observational, prospective study aimed to evaluate the ability and the time to detect a significant reduction of adiposity estimated by body mass index (BMI), percentage of fat...
Article
Introduction: Knowledge on the metabolic changes and nutritional needs during the postsurgical anabolic phase in infants is scarce. This analysis explores the associations of resting energy expenditure (REE) and macronutrient utilization with body composition of full-term infants, during catch-up growth after corrective surgery of major congenital...
Article
Full-text available
A novel RFX6 homozygous missense mutation was identified in an infant with Mitchell-Riley syndrome. The most common features of Mitchell-Riley syndrome were present, including severe neonatal diabetes associated with annular pancreas, intestinal malrotation, gallbladder agenesis, cholestatic disease, chronic diarrhea, and severe intrauterine growth...
Article
Full-text available
Very preterm infants (<32 weeks’ gestation) are at high risk for impaired skeletal development because of factors that limit the provision of extrauterine nutrients. Cumulative net deficiencies of calcium, phosphorus, docosahexaenoic acid (DHA), and arachidonic acid (ARA) are evident in these infants after prolonged administration of total parenter...
Article
We read with great interest the study by Moe et al. (1) that assessed the effect of different levels of parenteral phosphate and amino acids on the growth of preterm infants, using body weight as a surrogate for growth. In preterm neonates, optimal parenteral intakes of energy, amino acids and minerals are necessary during the first days after birt...
Conference Paper
Full-text available
Introduction: A new teaching-learning program of adolescent medicine was recently included in the medicine course at NOVA Medical School. A specific content was created mainly based on clinical and educational competences identified in the field with potential to provide qualified practical training. Objective: To evaluate the performance of a str...
Article
Full-text available
In the present update of the guideline on vitamins, minerals and trace elements by enteral route in newborn infants, special attention is paid to nutritional requirements of these micronutrients in term and preterm infants, intakes provided by mother’s milk, fortified human milk, infant formulas for term and preterm infants commercialized in Portug...
Chapter
Full-text available
Very premature infants are at an increased risk for metabolic bone disease because they forego the last trimester of pregnancy, the period of greatest mineral accretion. Most of these infants cannot tolerate full enteral feedings within the first postnatal days or weeks, and nutrients including calcium and phosphorus need to be delivered by parente...
Article
Objective: The adjusted effect of long-chain polyunsaturated fatty acid (LCPUFA) intake during pregnancy on adiposity at birth of healthy full-term appropriate-for-gestational age neonates was evaluated. Study design: In a cross-sectional convenience sample of 100 mother and infant dyads, LCPUFA intake during pregnancy was assessed by food frequ...
Thesis
INTRODUCTION: Knowledge on the metabolic changes and nutritional needs during the postsurgical anabolic phase in infants is scarce. This analysis explores the associations of resting energy expenditure (REE) and macronutrient utilization with body composition of full-term infants, during catch-up growth after corrective surgery of major congenital...
Article
Full-text available
Objective: To evaluate the practices of neonatal parenteral nutrition (PN) compounding in Portugal and the agreement to the recommendations from the Spanish Consensus on Compounding of Parenteral Nutrition Mixtures 2008. Methods: Survey based on an electronic questionnaire on PN preparation emailed, between July and October 2009, to the pharmaci...
Article
Full-text available
When using the useful 2013 Fenton Chart, data should be interpreted with caution taking into account two aspects: the physiologic loss of body water after birth for the weight curves, and the questionable accuracy of the birth length curves considering the heterogeneity and reliability of the methods used in the original measurements.
Article
The use of guidelines for neonatal parenteral nutrition (PN) improves its clinical efficiency and the safety of prescription. To evaluate the practices of neonatal parenteral nutrition prescription in Portugal, and the adherence to the National Consensus on neonatal PN (2008). A questionnaire based on a multiple choice response on parenteral nutrit...