Luis Arnoldo Ordoñez Vela

Fundación Interconectados

El presente artículo teórico se fundamenta en una revisión de la literatura relativa al deber ser de la universidad hispanoamericana, en particular la venezolana, en la actual coyuntura sociopolítica. Frente a un mundo globalizado, encontramos una universidad que maneja el conocimiento basada en características culturales que priorizan las relacion...

RESUMEN Venezuela ha perdido el 16% de su fuerza de investigación científica en los últimos años a través de la emigración. Este estudio utiliza BIBLIOS, una base de datos de publicaciones venezolanas, una encuesta y entrevistas abiertas, para indagar la relación entre los investigadores migrados y aquellos que han permanecido en el país. Se revisa...

Este artículo sintetiza los alcances y las implicaciones del foro invertido Movilización del conocimiento entre Universidad y Sociedad, desarrollado por la Fundación InterConectados (Venezuela). Este foro, inspirado en la clase invertida, es una estrategia apoyada en las TIC, concebido como un espacio para gestionar y movilizar conocimiento e infor...

Los foros invertidos InterConectados-AsoVAC son un espacio de debate y discusión mediado por las TIC, dirigidos a profesores universitarios para que compartan sus experiencias de investigación en servicio comunitario. Se estudió la evolución de los foros hasta llegar a la modalidad actual de foro invertido. Se siguió la metodología de estudio de ca...

This chapter focuses on the risk that, when citizen science is introduced in social environments different from those in the Global North where it originated, it may be subject to the error of providing the right answer to the wrong question. To avoid this type of errors, it is necessary to train those who participate in citizen-science studies: ci...

La fundación y el blog Interconectados nacen en 2011 para contribuir con la generación, recopilación y movilización de conocimientos entre la universidad pública y la sociedad latinoamericana. Apoyados en la promesa de Internet y la web 2.0 de facilitar la información y la comunicación, nos hemos abocado al dictado de cursos abiertos masivos en lín...

The mobilization of knowledge in society: A challenge for doctoral programs in the Latin American public University. Doctoral programs are particularly suitable to support the paradigm shift required by the university organization in order to increase its efficiency for processing available and the “new to be created” knowledge, based on providing...

Los programas doctorales son particularmente adecuados para apoyar el proceso de cambio paradigmático de la organización universitaria e incrementar la eficiencia requerida para el procesamiento del conocimiento disponible, y el nuevo a ser creado, en función de proveer de evidencias a los tomadores de decisiones en la sociedad, al convertir la mov...

El paradigma del conocimiento universitario se encuentra en transformación. Partiendo de las ideas de Pierre Bourdieu de campo y habitus, y llegando a los postulados de Lev Vigotsky del compañero más capaz y la propuesta de conocimiento conectivista de Stephen Downes y George Siemens, el artículo explora los cambios que ha experimentado la universi...

El paradigma del conocimiento universitario se encuentra en transformación. Partiendo de las ideas de Pierre Bourdieu de campo y habitus, y llegando a los postulados de Lev Vigotsky del compañero más capaz y la propuesta de conocimiento conectivista de Stephen Downes y George Siemens, el artículo explora los cambios que ha experimentado la universi...

Resumen: Los programas doctorales son particularmente ade-cuados para apoyar el proceso de cambio paradigmático de la organización universitaria e incrementar la eficiencia requerida para el procesamiento del conocimiento disponible, y el nuevo a ser creado, en función de proveer de evidencias a los tomadores de decisiones en la sociedad, al conver...

The inclusion of digital technologies in our Latin American societies should be analyzed as an issue of technology transfer between different cultures. From this perspective it is easier to grasp the challenge involved in learning to make use of tools that reinforce a participative culture by solving problems based in accurate information, without...

Las tecnologías digitales están llamadas a jugar un papel fundamental en el desarrollo de la Educación Universitaria, p. ej. Teorías educativas como el conectivismo las incorporan en los procesos orientados a la construcción de saberes. Partiendo de la importancia que tienen, tanto la incorporación de lo digital en la acción educativa, como la visi...

Resumen El presente trabajo propone un esquema que organiza y engloba los distintos elementos y aspectos relevantes a ser considerados en el diseño de un programa de trabajo que, concibiendo el Movimiento Estudiantil Latinoamericano como una cantera de recursos humanos valiosos para la política, permita identificar, seleccionar, capacitar y comprom...

The organizational functioning of an “exemplary” political party was described using “The Total Performance System”, an organizational diagnostic tool of the Behavioral Systems Management theoretical approach. In addition, ten leaders of political parties were interviewed with regard to changes needed for the development, transformation and moderni...

The organizational functioning of an “exemplary” political party was described using “The Total Performance System”, an organizational diagnostic tool of the Behavioral Systems Management theoretical approach. In addition, ten leaders of political parties were interviewed with regard to changes needed for the development, transformation and moderni...

The financing of the political parties is one of the main themes of current political debate. In Venezuela, the Constitution expressly prohibits any form of public financing for political organizations which, as demonstrated in research for this article, provokes negative reactions from party leaders. However, the problem is not the public or priva...

The uptake and metabolism of CH 3 ‐[ ¹⁴ C]tetrahydrofolic acid (MTHF) by rat brain was studied in vitro. At physiological concentrations, (10 ⁻¹⁰ m ), a small net uptake of the labeled compound was observed in whole brain, as well as in the cerebrum, cerebellum and brain stem slices. The passive diffusion observed in the presence of KCN proceeded s...

The activities of the two folate-dependent enzymes in the de novo purine biosynthetic pathway (e.g., glycinamide ribonucleotide transformylase and aminoimidazolecarboxamide ribonucleotide transformylase), have been evaluated as a function of age in crude extracts from rat brain, liver, kidney, and spleen. The activities of the enzymes in brain are...

Rats administered intracerebroventricular (IVT) injections of 3-Carboxy-1,2,3,4-tetrahydroisoquinoline (I) or 6,7-Dihydroxy-1,2,3,4-tetrahydroisoquinoline (II), the condensation products of formaldehyde with phenylalanine and dopamine, respectively, were evaluated in the open field and shuttle box situation. In the open field, 45 min after the acut...

1.1. This article reviews some important aspects concerning the chemistry, biochemistry, and pharmacology of Tetrahydroisoquinolines.2.2. Special attention is given to the hypothesis which attempts to explain the physiopathology of certain behavioral disorders observed after chronic ingestion of alcohol.3.3. The possible role of Tetrahydroisoquinol...

The catecholamines dopamine, norepinephrine, and epinephrine are metabolized by oxidative deamination and by O-methylation. This latter pathway is catalyzed by the enzyme catechol-O-methyl-transferase (1); it utilizes S-adenosyl-methionine (SAMe) as the methyl donor (Fig. 1), and its products are, for the most part, methylated on the metahydroxyl g...

The uptake and metabolism of CH3-[14C]tetrahydrofolic acid (MTHF) by rat brain was studied in vitro. At physiological concentrations, (10-10M), a small net uptake of the labeled compound was observed in whole brain, as well as in the cerebrum, cerebellum and brain stem slices. The passive diffusion observed in the presence of KCN proceeded slowly,...

The present observations indicate that in the adult rat brain, the activities of the enzymes involved in de novo methyl group synthesis are fairly stable, contrasting with the early development period where changes in methylene reductase, B12 transmethylase and serine transhydroxymethylase occur.

— Animals maintained on rat chow and water ad libitum in quarters illuminated for 12 h/day show diurnal rhythms in serum methionine and brain S-adenosylmethionine (SAM) concentrations. Brain methionine exhibits no such variation, nor does the ratio of serum methionine to the serum concentrations of six neutral amino acids which are believed to comp...

Rats deficient in folic acid were found to have decreased concentrations of S-adenosylmethione in brain, kidney, and liver. They also showed decreased concentrations of methionine in serum, but not in brain. Administration of l-dopa (a methyl acceptor) in doses comparable to those used in the treatment of Parkinson's disease caused significant redu...

—Rat brain contains all three of the enzymes required for de novo synthesis of the methyl group of methionine (serine transhydroxymethylase, methylene reductase, and [B12]transmethylase) in activities comparable to those found in liver and kidney. The activities of methylene reductase in female kidney, and of [B12]transmethylase in female brain and...

The disaggregation of brain polysomes which is produced by giving large doses of (L)-dopa to rats is not reproduced by administering its metabolite, 3-O-methyldopa, by giving D-dopa, which also depletes the brain of S-adenosylmethionine but is not converted to catecholamines, or by giving the L-dopa after a decarboxylase inhibitor. Polysome disaggr...