Luis Hernandez-Nunez

Luis Hernandez-Nunez
Harvard University | Harvard · Department of Molecular and Cell Biology

Doctor of Philosophy

About

16
Publications
1,591
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325
Citations
Citations since 2017
8 Research Items
274 Citations
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2017201820192020202120222023020406080
2017201820192020202120222023020406080

Publications

Publications (16)
Article
Until now, most brain studies have focused on small numbers of neurons that interact in limited circuits, allowing analysis of individual computations or steps of neural processing. During behaviour, however, brain activity must integrate multiple circuits in different brain regions. Whole-brain recording with cellular resolution provides a new opp...
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Animals use their olfactory systems to avoid predators, forage for food, and identify mates. Olfactory systems detect and distinguish odors by responding to the concentration, temporal dynamics, and identities of odorant molecules. Studying the temporal neural processing of odors carried in air has been difficult because of the inherent challenge i...
Article
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Body temperature homeostasis is essential and reliant upon the integration of outputs from multiple classes of cooling- and warming-responsive cells. The computations that integrate these outputs are not understood. Here, we discover a set of warming cells (WCs) and show that the outputs of these WCs combine with previously described cooling cells...
Article
Full-text available
Animals exhibit different behavioral responses to the same sensory cue depending on their internal state at a given moment. How and where in the brain are sensory inputs combined with state information to select an appropriate behavior? Here, we investigate how food deprivation affects olfactory behavior in Drosophila larvae. We find that certain o...
Preprint
Full-text available
Body temperature homeostasis is an essential function that relies upon the integration of the outputs from multiple classes of cooling- and warming-responsive cells. The computations that integrate these diverse outputs to control body temperature are not understood. Here we discover a new set of Warming Cells (WCs), and show that the outputs of th...
Preprint
Full-text available
Animals can respond differently to a sensory cue when in different states. Here, we show that certain odors repel well-fed Drosophila larvae but attract food-deprived larvae and how feeding state flexibly alters neural processing in an early olfactory circuit, the antennal lobe, to determine the behavioral valence of a sensory cue. Odor valence is...
Article
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State-of-the-art algorithms for visual place recognition, and related visual navigation systems, can be broadly split into two categories: computer-science-oriented models including deep learning or image retrieval-based techniques with minimal biological plausibility, and neuroscience-oriented dynamical networks that model temporal properties unde...
Preprint
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State-of-the-art algorithms for visual place recognition can be broadly split into two categories: computationally expensive deep-learning/image retrieval based techniques with minimal biological plausibility, and computationally cheap, biologically inspired models that yield poor performance in real-world environments. In this paper we present a n...
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The sense of smell enables animals to react to long-distance cues according to learned and innate valences. Here, we have mapped with electron microscopy the complete wiring diagram of the Drosophila larval antennal lobe, an olfactory neuropil similar to the vertebrate olfactory bulb. We found a canonical circuit with uniglomerular projection neuro...
Article
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Nature Communications 7: Article number: 10687 (2016); Published: 11 February 2016; Updated: 14 March 2016. The affiliation details for Martino Colombo, Rémy Bruggmann and Richard Benton are incorrect in this article. The correct affiliations for these authors are listed below. Martino Colombo, RémyBruggmann Interfaculty Bioinformatics Unit and Swi...
Article
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Accurate perception of taste information is crucial for animal survival. In adult Drosophila, gustatory receptor neurons (GRNs) perceive chemical stimuli of one specific gustatory modality associated with a stereotyped behavioural response, such as aversion or attraction. We show that GRNs of Drosophila larvae employ a surprisingly different mode o...
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Neural circuits for behavior transform sensory inputs into motor outputs in patterns with strategic value. Determining how neurons along a sensorimotor circuit contribute to this transformation is central to understanding behavior. To do this, a quantitative framework to describe behavioral dynamics is needed. Here, we built a high-throughput optog...
Article
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Significance A previously unidentified set of thermosensory neurons embedded in the olfactory organ of the Drosophila larva is shown to be required to drive the animal up temperature gradients toward preferred environments. Optogenetics and optical neurophysiology reveal efficient sensory encoding of both favorable (warming) and unfavorable (coolin...
Data
Parameter values. DOI: http://dx.doi.org/10.7554/eLife.03526.019
Article
Full-text available
Inputs to signaling pathways can have complex statistics that depend on the environment and on the behavioral response to previous stimuli. Such behavioral feedback is particularly important in navigation. Successful navigation relies on proper coupling between sensors, which gather information during motion, and actuators, which control behavior....

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