Luis Miguel Gutiérrez-Robledo

Instituto Nacional De Geriatría · WHO Collaborating Centre on Integrated Care and Public Policy Lab

Background: Older adults have highly heterogeneous aging rates. Objective: To explore the association of biological age (BA) and accelerated aging with frailty in community-dwelling older adults. Material and methods: We assessed 735 community-dwelling older adults from the Coyocan Cohort. BA was measured using AnthropoAge, accelerated aging with A...

Antecedentes: El envejecimiento, la urbanización y cambios en los factores de riesgo han intensificado la epidemia de enfermedades crónicas no transmisibles (ECNT). Objetivo: Evaluar mortalidad, discapacidad, factores de riesgo y esperanza de vida en personas ≥ 60 años (EV-60) en México de 1990-2022, conforme a estimaciones del estudio de la Carga...

Background The Decade of Healthy Aging (2021–2030) emerges as a 10 years strategy to improve the lives of older adults, their families, and the communities in which they live. One of the actions defined in this framework is related to improving the measurement, monitoring, and understanding of characteristics, factors, and needs related to aging an...

Si bien el debate sobre el sistema nacional de cuidados está cobrando impulso en los ámbitos académico y político, es importante señalar que las cuestiones de género y cuidado de las infancias a menudo eclipsan el componente relativo a las personas mayores, tema que necesita un análisis más profundo. Este artículo tiene por objetivo apoyar en la co...

Objetivo. Estimar la proporción de sujetos vacunados y los factores asociados en personas adultas y adultas mayores en México. Material y métodos. Análisis de datos obtenidos de la Encuesta Nacional de Salud y Nutrición Continua 2021-2023 (Ensanut Continua 2021-2023) y analizar las variaciones comparando con la Ensanut 2012. Resultados. Dado que so...

OBJECTIVE Older adults have heterogeneous aging rates. Here, we explored the impact of biological age (BA) and accelerated aging on frailty in community-dwelling older adults. METHODS We assessed 735 community-dwelling older adults from the Coyocan Cohort. BA was measured using AnthropoAge, accelerated aging with AnthropoAgeAccel, and frailty usin...

OBJECTIVE: To validate AnthropoAge, a new metric of biological age (BA), for prediction of all-cause mortality and age-related outcomes and characterize population-specific aging patterns using multinational longitudinal cohorts. METHODS: We analyzed harmonized multinational data from the Gateway to Global Aging, including studies from the US, Engl...

Regardless of the operational definition used, complications when facing common stressors are the main feature of frailty. A variety of these complications or adverse outcomes have been used to characterize older adults living with frailty. Mortality is the most frequently recognized outcome of frail individuals. Currently, some experts advise on s...

Background Older adults are increasingly susceptible to prolonged illness, multiple chronic diseases, and disabilities, which can lead to the coexistence of multimorbidity and frailty. Multimorbidity may result in various noncommunicable disease (NCD) patterns or configurations that could be associated with frailty and death. Mortality risk may var...

El cambio demográfico y el aumento en la esperanza de vida plantean grandes desafíos sociales, económicos y de políticas públicas con enfoque en los derechos humanos. El Consenso de Montevideo sobre Población y Desarrollo (CMPD) proporciona un marco estratégico para la acción en materia de población y desarrollo en América Latina y el Caribe. En es...

Aim: To evaluate the readiness of the Mexican healthcare system to implement the integrated care for older people (ICOPE) approach into an existing healthcare model. Methods: We conducted a cross-sectional study with data from 2473 healthcare workers analyzed using the model for understanding success in quality (MUSIQ) framework to gather data from...

Background Older person’s ability to contribute covers contributions divided into five subdomains: assisting friends and neighbours, mentoring peers and younger people, caring for family, engaging in the workforce and voluntary activity. Objective To evaluate the psychometric properties of ability to contribute measurements as a domain of function...

The Mexican Health and Aging Study (MHAS) is a longitudinal study using a national sample of approximately 15,000 community-dwelling adults aged 50 years old and older in Mexico. Spanning over 20 years (2001-2021), six waves of data collection establish the MHAS as the leading data platform for the study of aging in Latin America.

Background A multicomponent staff training intervention was conducted to improve residential dementia care. The purpose of this work is to present the simulation of the effectiveness of the intervention design over time. Method Pilot study with mixed methods, two‐arm randomized controlled clinical outcomes in 7 care homes in Mexico City. Staff out...

Background We have developed a reminiscence program for people living with dementia to improve their autobiographical memory and reduce neuropsychiatric symptoms. In this paper, the objective is to present findings from a pilot’s virtual reality experience with elderly people without dementia. Method 4 people over 60 years of age from a non‐govern...

Background Frailty has been recognized as a growing issue in older adults, with recent evidence showing that this condition heralds several health-related problems, including cognitive decline. The objective of this work is to determine if frailty is associated with cognitive decline among older adults from different countries. Methods We analyzed...

In this article, we summarise the findings of the situational analysis of dementia care generated as part of the STRiDE: Strengthening responses to dementia care in developing countries project, including a desk review, a SWOT analysis and views from relevant stakeholders. In addition, the article incorporates the experience of 4 years of work with...

After the first wave of the COVID 19 pandemic, the severity of the disease in certain countries was attributed to a lack of basic education among the inhabitants. We therefore sought to elucidate the role of education and health literacy in health behaviours. This work demonstrates that, alongside genetics, the affective and educational family envi...

Le groupe de travail des Académies de Médecine de France et du Mexique a initié son travail après que la sévérité de la première vague de la pandémie Covid 19 de certains pays ait été corrélée à un manque d’éducation de base de leur population. La réflexion s’est poursuivie et étendue pour mieux comprendre les rôles de l’éducation de base et de l’é...

Background: Vaccination has been effective in ameliorating the impact of COVID-19. Here, we report vaccine effectiveness (VE) for nationally available COVID-19 vaccines in Mexico. Methods: Retrospective analysis of a COVID-19 surveillance system to assess VE of the BNT162b2, mRNA-12732, Gam-COVID-Vac, Ad5-nCoV, Ad26.COV2.S, ChAdOx1 and CoronaVac...

Aging is believed to occur across multiple domains, one of which is body composition; however, attempts to integrate it into biological age (BA) have been limited. Here, we consider the sex-dependent role of anthropometry for the prediction of 10-year all-cause mortality using data from 18,794 NHANES participants to generate and validate a new BA m...

Blood‐based biomarker tests are critical tools with the potential to change pathways for dementia diagnosis and care. These tests are less invasive than PET scan or lumbar puncture, potentially more affordable, and thus more accessible across more care settings and in more countries. Utilization in primary care settings together with brief cognitiv...

Background In 2020, Mexico experienced one of the highest rates of excess mortality globally. However, the extent of non-COVID deaths on excess mortality, its regional distribution and the association between socio-demographic inequalities have not been characterized. Methods We conducted a retrospective municipal and individual-level study using...

Identifying relationships between components of an index helps to gain a better understanding of the condition they define. The Frailty Index (FI) measures the global health of individuals and can be used to predict outcomes as mortality. Previously, we modelled the relationship between the FI components (deficits) and death through an undirected g...

Objective Identify the association between low physical performance and quality of life in older adults. Methods Cross-sectional analysis of the FraDySMex cohort study (Frailty, Daphnia and Sarcopenia in Mexican Adults). The physical performance was evaluated by Short Physical Performance Battery (SPPB), and the quality of life through the Visual A...

The development of synthetic indexes to measure how societies undertake population aging has become relevant during the last decade due to international interest in responding to demographical changes and in elevating older adults’ standards of living. The measurements proposed are the Global Age Watch Index (GAI), the Active Aging Index (AAI), and...

A two-arm mixed-method RTC pilot study was conducted in Mexico City to improve residential dementia care (PROCUIDA-Dementia). To assess the power of our study design, a sensitivity analysis was conducted that showed the importance of site and person variability. Here we present an example of sample size simulation for a large-scale replication of t...

Barker's hypothesis affirms that undernourishment in early-life induces metabolic reprogramming that compromises organism functions later in life, leading to age-related diseases. We are exposed to environmental and social conditions that impact our life trajectories, leading to ageing phenotypes as we grow. Epigenetic mechanisms constitute the lin...

Background: Research suggests a significant association between increasing age and memory impairments. Nevertheless, for some individuals, memory performance stays within or above the normative values of younger subjects. This is known as successful memory aging and is associated with specific neurophysiological features and psychological and life...

BACKGROUND In 2020, Mexico experienced one of the highest rates of excess mortality globally. However, the extent to which non-COVID deaths contributed to excess mortality, its regional characterization, and the association between municipal-and individual-level sociodemographic inequality has not been characterized. METHODS We conducted a retrosp...

Latin American countries (LAC), with their culturally and ethnically diverse populations, form a region that is difficult to define and to understand. The region's health systems are deeply fragmented, which poses great challenges to overall equity levels in health. This is also one of the fastest ageing regions in the world, with increasing demand...

BACKGROUND Vaccination has been effective in ameliorating the impact of COVID-19. However, estimation of vaccine effectiveness (VE) is still unavailable for some widely used vaccines and underrepresented groups. Here, we report on the effectiveness of a nation-wide COVID-19 vaccination program in Mexico. METHODS We used a test-negative design with...

Identifying relationships between components of an index helps to have a better understanding of the condition they define. The Frailty Index (FI) measures the global health of individuals and can be used to predict outcomes as mortality. Previously, we modelled the relationship between the FI components (deficits) and death through an undirected g...

Introduction Midlife physical capability (PC) is associated with developmental factors in the populations of economically developed countries. As far as we know, there is no information for rural populations of low- and middle-income countries. The aim of the study was to investigate the influence of pre- and postnatal factors on midlife objective...

The study of ageing in developing countries is a relatively new endeavour, which has expanded. Comparative research involving low‐ and middle‐income countries has improved our understanding of the influences of culture and ethnicity, the effects of ageing in low‐income environments, the changing roles of families, and the consequences of new polici...

This study estimates the monetary cost of caregiving - assumed by society and government - for functionally dependent older adults in Mexico. It is a secondary database analysis based on the Mexican Health and Ageing Study 2015 and the National Survey of Household Income and Expenditure 2016. The component costs included were: loss of labor income...

Objective: To identify and quantify potentially inappropriate prescribing (prescripción potencialmente inapropiada, PPI) and other drug prescribing problems in public health care services in a population-based study at the three existing levels of complexity in Mexico. Methods: Descriptive analysis of the Study on Satisfaction of Users of the So...

Objectives To evaluate the feasibility outcomes of implementing a multicomponent staff training intervention (PROCUIDA-Demencia) to promote psychosocial interventions and reduce antipsychotic prescription in Mexican care homes and study its effect on staff's care experience and residents' quality of life. Design A mixed-methods 2-arm cluster rando...

Introduction: Competency-based education has been considered a pedagogical proposal in medicine in recent decades. In clinical contexts, Entrustable Professional Activities (EPA) have been used for the application of competencies. The development of this strategy has been implemented in various specialties to improve the quality of postgraduate med...

Aging is believed to occur across multiple domains, one of which is body composition; however, attempts to integrate it into biological age (BA) have been limited. Here, we consider the sex-dependent role of anthropometry for prediction of 10-year all-cause mortality using data from 18,794 NHANES participants to generate and validate a new BA metri...

Abstract: Adverse conditions in early life, including environmental, biological and social influences, are risk factors for ill-health during aging and the onset of age-related disorders. In this context, the recent field of social epigenetics offers a valuable method for establishing the relationships among them However, current clinical studies o...

Objective. To describe the levels of intrinsic capacity and those factors related to its decline in Mexican older adults, using the Mexican Health and Aging Study. Methods. This is a cross-sectional secondary analysis of the 2015 data of the Mexican Health and Aging Study, including adults aged 50 years and above. Selected questions were included t...

RESUMEN Desde 1948, la Organización Mundial de la Salud ha venido publicando un sistema codificado de causas de enfermedad y muerte bajo el nombre genérico de Clasificación Estadística Internacional de Enfermedades (CIE), con revisiones en profundidad cada 10-15 años. En su última versión, CIE-11, se utiliza una terminología para caracterizar la ve...

By 2025, at least one-fifth of the population of 15 countries in the Americas will be 60 or older (Pan American Health Organization, 2017). The populations of older adults in Mexico and older Latinos in the United States continue to grow dramatically (Central Intelligence Agency, 2015). Population aging is the most important, inevitable feature of...

There is a surge of public awareness globally about brain disease, often expressed as apprehension, fear, and requests for more information. Much of this heightened concern is based on knowing someone, or some family member, experiencing a brain disease. As a guiding principle, we could agree that every person has a unique brain capacity that shoul...

The human ageing process is universal, ubiquitous and inevitable. Every physiological function is being continuously diminished. There is a range between two distinct phenotypes of ageing, shaped by patterns of living - experiences and behaviours, and in particular by the presence or absence of physical activity (PA) and structured exercise (i.e.,...

Background To determine the association between oral health condition and development of frailty over a 12-month period in community-dwelling older adults. Methods Population-based, case-cohort study derived from the Cohort of Obesity, Sarcopenia, and Frailty of Older Mexican Adults (COSFOMA) study, including data from years 2015 and 2016. Using l...

In this article, we report on the recommendations of a bi-national conference that examined the institutional capacities and future ability of Mexico and the United States to address the need for affordable and sustainable dementia care that results from growing older adult populations. These recommendations reflect the large difference in resource...

The frailty syndrome is a common clinical marker of vulnerability in older adults conducive to an overall decline in inflamma-tory stress responsiveness; yet little is known about the genetic risk factors for frailty in elderly. Our aim was to investigate theassociation between the rs2476601 polymorphism in PTPN22 gene and susceptibility to frailty...

BACKGROUND: The impact of the COVID-19 pandemic in Mexico City has been sharp, as several social inequalities at all levels coexist. Here, we conducted an in-depth evaluation of the impact of individual and municipal-level social inequalities on the COVID-19 pandemic in Mexico City. METHODS: We analyzed suspected SARS-CoV-2 cases, from the Mexico...

Objective: To calculate the cost assumed by society for having underaged individuals who do not study and provide care to dependent older adults. Materials and methods: The Mexican Health and Ageing Study (MHAS) 2015 was used to calculate the number of underage caregivers who do not attend school. The Household Income and Expenditure Survey (ENI...

Background Whether the metabolically healthy obese (MHO) phenotype is a single, stable or a transitional, fluctuating state is currently unknown. The Mexican-Mestizo population has a genetic predisposition for the development of type 2 diabetes (T2D) and other cardiometabolic complications. Little is known about the natural history of metabolic hea...

Background: Falls are a significant public health problem among older people worldwide. The aim was to perform a new systematic review and meta-analysis to assess whether cataract surgery is effective in reducing the rate of falls in older persons. Methods: The systematic review was performed following the recommendations by the Cochrane Collabo...

BACKGROUND: Chronological age (CA) is a predictor of adverse COVID-19 outcomes; however, CA alone does not capture individual responses to SARS-CoV-2 infection. Here, we evaluated the influence of aging metrics PhenoAge and PhenoAgeAccel to predict adverse COVID-19 outcomes. Furthermore, we sought to model adaptive metabolic and inflammatory respon...

The impact of the COVID-19 pandemic in Mexico City has been sharp, as several social inequalities coexist with chronic comorbidities. Here, we conducted an in-depth evaluation of the impact of social, municipal, and individual factors on the COVID-19 pandemic in working-age population living in Mexico City. To this end, we used data from the Nation...

Since the emergence of the COVID-19 pandemic, the most affected population group has been that of older people living in long-term care facilities (LTCFs), which has accumulated between 30 and 60 % of total number of deaths in the world. In Mexico, outbreaks have been reported in LTCFs of at least eight states. Various factors make this population...

The frailty syndrome is a common clinical marker of vulnerability in older adults conducive to an overall decline in inflammatory stress responsiveness; yet little is known about the genetic risk factors for frailty in elderly. Our aim was to investigate the association between the rs2476601 polymorphism in PTPN22 gene and susceptibility to frailty...

The frailty syndrome is a common clinical marker of vulnerability in older adults conducive to an overall decline in inflamma-tory stress responsiveness; yet little is known about the genetic risk factors for frailty in elderly. Our aim was to investigate the association between the rs2476601 polymorphism in PTPN22 gene and susceptibility to frailt...

Objectives The aim of this study was to compare a short and a long version of an intrinsic capacity index and test their cross-sectional association with relevant health outcomes in older adults.DesignCross-sectional analysis of the baseline data of the FraDySMex study.Participants543 community-dwelling adults aged 50 years and older living in 2 mu...

This study examines sources of vulnerabilities to dementia in low resource populations in two specific contexts—Mexico and the United States. Data are drawn from comparable waves of the Mexican Health and Aging Study (MHAS) and the Hispanic Established Populations for the Epidemiologic Study of the Elderly (H-EPESE) in 2012, which include represent...

Introduction: Substantial gaps in research remain across oldest-old ethnic populations while the burden of dementia increases exponentially with age among Mexican and Mexican American older adults. Methods: Prevalence and correlates of dementia among individuals ≥82 years of age were examined using two population-based cohort studies: The Mexica...