Luis A. J. Mur

Luis A. J. Mur
Aberystwyth University | AU · Institute of Biological, Environmental and Rural Sciences

PhD

About

322
Publications
62,059
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11,552
Citations
Introduction
https://www.clinicalhubaberystwyth.com/ Luis A. J. Mur currently works at the Institute of Biological, Environmental and Rural Sciences, Aberystwyth University. Luis does research in Pathology in various Kingdoms and Respiratory Disease in Humans. Luis' interests extend to screening for novel antimicrobial agents
Additional affiliations
September 1998 - present
Aberystwyth University
Position
  • Professor (Full)
November 1991 - September 1998
University of Leicester
Position
  • Research Associate

Publications

Publications (322)
Article
Abstract Locoweeds are perennial forbs poisonous to livestock and cause extreme losses to animal husbandry. Locoweed toxicity is attributed to the symbiotic endophytes in Alternaria sect. Undifilum, which produce a mycotoxin swainsonine (SW). We performed a de novo whole genome sequencing of the most common locoweed in China, Oxytropis ochrocephala...
Article
Full-text available
Introduction Mycobacterium bovis, the causative agent of bovine tuberculosis (bTB) in cattle, represents a major disease burden to UK cattle farming, with considerable costs associated with its control. The European badger (Meles meles) is a known wildlife reservoir for bTB and better knowledge of the epidemiology of bTB through testing wildlife is...
Article
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The use of exogenous compounds such as ‘gasotransmitter’ molecules is a well-established agronomic strategy to improve the crop tolerance to environmental stresses. In this current work, when Cr (200 µM) was combined with the nitric oxide (NO) generator sodium nitroprusside SNP, 500 µM) there was a suppression of metal-induced alterations in embryo...
Article
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It has been 20 years since Brachypodium distachyon was suggested as a model grass species, but ongoing research now encompasses the entire genus. Extensive Brachypodium genome sequencing programmes have provided resources to explore the determinants and drivers of population diversity. This has been accompanied by cytomolecular studies to make Brac...
Preprint
Traditional Chinese Medicine (TCM) has been used to treat infectious diseases and could offer potential drug leads. This study evaluates the in vitro antimicrobial activities commercially sourced Dryopteris crassirhizoma Nakai whose authenticity was confirmed by DNA barcoding based on the ribulose bisphosphate carboxylase ( rbcL ) gene. Powdered rh...
Article
Full-text available
Introduction The European badger ( Meles meles ) is a known wildlife reservoir for bovine tuberculosis (bTB) and a better understanding of the epidemiology of bTB in this wildlife species is required for disease control in both wild and farmed animals. Flow infusion electrospray—high-resolution mass spectrometry (FIE-HRMS) may potentially identify...
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Salicylic acid (SA) is a key phytohormone regulating plant immunity. Although the transcriptional regulation of SA biosynthesis has been well‐studied, its post‐translational regulation is largely unknown. We report that a Kelch repeats‐containing F‐box (KFB) protein, SMALL AND GLOSSY LEAVES 1 (SAGL1), negatively influences SA biosynthesis in Arabid...
Article
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After birth, as effectively monogastric animals, calves undergo substantial physiological changes to become ruminants by 3 months of age and reach sexual maturity at approximately 15 months of age. Herein, we assess longitudinal metabolomic changes in Holstein-Friesian (HF) heifers from birth until sexual maturity during this developmental process....
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Alchornea cordifolia Müll. Arg. (commonly known as Christmas Bush) has been used traditionally in Africa to treat sickle cell anaemia (a recessive disease, arising from the S haemoglobin (Hb) allele), but the active compounds are yet to be identified. Herein, we describe the use of sequential fractionation coupled with in vitro anti-sickling assays...
Article
Full-text available
Mosses of the genus Sphagnum are the main components of peatlands, a major carbon-storing ecosystem. Changes in precipitation patterns are predicted to affect water relations in this ecosystem, but the effect of desiccation on the physiological and molecular processes in Sphagnum are still largely unexplored. Here we show that different Sphagnum sp...
Article
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Introduction Paratuberculosis, commonly known as Johne’s disease, is a chronic granulomatous infection of ruminants caused by Mycobacterium avium subspecies paratuberculosis (MAP). Clinical signs, including reduced milk yields, weight loss and diarrhoea, are typically absent until 2 to 6 years post exposure. Objectives To identify metabolomic chang...
Article
Drought is a major abiotic stress that limits crop productivity and is driving the need to introduce new tolerant crops with better economic yield. Tef (Eragrostis tef) is a neglected (orphan) Ethiopian warm-season annual gluten-free cereal with high nutritional and health benefits. Further, tef is resilient to environmental challenges such as drou...
Preprint
Here we investigate the faecal microbiome of wild European badgers Meles meles using samples collected at post-mortem as part of the All Wales Badger Found Dead study based on sequencing the V3-V4 region of the 16S rRNA gene. This is the first published characterisation of the badger microbiome. We initially undertook a sex-matched age comparison b...
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Pathogenic fungi can lose virulence after protracted periods of culture, but little is known of the underlying mechanisms. Here, we present the first analysis of DNA methylation flux at a single-base resolution for the plant pathogen B. cinerea and identify differentially methylated genes/genomic regions associated with virulence erosion during in...
Article
Tef is a highly nutritious gluten-free Ethiopian cereal with food-feed potential. However, its productivity is affected by lodging, weed infestation, terminal drought, small seed size, and shattering. Following the recent availability of tef genome sequences, we highlight the need to harness the benefits that this underutilised crop offers to impro...
Article
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The recretohalophyte Karelinia caspia is of forage and medical value and can remediate saline soils. We here assess the contribution of primary/secondary metabolism to osmotic adjustment and ROS homeostasis in K. caspia under salt stress using multi‐omic approaches. Computerized phenomic assessments, tests for cellular osmotic changes and lipid per...
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Oxytropis plants are widely distributed in the grasslands in northern China. Some Oxytropis species have been reported to contain the mycotoxin swainsonine, an alkaloid which causes poisoning in livestock, referred to as locoism. Previous studies showed that endophytic fungi (Alternaria oxytropis) symbiotically associate with these Oxytropis specie...
Article
Les courant recherche visé évaluer les protecteur rôle de nitrique oxyde (NON) contre chrome (Cr) toxicité dans maïs semis. Chrome (200 ??M) abaissé osmotique potentiel en épicotyles et principalement en radicules (par 38% et 63%, respectivement) par rapport à la contrôler. Sodium nitroprussiate (SNP, NON donneur) restauré semis biomasse (+90% pour...
Article
Full-text available
Background: Osteoporosis is a common metabolic skeletal disease and usually lacks obvious symptoms. Many individuals are not diagnosed until osteoporotic fractures occur. Bone mineral density (BMD) measured by dual-energy X-ray absorptiometry (DXA) is the gold standard for osteoporosis detection. However, only a limited percentage of people with o...
Article
Full-text available
Silicon (Si), the second most abundant element in Earth’s crust, exerts beneficial effects on the growth and productivity of a variety of plant species under various environmental conditions. However, the benefits of Si and its importance to plants are controversial due to differences among the species, genotypes, and the environmental conditions....
Preprint
Full-text available
Alchornea cordifolia MÜll. Arg. (commonly known as Christmas Bush) has been used traditionally in Africa to treat sickle cell anaemia (a recessive disease, arising from the S haemoglobin [Hb] allele) but the active compounds are yet to be characterised. Herein we describe the use of sequential fractionation coupled with in vitro anti-sickling assay...
Article
Full-text available
Tef ( Eragrostis tef ), is a gluten-free orphan cereal, crop of nutritional and economical significance. Here we used untargeted metabolomics to survey metabolite variation in 14 diverse tef accessions at 15-days post germination. Tef genotypes were classified into four metabolomic groups where variation was linked to flavones and flavonols. Furthe...
Article
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As efforts are made to increase food security, millets are gaining increasing importance due to their excellent nutritional credentials. Among the millets, pearl millet is the predominant species possessing several health benefiting nutritional traits in its grain that are helpful in mitigating chronic illnesses such as type−2 diabetes and obesity....
Article
Full-text available
Johne’s disease, caused by Mycobacterium avium subsp. paratuberculosis (MAP), causes weight loss, diarrhoea, and reduced milk yields in clinically infected cattle. Asymptomatic, subclinically infected cattle shed MAP bacteria but are frequently not detected by diagnostic tests. Herein, we compare the metabolite profiles of sera from subclinically i...
Article
Full-text available
Phytophthora capsici is one of the most destructive pathogens causing quick wilt (foot rot) disease in black pepper (Piper nigrum L.) to which no effective resistance has been defined. To better understand the P. nigrum-P. capsici pathosystem, we employed metabolomic approaches based on flow-infusion electrospray-high-resolution mass spectrometry....
Preprint
Please cite this article as: D. Cao, P. Sun, S. Bhowmick, et al., Secondary metabolites of endophytic fungi isolated from Huperzia serrata, Fitoterapia (2018), https://doi. Abstract The natural product Huperzine A isolated from Huperzia serrata is a targeted inhibitor of acetylcholinesterase that has been approved for clinical use in the treatment...
Article
Please cite this article as: D. Cao, P. Sun, S. Bhowmick, et al., Secondary metabolites of endophytic fungi isolated from Huperzia serrata, Fitoterapia (2018), https://doi. Abstract The natural product Huperzine A isolated from Huperzia serrata is a targeted inhibitor of acetylcholinesterase that has been approved for clinical use in the treatment...
Article
Full-text available
Wild plant populations show extensive genetic subdivision and are far from the ideal of panmixia which permeates population genetic theory. Understanding the spatial and temporal scale of population structure is therefore fundamental for empirical population genetics – and of interest in itself, as it yields insights into the history and biology of...
Chapter
This article discusses the role of chlorophyll metabolism in plant responses and adaptations to biotic and abiotic stresses. The metabolic pathways of chlorophyll (Chl) biosynthesis and catabolism are summarised. The precursor of tetrapyrrole synthesis is δ‐aminolaevulinic acid. Protoporphyrin IX is the branchpoint intermediate between the haem/bil...
Article
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Climate change and an increasing population, present a massive global challenge with respect to environmentally sustainable nutritious food production. Crop yield enhancements, through breeding, are decreasing, whilst agricultural intensification is constrained by emerging, re-emerging, and endemic pests and pathogens, accounting for ~30% of global...
Article
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Legumes express two major types of hemoglobins: symbiotic (leghemoglobins) and non-symbiotic (phytoglobins). The latter are categorized into three classes according to phylogeny and biochemistry. Using knock-out mutants, we show that all three phytoglobin classes are required for optimal vegetative and reproductive development of Lotus japonicus. F...
Article
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Nitrogen forms (nitrate (NO3−) or ammonium (NH4+)) are vital to plant growth and metabolism. In stevia (Stevia rebaudiana), it is important to assess whether nitrogen forms can influence the synthesis of the high-value terpene metabolites-steviol glycosides (SGs), together with the underlying mechanisms. Field and pot experiments were performed whe...
Article
The natural product Huperzine A isolated from Huperzia serrata is a targeted inhibitor of acetylcholinesterase that has been approved for clinical use in the treatment of Alzheimer's disease. Given the large demand for natural sources of Huperzine A, efforts have been made to explore whether Huperzine A (Hup. A) is also produced by endophytic fungi...
Article
Full-text available
Global wheat production is constantly threatened by rust diseases. Identifying resistant genes is a useful tactic to control wheat rust pathogen. Twenty-six wheat varieties were screened with twelve Simple Sequence Repeats (SSR) markers to detect rust resistant genes and the efficacy of genes was validated through field testing. The alleles Lr32, L...
Article
Full-text available
Persistent mating-induced endometritis is a major cause of poor fertility rates in the mare. Endometritis can be investigated using an ex vivo equine endometrial explant system which measures uterine inflammation using prostaglandin F2α as a biomarker. However, this model has yet to undergo a wide-ranging assessment through transcriptomics. In this...
Poster
Full-text available
Mycobacterium avium subsp. paratuberculosis (MAP) is the causative agent of Johne’s Disease, a chronic intestinal infection of ruminants causing weight loss and diarrhoea in infected cattle. Subclinically infected cattle shed MAP bacteria in their milk and faeces, despite showing no visible symptoms. Thus, these cattle are a major source of disease...
Article
Fusarium wilt is one of the major biotic factors limiting cucumber (Cucumis sativus L.) growth and yield. The outcomes of cucumber-Fusarium interactions can be influenced by the form of nitrogen nutrition (nitrate [NO3⁻] or ammonium [NH4⁺]); however, the physiological mechanisms of N-regulated cucumber disease resistance are still largely unclear....
Article
Full-text available
Plants in the Oxytropis genus can live with the endophytic fungi Alternaria sect. Undifilum. Swainsonine, the mycotoxin produced by the endophyte render the host plant toxic and this has been detrimental to grazing livestock in both China and U.S.A. Despite previous efforts, many questions remain to be solved, such as the transmission mode and life...
Article
Full-text available
Citation: Skalska, A.; Wolny, E.; Beckmann, M.; Doonan, J.H.; Hasterok, R.; Mur, L.A.J. Allotetraploidization in Brachypodium May Have Led to the Dominance of One Parent's Metabolome in Germinating Seeds. Cells 2021, 10, 828.
Conference Paper
Full-text available
Application: Diets containing high levels of starch alter phenylalanine and tyrosine metabolism and increase milk protein concentration. This information can be used to more accurately formulate diets to alter milk protein content in dairy cows. Introduction: Starch is frequently included in dairy cow rations to fulfil energy and protein requiremen...
Conference Paper
Full-text available
Application: Identified metabolites successfully differentiated between Mycobacterium avium subspecies paratuberculosis (MAP) inoculated and control cattle during the incubation stage of infection. If validated, these metabolites would enable farmers to identify MAP exposed cattle before shedding or clinical signs develop. Introduction: Paratubercu...
Article
Full-text available
Brachypodium distachyon (Brachypodium) is a non-domesticated model grass that has been used to assess population level genomic variation. We have previously established a collection of 55 Brachypodium accessions that were sampled to reflect five different climatic regions of Turkey; designated 1a, 1c, 2, 3 and 4. Genomic and methylomic variation di...
Article
Full-text available
With diverse genetic backgrounds, soybean landraces are valuable resource for breeding programs. Herein, we apply multi‐omic approaches to extensively characterise the molecular basis of drought tolerance in the soybean landrace LX. Initial screens established that LX performed better with PEG6000 treatment than control cultivars. LX germinated bet...
Article
Full-text available
Excess salinity is a major stress that limits crop yields. Here, we used the model grass Brachypodium distachyon (Brachypodium) reference line Bd21 in order to define the key molecular events in the responses to salt during germination. Salt was applied either throughout the germination period (“salt stress”) or only after root emergence (“salt sho...
Article
Full-text available
Tuberculosis (TB) is a major global threat, mostly due to the development of antibiotic-resistant forms of Mycobacterium tuberculosis, the causal agent of the disease. Driven by the pressing need for new anti-mycobacterial agents several natural products (NPs) have been shown to have in vitro activities against M. tuberculosis. The utility of any N...
Article
Full-text available
Drought priming is a promising approach to improve tolerance to further drought in wheat. The root apex plays important roles in drought however, its contribution to drought priming remains unknown. To provide mechanistic insights into this process, the transcriptomes and proteomes at three different zones along the root axis under drought stress w...
Article
Background/aims: Lung carcinoids are uncommon neuroendocrine tumours. Molecular features of lung carcinoids have been poorly defined. microRNAs (miRNAs) are potent gene expression regulators with important roles in cancer development and progression. However, little is known on the role of miRNAs in the pathogenesis of lung carcinoids. Our goals w...
Article
The regulation of plant physiology by plant mineral nutrient transporter (MNT) is well understood. Recently, the extensive characterization of beneficial and pathogenic plant‐microbe interactions has defined the roles for MNTs in such relationships. In this review, we summarize the roles of diverse nutrient transporters in the symbiotic or pathogen...
Preprint
Tuberculosis (TB) is a major global threat mostly due to the development of antibiotic resistant forms of Mycobacterium tuberculosis, the causal agent of the disease. Driven by the pressing need for new anti-mycobacterial agents, several natural products (NPs) have been shown to have in vitro activities against M. tuberculosis. The utility of any N...
Article
Full-text available
Aims The form of nitrogen (N) supply influences photorespiration in C3 plants, but whether nitrate (NO3⁻) regulates photorespiration and, if so, the underlying mechanisms for such regulation are still unclear. Methods Three hydroponic experiments were conducted in a greenhouse to investigate the relationships between leaf NO3⁻ concentrations and p...
Article
Heavy metal uptake by agricultural crops poses great danger to human health. Application of compost and biochar has been used extensively for metal immobilization in soil and to reduce metal uptake by crop plant. Their efficiency is however, limited by other environmental factors like water and light intensity. In this study, the effects of organic...
Article
The present study aims to analyse the potential crosstalk between nitric oxide (NO) and hydrogen sulfide (H2S) in triggering resilience of maize (Zea mays L.) seedlings to hexavalent chromium (Cr VI). Exogenous application of 500 μM sodium nitroprusside (SNP, as a NO donor) or sodium hydrosulfide (NaHS, as a H2S donor) to 9-day-old maize seedlings,...
Preprint
Full-text available
The discovery of antimalarial artemisinin from Artemisia annua L. is an example of how Traditional Chinese Medicine (TCM) may be exploited to meet a recognized need. In this study, we systemically investigated A. annua L. for its antimicrobial activity and assessed it as a source of bioactive natural products for anti-mycobacterial activity. We use...
Article
Full-text available
Brachypodium distachyon (Brachypodium) is a non-domesticated model grass species that can be used to test if variation in genetic sequence or methylation are linked to environmental differences. To assess this, we collected seeds from 12 sites within five climatically distinct regions of Turkey. Seeds from each region were grown under standardized...
Data
Supplementary Tables (Excel file) and Supplementary Figures (PDF file) packed in a ZIP archive
Preprint
Full-text available
Whole genome sequences and coalescence theory allow the study of plant evolution in unprecedented detail. In this study we extend the genomic resources for the wild Mediterranean grass Brachypodium distachyon to investigate the scale of population structure and its underlying history at whole-genome resolution. The analysis of 196 accessions, spann...