Lufei Young

Lufei Young
Augusta University · Department of Physiological and Technological Nursing

PhD APRN-NP

About

93
Publications
9,121
Reads
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814
Citations
Additional affiliations
November 2011 - present
University of Nebraska Medical Center
Position
  • Research Assistant
December 2010 - June 2016
University of Nebraska Medical Center
Position
  • Faculty Member

Publications

Publications (93)
Article
Background Previous research in non-dialysis patients suggests that the inflammatory skin disease psoriasis is associated with an increased risk of severe vascular events like myocardial infarction (MI). Thus, we determined whether psoriasis represents a significant risk factor for MI in end-stage renal disease (ESRD) patients. Methods We queried...
Article
Introduction The left ventricular assist device (VAD) is commonly used as the bridge-to-transplantation therapy for heart failure patients who are on waitlist of heart transplant. The caregivers’ adherence to the homecare regimen plays a vital role in patient outcomes. There is little evidence about the factors related to the caregiver adherence. T...
Article
Patients with end-stage renal disease (ESRD) are 8-10 times more likely to suffer from a stroke compared with the general public. Despite this risk, there are minimal data elucidating which hemodialysis modality is best for patients with ESRD following a stroke, and guidelines for their management are lacking. We retrospectively queried the US Rena...
Article
Background : Psoriasis is a common chronic inflammatory skin disease associated with an increased risk for acute infections. Because chronic kidney disease is a risk factor for pneumonia, end-stage renal disease (ESRD) patients with psoriasis may have an increased risk for acquiring pneumonia. Methods : A retrospective cohort analysis was performe...
Article
Full-text available
PGD2 released from immune cells or other cell types activates its receptors, DP1 and DP2, to promote inflammatory responses in allergic and lung diseases. Prostaglandin-mediated inflammation may also contribute to vascular diseases such as abdominal aortic aneurysms (AAA). However, the role of DP receptors in the pathogenesis of AAA has not been sy...
Article
Introduction: Within the hospital setting, analgesics are prescribed for use with specific parameters of pain; often labeled as (a) mild, (b) moderate, (c) severe, or (d) breakthrough. These subjective parameters are utilized casually. From a clinician perspective, analgesic regimens are discussed collaboratively, though there is a question about t...
Article
Renal transplant patients are immunosuppressed and are at increased risk of opportunistic infections, including Nocardia infection. In renal transplant patients, information on the incidence and risk factors associated with nocardiosis is limited. To address the incidence and risk factors associated with nocardiosis in a large renal transplant popu...
Article
The concept of breakthrough pain (BTP) is examined through the development of a conceptual model with a long-term goal of positively impacting the management of chronic pain patients who experience BTP when hospitalized. The model is based on a 2008 Health Economic Model of Breakthrough Pain developed by Abernethy, Wheeler, and Fortner, which will...
Article
Full-text available
Studies have suggested that handgrip strength might be a marker for cardiometabolic risk (CMR), but it has not been studied in Hispanic/Latino farmworker population. This study aimed to characterize absolute and relative handgrip strength in Hispanic/Latino farmworkers, and investigate the sex-specific association between handgrip strength and CMR...
Article
Background Psoriasis impairs the quality of life of approximately 7.5 million Americans and is associated with serious comorbidities. Because of chronic vascular access and epidermal dysfunction, end-stage renal disease (ESRD) patients with psoriasis may be at greater risk for infection, and psoriasis treatment could affect this risk. Methods A re...
Article
Intraocular pressure was found to be significantly correlated with body mass index (BMI), waist circumference, and diastolic blood pressure (DBP) in a farmworker population located in the southeast Georgia, USA. BMI was correlated with intraocular pressure, independent of systemic blood pressures. Purpose: Elevated intraocular pressure (IOP) is a...
Article
Background Spinal epidural abscess (SEA) is an uncommon and highly morbid infection of the epidural space. End-stage renal disease (ESRD) patients are known to be at increased risk of developing SEA; however, there are no studies that have described the risk factors and outcomes of SEA in ESRD patients utilizing the United States Renal Data System...
Article
Full-text available
Introduction: Abdominal aortic aneurysms (AAA) are characterized by localized inflammation, extracellular matrix degradation, and apoptosis of smooth muscle cells, which together lead to progressive and irreversible aortic dilation. Major risk factors for AAA include smoking and aging, both of which prominently alter gene expression via epigenetic...
Article
Although cardiac rehabilitation (CR) is clearly beneficial to improving patients' physical functioning and reducing heart disease progression, significant proportions of patients do not complete CR programs. To evaluate the prevalence and predictors of completion of a center-based CR program in eligible cardiac patients, existing data collected fro...
Article
Full-text available
Social determinants of health that have been examined in relation to myocardial infarction incidence and survival include socioeconomic status (income, education), neighbourhood disadvantage, immigration status, social support, and social network. Other social determinants of health include geographic factors such as neighborhood access to health s...
Article
Background Resuming participation in society is an important goal of post-stroke rehabilitation. Exercise-based interventions have been shown to be effective non-pharmacological methods for improving social participation in post-stroke survivors, however it is unclear what the most effective types of exercise interventions are. Objective To assess...
Article
Full-text available
Background: For those living with type 2 diabetes mellitus (T2DM), failing to engage in self-management behaviors leads to poor glycemic control. Social cognitive theory (SCT) has been shown to improve health behaviors by altering cognitive processes and increasing an individual's belief in their ability to accomplish a task. Objective: We aim t...
Article
Human papillomavirus (HPV) causes the majority of cervical, anal/rectal, and oropharyngeal cancers in women. End-stage renal disease (ESRD) is also associated with an increased risk of malignancy, but the incidence of and risk factors for HPV-associated cancers in US dialysis patients are not defined. We queried the US Renal Data System for women w...
Article
Objectives Compare the daily calories and protein intake of hemodialysis patients by plant- vs. animal-based food consumption. Methods A retrospective, secondary analysis of baseline data from food frequency questionnaire and laboratory testing data of the Dialysis survey (CDS) study was performed. The CDS survey was conducted in hemodialysis pati...
Article
Full-text available
It is essential to have an effective care process to promote colorectal cancer (CRC) screening particularly in rural areas. Primary care health care providers may have a significant impact on improving CRC screening rates among rural residents through systematic screening processes in their clinics. In this qualitative study, we aimed to explore th...
Article
Background: Arthritis is one of the most common comorbidities in heart failure (HF) patients, and is associated with decreased activity levels. Few studies have examined sedentary behavior (SB) in HF patients with arthritis, and little is known about the factors that may influence SB in this population. Methods: This is a retrospective, secondar...
Article
Objective To determine the sources of protein and phosphorus levels from the food consumed by patients on dialysis. Design and Methods This is a retrospective, secondary data analysis of the Comprehensive Dialysis Survey study participants who had a baseline food frequency questionnaire and baseline lab data (N = 358). We examined intake of protei...
Article
Full-text available
Background Patients with human immunodeficiency virus (HIV) or end-stage renal disease receiving dialysis have an increased risk of developing malignancies, but few data are available on cancer in patients with both conditions. Thus, the objective of this study was to determine the incidence of selected malignancies and identify their potential ris...
Preprint
BACKGROUND For those living with type 2 diabetes mellitus (T2DM), failing to engage in self-management behaviors leads to poor glycemic control. Social cognitive theory (SCT) has been shown to improve health behaviors by altering cognitive processes and increasing an individual’s belief in their ability to accomplish a task. OBJECTIVE We aim to pr...
Article
Background: Nonactionable alarms comprise over 70% of alarms and contribute a threat to patient safety. Few studies have reported approaches to translate and sustain these interventions in clinical settings. Purpose: This study tested whether an interprofessional team-based approach can translate and implement effective alarm reduction intervent...
Article
Full-text available
Background: Increasing efforts have been made in primary care settings to screen for a broad array of social determinants of health including inadequate food and nutrition, lack of education, unemployment, and inadequate housing, and to refer patients to community resources. Core tenets of primary care include integration with community resources....
Article
Full-text available
It is essential to have an effective care process to promote colorectal cancer (CRC) screening particularly in rural areas. Primary care health care providers may have a significant impact on improving CRC screening rates among rural residents through systematic screening processes in their clinics. In this qualitative study, we aimed to explore th...
Article
ABSTRACT To compare the effectiveness of different non-pharmacological interventions on pain relief in older adults with osteoarthritis (OA), literature databases, bibliographies, and other relevant sources were searched. No language limitations were applied. Thirty-two trials published from 1997 to 2017 were included in the systematic review and n...
Article
Full-text available
Although they have been widely studied, important questions remain about the impact of breast cancer survivorship care plans on improving health outcomes. The goal of this article was to review published studies on the impact of cancer survivorship care plans on health outcomes and health care delivery among breast cancer survivors. A total of 111...
Article
Group-based physiotherapy-led behavioral psychological interventions (GPBPIs) are an emerging treatment for chronic low back pain (CLBP), but the efficacy of these interventions is uncertain. A review of relevant randomized controlled trials and a meta-analysis was conducted to evaluate the effectiveness of GPBPIs on pain relief in adults with CLBP...
Article
Background: Caring for individuals with progressive, disabling forms of multiple sclerosis (MS) presents ongoing, complex challenges in health care delivery, especially access to care. While limitations in mobility represent a major hurdle to accessing comprehensive and coordinated care,7 fragmentation in current models of health care delivery magn...
Article
The purpose of this updated meta-analysis was to investigate the effect of nitric oxide synthase-3 (NOS3) G894T polymorphisms, air pollution and their interaction on ischemic heart disease (IHD) risk across populations worldwide. Recursive partition trees, nonlinear association curve fit and geographic information system maps were incorporated to v...
Article
Objective: To identify patient, provider, and delivery system-level factors associated with colorectal cancer (CRC) screening and validate findings across multiple data sets. Design: A concurrent mixed-methods design using electronic health records, provider survey, and provider interview. Setting: Eight primary care accountable care organizat...
Article
Many Veterans Affairs (VA) patients with the complications of cardiometabolic syndrome (CMS) use both VA and community providers and facilities outside of VA. Although dual health care systems increase care options, dual use also increases coordination needs. The fragmentation and duplication of health care due to the use of multiple facilities and...
Article
Ischemic heart disease (IHD) is among the leading causes of death worldwide. Methylenetetrahydrofolate reductase (MTHFR) polymorphisms have been associated with IHD risk, but the findings presented with heterogeneity. The purpose of the present meta-analysis was to provide an updated evaluation by integrating machine-learning based analytics to exa...
Article
The fragmentation and lack of coordination of health care may result in less efficient and more costly care and lead to poorer outcomes. There has been increasing interest in examining cancer outcomes among persons who are dually enrolled in Medicare and Medicaid. Previous studies have identified disparities in the quality of cancer treatment accor...
Article
Background: Simulation plays a vital role in nursing education, however, modifiable factors influencing students' simulation performance have not been sufficiently examined. The purpose of this study was examine relationships among anxiety, self-efficacy, nursing knowledge, and performance during simulation. Methods: The study used a mixed-methods...
Article
Background: High mortality in dialysis patients may be associated with protein-energy wasting (PEW) syndrome characterized by progressively depleted protein and energy stores. While early diagnosis and treatment of PEW can reduce mortality, clinically practical measures for its detection are lacking. Poor dietary protein intake (DPI) is associated...
Article
Background: There has been increasing interest in the use of web portals by patients with type 2 diabetes mellitus (T2DM). Studies of web portal use by patients with pre-diabetes have not been reported. To plan studies of web portal use by adult clinic patients seen for pre-diabetes and T2DM at an academic medical center, we examined characteristic...
Article
Full-text available
Background Patient portals and other Internet-based technologies have been increasingly used to improve cancer care coordination. Patient portals may introduce special considerations in oncology populations where longitudinal outpatient care is often more intensive than in most other specialties. Methods This article, which is based upon bibliogra...
Poster
BACKGROUND: Antipsychotic-associated obesity is prevalent, causing significant non-adherence and development of cardiovascular. To make matters worse, the antipsychotic related weight gain is heterogeneous with large inter-individual variability. Much of the inter-individual variability is due to genetic factors. OBJECTIVES: The objective of this s...
Article
Full-text available
1) Background: Physical inactivity is prevalent in rural heart failure (HF) patients. To evaluate the effectiveness of interventions aimed at improving physical activity (PA), we need an accurate, reliable PA assessment tool that is feasible and acceptable to HF patients. The purpose of this study was to examine the feasibility of using an accelero...
Article
Colorectal Cancer (CRC) screening is vital to reduce CRC motility rate and primary care providers (PCP) play an essential role in promoting CRC screening. This study examines the CRC screening barriers perceived by PCPs and their associations with provider characteristics and practice features using data collected through a survey administered in f...
Article
Purpose: The purpose of this study was to validate methyl donor intakes between 30-day food frequency questionnaire (FFQ) and 24-hour food record (FR) in a colorectal cancer study. Background: Dietary methyl donors play pivotal roles in cancer prevention by promoting adequate metabolism and DNA methylation. The FFQ and 24-hour FR are the most commo...
Article
Purpose: The purpose of this new ground-breaking project is to identify different methylation patterns across human genome for oncogenes and genes in the methylation pathways for cancer prevention. Background: Chronic health conditions can lead to cancer with altered epigenetics cardiovascular phenotypes including differential methylation and gene...
Poster
Purpose: The purpose of this study was to validate methyl donor intakes between 30-day food frequency questionnaire (FFQ) and 24-hour food record (FR) in a colorectal cancer study. Background: Dietary methyl donors play pivotal roles in cancer prevention by promoting adequate metabolism and DNA methylation. The FFQ and 24-hour FR are the most commo...
Article
Introduction: Despite the known benefits of colorectal cancer (CRC) screening, rural areas have consistently reported lower screening rates than their urban counterparts. Alternative healthcare delivery models, such as accountable care organizations (ACOs), have the potential to increase CRC rates through collaboration among healthcare providers w...
Article
Background: Alzheimer’s disease (AD) is a significant public health issue. AD has been linked with methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism, but findings have been inconsistent. The purpose of this meta-predictive analysis is to examine the associations between MTHFR polymorphisms and epigenetic factors including air pollution...
Article
Full-text available
Background: Self-management (SM) is an essential component of heart failure (HF) management. The mechanisms to improve SM behaviors are unclear. Objective: The objective of this study is to examine whether patient activation mediates the effect of self-efficacy on SM behaviors in rural HF patients. Methods: A secondary analysis was conducted u...
Article
Full-text available
The major objective of this study was to examine the association between Methylenetetrahydrofolate Reductase (MTHFR) polymorphisms and the risk of various types of leukemias across the lifespans of children and adults by using the meta-predictive techniques. The secondary objective was to examine the interactions among epigenetic risk factors (incl...
Article
Using the meta-predictive techniques, the major objective of this study was to examine the association between Methylenetetrahydrofolate Reductase (MTHFR) polymorphisms and the risk of various types of leukemias across lifespan of children and adults. And, the secondary objective was to examine the interactions between epigenetic risk factors inclu...
Presentation
Background: CBPC programs have potential to deliver improved quality of life & cost-effective health outcomes for a vulnerable population. Research in the development & evaluation of CBPC programs is scant. Lack of evidence has significant implications for a population in need of cost-effective care solutions that promote QoL, &drive quality health...
Article
Full-text available
Background: Delayed admission to palliative and hospice services is prevalent and, especially in rural areas, contributing to poor quality of care, caregiver stress and burden, reducing patients’ and their caregivers' quality of life and increasing healthcare costs. A reliable and sensitive screening tool would help clinicians identify patients in...
Article
Heart failure (HF) is one of the most common chronic and disabling illnesses, resulting in high morbidity and mortality. Readmission rate, one key indicator of healthcare quality and healthcare utilization, is prevalent in HF patients. Inconsistent evidences exist about the impact of rural health disparities on HF patients’ readmission. The purpose...
Article
Full-text available
Background Heart failure (HF) patients discharged from rural hospitals have higher 30-day readmission rates. Self-management (SM) reduces readmissions, but adherence to SM guidelines is low in the rural HF population. We tested a home-based intervention to enhance patient activation and lead to improved SM adherence. Methods In this two-group, repe...
Article
Background: Heart failure is a major public health problem, and self-management is the primary approach to control the progression of heart failure. The low research participation rate among rural patients hinders the generation of new evidence for improving self-management in rural heart failure patients. Purpose: The purpose of this study is to i...
Article
Self-management plays a vital role in improving health outcomes and reducing costs in patients with cardiovascular disease (CVD) and associated risk factors. Based on existing studies, rural residents with CVD and/or risk factors show low engagement in self-management behaviors. Due to low participation in behavioral intervention trials, the most p...
Article
Aim: The purpose of this study was to examine the relationships among self-efficacy, patient activation and SM in rural heart failure patients discharged from critical access hospitals. Background: Heart failure is one of the most disabling and resource-consuming chronic conditions. Compared to their urban counterparts, rural heart failure patients...
Article
Background Disability is prevalent in individuals with multiple sclerosis (MS), leading to difficulty in care access, significant caregiver burden, immense challenges in self-care and great societal burden. Without highly coordinated, competent and accessible care, individuals living with progressive MS experience psychological distress, poor quali...
Article
Rural residents diagnosed with cardiovascular disease (CVD) or with CVD-related risks are underrepresented in behavioral intervention trials based on an extensive review of published studies. The low participation rate of rural residents weakens both the internal and external validity of published studies. Moreover, compared to urban residents, lim...
Article
Although mortality rates of colorectal cancer (CRC) can be significantly reduced through increased screening, rural communities are still experiencing lower rates of screening compared to urban counterparts. Understanding and eliminating barriers to cancer screening will decrease cancer burden and lead to substantial gains in quality and quantity o...
Article
Non-adherence to self-management guidelines accounted for 50% of hospital readmissions in heart failure patients. Evidence showed that patient activation affects self-management behaviors in populations living with chronic conditions. The purpose of this study was to describe patient activation level and its relationship with knowledge, self-effica...
Article
Background Heart failure is one of the most prevalent chronic conditions in adults, leading to prolonged morbidity, repeated hospitalizations, and placing tremendous economic burden on the healthcare system. Heart failure patients discharged from rural hospitals, or primarily critical access hospitals, have higher 30-day readmission and mortality r...
Article
Full-text available
Lufei Young, PhD, APRN-NP, Susan Barnason, PhD, APRN-CNS, Krystal Hays, MSN, RN, Van Do, MD Medication discrepancies are common in cardiac patients discharged from hospital to home, leading to increased risk for adverse drug events and hospital readmissions. Medication reconciliation identifies discrepancies and reduces medication error–related ad...
Article
PurposeHigh sodium intake increases the risk of cardiovascular diseases. Cardiac patients are recommended a daily sodium restriction of ≤1,500 mg. The purpose of this article is to describe daily sodium intake and sodium restriction adherence and its correlates in cardiac rehabilitation (CR) program participants following cardiac revascularizations...
Article
Background Heart failure is one of the most prevalent chronic conditions in adults, leading to prolonged morbidity, repeated hospitalizations, and placing tremendous economic burden on the healthcare system. Heart failure patients discharged from rural hospitals, or primarily critical access hospitals, have higher 30-day readmission and mortality r...