Luís Crisóstomo

Luís Crisóstomo
University of Porto | UP · Unit for Multidisciplinary Research in Biomedicine (UMIB)

MSc Biomedical Sciences
PhD Student in Biomedical Sciences, UMIB/ICBAS-UP

About

24
Publications
6,325
Reads
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157
Citations
Introduction
Luís Crisóstomo completed his LSc degree on Biomedical Sciences in 2011. In July of 2013 he finished his MSc Degree on Biomedical Sciences at the University of Beira Interior, Covilhã, Portugal. He is presently a PhD student on Biomedical Sciences, at the Biomedical Sciences Institute of Abel Salazar, University of Porto, Porto, Portugal (ICBAS-UP). His research interests are in the role of glycerol and its metabolism in the testicular cells, particularly in Sertoli cells, and in the paternally induced transgenerational effects of high-fat diets.
Additional affiliations
September 2016 - present
University of Porto
Position
  • PhD Student
September 2016 - January 2019
University of Porto
Position
  • PhD Student
January 2013 - January 2013
Polytechnic Institute of Guarda
Position
  • Lecturer
Description
  • Lecturer of a practical class on Exercise Physiology, “Data acquisition and treatment using the Kosmed® K4b2 device and its physiological principles”, L.Sc. in Sport (4 hours; 40 students).
Education
October 2017 - June 2022
University of Porto
Field of study
  • Biomedical Sciences
October 2013 - July 2014
Universidade da Beira Interior
Field of study
  • Biomedicine
September 2011 - July 2013
Universidade da Beira Interior
Field of study
  • Biomedical Sciences

Publications

Publications (24)
Article
Non-communicable diseases have become the leading cause of death, morbidity, and loss of healthy years worldwide, according to the World Health Organization [...]
Article
Full-text available
Excessive adiposity caused by high-fat diets (HFDs) is associated with testicular metabolic and functional abnormalities up to grand-offspring, but the mechanisms of this epigenetic inheritance are unclear. Here we describe an association of sperm small non-coding RNA (sncRNA) with testicular “inherited metabolic memory” of ancestral HFD, using a t...
Article
Full-text available
Purpose: This study provides a comprehensive analysis of research trends on the etiology, mechanisms, potential risk factors, diagnosis, prognosis, surgical and non-surgical treatment of varicocele, and clinical outcomes before and after varicocele repair. Materials and methods: Varicocele studies published between 1988 and 2020 were retrieved f...
Article
Exposure to a high-fat diet (HFD) from early-life is associated with a testicular metabolic signature linked to abnormal sperm parameters up to two generations after exposure in mice. Hereby, we describe a testicular lipid signature associated with “inherited metabolic memory” of exposure to HFD, persisting up to two generations in mice. Diet-chall...
Article
The renewal of the natural resources is one of the most concerning aspects of modern farming. In animal production, there are many barriers breeders and researchers have to overcome to develop new practices to improve reproductive potential and hasten sexual maturation of the commercially viable species, while maintaining meat quality and sustainab...
Article
Full-text available
The consumption of energy-dense diets has contributed to an increase in the prevalence of obesity and its comorbidities worldwide. The adoption of unhealthy feeding habits often occurs at early age, prompting the early onset of metabolic disease with unknown consequences for reproductive function later in life. Recently, evidence has emerged regard...
Article
The importance of environmental variables in utero has been acknowledged for several decades. Clinical evidence regarding the negative impact of maternal alcohol and drug consumption, tobacco and prescription drug use, unhealthy diet and sedentarism, obesity and diabetes, and pollutant and chemical exposures, have originated guidelines for pregnant...
Article
Full-text available
The most prevalent diseases worldwide are non-communicable such as obesity and type 2 diabetes. Noteworthy, the prevalence of obesity and type 2 diabetes is expected to steadily increase in the next decades, mostly fueled by bad feeding habits, stress, and sedentarism. The reproductive function of individuals is severely affected by abnormal metabo...
Conference Paper
Full-text available
The adoption of high-fat diets (HFDs) is a major contributor to the increasing prevalence of obesity worldwide. Herein, we study the impact of an HFD from early age in testicular physiology and sperm parameters in two generations of mice, with a focus on testicular oxidative status. Mice of the diet-challenged generation (F0; n = 36) were randomly...
Article
Childhood obesity is a serious concern associated with ill health later in life. Emerging data suggest that obesity has long-term adverse effects upon male sexual and reproductive health but few studies addressed this issue. We hypothesized that exposure to high-fat diet during early life alters testicular lipid content and metabolism leading to pe...
Article
Hypogonadism is more frequent among men with common metabolic diseases, notably obesity and type 2 diabetes. Indeed, endocrine disruption caused by metabolic diseases can trigger the onset of hypogonadism, although the underlying molecular mechanisms are not entirely understood. Metabolic diseases are closely related to unhealthy lifestyle choices,...
Article
In recent decades, the prevalence of metabolic diseases has concomitantly increased with a decline on fertility rates and sperm quality. High-fat diets (HFD) are seldom considered part of the problem, but the molecular mechanisms underlying its effects on male fertility remain poorly understood. Herein we postulated that HFD alter sperm quality. We...
Article
Despite conflicting data on doxorubicin (DOX) reproductive toxicity, its chemotherapeutic potential sustains its use to treat different types of cancer. This work was designed to study the protective effect of a newly synthesized thiocyanoacetamide (TA), in comparison with selenium (Se), against doxorubicin-induced in vitro toxicity in rat Sertoli...
Preprint
Full-text available
Mitochondrial respiratory states and rates MitoEAGLE Task Group
Poster
Full-text available
O estilo de vida é um dos principais responsáveis pelo desenvolvimento de doenças metabólicas, nomeadamente obesidade e diabetes tipo II. Os homens afectados por estas doenças demonstram baixos níveis de fertilidade, embora ainda esteja por apurar a relação causa-efeito entre estilo de vida e problemas de fertilidade. Neste estudo foi usado um mode...
Chapter
Sertoli cells play a central role in spermatogenesis. They maintain the blood-testis barrier, an essential feature of seminiferous tubules which creates the proper environment for the occurrence of the spermatogenesis. However, this confinement renders germ cells almost exclusively dependent on Sertoli cells’ nursing function and support. Throughou...
Article
Over the past decades, there have been several studies suggesting that semen quality is declining. Interestingly, these observations are paired with a significant increase in the number of individuals diagnosed with metabolic diseases, including obesity and diabetes mellitus. Hence, it is tempting to hypothesize that obesity and its associated como...
Poster
• During the last decades, we have witnessed a global increasing trend in obesity and metabolic disorders linked to poor food habits, sedentarism and overeating. • By the same time-lapse, fertility levels have dwindled worldwide. Notably, male fertility parameters have shown a downward trend. • Since reproductive function heavily depends on bioener...
Article
Full-text available
The main purpose of this article was to analyse the perceptions of Portuguese swimmers about their context of sport development. We studied the perceptions of 207 Portuguese national level swimmers (Junior and Senior), both males and females, from 28 swimming clubs. The swimmers were differentiated into three groups, according to the club performan...
Article
Full-text available
During the recent decades, we have witnessed fertility rates dwindling worldwide, while metabolic diseases followed an opposite tendency, with their prevalence dramatically increasing [1-3]. Those trends are particularly marked in both developed and under-development countries, where type 2 diabetes mellitus (T2DM) and obesity are key players in th...
Article
Endogenous hormones are essential on the control of physiological reactions and adaptations during sport performance. This study aims to compare the mood state and the salivary levels of cortisol and testosterone during an official female association football tournament. Twenty female football players (22.85 ± 4.2 yrs) from the Portuguese women's n...
Article
Background: Variants genotypes of glutathione S-transferases (GSTs) lead to the inactive or less active form of the isoenzymes, which may alter protection against oxidative stress. Research question: Analyse the influence of GSTM1 and GSTT1 null polymorphisms on event expertise in high-level Portuguese swimmers. Methods: A group of high-level Portu...
Thesis
Full-text available
Physical exercise have several health benefits, but it can also be a source of cellular damage. The energetic demands of physical exercise and training promote an increase on metabolic rate, and its pathways may produce secondary harmful compounds that will cause cellular damage. Some of those compounds are the free radicals and Reactive Oxygen spe...
Presentation
Full-text available
Neste estudo, o objectivo foi verificar as variações na expressão de dois genes, relativos às enzimas Glutationa S-transferase T1 e M1, as quais têm influência na protecção antioxidante (Ramalhinho et al., 2011). O treino é uma importante fonte de stress oxidativo nos atletas, uma vez que a actividade física requer um maior consumo de oxigénio, de...

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Projects

Project (1)
Archived project
- Highlight some mechanism and metabolic process involved in this newly produced form of thioamide. - Reduce doxorubicin toxicity in testis. - Study the ability of selenium to prevent or not the toxicity of doxorubicin. - Investigate the impact of doxorubicin on Sertoli and Leydig cells.... - Study the impact of the association of selenium or thiocyanoacetamide with doxorubicin on mitochondria function and apoptosis.